Camk4 (calcium/calmodulin dependent protein kinase IV)

Gene: Camk4 (calcium/calmodulin dependent protein kinase IV) Chinchilla lanigera

Analyze

Symbol:

Camk4

Name:

calcium/calmodulin dependent protein kinase IV

RGD ID:

8889919

Description:

ENCODES a protein that exhibits calmodulin-dependent protein kinase activity (ortholog); INVOLVED IN long-term memory (ortholog); myeloid dendritic cell differentiation (ortholog); neuron-neuron synaptic transmission (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); Cocaine-Related Disorders (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN cytoplasm (ortholog); fibrillar center (ortholog); GABA-ergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase type IV

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	3,664,479 - 3,887,175 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	3,664,352 - 3,887,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

cocaine dependence (ISO)

Cocaine-Related Disorders (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

intellectual disability (ISO)

male infertility (ISO)

Neurodevelopmental Disorders (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

long-term memory (ISO)

myeloid dendritic cell differentiation (ISO)

neuron-neuron synaptic transmission (ISO)

nucleocytoplasmic transport (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of myeloid dendritic cell cytokine production (ISO)

positive regulation of protein export from nucleus (ISO)

postsynapse to nucleus signaling pathway (ISO)

postsynaptic modulation of chemical synaptic transmission (ISO)

protein phosphorylation (ISO)

signal transduction (ISO)

Cellular Component

cytoplasm (ISO)

fibrillar center (ISO)

GABA-ergic synapse (ISO)

glutamatergic synapse (ISO)

nucleoplasm (ISO)

nucleus (ISO)

postsynapse (ISO)

Molecular Function

calmodulin-dependent protein kinase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Camk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	3,664,479 - 3,887,175 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	3,664,352 - 3,887,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

CAMK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	111,223,583 - 111,494,886 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	111,223,653 - 111,494,886 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	110,559,281 - 110,830,584 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	110,587,981 - 110,848,648 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	110,587,980 - 110,848,645	NCBI
Celera	5	106,506,012 - 106,766,350 (+)	NCBI		Celera
Cytogenetic Map	5	q22.1	NCBI
HuRef	5	105,739,000 - 105,999,500 (+)	NCBI		HuRef
CHM1_1	5	109,993,303 - 110,254,043 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	111,734,219 - 112,005,186 (+)	NCBI		T2T-CHM13v2.0

Camk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	33,067,995 - 33,328,820 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	33,067,984 - 33,324,281 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	32,934,941 - 33,195,767 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	32,934,931 - 33,191,228 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	33,098,695 - 33,355,421 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	33,082,366 - 33,311,737 (+)	NCBI		MGSCv36	mm8
Celera	18	33,410,258 - 33,643,822 (+)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.15	NCBI

Camk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	24,857,152 - 25,076,054 (+)	NCBI		GRCr8
mRatBN7.2	18	24,582,988 - 24,811,918 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	24,585,269 - 24,802,487 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	24,711,029 - 24,929,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	25,476,377 - 25,693,513 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	24,806,056 - 25,024,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	25,746,878 - 25,975,962 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	25,749,098 - 25,965,957 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	25,461,935 - 25,690,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	25,404,123 - 25,625,785 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	25,434,889 - 25,652,443 (+)	NCBI
Celera	18	24,329,977 - 24,549,475 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

CAMK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	106,415,303 - 106,751,790 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	104,568,958 - 104,905,445 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	106,590,803 - 106,855,592 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	112,393,674 - 112,657,593 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	112,393,211 - 112,647,203 (+)	Ensembl	panpan1.1		panPan2

CAMK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	1,174,975 - 1,369,640 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	1,180,401 - 1,369,803 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	2,578,244 - 2,850,336 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	1,020,594 - 1,293,824 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	1,020,667 - 1,218,126 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	1,010,019 - 1,282,970 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	1,006,461 - 1,284,714 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	1,170,193 - 1,449,448 (-)	NCBI		UU_Cfam_GSD_1.0

Camk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	155,752,531 - 155,995,704 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	5,616,746 - 5,849,088 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	5,615,442 - 5,858,968 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAMK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	116,000,791 - 116,229,758 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	115,910,403 - 116,234,835 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	120,705,517 - 120,814,660 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAMK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	14,563,476 - 14,828,128 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	14,563,034 - 14,826,821 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	63,642,472 - 63,910,617 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Camk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	29,047,004 - 29,266,685 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	29,045,998 - 29,276,801 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005382166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01018797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01018798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01018799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01018800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01018801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01152935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01152936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000008199 ⟹ ENSCLAP00000008075

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955418	3,664,479 - 3,887,175 (-)	Ensembl

RefSeq Acc Id:

XM_005382166 ⟹ XP_005382223

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955418	3,664,352 - 3,887,175 (-)	NCBI

Sequence:

show sequence

GCGGCGGCCAGGCGCGCGCTCAGAGCCCCTCCCGCTGGCTGGCGCGCTCGGCGCGGCTCGGCTC
GCAGGCGGCGGCGCGGCGGGGCTTCCAGCTCGGCCAGCGGCTGCGGCGGCGCCGGCTTCGGAGT
CGCGGCGCGAAGATGCTCAAAGTCACCGTGCCCTCCTGCTCCTCCTCGTCCTGCTCTTCGGTCG
CCGCCGGTGCGGCCCCGGGGGCCGGGAGCCTCGTCCCGGATTACTGGATCGACGGCTCCAACCG
GGATGCGCTGAGCGATTTCTTCGAGGTGGAGTCGGAGCTGGGACGGGGTGCTACATCCATTGTG
TACAGATGCAAACAGAAGGGGACCCAGAAGCCTTATGCTCTCAAAGTGTTAAAGAAAACAGTGG
ACAAGAAAATCGTAAGAACTGAGATAGGAGTTCTGCTTCGCCTCTCACATCCAAACATTATAAA
ACTTAAGGAAATATTTGAAACCCCTACAGAAATCAGTCTGGTCCTAGAACTCGTCACAGGAGGA
GAGCTATTTGACAGGATTGTGGAGAAGGGGTATTACAGTGAGCGAGACGCTGCAGATGCTGTTA
AACAAATCCTGGAGGCCGTTGCTTACTTACATGAAAATGGGATCGTCCATCGTGACCTCAAGCC
AGAGAATCTTCTGTATGCCACCCCAGCCCCAGATGCACCACTTAAAATCGCTGATTTTGGACTC
TCTAAAATCGTGGAACATCAAGTGCTCATGAAGACAGTGTGTGGAACCCCAGGGTACTGTGCAC
CTGAAATTCTTAGAGGGTGTGCCTATGGACCTGAGGTGGACATGTGGTCTGTAGGAATAATCAC
CTACATCTTACTTTGTGGGTTTGAACCATTCTATGATGAAAGAGGTGATCAGTTCATGTTCAGG
AGAATTCTGAATTGTGAATATTACTTTATCTCCCCCTGGTGGGATGAAGTATCTCTAAATGCCA
AGGACTTGGTCAGGAAATTAATTGTTTTGGATCCTAAGAAGCGGCTGACTACCTTTCAAGCTCT
CCAACATCCATGGGTGACCGGTAAAGCAGCCAACTTTGTACACATGGATACTGCTCAGAAGAAG
CTCCAGGAGTTCAATGCTCGGCGCAAGCTGAAGGCAGCAGTAAAGGCAGTAGTGGCCTCCTCCC
GCCTGGGAAGTGCGAGCAGCAGTCATAGCAGCGTTCAAGAGAGTCATAAATCCGGTGGAGAGCC
ATCGCCAACCCAAGAGGGCAATGAGGACATCAGAGCTATTCCACAAGAAGACAGCATCCAAGGA
GACAGGGCCAGCATGACCACTGAGAGCACAGCGGCTGAGCTGATAGAGGAGGTGGAAGATGCGG
ATACAAATGTGGAAGAGGCCCCCAAGACGGTGTCCGGGGCACTGGAGGGTGGTGTAAAGGTGGC
CGATTTGGCCAGAGAGAAGGGCCTAGTGGAGAAGCTGAGGCCGATGGAGGAAGCAGCAGACCCC
GAAGAAGAACAAGAAATCCCTGATGTGGGACTCGGACTTTCACAGCAAGACGTGATCCTGCCGG
AGCACTAAGTCTGCGTCCTTCGGATCTGGAGGCCCAACTCCAGCACTGTATGTACTTTGTCTTT
CAGCAAGGAAGGTGTGGAAGCATGATAAGCACTATAATGATTCTGTTTTTGAGGTGAAAAAAAA
AAAAATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005382223	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000008075
	ENSCLAP00000008075.1

RefSeq Acc Id:

XP_005382223 ⟸ XM_005382166

- UniProtKB:

A0A8C2YLT3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLKVTVPSCSSSSCSSVAAGAAPGAGSLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCK
QKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFD
RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIV
EHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILN
CEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEF
NARRKLKAAVKAVVASSRLGSASSSHSSVQESHKSGGEPSPTQEGNEDIRAIPQEDSIQGDRAS
MTTESTAAELIEEVEDADTNVEEAPKTVSGALEGGVKVADLAREKGLVEKLRPMEEAADPEEEQ
EIPDVGLGLSQQDVILPEH

hide sequence

RefSeq Acc Id:

ENSCLAP00000008075 ⟸ ENSCLAT00000008199

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005659	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008199	ENTREZGENE
	ENSCLAT00000008199.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Camk4	ENTREZGENE
PANTHER	CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE IV	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2YLT3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Camk4	calcium/calmodulin dependent protein kinase IV		calcium/calmodulin-dependent protein kinase IV	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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