Dgkb (diacylglycerol kinase, beta) - Rat Genome Database

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Pathways
Gene: Dgkb (diacylglycerol kinase, beta) Rattus norvegicus
Analyze
Symbol: Dgkb
Name: diacylglycerol kinase, beta
RGD ID: 2488
Description: Enables ATP-dependent diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human DGKB (diacylglycerol kinase beta); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 90 kDa diacylglycerol kinase; DAG kinase beta; Dagk; DGK-beta; Diacylglycerol kinase 90kDa; diacylglycerol kinase beta; diacylglycerol kinase beta 90kDa; diacylglycerol kinase beta, 90kDa; diglyceride kinase beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8660,368,101 - 61,124,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl660,368,519 - 61,124,420 (+)EnsemblGRCr8
mRatBN7.2654,640,948 - 55,397,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl654,641,614 - 55,397,043 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx654,944,919 - 55,700,844 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0655,259,803 - 56,015,739 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0654,718,536 - 55,474,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0657,516,351 - 58,277,385 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl657,516,713 - 58,277,279 (+)Ensemblrn6Rnor6.0
Rnor_5.0667,113,446 - 67,580,128 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0667,693,661 - 67,868,706 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4656,715,327 - 57,479,656 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera653,755,433 - 54,502,520 (+)NCBICelera
RGSC_v3.1656,718,452 - 57,482,782 (+)NCBI
RH 3.4 Map6394.3RGD
Cytogenetic Map6q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. Caricasole A, etal., J Biol Chem. 2002 Feb 15;277(7):4790-6. Epub 2001 Nov 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Goto K and Kondo H, Proc Natl Acad Sci U S A 1993 Aug 15;90(16):7598-602.
4. Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Hozumi Y, etal., Eur J Neurosci. 2008 Dec;28(12):2409-22.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. Sato M, etal., Pharmacology. 2013;92(1-2):99-107. doi: 10.1159/000351849. Epub 2013 Aug 16.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12832407   PMID:15896305   PMID:16019106   PMID:19691842   PMID:19826069   PMID:20657643   PMID:22627129   PMID:23012479   PMID:23467923   PMID:23503970   PMID:30053369  


Genomics

Comparative Map Data
Dgkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8660,368,101 - 61,124,420 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl660,368,519 - 61,124,420 (+)EnsemblGRCr8
mRatBN7.2654,640,948 - 55,397,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl654,641,614 - 55,397,043 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx654,944,919 - 55,700,844 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0655,259,803 - 56,015,739 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0654,718,536 - 55,474,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0657,516,351 - 58,277,385 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl657,516,713 - 58,277,279 (+)Ensemblrn6Rnor6.0
Rnor_5.0667,113,446 - 67,580,128 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0667,693,661 - 67,868,706 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4656,715,327 - 57,479,656 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera653,755,433 - 54,502,520 (+)NCBICelera
RGSC_v3.1656,718,452 - 57,482,782 (+)NCBI
RH 3.4 Map6394.3RGD
Cytogenetic Map6q21NCBI
DGKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38714,145,049 - 14,974,858 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl714,145,049 - 14,974,833 (-)Ensemblhg38GRCh38
GRCh37714,184,674 - 15,014,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36714,153,770 - 14,847,413 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34713,988,847 - 14,654,128NCBI
Celera714,163,789 - 14,859,377 (-)NCBICelera
Cytogenetic Map7p21.2NCBI
HuRef714,066,966 - 14,764,852 (-)NCBIHuRef
CHM1_1714,184,411 - 14,880,671 (-)NCBICHM1_1
T2T-CHM13v2.0714,277,079 - 15,107,587 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2714,235,562 - 14,932,596 (-)NCBI
Dgkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,930,169 - 38,684,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,867,725 - 38,684,238 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381237,880,169 - 38,634,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,817,726 - 38,634,239 (+)Ensemblmm10GRCm38
MGSCv371238,607,292 - 39,359,997 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361238,390,971 - 39,143,797 (+)NCBIMGSCv36mm8
Celera1239,316,859 - 40,057,925 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1217.11NCBI
Dgkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541017,676,930 - 18,243,869 (-)Ensembl
ChiLan1.0NW_00495541017,677,375 - 18,304,409 (-)NCBIChiLan1.0ChiLan1.0
DGKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2618,981,332 - 19,816,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1767,306,052 - 68,141,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0714,803,023 - 15,638,280 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1714,142,951 - 14,896,676 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl714,165,933 - 14,969,825 (-)EnsemblpanPan2panpan1.1
DGKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11428,916,630 - 29,609,138 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1428,918,351 - 29,537,303 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1428,434,629 - 29,133,432 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01428,827,965 - 29,521,435 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1428,826,426 - 29,521,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11428,918,649 - 29,617,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01428,647,672 - 29,348,080 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01428,958,514 - 29,660,097 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dgkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511873,288,180 - 74,005,408 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936546963,064 - 1,615,984 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936546964,387 - 1,615,928 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl983,569,932 - 84,510,087 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1983,571,927 - 84,358,712 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2992,175,666 - 92,485,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DGKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12143,176,715 - 43,929,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2143,176,989 - 43,746,258 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604260,567,411 - 61,318,935 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473915,186,115 - 15,821,907 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473915,185,294 - 15,821,293 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dgkb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1751,149,152 - 51,863,944 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dgkb
6942 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:441
Count of miRNA genes:238
Interacting mature miRNAs:313
Transcripts:ENSRNOT00000063874
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
D6Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,641,001 - 54,641,141 (+)MAPPERmRatBN7.2
Rnor_6.0657,516,400 - 57,516,539NCBIRnor6.0
Rnor_5.0667,112,834 - 67,112,973UniSTSRnor5.0
RGSC_v3.4656,714,714 - 56,714,969RGDRGSC3.4
RGSC_v3.4656,714,715 - 56,714,854UniSTSRGSC3.4
Celera653,754,821 - 53,754,960UniSTS
RGSC_v3.1656,717,841 - 56,717,980RGD
RH 3.4 Map6395.5RGD
RH 3.4 Map6395.5UniSTS
RH 2.0 Map6579.9RGD
SHRSP x BN Map640.9199RGD
Cytogenetic Map6q21UniSTS
D6Got70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,224,992 - 55,225,108 (+)MAPPERmRatBN7.2
Rnor_6.0658,104,802 - 58,104,917NCBIRnor6.0
Rnor_5.0667,696,162 - 67,696,277UniSTSRnor5.0
RGSC_v3.4657,302,954 - 57,303,070RGDRGSC3.4
RGSC_v3.4657,302,955 - 57,303,070UniSTSRGSC3.4
Celera654,332,731 - 54,332,846UniSTS
RGSC_v3.1657,306,081 - 57,306,196RGD
RH 3.4 Map6391.1UniSTS
RH 3.4 Map6391.1RGD
RH 2.0 Map6569.1RGD
Cytogenetic Map6q21UniSTS
D6Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,856,132 - 54,856,244 (+)MAPPERmRatBN7.2
Rnor_6.0657,732,401 - 57,732,512NCBIRnor6.0
Rnor_5.0667,327,923 - 67,328,034UniSTSRnor5.0
RGSC_v3.4656,930,193 - 56,930,305RGDRGSC3.4
RGSC_v3.4656,930,194 - 56,930,305UniSTSRGSC3.4
Celera653,969,571 - 53,969,682UniSTS
RGSC_v3.1656,933,319 - 56,933,431RGD
Cytogenetic Map6q21UniSTS
BF400076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,994,939 - 54,995,174 (+)MAPPERmRatBN7.2
Rnor_6.0657,870,846 - 57,871,080NCBIRnor6.0
Rnor_5.0667,465,896 - 67,466,130UniSTSRnor5.0
RGSC_v3.4657,070,530 - 57,070,764UniSTSRGSC3.4
Celera654,108,428 - 54,108,662UniSTS
RH 3.4 Map6394.5UniSTS
Cytogenetic Map6q21UniSTS
RH127545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,396,852 - 55,397,058 (+)MAPPERmRatBN7.2
Rnor_6.0658,277,028 - 58,277,233NCBIRnor6.0
Rnor_5.0667,868,518 - 67,868,723UniSTSRnor5.0
RGSC_v3.4657,479,468 - 57,479,673UniSTSRGSC3.4
Celera654,502,332 - 54,502,537UniSTS
RH 3.4 Map6394.8UniSTS
Cytogenetic Map6q21UniSTS
