Cth (cystathionine gamma-lyase) - Rat Genome Database

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Gene: Cth (cystathionine gamma-lyase) Rattus norvegicus
Analyze
Symbol: Cth
Name: cystathionine gamma-lyase
RGD ID: 2443
Description: Predicted to enable carbon-sulfur lyase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in glutathione metabolic process; negative regulation of cell growth; and negative regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Used to study cataract. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase); PARTICIPATES IN cystathioninuria pathway; cysteine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGL; CSE; CTL target antigen; cystathionase (cystathionine gamma-lyase); cysteine desulfhydrase; cysteine-protein sulfhydrase; gamma-cystathionase; H; homocysteine desulfhydrase; LOC103691744; PRB-RA; probasin-related antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,634,731 - 249,661,066 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2249,634,731 - 249,661,066 (-)EnsemblGRCr8
mRatBN7.22246,975,888 - 247,002,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2254,708,251 - 254,734,585 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,602,078 - 252,628,090 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,570,449 - 247,596,765 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)Ensemblrn6Rnor6.0
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2238,776,532 - 238,802,647 (-)NCBICelera
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Cytogenetic Map2q45NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amino acid  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (EXP)
diiodine  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glyphosate  (EXP,ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-cysteine  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
motexafin gadolinium  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalenes  (EXP)
nefazodone  (EXP)
neomycin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
nitroflurbiprofen  (EXP)
O-methyleugenol  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
orotic acid  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prothioconazole  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (ISO)
torcetrapib  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (TAS)

References

References - curated
# Reference Title Reference Citation
1. Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Erickson PF, etal., Biochem J 1990 Jul 15;269(2):335-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of homocysteine metabolism in the rat kidney. House JD, etal., Biochem J 1997 Nov 15;328 ( Pt 1):287-92.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. Martinez M, etal., J Nutr 2000 May;130(5):1115-23.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Identification of probasin-related antigen as cystathionine gamma-lyase by molecular cloning. Nishi N, etal., J Biol Chem 1994 Jan 14;269(2):1015-9.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. Renga B, etal., World J Gastroenterol. 2009 May 7;15(17):2097-108. doi: 10.3748/wjg.15.2097.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Sastre J, etal., Free Radic Biol Med. 2005 Mar 1;38(5):575-82.
18. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Stipanuk MH and Ueki I, J Inherit Metab Dis. 2011 Feb;34(1):17-32. doi: 10.1007/s10545-009-9006-9. Epub 2010 Feb 17.
19. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). Wang J and Hegele RA, Hum Genet. 2003 Apr;112(4):404-8. Epub 2003 Feb 6.
20. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. Yang G, etal., J Biol Chem. 2004 Nov 19;279(47):49199-205. Epub 2004 Sep 3.
Additional References at PubMed
PMID:10212249   PMID:12477932   PMID:15038791   PMID:16189514   PMID:16396499   PMID:16507767   PMID:18184479   PMID:19019829   PMID:19056867   PMID:19428278   PMID:19903941   PMID:20439489  
PMID:21055229   PMID:21158086   PMID:21659522   PMID:22093698   PMID:22133746   PMID:22169477   PMID:22244329   PMID:22428706   PMID:22870268   PMID:24610811   PMID:25416956   PMID:25901909  
PMID:26021843   PMID:26319795   PMID:26378818   PMID:26519030   PMID:26963622   PMID:27324218   PMID:27468988   PMID:29880385   PMID:32900241   PMID:33123916   PMID:36197015   PMID:38613810  


