Camk4 (calcium/calmodulin-dependent protein kinase IV) - Rat Genome Database

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Gene: Camk4 (calcium/calmodulin-dependent protein kinase IV) Rattus norvegicus
Analyze
Symbol: Camk4
Name: calcium/calmodulin-dependent protein kinase IV
RGD ID: 2264
Description: Enables calcium/calmodulin-dependent protein kinase activity. Predicted to be involved in several processes, including long-term memory; myeloid dendritic cell differentiation; and postsynapse to nucleus signaling pathway. Predicted to act upstream of or within several processes, including neuron-neuron synaptic transmission; nucleocytoplasmic transport; and positive regulation of protein export from nucleus. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV); PARTICIPATES IN calcium/calcium-mediated signaling pathway; long term potentiation; neurotrophic factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium/calmodulin-dependent protein kinase type IV; Calmodulin-dependent protein kinase IV; calspermin; CAM kinase-GR; caMK IV; Ccdpk; RATCCDPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,857,152 - 25,076,054 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,857,146 - 25,077,193 (+)EnsemblGRCr8
mRatBN7.21824,582,988 - 24,811,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,585,269 - 24,802,487 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1824,711,029 - 24,929,241 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01825,476,377 - 25,693,513 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,806,056 - 25,024,906 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01825,746,878 - 25,975,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,749,098 - 25,965,957 (+)Ensemblrn6Rnor6.0
Rnor_5.01825,461,935 - 25,690,666 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41825,404,123 - 25,625,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1824,329,977 - 24,549,475 (+)NCBICelera
RGSC_v3.11825,434,889 - 25,652,443 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acrolein  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
casticin  (ISO)
clozapine  (EXP)
cocaine  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
kainic acid  (ISO)
KN-93  (EXP)
lanthanum atom  (EXP)
lanthanum trichloride  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
maneb  (ISO)
melatonin  (EXP)
methapyrilene  (ISO)
methylseleninic acid  (ISO)
N-Nitrosopyrrolidine  (ISO)
nicardipine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
resveratrol  (EXP)
risperidone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrodotoxin  (EXP)
thapsigargin  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
fibrillar center  (IEA,ISO)
GABA-ergic synapse  (ISO)
glutamatergic synapse  (IDA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IEA,ISO)
postsynapse  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Bilbao A, etal., Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17549-54. doi: 10.1073/pnas.0803959105. Epub 2008 Nov 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Calcium/calmodulin-dependent protein kinase IV gene polymorphisms in Korean alcohol-dependent patients. Jung WY, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):386-391. doi: 10.1016/j.pnpbp.2017.07.016. Epub 2017 Jul 20.
5. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Kang H, etal., Cell 2001 Sep 21;106(6):771-83.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. An immunohistochemical study of Ca2+/calmodulin-dependent protein kinase IV in the rat central nervous system: light and electron microscopic observations. Nakamura Y, etal., Neuroscience. 1995 Sep;68(1):181-94.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase. Ohmstede CA, etal., J Biol Chem 1989 Apr 5;264(10):5866-75.
10. Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene. Ohmstede CA, etal., Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5784-8.
11. Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex. Pandey SC, etal., J Pharmacol Exp Ther. 2001 Mar;296(3):857-68.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells. Sakagami H and Kondo H, Brain Res Mol Brain Res 1993 Aug;19(3):215-8.
16. Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene. Sun Z, etal., J Biol Chem 1995 Dec 8;270(49):29507-14.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Wu JY, etal., Nat Genet 2000 Aug;25(4):448-52.
Additional References at PubMed
PMID:1646483   PMID:1649385   PMID:2914893   PMID:7592527   PMID:7615569   PMID:7961813   PMID:8065343   PMID:8107230   PMID:8299971   PMID:8621702   PMID:8631893   PMID:8636117  
PMID:8855261   PMID:9596578   PMID:9822657   PMID:10336483   PMID:10964952   PMID:11081517   PMID:12086646   PMID:12130539   PMID:12403833   PMID:12477932   PMID:14701808   PMID:15262966  
PMID:15308608   PMID:15537635   PMID:15719015   PMID:15748849   PMID:15919723   PMID:16822951   PMID:16923323   PMID:17273866   PMID:17909078   PMID:18029144   PMID:18381242   PMID:18559891  
PMID:18829949   PMID:19056867   PMID:19292454   PMID:19506079   PMID:19711354   PMID:19874424   PMID:20056827   PMID:20423744   PMID:20799369   PMID:21762679   PMID:21989476   PMID:23680840  
PMID:23817991   PMID:27216039   PMID:28592691   PMID:30053369   PMID:34586897  


Genomics

Comparative Map Data
Camk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,857,152 - 25,076,054 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,857,146 - 25,077,193 (+)EnsemblGRCr8
mRatBN7.21824,582,988 - 24,811,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,585,269 - 24,802,487 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1824,711,029 - 24,929,241 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01825,476,377 - 25,693,513 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,806,056 - 25,024,906 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01825,746,878 - 25,975,962 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,749,098 - 25,965,957 (+)Ensemblrn6Rnor6.0
Rnor_5.01825,461,935 - 25,690,666 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41825,404,123 - 25,625,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1824,329,977 - 24,549,475 (+)NCBICelera
RGSC_v3.11825,434,889 - 25,652,443 (+)NCBI
Cytogenetic Map18p12NCBI
CAMK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,223,583 - 111,494,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5111,223,653 - 111,494,886 (+)Ensemblhg38GRCh38
GRCh375110,559,281 - 110,830,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,587,981 - 110,848,648 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345110,587,980 - 110,848,645NCBI
Celera5106,506,012 - 106,766,350 (+)NCBICelera
Cytogenetic Map5q22.1NCBI
HuRef5105,739,000 - 105,999,500 (+)NCBIHuRef
CHM1_15109,993,303 - 110,254,043 (+)NCBICHM1_1
T2T-CHM13v2.05111,734,219 - 112,005,186 (+)NCBIT2T-CHM13v2.0
Camk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391833,067,995 - 33,328,820 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1833,067,984 - 33,324,281 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381832,934,941 - 33,195,767 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,934,931 - 33,191,228 (+)Ensemblmm10GRCm38
MGSCv371833,098,695 - 33,355,421 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361833,082,366 - 33,311,737 (+)NCBIMGSCv36mm8
Celera1833,410,258 - 33,643,822 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.15NCBI
Camk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554183,664,479 - 3,887,175 (-)Ensembl
ChiLan1.0NW_0049554183,664,352 - 3,887,175 (-)NCBIChiLan1.0ChiLan1.0
CAMK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24106,415,303 - 106,751,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15104,568,958 - 104,905,445 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05106,590,803 - 106,855,592 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15112,393,674 - 112,657,593 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5112,393,211 - 112,647,203 (+)EnsemblpanPan2panpan1.1