RH144556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,394,730 - 55,394,897 (+)MAPPERmRatBN7.2
Rnor_6.0658,274,906 - 58,275,072NCBIRnor6.0
Rnor_5.0667,866,396 - 67,866,562UniSTSRnor5.0
RGSC_v3.4657,477,346 - 57,477,512UniSTSRGSC3.4
Celera654,500,210 - 54,500,376UniSTS
RH 3.4 Map6386.5UniSTS
Cytogenetic Map6q21UniSTS
BF386108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,014,897 - 55,015,060 (+)MAPPERmRatBN7.2
Rnor_6.0657,891,687 - 57,891,849NCBIRnor6.0
Rnor_5.0667,487,047 - 67,487,209UniSTSRnor5.0
RGSC_v3.4657,090,486 - 57,090,648UniSTSRGSC3.4
Celera654,128,840 - 54,129,002UniSTS
RH 3.4 Map6394.5UniSTS
Cytogenetic Map6q21UniSTS
BF386309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,932,902 - 54,933,055 (+)MAPPERmRatBN7.2
Rnor_6.0657,808,787 - 57,808,939NCBIRnor6.0
Rnor_5.0667,403,967 - 67,404,119UniSTSRnor5.0
RGSC_v3.4657,006,994 - 57,007,146UniSTSRGSC3.4
Celera654,046,210 - 54,046,362UniSTS
RH 3.4 Map6395.0UniSTS
Cytogenetic Map6q21UniSTS
RH94439  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,395,182 - 55,395,382 (+)MAPPERmRatBN7.2
Rnor_6.0658,275,358 - 58,275,557NCBIRnor6.0
Rnor_5.0667,866,848 - 67,867,047UniSTSRnor5.0
RGSC_v3.4657,477,798 - 57,477,997UniSTSRGSC3.4
Celera654,500,662 - 54,500,861UniSTS
RH 3.4 Map6394.3UniSTS
Cytogenetic Map6q21UniSTS
RH135215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,868,283 - 54,868,464 (+)MAPPERmRatBN7.2
Rnor_6.0657,744,550 - 57,744,730NCBIRnor6.0
Rnor_5.0667,340,072 - 67,340,252UniSTSRnor5.0
RGSC_v3.4656,942,343 - 56,942,523UniSTSRGSC3.4
Celera653,981,653 - 53,981,833UniSTS
RH 3.4 Map6385.4UniSTS
Cytogenetic Map6q21UniSTS
AU049028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,012,819 - 55,013,036 (+)MAPPERmRatBN7.2
Rnor_6.0657,889,315 - 57,889,531NCBIRnor6.0
Rnor_5.0667,484,675 - 67,484,891UniSTSRnor5.0
RGSC_v3.4657,088,409 - 57,088,625UniSTSRGSC3.4
Celera654,126,763 - 54,126,979UniSTS
Cytogenetic Map6q21UniSTS
S0226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2655,349,322 - 55,349,902 (+)MAPPERmRatBN7.2
Rnor_6.0658,229,234 - 58,229,814NCBIRnor6.0
Rnor_5.0667,820,724 - 67,821,304UniSTSRnor5.0
RGSC_v3.4657,431,934 - 57,432,513UniSTSRGSC3.4
RGSC_v3.41261,970,823 - 261,971,685UniSTSRGSC3.4
Celera654,454,803 - 54,455,382UniSTS
Celera1250,430,238 - 250,431,100UniSTS
Cytogenetic Map6q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 65 156 64 63 32 37 32 6 265 135 11 134 75 89 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide D16100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000063874   ⟹   ENSRNOP00000058842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl660,368,588 - 61,124,420 (+)Ensembl
mRatBN7.2 Ensembl654,641,614 - 55,397,043 (+)Ensembl
Rnor_6.0 Ensembl657,516,713 - 58,277,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111621   ⟹   ENSRNOP00000082015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl660,368,519 - 61,124,251 (+)Ensembl
mRatBN7.2 Ensembl654,641,614 - 55,397,043 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134799   ⟹   ENSRNOP00000106123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl660,368,519 - 61,121,637 (+)Ensembl
RefSeq Acc Id: NM_019304   ⟹   NP_062177
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,588 - 61,124,420 (+)NCBI
mRatBN7.2654,641,380 - 55,397,210 (+)NCBI
Rnor_6.0657,517,012 - 58,277,216 (+)NCBI
Rnor_5.0667,113,446 - 67,580,128 (+)NCBI
Rnor_5.0667,693,661 - 67,868,706 (+)NCBI
RGSC_v3.4656,715,327 - 57,479,656 (+)RGD
Celera653,755,433 - 54,502,520 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764649   ⟹   XP_008762871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,393 - 61,124,253 (+)NCBI
mRatBN7.2654,641,591 - 55,393,530 (+)NCBI
Rnor_6.0657,517,038 - 58,277,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594328   ⟹   XP_017449817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,138 - 61,124,253 (+)NCBI
mRatBN7.2654,640,948 - 55,393,530 (+)NCBI
Rnor_6.0657,516,351 - 58,277,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594329   ⟹   XP_017449818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,383 - 61,124,253 (+)NCBI
mRatBN7.2654,641,591 - 55,393,530 (+)NCBI
Rnor_6.0657,517,038 - 58,277,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594330   ⟹   XP_017449819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,140 - 61,124,253 (+)NCBI
mRatBN7.2654,640,950 - 55,393,530 (+)NCBI
