Ost4 (oligosaccharyltransferase complex subunit 4, non-catalytic) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ost4 (oligosaccharyltransferase complex subunit 4, non-catalytic) Rattus norvegicus
Analyze
Symbol: Ost4
Name: oligosaccharyltransferase complex subunit 4, non-catalytic
RGD ID: 2300150
Description: Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. Orthologous to human OST4 (oligosaccharyltransferase complex subunit 4, non-catalytic); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; LOC100188932; MGC187574; oligosaccharyltransferase 4 homolog; oligosaccharyltransferase 4 homolog (S. cerevisiae); oligosaccharyltransferase complex subunit 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,191,198 - 31,192,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,191,198 - 31,192,422 (+)EnsemblGRCr8
mRatBN7.2625,471,254 - 25,472,478 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx625,771,579 - 25,772,803 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,087,443 - 26,088,667 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,566,614 - 25,567,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,836,216 - 26,837,440 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,836,216 - 26,837,440 (+)Ensemblrn6Rnor6.0
Rnor_5.0636,651,831 - 36,653,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4625,453,992 - 25,455,216 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera624,962,051 - 24,963,275 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15489334   PMID:23606741  


Genomics

Comparative Map Data
Ost4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,191,198 - 31,192,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,191,198 - 31,192,422 (+)EnsemblGRCr8
mRatBN7.2625,471,254 - 25,472,478 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx625,771,579 - 25,772,803 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,087,443 - 26,088,667 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,566,614 - 25,567,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,836,216 - 26,837,440 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,836,216 - 26,837,440 (+)Ensemblrn6Rnor6.0
Rnor_5.0636,651,831 - 36,653,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4625,453,992 - 25,455,216 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera624,962,051 - 24,963,275 (+)NCBICelera
Cytogenetic Map6q14NCBI
OST4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,070,472 - 27,071,654 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,070,470 - 27,071,685 (-)Ensemblhg38GRCh38
GRCh37227,293,340 - 27,294,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,146,844 - 27,148,587 (-)NCBIBuild 36Build 36hg18NCBI36
Celera227,139,684 - 27,140,911 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,035,493 - 27,036,720 (-)NCBIHuRef
CHM1_1227,223,256 - 27,224,483 (-)NCBICHM1_1
T2T-CHM13v2.0227,112,145 - 27,113,327 (-)NCBIT2T-CHM13v2.0
Ost4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,063,860 - 31,065,155 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,063,229 - 31,065,132 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38530,906,516 - 30,907,807 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,905,885 - 30,907,788 (-)Ensemblmm10GRCm38
MGSCv37531,208,891 - 31,210,161 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36531,183,099 - 31,184,306 (-)NCBIMGSCv36mm8
Celera528,386,153 - 28,387,423 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Ost4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,041,549 - 9,042,949 (-)Ensembl
ChiLan1.0NW_0049554699,041,549 - 9,042,949 (-)NCBIChiLan1.0ChiLan1.0
OST4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,443,771 - 99,445,044 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,447,741 - 99,449,012 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,069,526 - 27,070,789 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,158,388 - 27,159,641 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,159,261 - 27,159,374 (-)EnsemblpanPan2panpan1.1
OST4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,064,737 - 21,066,524 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,956,712 - 20,958,024 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01721,384,511 - 21,385,825 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11721,071,744 - 21,072,939 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,082,836 - 21,084,027 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,129,265 - 21,130,464 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ost4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,368,798 - 65,370,000 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,469,512 - 5,470,781 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,469,511 - 5,470,773 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OST4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,046,398 - 112,046,511 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13112,046,116 - 112,055,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,044,744 - 119,053,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OST4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,546,677 - 80,547,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,546,839 - 80,547,912 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604531,591,872 - 31,593,162 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ost4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,171,706 - 9,172,909 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247389,171,708 - 9,172,993 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ost4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1723,176,370 - 23,177,655 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ost4
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:100
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000011373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011373   ⟹   ENSRNOP00000011373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl626,836,244 - 26,837,440 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077903   ⟹   ENSRNOP00000075594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl626,836,216 - 26,837,440 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149100   ⟹   ENSRNOP00000108552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,191,198 - 31,192,422 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169806   ⟹   ENSRNOP00000104721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,191,226 - 31,192,422 (+)Ensembl
RefSeq Acc Id: NM_001134690   ⟹   NP_001128162
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,191,226 - 31,192,422 (+)NCBI
mRatBN7.2625,471,282 - 25,472,478 (+)NCBI
Rnor_6.0626,836,244 - 26,837,440 (+)NCBI
Rnor_5.0636,651,831 - 36,653,055 (+)NCBI
RGSC_v3.4625,453,992 - 25,455,216 (+)RGD
Celera624,962,079 - 24,963,275 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001134691   ⟹   NP_001128163
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,191,198 - 31,192,422 (+)NCBI
mRatBN7.2625,471,254 - 25,472,478 (+)NCBI
Rnor_6.0626,836,216 - 26,837,440 (+)NCBI
Rnor_5.0636,651,831 - 36,653,055 (+)NCBI
RGSC_v3.4625,453,992 - 25,455,216 (+)RGD
Celera624,962,051 - 24,963,275 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128162 (Get FASTA)   NCBI Sequence Viewer  
  NP_001128163 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI57815 (Get FASTA)   NCBI Sequence Viewer  
  B0BLS0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000104721
  ENSRNOP00000108552
RefSeq Acc Id: NP_001128163   ⟸   NM_001134691
- UniProtKB: B0BLS0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001128162   ⟸   NM_001134690
- UniProtKB: B0BLS0 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075594   ⟸   ENSRNOT00000077903
Ensembl Acc Id: ENSRNOP00000011373   ⟸   ENSRNOT00000011373
Ensembl Acc Id: ENSRNOP00000104721   ⟸   ENSRNOT00000169806
Ensembl Acc Id: ENSRNOP00000108552   ⟸   ENSRNOT00000149100

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BLS0-F1-model_v2 AlphaFold B0BLS0 1-37 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694458
Promoter ID:EPDNEW_R4980
Type:initiation region
Name:Ost4_1
Description:oligosaccharyltransferase complex subunit 4, non-catalytic
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,836,241 - 26,836,301EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2300150 AgrOrtholog
BioCyc Gene G2FUF-38332 BioCyc
BioCyc Pathway MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS [protein N-glycosylation initial phase (eukaryotic)] BioCyc
BioCyc Pathway Image MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS BioCyc
Ensembl Genes ENSRNOG00000008605 Ensembl
  ENSRNOG00000074074 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000149100 ENTREZGENE
  ENSRNOT00000169806 ENTREZGENE
InterPro Oligosaccaryltransferase UniProtKB/Swiss-Prot
  OST4 UniProtKB/Swiss-Prot
  Ost4p_sf UniProtKB/Swiss-Prot
KEGG Report rno:100188932 UniProtKB/Swiss-Prot
NCBI Gene 100188932 ENTREZGENE
PANTHER DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4 UniProtKB/Swiss-Prot
  DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4 UniProtKB/Swiss-Prot
Pfam Ost4 UniProtKB/Swiss-Prot
PhenoGen Ost4 PhenoGen
RatGTEx ENSRNOG00000008605 RatGTEx
  ENSRNOG00000074074 RatGTEx
Superfamily-SCOP SSF103464 UniProtKB/Swiss-Prot
UniProt B0BLS0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Ost4  oligosaccharyltransferase complex subunit 4, non-catalytic  Ost4  oligosaccharyltransferase complex subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-17 Ost4  oligosaccharyltransferase complex subunit 4  Ost4  oligosaccharyltransferase 4 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Ost4  oligosaccharyltransferase 4 homolog (S. cerevisiae)  LOC100188932  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-06 LOC100188932  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4      Symbol and Name status set to provisional 70820 PROVISIONAL