Cyp2a3 (cytochrome P450, family 2, subfamily a, polypeptide 3) - Rat Genome Database

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Gene: Cyp2a3 (cytochrome P450, family 2, subfamily a, polypeptide 3) Rattus norvegicus
Analyze
Symbol: Cyp2a3
Name: cytochrome P450, family 2, subfamily a, polypeptide 3
RGD ID: 2465
Description: Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in several processes, including coumarin metabolic process; epoxygenase P450 pathway; and response to stilbenoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Orthologous to several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13) and CYP2A7 (cytochrome P450 family 2 subfamily A member 7); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coumarin 7-hydroxylase; Cyp2a3a; CYPIIA3; cytochrome P450 2A3; cytochrome P450, family 2, subfamily A, polypeptide 3a; Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3); RATCYP2A3A
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,299,584 - 91,307,650 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,299,561 - 91,307,649 (+)EnsemblGRCr8
mRatBN7.2182,171,914 - 82,179,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,588,938 - 87,597,006 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,075,221 - 96,083,279 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,344,793 - 89,352,861 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,653,248 - 83,662,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,869,280 - 84,876,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,944,896 - 81,953,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,591,113 - 76,599,123 (+)NCBICelera
RGSC_v3.1182,023,006 - 82,030,923 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxyindole  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
cholesterol  (ISO)
cholic acid  (ISO)
cobalt atom  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
daidzein  (ISO)
dextromethorphan  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydroergotamine  (ISO)
diquat  (ISO)
doramapimod  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (EXP)
fenofibrate  (EXP)
fipronil  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
glyphosate  (ISO)
griseofulvin  (ISO)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
isoproturon  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
Lasiocarpine  (ISO)
lithocholic acid  (ISO)
lycopene  (ISO)
MeIQx  (EXP)
mephenytoin  (ISO)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
quinidine  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
valproic acid  (EXP,ISO)
verapamil  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus. Gopalakrishnan R, etal., J Toxicol Environ Health A 2002 Aug 9;65(15):1077-91.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Complete sequence of the rat CYP2A3 gene specifically transcribed in lung. Ueno T and Gonzalez FJ, Nucleic Acids Res 1990 Aug 11;18(15):4623-4.
Additional References at PubMed
PMID:2751996   PMID:8889548   PMID:15123731   PMID:16183037   PMID:17086191  


Genomics

Comparative Map Data
Cyp2a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,299,584 - 91,307,650 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,299,561 - 91,307,649 (+)EnsemblGRCr8
mRatBN7.2182,171,914 - 82,179,980 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,588,938 - 87,597,006 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,075,221 - 96,083,279 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,344,793 - 89,352,861 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,653,248 - 83,662,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,869,280 - 84,876,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,944,896 - 81,953,007 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,591,113 - 76,599,123 (+)NCBICelera
RGSC_v3.1182,023,006 - 82,030,923 (+)NCBI
Cytogenetic Map1q21NCBI
CYP2A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,875,439 - 40,882,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,875,432 - 40,882,752 (-)Ensemblhg38GRCh38
GRCh371941,381,344 - 41,388,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,073,184 - 46,080,497 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341946,073,183 - 46,080,497NCBI
Celera1938,181,466 - 38,188,779 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,814,479 - 37,821,742 (-)NCBIHuRef
CHM1_11941,381,111 - 41,388,380 (-)NCBICHM1_1
T2T-CHM13v2.01943,696,148 - 43,702,882 (-)NCBIT2T-CHM13v2.0
Cyp2a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,006,617 - 26,014,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,006,594 - 26,014,513 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38726,307,192 - 26,315,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,307,169 - 26,315,088 (+)Ensemblmm10GRCm38
MGSCv37727,092,211 - 27,100,107 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36726,015,952 - 26,023,848 (+)NCBIMGSCv36mm8
Celera720,896,679 - 20,902,855 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.39NCBI

Variants

.
Variants in Cyp2a3
72 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir126brno-miR-126a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18780894

