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Gene: Cmc2 (C-x(9)-C motif containing 2) Rattus norvegicus

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Symbol:

Cmc2

Name:

C-x(9)-C motif containing 2

RGD ID:

2324599

Description:

Predicted to be active in mitochondrion. Orthologous to human CMC2 (C-X9-C motif containing 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

COX assembly mitochondrial protein 2; COX assembly mitochondrial protein 2 homolog; LOC100363376; LOC108348946; rCG51296-like; uncharacterized LOC108348946

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CMC2 (C-X9-C motif containing 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cmc2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cmc2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CMC2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC102155476 (COX assembly mitochondrial protein 2 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cmc2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CMC2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CMC2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cmc2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cmc2 (C-X9-C motif containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CMC2 (C-X9-C motif containing 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CMC2 (C-X9-C motif containing 2)	Alliance	DIOPT (HGNC\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cmc2 (C-X9-C motif containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cmc2 (C-X9-C motif containing 2)	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cmc2 (C-x(9)-C motif containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cmc2 (C-x(9)-C motif containing 2)	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C35D10.17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C35D10.17	Alliance	DIOPT (OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42375	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42375	Alliance	DIOPT (OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CMC2	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cmc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cmc2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	61,852,126 - 61,880,768 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	61,852,126 - 61,881,019 (-)	Ensembl				GRCr8
mRatBN7.2	19	44,943,283 - 44,971,930 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	44,943,285 - 44,971,983 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	51,755,620 - 51,781,512 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	52,408,640 - 52,434,528 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	54,652,875 - 54,678,768 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	49,433,332 - 49,457,641 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	49,433,590 - 49,448,072 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	60,224,644 - 60,248,869 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	47,002,952 - 47,028,957 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	44,218,029 - 44,244,870 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2-hydroxypropanoic acid (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

daunorubicin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

Enterolactone (ISO)

ethanol (ISO)

ivermectin (ISO)

lead(0) (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

topotecan (EXP)

tungsten (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

mitochondrion (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20220131

Genomics

Comparative Map Data

Cmc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	61,852,126 - 61,880,768 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	61,852,126 - 61,881,019 (-)	Ensembl				GRCr8
mRatBN7.2	19	44,943,283 - 44,971,930 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	44,943,285 - 44,971,983 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	51,755,620 - 51,781,512 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	52,408,640 - 52,434,528 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	54,652,875 - 54,678,768 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	49,433,332 - 49,457,641 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	49,433,590 - 49,448,072 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	60,224,644 - 60,248,869 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	47,002,952 - 47,028,957 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	44,218,029 - 44,244,870 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

CMC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	80,966,448 - 81,006,885 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	80,966,448 - 81,020,270 (-)	Ensembl			hg38	GRCh38
GRCh37	16	81,000,345 - 81,040,490 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	79,567,200 - 79,597,991 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	16	65,308,104 - 65,338,903 (-)	NCBI		Celera
Cytogenetic Map	16	q23.2	NCBI
HuRef	16	66,766,556 - 66,797,378 (-)	NCBI		HuRef
CHM1_1	16	82,421,068 - 82,451,870 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	87,028,306 - 87,068,420 (-)	NCBI		T2T-CHM13v2.0

Cmc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	117,615,424 - 117,671,061 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	117,615,424 - 117,648,194 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	116,888,685 - 116,944,322 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	116,888,685 - 116,921,455 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	119,412,585 - 119,445,336 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	119,775,495 - 119,807,413 (-)	NCBI		MGSCv36	mm8
Celera	8	121,107,831 - 121,140,821 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	63.28	NCBI

Cmc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955522	3,773,997 - 3,802,336 (-)	Ensembl
ChiLan1.0	NW_004955522	3,774,136 - 3,801,892 (-)	NCBI	ChiLan1.0	ChiLan1.0

CMC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	90,726,744 - 90,757,303 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	96,646,245 - 96,676,782 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	61,582,018 - 61,612,597 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	81,009,625 - 81,040,354 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	81,009,625 - 81,040,355 (-)	Ensembl			panPan2	panpan1.1

LOC102155476
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	6,581,983 - 6,582,314 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	70,821,294 - 70,836,763 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	6,510,190 - 6,511,912 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	6,618,965 - 6,620,687 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0

Cmc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	30,906,128 - 30,931,491 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	28,657,630 - 28,682,932 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	28,657,623 - 28,682,947 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CMC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	7,254,937 - 7,278,714 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CMC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	66,426,682 - 66,459,610 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	66,426,557 - 66,460,003 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	9,375,751 - 9,409,032 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cmc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	6,347,006 - 6,369,981 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	6,330,932 - 6,369,245 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cmc2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	36,528,773 - 36,553,964 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	125
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000014997
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	61249161	74246245	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat

Markers in Region

RH134044

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	44,943,371 - 44,943,569 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	49,433,419 - 49,433,616	NCBI	Rnor6.0
Rnor_5.0	19	60,224,731 - 60,224,928	UniSTS	Rnor5.0
RGSC_v3.4	19	47,003,041 - 47,003,238	UniSTS	RGSC3.4
Celera	19	44,218,116 - 44,218,313	UniSTS
RH 3.4 Map	19	596.8	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001402209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001402210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001402211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001402212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002725419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002725420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014997 ⟹ ENSRNOP00000014997

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	19	49,433,590 - 49,448,072 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095441 ⟹ ENSRNOP00000087382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	61,852,128 - 61,880,241 (-)	Ensembl
mRatBN7.2 Ensembl	19	44,943,285 - 44,971,403 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117703 ⟹ ENSRNOP00000078459

