Canx (calnexin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Canx (calnexin) Rattus norvegicus
Analyze
Symbol: Canx
Name: calnexin
RGD ID: 2266
Description: Enables apolipoprotein binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in ERAD pathway; endocytosis; and protein folding. Located in several cellular components, including dendrite; ribosome; and smooth endoplasmic reticulum. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Orthologous to human CANX (calnexin); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,124,941 - 35,157,954 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1035,124,941 - 35,157,857 (-)EnsemblGRCr8
mRatBN7.21034,623,865 - 34,656,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,625,191 - 34,656,821 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1039,295,127 - 39,328,327 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,834,377 - 7,867,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,288,797 - 34,322,002 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,800,942 - 35,833,939 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,800,942 - 35,833,861 (-)Ensemblrn6Rnor6.0
Rnor_5.01035,562,608 - 35,595,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41035,850,944 - 35,883,494 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1033,972,278 - 34,005,640 (-)NCBICelera
RGSC_v3.11035,855,099 - 35,870,453 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcidiol  (EXP)
capecitabine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
CCCP  (ISO)
cefaloridine  (EXP)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDT  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoniazide  (ISO)
ivermectin  (ISO)
L-serine  (ISO)
lead(0)  (ISO)
menadione  (ISO)
metformin  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miglustat  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
NMS-873  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Blanco EH, etal., Neuropeptides. 2011 Aug;45(4):273-9. doi: 10.1016/j.npep.2011.05.002. Epub 2011 May 31.
2. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Boden G, etal., Diabetes. 2008 Sep;57(9):2438-44. Epub 2008 Jun 20.
3. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
4. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Brothers SP, etal., J Mol Endocrinol. 2006 Dec;37(3):479-88.
5. Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes. Chevet E, etal., EMBO J. 1999 Jul 1;18(13):3655-66.
6. Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum. Di Jeso B, etal., Biochem J. 2003 Mar 1;370(Pt 2):449-58.
7. Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases. Dickson KM, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):9852-7. Epub 2002 Jul 15.
8. The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age. Erickson RR, etal., J Gerontol A Biol Sci Med Sci. 2006 May;61(5):435-43.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. NMDA receptor-dependent recruitment of calnexin to the neuronal plasma membrane. Itakura M, etal., Neurosci Lett. 2013 Aug 29;550:173-8. doi: 10.1016/j.neulet.2013.06.064. Epub 2013 Jul 9.
12. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
13. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, etal., Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18.
14. Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexin. Joseph SK, etal., Biochem J. 1999 Aug 15;342 ( Pt 1):153-61.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Apolipoprotein secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation. Nassir F, etal., J Lipid Res. 2003 Apr;44(4):816-27. Epub 2003 Feb 1.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Overexpression of ERp29 in the thyrocytes of FRTL-5 cells. Park S, etal., Mol Biol Rep. 2005 Mar;32(1):7-13.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, etal., J Neurosci. 2009 May 27;29(21):6883-96. doi: 10.1523/JNEUROSCI.4723-08.2009.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. Rubio ME and Wenthold RJ, J Neurochem. 1999 Sep;73(3):942-8.
25. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. Tjoelker LW, etal., Biochemistry 1994 Mar 22;33(11):3229-36.
26. The endoplasmic reticulum of Purkinje neuron body and dendrites: molecular identity and specializations for Ca2+ transport. Villa A, etal., Neuroscience. 1992 Jul;49(2):467-77.
27. Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons. Weclewicz K, etal., Brain Res Bull. 1998 Jul 1;46(4):353-60.
Additional References at PubMed
PMID:8440713   PMID:9034150   PMID:9094723   PMID:11408579   PMID:12646573   PMID:12847084   PMID:12927782   PMID:14525949   PMID:14966132   PMID:15152008   PMID:15184384   PMID:15452145  
PMID:16204232   PMID:16260597   PMID:16396499   PMID:17203246   PMID:17204322   PMID:17634366   PMID:18458083   PMID:19723497   PMID:19766735   PMID:19913121   PMID:19946888   PMID:20049854  
PMID:20531390   PMID:20628086   PMID:20700529   PMID:20720009   PMID:20732873   PMID:21190736   PMID:21235781   PMID:21606205   PMID:21747946   PMID:22375059   PMID:22486777   PMID:22572157  
PMID:22658674   PMID:22681889   PMID:23093945   PMID:23376485   PMID:23455425   PMID:23533145   PMID:23814182   PMID:23826168   PMID:23979707   PMID:24263861   PMID:24454821   PMID:26582200  
PMID:27425249   PMID:28912545   PMID:29522763   PMID:30188326   PMID:35352799  


Genomics

Comparative Map Data
Canx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,124,941 - 35,157,954 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1035,124,941 - 35,157,857 (-)EnsemblGRCr8
mRatBN7.21034,623,865 - 34,656,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,625,191 - 34,656,821 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1039,295,127 - 39,328,327 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,834,377 - 7,867,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,288,797 - 34,322,002 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,800,942 - 35,833,939 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,800,942 - 35,833,861 (-)Ensemblrn6Rnor6.0
Rnor_5.01035,562,608 - 35,595,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41035,850,944 - 35,883,494 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1033,972,278 - 34,005,640 (-)NCBICelera
RGSC_v3.11035,855,099 - 35,870,453 (-)NCBI
Cytogenetic Map10q22NCBI
CANX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,678,656 - 179,731,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,678,628 - 179,731,641 (+)Ensemblhg38GRCh38
GRCh375179,125,428 - 179,158,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,058,536 - 179,091,248 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345179,058,601 - 179,090,532NCBI
Celera5174,751,027 - 174,783,690 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,852,686 - 173,884,832 (+)NCBIHuRef
CHM1_15178,558,332 - 178,591,063 (+)NCBICHM1_1
T2T-CHM13v2.05180,233,830 - 180,286,826 (+)NCBIT2T-CHM13v2.0
Canx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,184,784 - 50,216,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,184,788 - 50,216,500 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381150,293,957 - 50,325,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,293,961 - 50,325,673 (-)Ensemblmm10GRCm38
MGSCv371150,107,459 - 50,139,175 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361150,137,890 - 50,169,014 (-)NCBIMGSCv36mm8
Celera1154,854,566 - 54,886,282 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.46NCBI
Canx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408848,808 - 894,362 (-)Ensembl
ChiLan1.0NW_004955408850,773 - 894,362 (-)NCBIChiLan1.0ChiLan1.0
CANX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,621,670 - 174,673,516 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,761,209 - 172,813,055 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,832,964 - 174,884,804 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,166,982 - 182,197,403 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,167,012 - 182,197,403 (+)EnsemblpanPan2panpan1.1
CANX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,966,612 - 1,998,620 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,927,888 - 1,998,604 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha112,089,958 - 2,121,930 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0111,940,260 - 1,973,222 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,940,276 - 1,973,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,912,686 - 1,944,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,991,514 - 2,023,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,232,031 - 2,264,021 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Canx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,842,076 - 119,892,055 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,051,240 - 1,086,405 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,051,853 - 1,085,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CANX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,879,033 - 78,915,827 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1278,879,031 - 78,915,828 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,445,609 - 80,482,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CANX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,422,701 - 81,454,683 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,422,693 - 81,482,332 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607512,804,176 - 12,829,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Canx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473342,588,680 - 42,616,624 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Canx
