Ctsh (cathepsin H) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ctsh (cathepsin H) Rattus norvegicus
Analyze
Symbol: Ctsh
Name: cathepsin H
RGD ID: 2447
Description: Enables aminopeptidase activity; identical protein binding activity; and kininogen binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; response to odorant; and spermatogenesis. Located in cytoskeleton; extracellular space; and secretory granule. Biomarker of polycystic kidney disease. Orthologous to human CTSH (cathepsin H); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathepsin B3; cathepsin BA; pro-cathepsin H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,488,756 - 99,507,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl899,488,874 - 99,509,181 (+)EnsemblGRCr8
mRatBN7.2890,608,941 - 90,627,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx896,288,760 - 96,307,655 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,488,180 - 94,507,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,330,819 - 92,349,671 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,439,155 - 97,458,293 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,439,161 - 97,458,287 (+)Ensemblrn6Rnor6.0
Rnor_5.0896,939,702 - 96,958,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4894,971,689 - 94,990,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera890,152,207 - 90,170,963 (+)NCBICelera
RGSC_v3.1894,991,143 - 95,009,889 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fipronil  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IDA)
alveolar lamellar body  (IDA,IEA,ISO,ISS)
axoneme  (IDA)
cytosol  (IEA,ISO,ISS)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
lysosome  (IBA,IEA,ISO,ISS)
outer dense fiber  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. Brasch F, etal., Am J Respir Cell Mol Biol 2002 Jun;26(6):659-70.
2. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Dahlmann B, etal., Biochim Biophys Acta. 1989 May 31;991(2):253-62.
3. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
4. Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1. Fukada Y, etal., Brain Res. 2007 Jul 30;1160:1-10. Epub 2007 Jun 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Potential participation of cystatin C in rapid eye movement sleep (REMS) modulation. Gonzalez-Rivera R, etal., Neurosci Lett. 2006 Nov 20;408(3):178-82. Epub 2006 Oct 5.
7. Expression of cathepsin H in differentiating rat spermatids: immunoelectron microscopic study. Haraguchi CM, etal., Histochem Cell Biol. 2003 Jul;120(1):63-71. Epub 2003 Jul 1.
8. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
9. Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases. Ishidoh K, etal., FEBS Lett 1987 Dec 21;226(1):33-7.
10. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. Ishii Y, etal., J Histochem Cytochem. 1991 Apr;39(4):461-8.
11. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
12. Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. Mantle D, etal., J Neurol Sci. 1995 Jul;131(1):65-70.
13. Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring. Mathur PP, etal., Biochem Mol Biol Int. 1997 Jun;42(2):217-33.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
16. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Nagai A, etal., Clin Chim Acta. 2003 Mar;329(1-2):53-60.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Biochemical properties and intracellular processing of lysosomal cathepsins B and H. Nishimura Y, etal., Biol Pharm Bull. 1995 Jun;18(6):829-36.
19. Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma. Qian F, etal., Int J Biochem 1990;22(12):1457-64.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Studies on the aminopeptidase activity of rat cathepsin H. Rothe M and Dodt J, Eur J Biochem. 1992 Dec 15;210(3):759-64.
23. Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat. Schaefer L, etal., Kidney Int. 1996 Aug;50(2):424-31.
24. Expression and the role of cathepsin H in human glioma progression and invasion. Sivaparvathi M, etal., Cancer Lett 1996 Jun 24;104(1):121-6.
25. Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. Staack A, etal., Urology. 2004 Jun;63(6):1089-94.
26. Functional interface between cathepsins and growth factors in the kidney development. Vattimo Mde F and Santos OF, Ren Fail. 2005;27(5):615-22.
27. Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Wu SM, etal., Oncogene. 2011 Apr 28;30(17):2057-69. doi: 10.1038/onc.2010.585. Epub 2011 Jan 10.
Additional References at PubMed
PMID:1837142   PMID:2759235   PMID:6203523   PMID:6574504   PMID:8811434   PMID:9050938   PMID:12189169   PMID:12477932   PMID:14766755   PMID:15127951   PMID:15196205   PMID:15489334  
PMID:16502470   PMID:16822283   PMID:17500053   PMID:18216060   PMID:20435891   PMID:20731543   PMID:23376485   PMID:23533145   PMID:24982147   PMID:27998776  


Genomics

Comparative Map Data
Ctsh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,488,756 - 99,507,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl899,488,874 - 99,509,181 (+)EnsemblGRCr8
mRatBN7.2890,608,941 - 90,627,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx896,288,760 - 96,307,655 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,488,180 - 94,507,075 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,330,819 - 92,349,671 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,439,155 - 97,458,293 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,439,161 - 97,458,287 (+)Ensemblrn6Rnor6.0
Rnor_5.0896,939,702 - 96,958,829 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4894,971,689 - 94,990,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera890,152,207 - 90,170,963 (+)NCBICelera
RGSC_v3.1894,991,143 - 95,009,889 (+)NCBI
Cytogenetic Map8q31NCBI
CTSH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,921,058 - 78,945,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,921,058 - 78,949,574 (-)Ensemblhg38GRCh38
GRCh371579,213,400 - 79,237,388 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,001,147 - 77,024,475 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341577,001,162 - 77,024,475NCBI
Celera1556,150,437 - 56,173,763 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,974,005 - 55,997,318 (-)NCBIHuRef
CHM1_11579,332,284 - 79,355,627 (-)NCBICHM1_1
T2T-CHM13v2.01576,784,722 - 76,808,716 (-)NCBIT2T-CHM13v2.0
Ctsh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,936,320 - 89,958,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl989,936,205 - 89,958,142 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38990,054,267 - 90,076,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl990,054,152 - 90,076,089 (+)Ensemblmm10GRCm38
MGSCv37989,949,105 - 89,970,933 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36989,852,402 - 89,873,982 (+)NCBIMGSCv36mm8
Celera989,669,599 - 89,691,657 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.4NCBI
Ctsh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553339,284 - 54,837 (-)Ensembl
ChiLan1.0NW_00495553339,237 - 54,881 (-)NCBIChiLan1.0ChiLan1.0
CTSH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21668,178,240 - 68,202,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11572,343,872 - 72,367,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,893,379 - 57,917,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,853,433 - 76,876,976 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,852,668 - 76,876,976 (-)EnsemblpanPan2panpan1.1
CTSH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1358,103,284 - 58,113,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl358,103,291 - 58,113,718 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha360,761,041 - 60,775,398 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0358,537,356 - 58,551,709 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,537,379 - 58,551,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1358,034,248 - 58,048,592 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,242,514 - 58,256,878 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,591,033 - 58,605,384 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ctsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,287,137 - 119,308,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647137,131,817 - 37,156,476 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647137,135,200 - 37,156,081 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl748,083,572 - 48,106,072 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1748,084,882 - 48,106,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,623,062 - 53,644,262 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,451,731 - 4,473,220 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,451,774 - 4,472,855 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048137,378,814 - 137,400,510 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462494182,209 - 98,182 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462494182,209 - 98,156 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ctsh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1125,281,772 - 5,300,233 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ctsh
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000019285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH127737  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8899,506,469 - 99,507,339 (+)Marker Load Pipeline
mRatBN7.2890,626,654 - 90,627,524 (+)MAPPERmRatBN7.2
Rnor_6.0897,457,124 - 97,457,993NCBIRnor6.0
Rnor_5.0896,957,660 - 96,958,529UniSTSRnor5.0
RGSC_v3.4894,989,267 - 94,990,136UniSTSRGSC3.4
Celera890,169,796 - 90,170,665UniSTS
RH 3.4 Map81001.6UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC085352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM135658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN800263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019285   ⟹   ENSRNOP00000019285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,488,874 - 99,507,636 (+)Ensembl
mRatBN7.2 Ensembl890,608,941 - 90,627,824 (+)Ensembl
Rnor_6.0 Ensembl897,439,216 - 97,458,287 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080142   ⟹   ENSRNOP00000074611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl899,488,881 - 99,509,181 (+)Ensembl
mRatBN7.2 Ensembl890,613,409 - 90,627,824 (+)Ensembl
Rnor_6.0 Ensembl897,439,161 - 97,458,267 (+)Ensembl
RefSeq Acc Id: NM_012939   ⟹   NP_037071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8899,488,756 - 99,507,639 (+)NCBI
mRatBN7.2890,608,941 - 90,627,824 (+)NCBI
Rnor_6.0897,439,204 - 97,458,291 (+)NCBI
Rnor_5.0896,939,702 - 96,958,829 (+)NCBI
RGSC_v3.4894,971,689 - 94,990,434 (+)RGD
Celera890,152,207 - 90,170,963 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037071 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63484 (Get FASTA)   NCBI Sequence Viewer  
  AAH85352 (Get FASTA)   NCBI Sequence Viewer  
  CAA68699 (Get FASTA)   NCBI Sequence Viewer  
  EDL77562 (Get FASTA)   NCBI Sequence Viewer  
  EDL77563 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019285.5
  ENSRNOP00000074611
GenBank Protein P00786 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037071   ⟸   NM_012939
- Peptide Label: precursor
- UniProtKB: P00786 (UniProtKB/Swiss-Prot),   A6I215 (UniProtKB/TrEMBL),   A0A0H2UHL6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074611   ⟸   ENSRNOT00000080142
Ensembl Acc Id: ENSRNOP00000019285   ⟸   ENSRNOT00000019285
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00786-F1-model_v2 AlphaFold P00786 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696181
Promoter ID:EPDNEW_R6701
Type:initiation region
Name:Ctsh_1
Description:cathepsin H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0897,439,194 - 97,439,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2447 AgrOrtholog
BioCyc Gene G2FUF-29569 BioCyc
Ensembl Genes ENSRNOG00000014064 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019285.6 UniProtKB/Swiss-Prot
  ENSRNOT00000080142 ENTREZGENE
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115929 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report rno:25425 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105498 IMAGE-MGC_LOAD
NCBI Gene 25425 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Ctsh PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014064 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt A0A0G2K8H6_RAT UniProtKB/TrEMBL
  A0A0H2UHL6 ENTREZGENE, UniProtKB/TrEMBL
  A6I214_RAT UniProtKB/TrEMBL
  A6I215 ENTREZGENE, UniProtKB/TrEMBL
  CATH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctsh  Cathepsin H      Symbol and Name status set to approved 70586 APPROVED