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	61,852,126 - 61,880,258 (-)	Ensembl
mRatBN7.2 Ensembl	19	44,943,285 - 44,971,480 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119763 ⟹ ENSRNOP00000087344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	61,852,126 - 61,881,019 (-)	Ensembl
mRatBN7.2 Ensembl	19	44,943,285 - 44,971,983 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134060 ⟹ ENSRNOP00000106098

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	61,852,128 - 61,880,415 (-)	Ensembl

RefSeq Acc Id:

NM_001402209 ⟹ NP_001389138

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	61,852,126 - 61,880,258 (-)	NCBI
mRatBN7.2	19	44,943,283 - 44,971,420 (-)	NCBI

RefSeq Acc Id:

NM_001402210 ⟹ NP_001389139

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	61,852,126 - 61,880,258 (-)	NCBI
mRatBN7.2	19	44,943,283 - 44,971,420 (-)	NCBI

RefSeq Acc Id:

NM_001402211 ⟹ NP_001389140

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	61,852,126 - 61,880,258 (-)	NCBI
mRatBN7.2	19	44,943,283 - 44,971,420 (-)	NCBI

RefSeq Acc Id:

NM_001402212 ⟹ NP_001389141

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	61,852,128 - 61,880,768 (-)	NCBI
mRatBN7.2	19	44,943,285 - 44,971,930 (-)	NCBI

RefSeq Acc Id:

XM_039098177 ⟹ XP_038954105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	61,852,128 - 61,879,956 (-)	NCBI
mRatBN7.2	19	44,943,283 - 44,971,124 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001389138	(Get FASTA)	NCBI Sequence Viewer
	NP_001389139	(Get FASTA)	NCBI Sequence Viewer
	NP_001389140	(Get FASTA)	NCBI Sequence Viewer
	NP_001389141	(Get FASTA)	NCBI Sequence Viewer
	XP_038954105	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL92636	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078459
	ENSRNOP00000078459.1
	ENSRNOP00000087344.1
	ENSRNOP00000087382
	ENSRNOP00000087382.1
	ENSRNOP00000106098.1

Ensembl Acc Id:

ENSRNOP00000014997 ⟸ ENSRNOT00000014997

RefSeq Acc Id:	XP_038954105 ⟸ XM_039098177
- Peptide Label:	isoform X1
- UniProtKB:	D4A471 (UniProtKB/TrEMBL), A6IZF8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078459 ⟸ ENSRNOT00000117703

Ensembl Acc Id:

ENSRNOP00000087344 ⟸ ENSRNOT00000119763

Ensembl Acc Id:

ENSRNOP00000087382 ⟸ ENSRNOT00000095441

RefSeq Acc Id:	NP_001389138 ⟸ NM_001402209
- Peptide Label:	isoform 1
- UniProtKB:	D4A471 (UniProtKB/TrEMBL), A6IZF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001389140 ⟸ NM_001402211
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I5ZLA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001389139 ⟸ NM_001402210
- Peptide Label:	isoform 1
- UniProtKB:	D4A471 (UniProtKB/TrEMBL), A6IZF8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001389141 ⟸ NM_001402212
- Peptide Label:	isoform 1
- UniProtKB:	D4A471 (UniProtKB/TrEMBL), A6IZF8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000106098 ⟸ ENSRNOT00000134060

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A471-F1-model_v2	AlphaFold	D4A471	1-79	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2324599	AgrOrtholog
BioCyc Gene	G2FUF-5562	BioCyc
Ensembl Genes	ENSRNOG00000011279	Ensembl
	ENSRNOG00000068690	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000095441	ENTREZGENE
	ENSRNOT00000095441.2	UniProtKB/TrEMBL
	ENSRNOT00000117703	ENTREZGENE
	ENSRNOT00000117703.2	UniProtKB/TrEMBL
	ENSRNOT00000119763.2	UniProtKB/TrEMBL
	ENSRNOT00000134060.1	UniProtKB/TrEMBL
InterPro	Cyt_c_biogenesis_Cmc1-like	UniProtKB/TrEMBL
NCBI Gene	100363376	ENTREZGENE
PANTHER	COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG	UniProtKB/TrEMBL
	PTHR22977	UniProtKB/TrEMBL
Pfam	Cmc1	UniProtKB/TrEMBL
PhenoGen	Cmc2	PhenoGen
PROSITE	CHCH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011279	RatGTEx
	ENSRNOG00000068690	RatGTEx
UniProt	A0A8I5ZLA6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A307_RAT	UniProtKB/TrEMBL
	A0ABK0LQL0_RAT	UniProtKB/TrEMBL
	A6IZF8	ENTREZGENE, UniProtKB/TrEMBL
	D4A471	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Cmc2	C-x(9)-C motif containing 2	Cmc2	C-x(9)-C motif containing 2	Data merged from RGD:149736354	737654	PROVISIONAL
2021-08-09	Cmc2	C-x(9)-C motif containing 2			Symbol and Name status set to provisional	45752	PROVISIONAL
2021-03-09	Cmc2	C-x(9)-C motif containing 2	LOC108348946	uncharacterized LOC108348946	Data merged from RGD:11497651	737654	PROVISIONAL
2016-08-02	LOC108348946	uncharacterized LOC108348946			Symbol and Name status set to provisional	70820	PROVISIONAL
2014-05-12	Cmc2	C-x(9)-C motif containing 2	Cmc2	COX assembly mitochondrial protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-09-11	Cmc2	COX assembly mitochondrial protein 2	LOC100363376	rCG51296-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100363376	rCG51296-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD