Cpe (carboxypeptidase E) - Rat Genome Database

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Gene: Cpe (carboxypeptidase E) Rattus norvegicus
Analyze
Symbol: Cpe
Name: carboxypeptidase E
RGD ID: 2394
Description: Enables carboxypeptidase activity; cobalt ion binding activity; and protein domain specific binding activity. Involved in negative regulation of branching morphogenesis of a nerve; peptide catabolic process; and peptide hormone processing. Located in several cellular components, including dense core granule; perikaryon; and synaptic membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E); PARTICIPATES IN melanocortin system pathway; type 1 diabetes mellitus pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CARBE; carboxypeptidase H; Cph; enkephalin convertase; MGC93638; prohormone-processing carboxypeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Niddm38
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,796,707 - 29,908,647 (+)NCBIGRCr8
mRatBN7.21625,030,276 - 25,142,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1625,030,276 - 25,142,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,395,455 - 28,506,245 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,829,813 - 31,940,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,784,887 - 27,896,603 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01626,906,716 - 27,014,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,906,716 - 27,014,813 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,785,642 - 26,888,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11626,748,589 - 26,748,986 (+)NCBI
Celera1625,114,655 - 25,226,598 (+)NCBICelera
RH 3.4 Map16298.1RGD
Cytogenetic Map16p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chitosan  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
kojic acid  (ISO)
lead(0)  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
methacholine chloride  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
organophosphorus compound  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
purine-6-thiol  (EXP)
raloxifene  (EXP)
reserpine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain. Billova S, etal., Neuroscience. 2007 Jun 29;147(2):403-18. Epub 2007 Jun 1.
2. NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway. Carrel D, etal., J Neurosci. 2009 Jun 24;29(25):8248-58.
3. Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Chen H, etal., Hum Mutat. 2001 Aug;18(2):120-31.
4. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Davidson HW and Hutton JC, Biochem J. 1987 Jul 15;245(2):575-82.
5. Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme. Fricker LD, etal., Mol Endocrinol 1989 Apr;3(4):666-73.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Hook VY and Loh YP, Proc Natl Acad Sci U S A. 1984 May;81(9):2776-80.
9. Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. Hosaka M, etal., J Biol Chem. 2004 Jan 30;279(5):3627-34. Epub 2003 Nov 3.
10. Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. Hosaka M, etal., J Cell Sci. 2005 Oct 15;118(Pt 20):4785-95.
11. Structural characterization of the rat carboxypeptidase-E gene. Jung YK, etal., Mol Endocrinol 1991 Sep;5(9):1257-68.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. Manser E, etal., Biochem J 1990 Apr 15;267(2):517-25.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
16. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Naggert JK, etal., Nat Genet. 1995 Jun;10(2):135-42.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS. Oiso S, etal., J Neurochem. 2009 Apr;109(1):158-67. Epub 2009 Jan 23.
19. A PC12 variant lacking regulated secretory organelles: aberrant protein targeting and evidence for a factor inhibiting neuroendocrine gene expression. Pance A, etal., J Neurochem. 1999 Jul;73(1):21-30.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
22. Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway. Qian Y, etal., J Biol Chem. 1999 Apr 23;274(17):11582-6.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor. Rodriguez C, etal., J Biol Chem 1989 Apr 5;264(10):5988-95.
27. The pro region is not required for the expression or intracellular routeing of carboxypeptidase E. Song L and Fricker LD, Biochem J. 1997 Apr 1;323 ( Pt 1):265-71.
28. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. Utsunomiya N, etal., Diabetologia. 1998 Jun;41(6):701-5.
29. The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing. Varlamov O and Fricker LD, J Biol Chem. 1996 Mar 15;271(11):6077-83.
30. Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Woronowicz A, etal., Hippocampus. 2008;18(10):1051-63.
31. Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells. Wu CM, etal., Biochem J. 2004 Sep 15;382(Pt 3):841-8.
32. Regulation of dopamine transporter activity by carboxypeptidase E. Zhang H, etal., Mol Brain. 2009 May 6;2:10.
33. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity. Zheng M, etal., J Neurosci. 1994 Aug;14(8):4656-73.
Additional References at PubMed
PMID:1955501   PMID:12477932   PMID:14661109   PMID:14715715   PMID:15181368   PMID:18573344   PMID:19428990   PMID:19593212   PMID:22824791   PMID:23376485   PMID:23533145   PMID:23941827  
PMID:24006456   PMID:25426952   PMID:34266900  


Genomics

Comparative Map Data
Cpe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,796,707 - 29,908,647 (+)NCBIGRCr8
mRatBN7.21625,030,276 - 25,142,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1625,030,276 - 25,142,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1628,395,455 - 28,506,245 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,829,813 - 31,940,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,784,887 - 27,896,603 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01626,906,716 - 27,014,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,906,716 - 27,014,813 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,785,642 - 26,888,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11626,748,589 - 26,748,986 (+)NCBI
Celera1625,114,655 - 25,226,598 (+)NCBICelera
RH 3.4 Map16298.1RGD
Cytogenetic Map16p13NCBI
CPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,379,008 - 165,498,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,361,194 - 165,498,547 (+)EnsemblGRCh38hg38GRCh38
GRCh374166,300,160 - 166,419,699 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,519,538 - 166,638,926 (+)NCBINCBI36Build 36hg18NCBI36
Build 344166,657,698 - 166,777,081NCBI
Celera4163,635,528 - 163,754,911 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4162,051,907 - 162,171,495 (+)NCBIHuRef
CHM1_14166,276,542 - 166,396,001 (+)NCBICHM1_1
T2T-CHM13v2.04168,724,998 - 168,844,639 (+)NCBIT2T-CHM13v2.0
Cpe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,045,576 - 65,146,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,045,576 - 65,146,088 (-)EnsemblGRCm39 Ensembl
GRCm38864,592,542 - 64,693,109 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,592,542 - 64,693,054 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,071,339 - 67,171,837 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,484,734 - 67,585,232 (-)NCBIMGSCv36mm8
Celera867,161,674 - 67,256,578 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.3NCBI
Cpe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540339,862,191 - 39,971,902 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540339,862,893 - 39,971,902 (-)NCBIChiLan1.0ChiLan1.0
CPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23163,128,657 - 163,248,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,486,663 - 163,606,756 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,575,157 - 157,705,173 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,658,534 - 169,781,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4169,659,007 - 169,780,739 (+)Ensemblpanpan1.1panPan2
CPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,321,588 - 61,422,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,321,227 - 61,414,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,629,383 - 61,730,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,182,343 - 62,284,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,182,273 - 62,285,019 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,363,671 - 61,466,350 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,406,929 - 61,508,661 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,801,266 - 61,902,997 (+)NCBIUU_Cfam_GSD_1.0
Cpe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,928,608 - 18,038,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555530,307 - 641,905 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936555531,842 - 641,905 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,565,054 - 43,696,268 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,568,744 - 43,695,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,475,586 - 45,592,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,747,265 - 111,867,548 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7111,747,172 - 111,868,754 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603791,600,315 - 91,727,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475811,463,012 - 11,604,224 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475811,464,418 - 11,603,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpe
944 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:216
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000064297
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat

Markers in Region
D16Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,029,330 - 25,029,518 (+)MAPPERmRatBN7.2
Rnor_6.01626,905,771 - 26,905,958NCBIRnor6.0
Rnor_5.01626,784,697 - 26,784,884UniSTSRnor5.0
RGSC_v3.41626,747,646 - 26,747,834RGDRGSC3.4
RGSC_v3.41626,747,647 - 26,747,834UniSTSRGSC3.4
RGSC_v3.11626,747,644 - 26,747,832RGD
Celera1625,113,710 - 25,113,897UniSTS
FHH x ACI Map1615.4998UniSTS
FHH x ACI Map1615.4998RGD
Cytogenetic Map16p13UniSTS
RH94584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,142,035 - 25,142,185 (+)MAPPERmRatBN7.2
Rnor_6.01627,014,616 - 27,014,765NCBIRnor6.0
Rnor_5.01626,888,687 - 26,888,836UniSTSRnor5.0
Celera1625,226,403 - 25,226,552UniSTS
RH 3.4 Map16298.1UniSTS
Cytogenetic Map16p13UniSTS
RH94773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,141,951 - 25,142,211 (+)MAPPERmRatBN7.2
Rnor_6.01627,014,532 - 27,014,791NCBIRnor6.0
Rnor_5.01626,888,603 - 26,888,862UniSTSRnor5.0
Celera1625,226,319 - 25,226,578UniSTS
Cytogenetic Map16p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 15
Medium 3 43 8 8 11 59 27 34 11 8
Low 42 34 19 34 8 7
Below cutoff 7 7 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064297   ⟹   ENSRNOP00000061172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1625,030,276 - 25,142,233 (+)Ensembl
Rnor_6.0 Ensembl1626,906,716 - 27,014,813 (+)Ensembl
RefSeq Acc Id: NM_013128   ⟹   NP_037260
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81629,796,707 - 29,908,647 (+)NCBI
mRatBN7.21625,030,276 - 25,142,231 (+)NCBI
Rnor_6.01626,906,716 - 27,014,811 (+)NCBI
Rnor_5.01626,785,642 - 26,888,882 (+)NCBI
Celera1625,114,655 - 25,226,598 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037260   ⟸   NM_013128
- Peptide Label: precursor
- UniProtKB: P15087 (UniProtKB/Swiss-Prot),   D4A8X4 (UniProtKB/TrEMBL),   Q5U322 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061172   ⟸   ENSRNOT00000064297
Protein Domains
Peptidase M14   Peptidase M14 carboxypeptidase A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15087-F1-model_v2 AlphaFold P15087 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700068
Promoter ID:EPDNEW_R10590
Type:initiation region
Name:Cpe_1
Description:carboxypeptidase E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01626,906,698 - 26,906,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2394 AgrOrtholog
BioCyc Gene G2FUF-11626 BioCyc
Ensembl Genes ENSRNOG00000043387 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064297 ENTREZGENE
  ENSRNOT00000064297.4 UniProtKB/TrEMBL
Gene3D-CATH Carboxypeptidase-like, regulatory domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn peptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193151 IMAGE-MGC_LOAD
InterPro CarboxyPept-like_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M14_CPE_CPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25669 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93638 IMAGE-MGC_LOAD
NCBI Gene 25669 ENTREZGENE
PANTHER CARBOXYPEPTIDASE E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASE M14 CARBOXYPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CarboxypepD_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpe PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYPEPT_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_M14 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043387 RatGTEx
SMART Zn_pept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KFP3_RAT UniProtKB/TrEMBL
  A6KFP5_RAT UniProtKB/TrEMBL
  CBPE_RAT UniProtKB/Swiss-Prot
  D4A8X4 ENTREZGENE
  P15087 ENTREZGENE
  Q5U322 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A8X4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cpe  Carboxypeptidase E      Symbol and Name status set to approved 70586 APPROVED