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000028231
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
D1Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8191,302,413 - 91,302,615 (+)Marker Load Pipeline
mRatBN7.2182,174,743 - 82,174,945 (+)MAPPERmRatBN7.2
Rnor_6.0183,656,882 - 83,657,083NCBIRnor6.0
Rnor_5.0184,871,364 - 84,871,565UniSTSRnor5.0
RGSC_v3.4181,947,770 - 81,947,972RGDRGSC3.4
RGSC_v3.4181,947,771 - 81,947,972UniSTSRGSC3.4
Celera176,593,887 - 76,594,088UniSTS
RGSC_v3.1182,025,881 - 82,026,083RGD
RH 3.4 Map1826.1RGD
RH 3.4 Map1826.1UniSTS
RH 2.0 Map1515.9RGD
Cytogenetic Map1q21UniSTS
D1Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1826.4UniSTS
RH 3.4 Map1826.4RGD
RH 2.0 Map1514.3RGD
Cytogenetic Map1q21UniSTS
RH127774  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,179,627 - 82,179,808 (+)MAPPERmRatBN7.2
Rnor_6.0183,661,766 - 83,661,946NCBIRnor6.0
Rnor_5.0184,876,248 - 84,876,428UniSTSRnor5.0
RGSC_v3.4181,952,655 - 81,952,835UniSTSRGSC3.4
Celera176,598,771 - 76,598,951UniSTS
RH 3.4 Map1840.5UniSTS
Cytogenetic Map1q21UniSTS
Cyp2a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0184,870,605 - 84,872,088UniSTSRnor5.0
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
13 1 6 2 1 12 4 13 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000028237   ⟹   ENSRNOP00000028237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Rnor_6.0 Ensembl183,711,251 - 83,724,936 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000028249   ⟹   ENSRNOP00000028249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,744,238 - 83,765,719 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084230   ⟹   ENSRNOP00000074544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,653,248 - 83,661,920 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085008   ⟹   ENSRNOP00000075563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085245   ⟹   ENSRNOP00000071749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,714,347 - 83,766,230 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090071   ⟹   ENSRNOP00000070405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,299,561 - 91,307,649 (+)Ensembl
mRatBN7.2 Ensembl182,169,949 - 82,179,979 (+)Ensembl
Rnor_6.0 Ensembl183,653,248 - 83,662,117 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092008   ⟹   ENSRNOP00000068901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,711,270 - 83,765,716 (+)Ensembl
RefSeq Acc Id: NM_012542   ⟹   NP_036674
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,299,584 - 91,307,650 (+)NCBI
mRatBN7.2182,171,914 - 82,179,980 (+)NCBI
Rnor_6.0183,653,248 - 83,662,118 (+)NCBI
Rnor_5.0184,869,280 - 84,876,600 (+)NCBI
RGSC_v3.4181,944,896 - 81,953,007 (+)RGD
Celera176,591,113 - 76,599,123 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036674 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41022 (Get FASTA)   NCBI Sequence Viewer  
  AAA88511 (Get FASTA)   NCBI Sequence Viewer  
  EDM07980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070405
GenBank Protein P20812 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036674   ⟸   NM_012542
- UniProtKB: P20812 (UniProtKB/Swiss-Prot),   A0A0G2JXU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068901   ⟸   ENSRNOT00000092008
Ensembl Acc Id: ENSRNOP00000070405   ⟸   ENSRNOT00000090071
Ensembl Acc Id: ENSRNOP00000028237   ⟸   ENSRNOT00000028237
Ensembl Acc Id: ENSRNOP00000028249   ⟸   ENSRNOT00000028249
Ensembl Acc Id: ENSRNOP00000071749   ⟸   ENSRNOT00000085245
Ensembl Acc Id: ENSRNOP00000075563   ⟸   ENSRNOT00000085008
Ensembl Acc Id: ENSRNOP00000074544   ⟸   ENSRNOT00000084230

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20812-F1-model_v2 AlphaFold P20812 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2465 AgrOrtholog
BioCyc Gene G2FUF-60333 BioCyc
Ensembl Genes ENSRNOG00000020817 Ensembl
  ENSRNOG00000068556 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090071 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:24299 UniProtKB/Swiss-Prot
NCBI Gene 24299 ENTREZGENE
PANTHER CYTOCHROME P450 2A6 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP2A7 RGD
PhenoGen Cyp2a3 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020817 RatGTEx
  ENSRNOG00000068556 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC234666
UniProt A0A0G2JXU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K193_RAT UniProtKB/TrEMBL
  CP2A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2a3    Cyp2a3a  cytochrome P450, family 2, subfamily A, polypeptide 3a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cyp2a3a  cytochrome P450, family 2, subfamily A, polypeptide 3a    Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3)  Name updated 1299863 APPROVED
2002-06-10 Cyp2a3a  Cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (Cytochrome P450 IIA3)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates NMBA metabolism in the esophagus 1298847