Scarb1 (scavenger receptor class B, member 1) - Rat Genome Database

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Gene: Scarb1 (scavenger receptor class B, member 1) Rattus norvegicus
Analyze
Symbol: Scarb1
Name: scavenger receptor class B, member 1
RGD ID: 2302
Description: Enables identical protein binding activity and phosphatidylserine binding activity. Involved in several processes, including androgen biosynthetic process; recognition of apoptotic cell; and response to vitamin B3. Located in cell surface and microvillus membrane. Biomarker of end stage renal disease. Orthologous to human SCARB1 (scavenger receptor class B member 1); PARTICIPATES IN retinol metabolic pathway; reverse cholesterol transport pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; Cd36l1; scavanger receptor class B type 1; scavenger receptor class B member 1; scavenger receptor class B type I; SR-B1; SR-BI; Srb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,957,302 - 37,023,982 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,957,496 - 37,023,980 (+)EnsemblGRCr8
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)Ensemblrn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,988,597 - 33,054,666 (+)NCBICelera
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Cytogenetic Map12q15NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-methylimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (EXP)
allethrin  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bifenthrin  (ISO)
bis(2-butoxyethyl)phthalate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
bromocriptine  (EXP)
bucladesine  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl hydrogen phosphate  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
Dimethyl phthalate  (EXP,ISO)
diosgenin  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
genistein  (EXP,ISO)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
iron trichloride  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (ISO)
lovastatin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methyltestosterone  (ISO)
Mezerein  (ISO)
mifepristone  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
organophosphorus compound  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propamocarb  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
saccharin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sucrose  (EXP)
sulfadimethoxine  (ISO)
sulpiride  (EXP)
temozolomide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thiamethoxam  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc dichloride  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adhesion of symbiont to host  (IEA)
androgen biosynthetic process  (IDA)
blood vessel endothelial cell migration  (ISO)
cholesterol catabolic process  (ISO)
cholesterol efflux  (IBA,IEA,ISO)
cholesterol homeostasis  (IEA,ISO)
cholesterol import  (IBA,IEA,ISO)
cholesterol transport  (ISO)
detection of lipopolysaccharide  (IEA,ISO)
endothelial cell proliferation  (ISO)
high density lipoprotein particle mediated signaling  (IEA,ISO)
high-density lipoprotein particle clearance  (IEA,ISO,ISS)
high-density lipoprotein particle remodeling  (IEA,ISO)
intestinal absorption  (ISO)
lipid transport  (IEA,IMP)
lipopolysaccharide transport  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA)
low-density lipoprotein particle clearance  (IEA,ISO)
phagocytosis, recognition  (IMP)
phospholipid transport  (IEA,ISO)
plasma lipoprotein particle clearance  (IBA)
positive regulation of cholesterol storage  (IEA,ISO,ISS)
positive regulation of nitric oxide mediated signal transduction  (IEA,ISO)
positive regulation of sphingolipid mediated signaling pathway  (IEA,ISO)
positive regulation of triglyceride biosynthetic process  (IEA,ISO)
recognition of apoptotic cell  (IBA,IDA,IEA,ISO,ISS)
regulation of phagocytosis  (IDA,TAS)
regulation of phosphatidylcholine catabolic process  (IEA,ISO)
response to vitamin B3  (IEP)
reverse cholesterol transport  (IEA,ISO,ISS)
steroid biosynthetic process  (TAS)
transcytosis  (ISO)
triglyceride homeostasis  (IEA,ISO)
vasodilation  (ISO)
vitamin transmembrane transport  (IEA,ISO)

Cellular Component
apical plasma membrane  (ISO)
basolateral plasma membrane  (ISO)
caveola  (IBA,IEA,ISO)
cell surface  (IBA,IDA,IEA,ISO)
cytoplasm  (IEA,ISO)
membrane  (IEA,ISO)
microvillus membrane  (IDA)
plasma membrane  (IDA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hormonal regulation of adrenal microvillar channel formation. Azhar S, etal., J Lipid Res. 2002 Jun;43(6):861-71.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
5. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence. Johnson MS, etal., Endocrinology 1998 Jan;139(1):72-80.
6. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells. Kawasaki Y, etal., J Biol Chem 2002 Jul 26;277(30):27559-66. Epub 2002 May 16.
7. Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways. Liu M, etal., Environ Toxicol. 2022 Oct;37(10):2419-2433. doi: 10.1002/tox.23607. Epub 2022 Jun 28.
8. Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis. Lv Y, etal., Toxicology. 2019 Jan 1;411:60-70. doi: 10.1016/j.tox.2018.10.020. Epub 2018 Nov 1.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Mizutani T, etal., Biochem Biophys Res Commun 1997 May 19;234(2):499-505.
11. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. Pardina E, etal., BBA Clin. 2016 Jan 8;5:54-65. doi: 10.1016/j.bbacli.2015.12.002. eCollection 2016 Jun.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. Reaven E, etal., J Lipid Res. 2004 Mar;45(3):513-28. Epub 2003 Dec 1.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders. Rhainds D and Brissette L, Int J Biochem Cell Biol. 2004 Jan;36(1):39-77.
22. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
23. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. Shiratsuchi A, etal., J Biol Chem 1999 Feb 26;274(9):5901-8.
24. Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. Varatharajalu R, etal., Am J Pathol. 2014 Jul;184(7):2035-44. doi: 10.1016/j.ajpath.2014.03.005. Epub 2014 May 6.
25. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Wu Q, etal., Endocrinology 2003 Jun;144(6):2437-45.
26. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Yeh YC, etal., Atherosclerosis 2002 Mar;161(1):95-103.
27. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Zhang S, etal., Circulation. 2005 Jun 28;111(25):3457-64. Epub 2005 Jun 20.
Additional References at PubMed
PMID:8753864   PMID:9148942   PMID:9211901   PMID:9254056   PMID:10221589   PMID:10559220   PMID:10579331   PMID:10764676   PMID:10829064   PMID:11208913   PMID:11240025   PMID:11278646  
PMID:11792700   PMID:12202492   PMID:12477932   PMID:12493702   PMID:12562842   PMID:12651854   PMID:14652019   PMID:14694755   PMID:14718538   PMID:14729860   PMID:15140193   PMID:15206959  
PMID:15210842   PMID:15210959   PMID:15489334   PMID:16297529   PMID:16298471   PMID:16339487   PMID:16530182   PMID:16530456   PMID:16584836   PMID:17241464   PMID:17897319   PMID:17905649  
PMID:18079677   PMID:18175806   PMID:19041881   PMID:19087225   PMID:19122200   PMID:19136670   PMID:20458337   PMID:21481393   PMID:22767607   PMID:23197320   PMID:23482569   PMID:25701869  
PMID:25817199   PMID:26567857   PMID:26965621   PMID:27155079   PMID:27881715   PMID:27934803   PMID:28669731   PMID:31344978  


Genomics

Comparative Map Data
Scarb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,957,302 - 37,023,982 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,957,496 - 37,023,980 (+)EnsemblGRCr8
mRatBN7.21231,296,143 - 31,362,649 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,296,156 - 31,362,647 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,468,363 - 32,534,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,079,673 - 33,146,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,131,509 - 32,197,925 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,694,952 - 36,761,445 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)Ensemblrn6Rnor6.0
Rnor_5.01238,572,152 - 38,638,465 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,390,183 - 32,457,661 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,988,597 - 33,054,666 (+)NCBICelera
RGSC_v3.11232,253,570 - 32,321,047 (+)NCBI
Cytogenetic Map12q15NCBI
SCARB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,776,856 - 124,863,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,776,856 - 124,882,668 (-)Ensemblhg38GRCh38
GRCh3712125,261,402 - 125,348,410 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,828,127 - 123,914,472 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412123,787,055 - 123,873,214NCBI
Celera12124,862,283 - 124,949,187 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,224,152 - 122,310,029 (-)NCBIHuRef
CHM1_112125,083,775 - 125,169,604 (-)NCBICHM1_1
T2T-CHM13v2.012124,782,134 - 124,869,001 (-)NCBIT2T-CHM13v2.0
Scarb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,354,151 - 125,418,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,354,151 - 125,418,158 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385125,277,087 - 125,341,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,277,087 - 125,341,094 (-)Ensemblmm10GRCm38
MGSCv375125,757,460 - 125,821,444 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365125,566,069 - 125,630,053 (-)NCBIMGSCv36mm8
Celera5122,296,944 - 122,361,197 (-)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.11NCBI
Scarb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,813,955 - 4,837,392 (+)Ensembl
ChiLan1.0NW_0049554824,813,502 - 4,836,479 (+)NCBIChiLan1.0ChiLan1.0
SCARB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210132,858,215 - 132,987,046 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112132,782,925 - 132,944,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,293,803 - 122,455,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,651,077 - 126,698,506 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,659,532 - 126,694,767 (-)EnsemblpanPan2panpan1.1
SCARB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,035,797 - 5,122,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,049,407 - 5,121,468 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha265,195,714 - 5,282,186 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0265,282,168 - 5,368,989 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,295,032 - 5,368,981 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,217,039 - 5,303,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,308,627 - 5,394,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,260,548 - 5,347,101 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scarb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118158,927,028 - 158,948,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558530,828 - 552,892 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936558530,828 - 555,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCARB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,301,294 - 28,393,568 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11428,301,421 - 28,393,568 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21430,050,898 - 30,093,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCARB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,134,485 - 120,223,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,134,874 - 120,216,904 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037125,058,937 - 125,145,319 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scarb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,973,648 - 24,010,820 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474723,970,782 - 24,010,683 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Scarb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11628,575,614 - 28,640,311 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Scarb1
526 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir455rno-miR-455-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399
Mir125arno-miR-125a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23045399

Predicted Target Of
Summary Value
Count of predictions:776
Count of miRNA genes:242
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000001299, ENSRNOT00000001301, ENSRNOT00000064276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH130563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,338,775 - 31,338,990 (+)MAPPERmRatBN7.2
Rnor_6.01236,737,576 - 36,737,790NCBIRnor6.0
Rnor_5.01238,614,596 - 38,614,810UniSTSRnor5.0
RGSC_v3.41232,433,792 - 32,434,006UniSTSRGSC3.4
Celera1233,030,797 - 33,031,011UniSTS
RH 3.4 Map12567.91UniSTS
Cytogenetic Map12q15-q16UniSTS
RH134480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2333,061,973 - 33,062,160 (+)MAPPERmRatBN7.2
mRatBN7.21231,362,360 - 31,362,548 (-)MAPPERmRatBN7.2
mRatBN7.21231,362,360 - 31,362,548 (+)MAPPERmRatBN7.2
Rnor_6.01236,761,157 - 36,761,344NCBIRnor6.0
Rnor_6.0332,805,794 - 32,805,980NCBIRnor6.0
Rnor_5.01238,638,177 - 38,638,364UniSTSRnor5.0
Rnor_5.0337,970,526 - 37,970,712UniSTSRnor5.0
RGSC_v3.41232,457,373 - 32,457,560UniSTSRGSC3.4
RGSC_v3.4329,564,155 - 29,564,341UniSTSRGSC3.4
Celera1233,054,378 - 33,054,565UniSTS
Celera331,275,513 - 31,275,699UniSTS
RH 3.4 Map12549.3UniSTS
Cytogenetic Map12q15-q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 355 192 11 139 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001299   ⟹   ENSRNOP00000001299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,957,515 - 37,023,980 (+)Ensembl
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,695,052 - 36,761,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000001301   ⟹   ENSRNOP00000001301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,996,852 - 37,020,296 (+)Ensembl
mRatBN7.2 Ensembl1231,335,515 - 31,359,274 (+)Ensembl
Rnor_6.0 Ensembl1236,734,372 - 36,760,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064276   ⟹   ENSRNOP00000060874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,957,507 - 37,023,980 (+)Ensembl
mRatBN7.2 Ensembl1231,296,251 - 31,362,647 (+)Ensembl
Rnor_6.0 Ensembl1236,694,960 - 36,761,455 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110392   ⟹   ENSRNOP00000085701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,957,496 - 37,020,296 (+)Ensembl
mRatBN7.2 Ensembl1231,296,156 - 31,359,274 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173383   ⟹   ENSRNOP00000105548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,957,496 - 37,018,709 (+)Ensembl
RefSeq Acc Id: NM_031541   ⟹   NP_113729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,957,496 - 37,023,982 (+)NCBI
mRatBN7.21231,296,156 - 31,362,649 (+)NCBI
Rnor_6.01236,694,957 - 36,761,445 (+)NCBI
Rnor_5.01238,572,152 - 38,638,465 (+)NCBI
RGSC_v3.41232,390,183 - 32,457,661 (+)RGD
Celera1232,988,597 - 33,054,666 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598269   ⟹   XP_017453758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,957,302 - 37,023,982 (+)NCBI
mRatBN7.21231,296,167 - 31,362,649 (+)NCBI
Rnor_6.01236,694,952 - 36,761,445 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113729   ⟸   NM_031541
- UniProtKB: P97943 (UniProtKB/Swiss-Prot),   A6J0X1 (UniProtKB/TrEMBL),   Q6SR89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453758   ⟸   XM_017598269
- Peptide Label: isoform X1
- UniProtKB: G3V636 (UniProtKB/TrEMBL),   A6J0X0 (UniProtKB/TrEMBL),   Q6B4I7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001299   ⟸   ENSRNOT00000001299
Ensembl Acc Id: ENSRNOP00000001301   ⟸   ENSRNOT00000001301
Ensembl Acc Id: ENSRNOP00000060874   ⟸   ENSRNOT00000064276
Ensembl Acc Id: ENSRNOP00000085701   ⟸   ENSRNOT00000110392
Ensembl Acc Id: ENSRNOP00000105548   ⟸   ENSRNOT00000173383

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97943-F1-model_v2 AlphaFold P97943 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698602
Promoter ID:EPDNEW_R9127
Type:initiation region
Name:Scarb1_1
Description:scavenger receptor class B, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,695,033 - 36,695,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2302 AgrOrtholog
BioCyc Gene G2FUF-19380 BioCyc
Ensembl Genes ENSRNOG00000000981 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001299 ENTREZGENE
  ENSRNOT00000110392 ENTREZGENE
InterPro CD36/SCARB1/SNMP1 UniProtKB/Swiss-Prot
  CD36_fam UniProtKB/Swiss-Prot
KEGG Report rno:25073 UniProtKB/Swiss-Prot
NCBI Gene 25073 ENTREZGENE
PANTHER PTHR11923 UniProtKB/Swiss-Prot
  SCAVENGER RECEPTOR CLASS B MEMBER 1 UniProtKB/Swiss-Prot
Pfam CD36 UniProtKB/Swiss-Prot
PhenoGen Scarb1 PhenoGen
PRINTS CD36ANTIGEN UniProtKB/Swiss-Prot
  CD36FAMILY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000981 RatGTEx
UniProt A0A8I6A220_RAT UniProtKB/TrEMBL
  A0A8L2QSW8_RAT UniProtKB/TrEMBL
  A0ABK0LQZ6_RAT UniProtKB/TrEMBL
  A6J0X0 ENTREZGENE, UniProtKB/TrEMBL
  A6J0X1 ENTREZGENE, UniProtKB/TrEMBL
  F8WFG6_RAT UniProtKB/TrEMBL
  G3V636 ENTREZGENE, UniProtKB/TrEMBL
  P97943 ENTREZGENE
  Q6B4I7 ENTREZGENE, UniProtKB/TrEMBL
  Q6SR89 ENTREZGENE, UniProtKB/TrEMBL
  SCRB1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Scarb1  scavenger receptor class B, member 1      Symbol and Name updated 629477 APPROVED
2003-03-17 Scarb1  scavenger receptor class B, member 1  Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2001-06-12 Srb1  Scavanger receptor class B type 1      Symbol withdrawn, duplicate entry of Cd36l1 (RGD:2302) 62408 WITHDRAWN
2001-06-12 Cd36l1  CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1      Name updated 62408 APPROVED