CAMK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,174,975 - 1,369,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,180,401 - 1,369,803 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha32,578,244 - 2,850,336 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.031,020,594 - 1,293,824 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl31,020,667 - 1,218,126 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.131,010,019 - 1,282,970 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031,006,461 - 1,284,714 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031,170,193 - 1,449,448 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Camk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213155,752,531 - 155,995,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365315,616,746 - 5,849,088 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365315,615,442 - 5,858,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2116,000,791 - 116,229,758 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12115,910,403 - 116,234,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22120,705,517 - 120,814,660 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12314,563,476 - 14,828,128 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2314,563,034 - 14,826,821 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603463,642,472 - 63,910,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474329,047,004 - 29,266,685 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474329,045,998 - 29,276,801 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Camk4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11511,104,675 - 11,317,674 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Camk4
1831 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:100
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000027771
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181221923726822399Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181221923726822399Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181221923726822399Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181221923726822399Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181221923726822399Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181221923726822399Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181221923726822399Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,586,534 - 24,586,682 (+)MAPPERmRatBN7.2
Rnor_6.01825,750,364 - 25,750,511NCBIRnor6.0
Rnor_5.01825,465,421 - 25,465,568UniSTSRnor5.0
RGSC_v3.41825,407,670 - 25,407,817UniSTSRGSC3.4
Celera1824,333,528 - 24,333,675UniSTS
Cytogenetic Map18p12UniSTS
D18Mgh9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81825,071,126 - 25,071,266 (+)Marker Load Pipeline
mRatBN7.21824,796,977 - 24,797,117 (+)MAPPERmRatBN7.2
Rnor_6.01825,961,026 - 25,961,165NCBIRnor6.0
Rnor_5.01825,675,732 - 25,675,871UniSTSRnor5.0
RGSC_v3.41825,620,884 - 25,621,024RGDRGSC3.4
RGSC_v3.41825,620,885 - 25,621,024UniSTSRGSC3.4
Celera1824,544,575 - 24,544,714UniSTS
RGSC_v3.11825,647,530 - 25,647,670RGD
RH 3.4 Map18338.4RGD
RH 3.4 Map18338.4UniSTS
RH 2.0 Map18571.8RGD
Cytogenetic Map18p12UniSTS
D18Rat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,768,796 - 24,769,009 (+)MAPPERmRatBN7.2
Rnor_6.01825,932,986 - 25,933,198NCBIRnor6.0
Rnor_5.01825,647,692 - 25,647,904UniSTSRnor5.0
RGSC_v3.41825,592,835 - 25,593,048RGDRGSC3.4
RGSC_v3.41825,592,836 - 25,593,048UniSTSRGSC3.4
Celera1824,516,452 - 24,516,664UniSTS
RGSC_v3.11825,619,401 - 25,619,957RGD
SHRSP x BN Map1811.4999UniSTS
SHRSP x BN Map1811.4999RGD
FHH x ACI Map1814.96RGD
Cytogenetic Map18p12UniSTS
D18Rat132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,732,271 - 24,732,519 (+)MAPPERmRatBN7.2
Rnor_6.01825,896,100 - 25,896,347NCBIRnor6.0
Rnor_5.01825,610,723 - 25,610,970UniSTSRnor5.0
RGSC_v3.41825,556,340 - 25,556,586RGDRGSC3.4
RGSC_v3.41825,556,341 - 25,556,586UniSTSRGSC3.4
Celera1824,479,152 - 24,479,397UniSTS
RGSC_v3.11825,582,986 - 25,583,232RGD
SHRSP x BN Map1811.4999UniSTS
SHRSP x BN Map1811.4999RGD
FHH x ACI Map1814.96RGD
Cytogenetic Map18p12UniSTS
D18Got37  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81824,904,970 - 24,905,218 (+)Marker Load Pipeline
mRatBN7.21824,630,802 - 24,631,052 (+)MAPPERmRatBN7.2
Rnor_6.01825,794,805 - 25,795,052NCBIRnor6.0
Rnor_5.01825,509,862 - 25,510,109UniSTSRnor5.0
RGSC_v3.41825,451,941 - 25,452,189RGDRGSC3.4
RGSC_v3.41825,451,942 - 25,452,189UniSTSRGSC3.4
Celera1824,377,826 - 24,378,073UniSTS
RGSC_v3.11825,478,588 - 25,478,835RGD
RH 3.4 Map18324.4RGD
RH 3.4 Map18324.4UniSTS
RH 2.0 Map18581.7RGD
Cytogenetic Map18p12UniSTS
D18Chm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,735,261 - 24,735,488 (+)MAPPERmRatBN7.2
Rnor_6.01825,899,090 - 25,899,314NCBIRnor6.0
Rnor_5.01825,613,713 - 25,613,937UniSTSRnor5.0
RGSC_v3.41825,559,329 - 25,559,553UniSTSRGSC3.4
Celera1824,482,140 - 24,482,364UniSTS
Cytogenetic Map18p12UniSTS
BF400657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,619,029 - 24,619,134 (+)MAPPERmRatBN7.2
Rnor_6.01825,783,028 - 25,783,132NCBIRnor6.0
Rnor_5.01825,498,085 - 25,498,189UniSTSRnor5.0
RGSC_v3.41825,440,165 - 25,440,269UniSTSRGSC3.4
Celera1824,366,044 - 24,366,148UniSTS
RH 3.4 Map18333.0UniSTS
Cytogenetic Map18p12UniSTS
BE107932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,682,558 - 24,682,711 (+)MAPPERmRatBN7.2
Rnor_6.01825,845,932 - 25,846,084NCBIRnor6.0
Rnor_5.01825,560,989 - 25,561,141UniSTSRnor5.0
RGSC_v3.41825,505,193 - 25,505,345UniSTSRGSC3.4
Celera1824,429,493 - 24,429,645UniSTS
RH 3.4 Map18334.6UniSTS
Cytogenetic Map18p12UniSTS
AU047213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,621,756 - 24,621,933 (+)MAPPERmRatBN7.2
Rnor_6.01825,785,755 - 25,785,931NCBIRnor6.0
Rnor_5.01825,500,812 - 25,500,988UniSTSRnor5.0
RGSC_v3.41825,442,892 - 25,443,068UniSTSRGSC3.4
Celera1824,368,771 - 24,368,947UniSTS
Cytogenetic Map18p12UniSTS
RH137597  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,792,955 - 24,793,148 (+)MAPPERmRatBN7.2
Rnor_6.01825,957,005 - 25,957,197NCBIRnor6.0
Rnor_5.01825,671,711 - 25,671,903UniSTSRnor5.0
RGSC_v3.41825,616,864 - 25,617,056UniSTSRGSC3.4
Celera1824,540,554 - 24,540,746UniSTS
Cytogenetic Map18p12UniSTS
RH138191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,801,575 - 24,801,824 (+)MAPPERmRatBN7.2
Rnor_6.01825,965,623 - 25,965,871NCBIRnor6.0
Rnor_5.01825,680,329 - 25,680,577UniSTSRnor5.0
RGSC_v3.41825,625,482 - 25,625,730UniSTSRGSC3.4
Celera1824,549,172 - 24,549,420UniSTS
RH 3.4 Map18336.1UniSTS
Cytogenetic Map18p12UniSTS
BE119628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,620,602 - 24,620,776 (+)MAPPERmRatBN7.2
Rnor_6.01825,784,601 - 25,784,774NCBIRnor6.0
Rnor_5.01825,499,658 - 25,499,831UniSTSRnor5.0
RGSC_v3.41825,441,738 - 25,441,911UniSTSRGSC3.4
Celera1824,367,617 - 24,367,790UniSTS
RH 3.4 Map18316.2UniSTS
Cytogenetic Map18p12UniSTS
STS-Z40708  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21824,732,046 - 24,733,183 (+)MAPPERmRatBN7.2
Rnor_6.01825,895,875 - 25,897,011NCBIRnor6.0
Rnor_5.01825,610,498 - 25,611,634UniSTSRnor5.0
RGSC_v3.41825,556,116 - 25,557,250UniSTSRGSC3.4
Celera1824,478,927 - 24,480,061UniSTS
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 65 64 33 92 33 6 330 192 11 139 81 90 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC128706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027771   ⟹   ENSRNOP00000027771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,857,146 - 25,076,052 (+)Ensembl
mRatBN7.2 Ensembl1824,585,269 - 24,801,869 (+)Ensembl
Rnor_6.0 Ensembl1825,749,098 - 25,965,916 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078822   ⟹   ENSRNOP00000072926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,861,066 - 25,077,193 (+)Ensembl
mRatBN7.2 Ensembl1824,587,103 - 24,802,487 (+)Ensembl
Rnor_6.0 Ensembl1825,962,855 - 25,965,957 (+)Ensembl
RefSeq Acc Id: NM_012727   ⟹   NP_036859
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,857,152 - 25,076,027 (+)NCBI
mRatBN7.21824,582,988 - 24,801,879 (+)NCBI
Rnor_6.01825,746,878 - 25,965,926 (+)NCBI
Rnor_5.01825,461,935 - 25,690,666 (+)NCBI
RGSC_v3.41825,404,123 - 25,625,785 (+)RGD
Celera1824,329,977 - 24,549,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254523   ⟹   XP_006254585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,861,253 - 25,076,054 (+)NCBI
mRatBN7.21824,587,187 - 24,811,918 (+)NCBI
Rnor_6.01825,750,924 - 25,975,962 (+)NCBI
Rnor_5.01825,461,935 - 25,690,666 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096574   ⟹   XP_038952502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81825,039,484 - 25,076,054 (+)NCBI
mRatBN7.21824,764,902 - 24,811,918 (+)NCBI
RefSeq Acc Id: XM_063277096   ⟹   XP_063133166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,861,332 - 25,076,054 (+)NCBI
RefSeq Acc Id: XM_063277097   ⟹   XP_063133167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,861,942 - 25,076,054 (+)NCBI
RefSeq Acc Id: NP_036859   ⟸   NM_012727
- UniProtKB: A1A5L5 (UniProtKB/Swiss-Prot),   Q63892 (UniProtKB/Swiss-Prot),   P13234 (UniProtKB/Swiss-Prot),   A6J2R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254585   ⟸   XM_006254523
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UQP4 (UniProtKB/TrEMBL),   A6J2R2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072926   ⟸   ENSRNOT00000078822
Ensembl Acc Id: ENSRNOP00000027771   ⟸   ENSRNOT00000027771
RefSeq Acc Id: XP_038952502   ⟸   XM_039096574
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063133166   ⟸   XM_063277096
- Peptide Label: isoform X1
- UniProtKB: A6J2R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133167   ⟸   XM_063277097
- Peptide Label: isoform X4
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13234-F1-model_v2 AlphaFold P13234 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700694
Promoter ID:EPDNEW_R11212
Type:multiple initiation site
Name:Camk4_1
Description:calcium/calmodulin-dependent protein kinase IV
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01825,962,844 - 25,962,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2264 AgrOrtholog
BioCyc Gene G2FUF-8003 BioCyc
Ensembl Genes ENSRNOG00000020478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027771 ENTREZGENE
  ENSRNOT00000027771.5 UniProtKB/Swiss-Prot
  ENSRNOT00000078822 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7455982 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:25050 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156504 IMAGE-MGC_LOAD
NCBI Gene 25050 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Camk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020478 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC206301
UniProt A0A8L2UQP4 ENTREZGENE, UniProtKB/TrEMBL
  A1A5L5 ENTREZGENE
  A6J2R2 ENTREZGENE, UniProtKB/TrEMBL
  A6J2R3 ENTREZGENE, UniProtKB/TrEMBL
  A6J2R5 ENTREZGENE, UniProtKB/TrEMBL
  A6J2R6_RAT UniProtKB/TrEMBL
  KCC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63892 ENTREZGENE
UniProt Secondary A1A5L5 UniProtKB/Swiss-Prot
  Q63892 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Camk4  calcium/calmodulin-dependent protein kinase IV    Calmodulin-dependent protein kinase IV  Name updated 625702 APPROVED
2002-06-10 Camk4  Calmodulin-dependent protein kinase IV      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression is enriched in the granule cells of the cerebellum 634691
gene_expression expressed in T-lymphocytes, granule cells of the cerebellum and meiotic male germ cells 634692
gene_function monomeric multifunctional enzyme 634692
gene_function phosphorylates synapsin I 634691
gene_process involved in neuronal Ca2+ signaling 634691
gene_transcript alternative splicing of the gene appears to produce calspermin protein transcript 634692
gene_transcript alternative splicing of the gene appears to produce calspermin protein transcript 1299832