Rnor_6.0657,516,352 - 58,277,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262360   ⟹   XP_063118430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,141 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262361   ⟹   XP_063118431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,393 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262362   ⟹   XP_063118432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,101 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262363   ⟹   XP_063118433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,393 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262364   ⟹   XP_063118434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,138 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262365   ⟹   XP_063118435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,393 - 61,124,253 (+)NCBI
RefSeq Acc Id: XM_063262366   ⟹   XP_063118436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8660,368,140 - 61,124,253 (+)NCBI
RefSeq Acc Id: NP_062177   ⟸   NM_019304
- UniProtKB: P49621 (UniProtKB/Swiss-Prot),   F1LP01 (UniProtKB/TrEMBL),   A6HBB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762871   ⟸   XM_008764649
- Peptide Label: isoform X1
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449817   ⟸   XM_017594328
- Peptide Label: isoform X1
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449819   ⟸   XM_017594330
- Peptide Label: isoform X3
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449818   ⟸   XM_017594329
- Peptide Label: isoform X3
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058842   ⟸   ENSRNOT00000063874
Ensembl Acc Id: ENSRNOP00000082015   ⟸   ENSRNOT00000111621
RefSeq Acc Id: XP_063118432   ⟸   XM_063262362
- Peptide Label: isoform X4
- UniProtKB: P49621 (UniProtKB/Swiss-Prot),   A0A8I5ZWT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118434   ⟸   XM_063262364
- Peptide Label: isoform X5
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118436   ⟸   XM_063262366
- Peptide Label: isoform X6
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118430   ⟸   XM_063262360
- Peptide Label: isoform X2
- UniProtKB: P49621 (UniProtKB/Swiss-Prot),   A6HBB8 (UniProtKB/TrEMBL),   F1LP01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118433   ⟸   XM_063262363
- Peptide Label: isoform X5
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118431   ⟸   XM_063262361
- Peptide Label: isoform X4
- UniProtKB: P49621 (UniProtKB/Swiss-Prot),   A0A8I5ZWT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118435   ⟸   XM_063262365
- Peptide Label: isoform X6
- UniProtKB: P49621 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000106123   ⟸   ENSRNOT00000134799
Protein Domains
DAGKc   EF-hand   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49621-F1-model_v2 AlphaFold P49621 1-801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2488 AgrOrtholog
BioCyc Gene G2FUF-37770 BioCyc
Ensembl Genes ENSRNOG00000030771 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000063874 ENTREZGENE
  ENSRNOT00000111621 ENTREZGENE
  ENSRNOT00000134799 ENTREZGENE
Gene3D-CATH 1.10.238.110 UniProtKB/Swiss-Prot
  2.60.200.40 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/Swiss-Prot
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C1_DGKbeta-like_rpt1 UniProtKB/Swiss-Prot
  C1_DGKbeta_rpt2 UniProtKB/Swiss-Prot
  DAG_kinase_typeI_N UniProtKB/Swiss-Prot
  DGK UniProtKB/Swiss-Prot
  DGK_typeI_N_sf UniProtKB/Swiss-Prot
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
KEGG Report rno:54248 UniProtKB/Swiss-Prot
NCBI Gene 54248 ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE BETA UniProtKB/Swiss-Prot
  PTHR11255 UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  DAG_kinase_N UniProtKB/Swiss-Prot
  DAGK_acc UniProtKB/Swiss-Prot
  DAGK_cat UniProtKB/Swiss-Prot
  EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Dgkb PhenoGen
PROSITE DAGK UniProtKB/Swiss-Prot
  EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030771 RatGTEx
SMART DAGKa UniProtKB/Swiss-Prot
  DAGKc UniProtKB/Swiss-Prot
  EFh UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
TIGR TC231297
UniProt A0A8I5ZWT2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQN6_RAT UniProtKB/TrEMBL
  A6HBB8 ENTREZGENE, UniProtKB/TrEMBL
  DGKB_RAT UniProtKB/Swiss-Prot
  F1LP01 ENTREZGENE, UniProtKB/TrEMBL
  P49621 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Dgkb  diacylglycerol kinase, beta   Dagk  Diacylglycerol kinase 90kDa  Symbol and Name updated 625702 APPROVED
2002-06-10 Dagk  Diacylglycerol kinase 90kDa      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein localized to membrane fractions 728585
gene_domains protein contains an EF-hand motif, a cysteine-rich zinc-finger like sequence, and a putative ATP-binding site 728585
gene_expression mRNA expressed specifically in neuronal populations, including caudate-putamen, accumbens nucleus and the olfactory tubercle 728585
gene_protein 90 kDA protein is made up of 801 amino acids 728585