Gene:	Cd8a ( Rattus norvegicus ) CD8a molecule
Description:	increased expression on mast cells is induced by nitric oxide; may play a role in inflammatory response
Synonyms:	CD8 antigen, alpha chain; CD8 antigen alpha-chain;  (details...)
ArrayIDs:	1369877_at; 1395116_at; 6324744; 6201303; A_44_P448964; 1385414_at; 6714276; 6111447; 5956206; 6483230; X03015_at; 6718597; 5982144; GE21080; A_43_P12578; A_44_P448431;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CD8A     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cd8a     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cd8a genome assembly 3.1 4 104834402 - 104838639     Rat Celera Assembly 4 92538482 - 92542731     RGSC genome assembly v3.4 4 104589922 - 104594159     Cytogenetic 4 q33 Mus musculus Cd8a Mouse genome assembly build 36.1 6 71323421 - 71329165     Cytogenetic 6 6 C Homo sapiens CD8A human genome assembly 2 86923391 - 86929725     Human genome assembly build 36.2 2 86865239 - 86871638     Cytogenetic 2 p12   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  protein homodimerization activity (details...)
Biological Process	Gene Ontology immune response,  positive regulation of calcium-mediated signaling,  T cell activation ...  (details...)
Cellular Component	Gene Ontology membrane,  integral to membrane,  external side of plasma membrane ...  (details...)
Expression	Note Reference expressed on alveolar macrophages and peritoneal mast cells 728221
External Links
Databases	DATABASE ID SOURCE SMART: IG IPI PROSITE: IG_LIKE IPI UNIPARC: UPI00001273B6 IPI KEGG Report: rno:24930 ENTREZGENE HomoloGene Group ID: 1339 ENTREZGENE Germonline: 2316 Pfam: ig IPI KEGG Pathway: 04514 ENTREZGENE KEGG Pathway: 04612 ENTREZGENE KEGG Pathway: 04640 ENTREZGENE KEGG Pathway: 05340 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: CD8_asu. IPI InterPro: Ig. IPI InterPro: Ig-like_fold. IPI InterPro: Ig_sub. IPI InterPro: Ig-like. IPI Ensembl Protein: ENSRNOP00000009516 IPI IPI: IPI00210541 IPI Gene3D-CATH: Ig-like_fold IPI Entrez Gene: Cd8a ENTREZGENE IMAGE_CLONE: IMAGE:7381324 IMAGE-MGC_LOAD MGC_CLONE: MGC:108655 IMAGE-MGC_LOAD UniProt: CD8A_RAT IPI Ensembl Genes: ENSRNOG00000007178 IPI RatMap: 34965 ENTREZGENE PANTHER: CD8_alpha IPI
Sequences	Nucleotide: NM_031538 Get FASTA Search GEO Profiles Nucleotide: CH473957 Get FASTA Search GEO Profiles Nucleotide: BC088126 Get FASTA Search GEO Profiles Nucleotide: X03015 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_113726 Get FASTA Protein: EDL90991 Get FASTA Protein: EDL90992 Get FASTA Protein: AAH88126 Get FASTA Protein: P07725 Get FASTA Protein: CAA26798 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 10306
References
Curated References	6 references in RGD related to Cd8a
Other References	10 other references at PubMed related to Cd8a
Database Information
RGD ID	2316
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 26-SEP-08: Cd8a CD8a molecule Cd8a CD8 antigen, alpha chain APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Cd8a CD8 antigen, alpha-chain APPROVED Symbol and Name status set to approved 70586