Genomics

Comparative Map Data
Cth
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,634,731 - 249,661,066 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2249,634,731 - 249,661,066 (-)EnsemblGRCr8
mRatBN7.22246,975,888 - 247,002,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2254,708,251 - 254,734,585 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,602,078 - 252,628,090 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,570,449 - 247,596,765 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,266,959 - 264,293,040 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)Ensemblrn6Rnor6.0
Rnor_5.02282,366,125 - 282,392,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42256,056,562 - 256,082,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2238,776,532 - 238,802,647 (-)NCBICelera
RGSC_v3.12256,071,168 - 256,096,855 (-)NCBI
Cytogenetic Map2q45NCBI
CTH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38170,411,268 - 70,439,851 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl170,406,194 - 70,442,771 (+)Ensemblhg38GRCh38
GRCh37170,876,951 - 70,905,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36170,649,543 - 70,677,841 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34170,588,975 - 70,617,273NCBI
Celera169,166,835 - 69,195,464 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef168,987,754 - 69,016,606 (+)NCBIHuRef
CHM1_1170,992,268 - 71,020,901 (+)NCBICHM1_1
T2T-CHM13v2.0170,289,775 - 70,318,361 (+)NCBIT2T-CHM13v2.0
Cth
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,599,885 - 157,630,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,599,885 - 157,630,714 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383157,894,248 - 157,925,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,894,248 - 157,925,077 (-)Ensemblmm10GRCm38
MGSCv373157,557,212 - 157,588,027 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363157,829,541 - 157,860,356 (-)NCBIMGSCv36mm8
Celera3164,361,761 - 164,392,686 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.55NCBI
Cth
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542321,542,179 - 21,567,786 (-)Ensembl
ChiLan1.0NW_00495542321,542,587 - 21,567,935 (-)NCBIChiLan1.0ChiLan1.0
CTH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21156,435,025 - 156,462,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11155,594,089 - 155,621,700 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,646,608 - 69,674,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,629,637 - 71,657,322 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,629,333 - 71,677,666 (+)EnsemblpanPan2panpan1.1
CTH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1675,324,328 - 75,348,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl675,324,787 - 75,349,451 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha677,937,741 - 77,962,253 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0675,916,530 - 75,940,965 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl675,916,532 - 75,941,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1675,469,819 - 75,494,076 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0675,365,148 - 75,389,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,865,823 - 75,890,332 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505882,845,843 - 82,870,103 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,619,446 - 1,643,665 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365911,619,446 - 1,643,667 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6142,454,914 - 142,486,367 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16142,454,922 - 142,486,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26132,027,445 - 132,050,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12062,672,820 - 62,718,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2062,690,906 - 62,718,980 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603354,904,075 - 54,931,820 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cth
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474225,619,277 - 25,642,875 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474225,619,261 - 25,642,477 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cth
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v133,650,880 - 3,676,997 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:193
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000067843
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 60 121 57 60 41 76 41 287 157 11 112 71 72 19 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000067843   ⟹   ENSRNOP00000058914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2249,634,731 - 249,661,066 (-)Ensembl
mRatBN7.2 Ensembl2246,975,894 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,266,984 - 264,293,046 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082532   ⟹   ENSRNOP00000072582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2249,637,283 - 249,661,066 (-)Ensembl
mRatBN7.2 Ensembl2246,978,440 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,270,096 - 264,293,010 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089714   ⟹   ENSRNOP00000073415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2249,644,124 - 249,661,066 (-)Ensembl
mRatBN7.2 Ensembl2246,985,281 - 247,002,234 (-)Ensembl
Rnor_6.0 Ensembl2264,746,485 - 264,765,085 (-)Ensembl
RefSeq Acc Id: NM_017074   ⟹   NP_058770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,634,731 - 249,661,066 (-)NCBI
mRatBN7.22246,975,888 - 247,002,219 (-)NCBI
Rnor_6.02264,267,029 - 264,293,016 (-)NCBI
Rnor_5.02282,366,125 - 282,392,112 (+)NCBI
RGSC_v3.42256,056,562 - 256,082,248 (-)RGD
Celera2238,776,532 - 238,802,647 (-)RGD
Sequence:
RefSeq Acc Id: NP_058770   ⟸   NM_017074
- UniProtKB: P18757 (UniProtKB/Swiss-Prot),   Q9EQS4 (UniProtKB/TrEMBL),   A6HWT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058914   ⟸   ENSRNOT00000067843
Ensembl Acc Id: ENSRNOP00000072582   ⟸   ENSRNOT00000082532
Ensembl Acc Id: ENSRNOP00000073415   ⟸   ENSRNOT00000089714

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18757-F1-model_v2 AlphaFold P18757 1-398 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691838
Promoter ID:EPDNEW_R2363
Type:multiple initiation site
Name:Cth_1
Description:cystathionine gamma-lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02264,293,054 - 264,293,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2443 AgrOrtholog
BioCyc Gene G2FUF-50708 BioCyc
Ensembl Genes ENSRNOG00000010658 Ensembl, ENTREZGENE
  ENSRNOG00000057089 Ensembl
Ensembl Transcript ENSRNOT00000067843 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109746 IMAGE-MGC_LOAD
InterPro Cys/Met-Metab_PyrdxlP-dep_enz UniProtKB/Swiss-Prot
  Cys_met_metab_PP UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:24962 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93537 IMAGE-MGC_LOAD
NCBI Gene 24962 ENTREZGENE
PANTHER CYSTATHIONINE GAMMA-LYASE UniProtKB/Swiss-Prot
  PTHR11808 UniProtKB/Swiss-Prot
Pfam Cys_Met_Meta_PP UniProtKB/Swiss-Prot
PharmGKB CTH RGD
PhenoGen Cth PhenoGen
PIRSF CGS UniProtKB/Swiss-Prot
PROSITE CYS_MET_METAB_PP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010658 RatGTEx
  ENSRNOG00000057089 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A0G2K3C5_RAT UniProtKB/TrEMBL
  A0A0G2K5G2_RAT UniProtKB/TrEMBL
  A6HWT2 ENTREZGENE, UniProtKB/TrEMBL
  CGL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9EQS4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cth  cystathionine gamma-lyase  LOC103691744  cystathionine gamma-lyase  Data merged from RGD:9153842 737654 PROVISIONAL
2014-08-25 LOC103691744  cystathionine gamma-lyase      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-09 Cth  cystathionine gamma-lyase  Cth  cystathionase (cystathionine gamma-lyase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cth  cystathionase (cystathionine gamma-lyase)    CTL target antigen  Name updated 1299863 APPROVED
2002-06-10 Cth  CTL target antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and brain 1298831
gene_product putative cystathionine gamma-lyase 1298831