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1932,960,477 - 32,991,509 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Canx
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:320
Count of miRNA genes:206
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000049942
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,625,261 - 34,625,477 (+)MAPPERmRatBN7.2
Rnor_6.01035,802,339 - 35,802,554NCBIRnor6.0
Rnor_5.01035,564,005 - 35,564,220UniSTSRnor5.0
RGSC_v3.41035,852,341 - 35,852,556UniSTSRGSC3.4
Celera1033,973,675 - 33,973,890UniSTS
RH 3.4 Map10362.8UniSTS
Cytogenetic Map10q22UniSTS
RH131159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,623,866 - 34,624,052 (+)MAPPERmRatBN7.2
Rnor_6.01035,800,944 - 35,801,129NCBIRnor6.0
Rnor_5.01035,562,610 - 35,562,795UniSTSRnor5.0
RGSC_v3.41035,850,946 - 35,851,131UniSTSRGSC3.4
Celera1033,972,280 - 33,972,465UniSTS
RH 3.4 Map10347.4UniSTS
Cytogenetic Map10q22UniSTS
RH140739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,625,004 - 34,625,168 (+)MAPPERmRatBN7.2
Rnor_6.01035,802,082 - 35,802,245NCBIRnor6.0
Rnor_5.01035,563,748 - 35,563,911UniSTSRnor5.0
RGSC_v3.41035,852,084 - 35,852,247UniSTSRGSC3.4
Celera1033,973,418 - 33,973,581UniSTS
RH 3.4 Map10368.6UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049942   ⟹   ENSRNOP00000040859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1035,124,941 - 35,157,857 (-)Ensembl
mRatBN7.2 Ensembl1034,625,191 - 34,656,821 (-)Ensembl
Rnor_6.0 Ensembl1035,800,942 - 35,833,861 (-)Ensembl
RefSeq Acc Id: NM_172008   ⟹   NP_742005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,124,941 - 35,157,857 (-)NCBI
mRatBN7.21034,623,865 - 34,656,786 (-)NCBI
Rnor_6.01035,800,942 - 35,833,861 (-)NCBI
Rnor_5.01035,562,608 - 35,595,530 (-)NCBI
RGSC_v3.41035,850,944 - 35,883,494 (-)RGD
Celera1033,972,278 - 34,005,640 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767679   ⟹   XP_008765901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,125,897 - 35,157,931 (-)NCBI
mRatBN7.21034,625,675 - 34,656,863 (-)NCBI
Rnor_6.01035,801,898 - 35,833,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767680   ⟹   XP_008765902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,125,897 - 35,157,954 (-)NCBI
mRatBN7.21034,625,675 - 34,656,866 (-)NCBI
Rnor_6.01035,801,898 - 35,833,939 (-)NCBI
Sequence:
RefSeq Acc Id: NP_742005   ⟸   NM_172008
- Peptide Label: precursor
- UniProtKB: P35565 (UniProtKB/Swiss-Prot),   A6HE13 (UniProtKB/TrEMBL),   A0A8L2QK91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765902   ⟸   XM_008767680
- Peptide Label: isoform X1
- UniProtKB: P35565 (UniProtKB/Swiss-Prot),   A6HE13 (UniProtKB/TrEMBL),   A0A8L2QK91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765901   ⟸   XM_008767679
- Peptide Label: isoform X1
- UniProtKB: P35565 (UniProtKB/Swiss-Prot),   A6HE13 (UniProtKB/TrEMBL),   A0A8L2QK91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040859   ⟸   ENSRNOT00000049942

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35565-F1-model_v2 AlphaFold P35565 1-591 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697154
Promoter ID:EPDNEW_R7678
Type:initiation region
Name:Canx_1
Description:calnexin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,833,882 - 35,833,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2266 AgrOrtholog
BioCyc Gene G2FUF-25241 BioCyc
Ensembl Genes ENSRNOG00000003343 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000049942 ENTREZGENE
Gene3D-CATH 2.10.250.10 UniProtKB/Swiss-Prot
  2.60.120.200 UniProtKB/Swiss-Prot
InterPro Calret/calnex UniProtKB/Swiss-Prot
  Calret/calnex_CS UniProtKB/Swiss-Prot
  Calreticulin/calnexin_P_dom_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29144 UniProtKB/Swiss-Prot
NCBI Gene 29144 ENTREZGENE
PANTHER CALNEXIN UniProtKB/Swiss-Prot
  PTHR11073 UniProtKB/Swiss-Prot
Pfam Calreticulin UniProtKB/Swiss-Prot
PhenoGen Canx PhenoGen
PRINTS CALRETICULIN UniProtKB/Swiss-Prot
PROSITE CALRETICULIN_1 UniProtKB/Swiss-Prot
  CALRETICULIN_2 UniProtKB/Swiss-Prot
  CALRETICULIN_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003343 RatGTEx
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
  SSF63887 UniProtKB/Swiss-Prot
UniProt A0A8L2QK91 ENTREZGENE, UniProtKB/TrEMBL
  A6HE13 ENTREZGENE, UniProtKB/TrEMBL
  CALX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Canx  calnexin       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 69792
gene_function binds Ca2+ and may function as a chaperone in the transition of proteins from the ER to the outer cellular membrane 69792
gene_protein 90 kDa protein 69792