Cfhr2l1 (complement factor H-related 2-like 1) - Rat Genome Database

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Gene: Cfhr2l1 (complement factor H-related 2-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cfhr2l1 (Ensembl: LOC100361907)
Name: complement factor H-related 2-like 1 (Ensembl:complement factor H-related protein B)
RGD ID: 2319172
Description: Human ortholog(s) of this gene implicated in age related macular degeneration 1 and atypical hemolytic-uremic syndrome. Orthologous to several human genes including CFHR4 (complement factor H related 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cfh protein-like; complement factor H-like; complement factor H-related protein 2-like; complement factor H-related protein 3-like; complement factor H-related protein B; LOC100360824; LOC100361907
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,813,350 - 53,847,482 (-)NCBIGRCr8
mRatBN7.21351,262,631 - 51,296,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,262,633 - 51,296,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,852,338 - 53,886,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,140,255 - 55,174,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,439,002 - 52,473,121 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,729,910 - 56,764,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,730,397 - 56,763,981 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,748,292 - 61,782,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,044,731 - 53,073,946 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1351,522,575 - 51,556,337 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cfhr2l1
218 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 41 41 1
Low 1 2 7 1 3 3 1 13 14 7 3
Below cutoff 12 9 15 5 6 6 8 14 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087916   ⟹   ENSRNOP00000070600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,262,633 - 51,296,723 (-)Ensembl
Rnor_6.0 Ensembl1356,730,397 - 56,763,981 (-)Ensembl
RefSeq Acc Id: NM_001402196   ⟹   NP_001389125
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,813,350 - 53,847,482 (-)NCBI
mRatBN7.21351,262,631 - 51,296,767 (-)NCBI
RefSeq Acc Id: XM_008769581   ⟹   XP_008767803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,813,350 - 53,847,479 (-)NCBI
mRatBN7.21351,262,635 - 51,296,754 (-)NCBI
Rnor_6.01356,729,910 - 56,764,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091342   ⟹   XP_038947270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,813,350 - 53,847,472 (-)NCBI
mRatBN7.21351,262,635 - 51,296,754 (-)NCBI
RefSeq Acc Id: XM_039091343   ⟹   XP_038947271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,813,350 - 53,847,472 (-)NCBI
mRatBN7.21351,262,635 - 51,296,754 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389125 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767803 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947270 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947271 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070600
  ENSRNOP00000070600.2
Reference Protein Sequences
RefSeq Acc Id: XP_008767803   ⟸   XM_008769581
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070600   ⟸   ENSRNOT00000087916
RefSeq Acc Id: XP_038947271   ⟸   XM_039091343
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947270   ⟸   XM_039091342
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001389125   ⟸   NM_001402196
- Peptide Label: precursor
- UniProtKB: A0A0G2JYC4 (UniProtKB/TrEMBL),   Q5FVP9 (UniProtKB/TrEMBL)
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYC4-F1-model_v2 AlphaFold A0A0G2JYC4 1-389 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698881
Promoter ID:EPDNEW_R9391
Type:initiation region
Name:LOC100361907_1
Description:complement factor H-related protein B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01356,764,039 - 56,764,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319172 AgrOrtholog
BioCyc Gene G2FUF-18071 BioCyc
Ensembl Genes ENSRNOG00000052604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087916 ENTREZGENE
  ENSRNOT00000087916.2 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
InterPro Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
NCBI Gene 100361907 ENTREZGENE
PANTHER COMPLEMENT FACTOR H UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cfhr2l1 PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052604 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/TrEMBL
UniProt A0A0G2JYC4 ENTREZGENE
  Q5FVP9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JYC4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cfhr2l1  complement factor H-related 2-like 1  LOC100361907  complement factor H-related protein B  Symbol and Name Changed 1299863 APPROVED
2015-07-29 LOC100361907  complement factor H-related protein B  LOC100360824  Cfh protein-like  Data merged from RGD:2321334 737654 PROVISIONAL
2010-05-05 LOC100361907  complement factor H-related protein B      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100360824  Cfh protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL