Igll1 (immunoglobulin lambda-like polypeptide 1) - Rat Genome Database

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Gene: Igll1 (immunoglobulin lambda-like polypeptide 1) Rattus norvegicus
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Symbol: Igll1
Name: immunoglobulin lambda-like polypeptide 1
RGD ID: 2321140
Description: Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be part of IgG immunoglobulin complex. Human ortholog(s) of this gene implicated in agammaglobulinemia 2. Orthologous to several human genes including IGLL5 (immunoglobulin lambda like polypeptide 5); INTERACTS WITH bisphenol A (ortholog); crocidolite asbestos (ortholog); diuron (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Immunoglobulin lambda-like polypeptide 1-like; immunoglobulin lambda-like polypeptide 5; LOC100360919
RGD Orthologs
Human
Bonobo
Dog
Pig
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,643,059 - 97,646,441 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,643,187 - 97,646,438 (+)EnsemblGRCr8
mRatBN7.21184,138,847 - 84,142,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,863,043 - 92,866,028 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,524,170 - 85,527,155 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,577,768 - 84,580,753 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,388,378 - 88,391,524 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)Ensemblrn6Rnor6.0
Rnor_5.01191,443,556 - 91,446,702 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,159,013 - 86,162,005 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,893,848 - 82,896,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23533145  


Genomics

Comparative Map Data
Igll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,643,059 - 97,646,441 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1197,643,187 - 97,646,438 (+)EnsemblGRCr8
mRatBN7.21184,138,847 - 84,142,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1192,863,043 - 92,866,028 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,524,170 - 85,527,155 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,577,768 - 84,580,753 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,388,378 - 88,391,524 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)Ensemblrn6Rnor6.0
Rnor_5.01191,443,556 - 91,446,702 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,159,013 - 86,162,005 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1182,893,848 - 82,896,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
IGLL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,887,816 - 22,896,111 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,887,780 - 22,896,111 (+)Ensemblhg38GRCh38
GRCh372223,229,996 - 23,238,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera227,044,543 - 7,052,595 (+)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef226,197,809 - 6,205,863 (+)NCBIHuRef
CHM1_12223,242,250 - 23,250,304 (+)NCBICHM1_1
T2T-CHM13v2.02223,310,731 - 23,319,020 (+)NCBIT2T-CHM13v2.0
IGLL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22332,563,069 - 32,725,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12235,357,083 - 35,533,238 (-)NCBINHGRI_mPanPan1
PanPan1.12221,510,540 - 21,518,611 (+)NCBIPanPan1.1PanPan1.1panPan2
LOC100687054
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,793,360 - 28,804,589 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,866,346 - 27,877,439 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02630,198,265 - 30,211,125 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12628,279,681 - 28,292,353 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,897,421 - 27,908,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,885,493 - 28,898,314 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100523213
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11449,951,542 - 49,960,517 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,393,870 - 53,403,011 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Igll5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v142,139,133 - 2,142,124 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000029851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 2 24 33 38 43 34 43 34 143 80 11 21 25 26 9 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000029851   ⟹   ENSRNOP00000031750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1197,643,187 - 97,646,438 (+)Ensembl
mRatBN7.2 Ensembl1184,138,910 - 84,142,216 (+)Ensembl
Rnor_6.0 Ensembl1188,388,378 - 88,391,370 (+)Ensembl
RefSeq Acc Id: NM_001190341   ⟹   NP_001177270
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,643,187 - 97,646,438 (+)NCBI
mRatBN7.21184,138,982 - 84,142,233 (+)NCBI
Rnor_6.01188,388,378 - 88,391,370 (+)NCBI
Rnor_5.01191,443,556 - 91,446,702 (+)NCBI
Celera1182,893,848 - 82,896,756 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248656   ⟹   XP_006248718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,643,059 - 97,646,441 (+)NCBI
mRatBN7.21184,138,847 - 84,142,238 (+)NCBI
Rnor_6.01188,388,378 - 88,391,524 (+)NCBI
Rnor_5.01191,443,556 - 91,446,702 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001177270 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248718 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA92268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031750
  ENSRNOP00000031750.4
RefSeq Acc Id: NP_001177270   ⟸   NM_001190341
- Peptide Label: precursor
- UniProtKB: F1MAM7 (UniProtKB/TrEMBL),   A0NA94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248718   ⟸   XM_006248656
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000031750   ⟸   ENSRNOT00000029851
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAM7-F1-model_v2 AlphaFold F1MAM7 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321140 AgrOrtholog
BioCyc Gene G2FUF-20560 BioCyc
Ensembl Genes ENSRNOG00000025990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029851 ENTREZGENE
  ENSRNOT00000029851.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC/Immunoglobulin UniProtKB/TrEMBL
KEGG Report rno:100360919 UniProtKB/TrEMBL
NCBI Gene 100360919 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
PhenoGen Igll1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025990 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0NA94 ENTREZGENE, UniProtKB/TrEMBL
  F1MAM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-09 Igll1  immunoglobulin lambda-like polypeptide 1  LOC100360919  Immunoglobulin lambda-like polypeptide 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360919  Immunoglobulin lambda-like polypeptide 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL