Cacnb3 (calcium voltage-gated channel auxiliary subunit beta 3) - Rat Genome Database

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Gene: Cacnb3 (calcium voltage-gated channel auxiliary subunit beta 3) Rattus norvegicus
Analyze
Symbol: Cacnb3
Name: calcium voltage-gated channel auxiliary subunit beta 3
RGD ID: 2248
Description: Enables calcium channel regulator activity; protein kinase binding activity; and voltage-gated calcium channel activity. Involved in several processes, including calcium ion transmembrane transport; detection of mechanical stimulus involved in sensory perception of pain; and regulation of nervous system process. Located in apical plasma membrane. Part of L-type voltage-gated calcium channel complex. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 6-propyl-2-thiouracil; allopurinol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAB3; CACH3B; calcium channel subunit beta 3; calcium channel voltage-dependent subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit; voltage-dependent L-type calcium channel subunit beta-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,663,810 - 131,676,085 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7131,662,545 - 131,676,085 (+)EnsemblGRCr8
mRatBN7.27129,784,799 - 129,797,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,783,674 - 129,797,074 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7131,594,886 - 131,604,409 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,820,432 - 133,829,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,732,933 - 133,742,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,311,120 - 140,324,902 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,315,368 - 140,324,902 (+)Ensemblrn6Rnor6.0
Rnor_5.0X114,814,959 - 114,828,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47137,384,752 - 137,394,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7126,277,809 - 126,287,303 (+)NCBICelera
RGSC_v3.17137,461,187 - 137,470,720 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
allopurinol  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
DDE  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gabapentin  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
linuron  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nonanoic acid  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
triticonazole  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. Agrawal M, etal., ACS Chem Neurosci. 2013 Feb 20;4(2):285-94. doi: 10.1021/cn300143m. Epub 2012 Nov 9.
2. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. Beguin P, etal., J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.
3. Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel. Bourdin B, etal., J Biol Chem. 2010 Jul 23;285(30):22853-63. doi: 10.1074/jbc.M110.111062. Epub 2010 May 17.
4. Functional characterization of CaValpha2delta mutations associated with sudden cardiac death. Bourdin B, etal., J Biol Chem. 2015 Jan 30;290(5):2854-69. doi: 10.1074/jbc.M114.597930. Epub 2014 Dec 19.
5. Cloning and expression of a third calcium channel beta subunit. Castellano A, etal., J Biol Chem 1993 Feb 15;268(5):3450-5.
6. Cloning and expression of a neuronal calcium channel beta subunit. Castellano A, etal., J Biol Chem 1993 Jun 15;268(17):12359-66.
7. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
8. Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Chen YH, etal., Nature. 2004 Jun 10;429(6992):675-80. Epub 2004 May 30.
9. Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction. Fan M, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14887-92. doi: 10.1073/pnas.1007543107. Epub 2010 Aug 2.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19.
13. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. Leroy J, etal., J Neurosci. 2005 Jul 27;25(30):6984-96.
14. Up-regulation of Cavß3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. Li L, etal., J Biol Chem. 2012 Feb 17;287(8):6002-13. doi: 10.1074/jbc.M111.310110. Epub 2011 Dec 20.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. The voltage-dependent calcium channel beta subunit contains two stable interacting domains. Opatowsky Y, etal., J Biol Chem 2003 Dec 26;278(52):52323-32. Epub 2003 Oct 14.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells. Wei SK, etal., Circ Res. 2000 Feb 4;86(2):175-84.
24. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. Yasuda T, etal., J Gen Physiol. 2004 Apr;123(4):401-16. doi: 10.1085/jgp.200308967. Epub 2004 Mar 15.
Additional References at PubMed
PMID:10328888   PMID:11160515   PMID:16525042   PMID:17028169   PMID:17303572   PMID:19755851   PMID:19917615   PMID:24566975   PMID:25964431   PMID:28131823   PMID:29476059   PMID:34426509  


Genomics

Comparative Map Data
Cacnb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,663,810 - 131,676,085 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7131,662,545 - 131,676,085 (+)EnsemblGRCr8
mRatBN7.27129,784,799 - 129,797,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,783,674 - 129,797,074 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7131,594,886 - 131,604,409 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,820,432 - 133,829,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,732,933 - 133,742,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,311,120 - 140,324,902 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,315,368 - 140,324,902 (+)Ensemblrn6Rnor6.0
Rnor_5.0X114,814,959 - 114,828,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47137,384,752 - 137,394,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7126,277,809 - 126,287,303 (+)NCBICelera
RGSC_v3.17137,461,187 - 137,470,720 (+)NCBI
Cytogenetic Map7q36NCBI
CACNB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,814,480 - 48,828,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,813,794 - 48,828,941 (+)Ensemblhg38GRCh38
GRCh371249,208,263 - 49,222,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,498,779 - 47,508,991 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341247,498,778 - 47,508,991NCBI
Celera1248,008,638 - 48,018,850 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,241,454 - 46,255,965 (+)NCBIHuRef
CHM1_11249,174,031 - 49,188,542 (+)NCBICHM1_1
T2T-CHM13v2.01248,776,505 - 48,790,968 (+)NCBIT2T-CHM13v2.0
Cacnb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,526,317 - 98,542,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,528,721 - 98,542,410 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381598,628,436 - 98,644,536 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,630,840 - 98,644,529 (+)Ensemblmm10GRCm38
MGSCv371598,462,651 - 98,474,961 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361598,463,139 - 98,472,563 (+)NCBIMGSCv36mm8
Celera15100,780,822 - 100,793,130 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.64NCBI
Cacnb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,672,828 - 7,687,420 (+)Ensembl
ChiLan1.0NW_0049555007,676,331 - 7,685,174 (+)NCBIChiLan1.0ChiLan1.0
CACNB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,352,328 - 45,367,080 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,349,089 - 45,362,466 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,918,022 - 39,931,386 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,797,293 - 40,811,409 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,797,293 - 40,811,409 (-)EnsemblpanPan2panpan1.1
CACNB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,705,587 - 5,714,620 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,706,064 - 5,717,647 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2740,539,137 - 40,552,356 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0275,756,425 - 5,769,646 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,756,425 - 5,769,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,720,277 - 5,733,496 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,710,377 - 5,723,584 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02740,931,388 - 40,944,607 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cacnb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,498,659 - 66,511,978 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,653,777 - 6,666,758 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,652,836 - 6,666,171 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,874,465 - 14,888,223 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1514,875,524 - 14,888,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,172,444 - 15,182,010 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,056,116 - 45,071,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,061,046 - 45,071,544 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037201,075,907 - 201,090,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacnb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,334,684 - 3,347,842 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248163,334,934 - 3,348,355 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cacnb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11271,458,765 - 271,471,198 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cacnb3
106 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:182
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000017490
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH128224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,796,661 - 129,796,846 (+)MAPPERmRatBN7.2
Rnor_6.07140,324,490 - 140,324,674NCBIRnor6.0
Rnor_5.0X114,827,768 - 114,827,952UniSTSRnor5.0
RGSC_v3.47137,393,872 - 137,394,055UniSTSRGSC3.4
Celera7126,286,891 - 126,287,075UniSTS
RH 3.4 Map71087.8UniSTS
Cytogenetic Map7q36UniSTS
PMC21756P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,795,881 - 129,796,336 (+)MAPPERmRatBN7.2
Rnor_6.07140,323,710 - 140,324,164NCBIRnor6.0
Rnor_5.0X114,826,988 - 114,827,442UniSTSRnor5.0
RGSC_v3.47137,393,092 - 137,393,546UniSTSRGSC3.4
Celera7126,286,111 - 126,286,565UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 78 59 6 342 178 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000081206   ⟹   ENSRNOP00000073026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,662,545 - 131,676,072 (+)Ensembl
mRatBN7.2 Ensembl7129,787,539 - 129,797,074 (+)Ensembl
Rnor_6.0 Ensembl7140,315,368 - 140,324,902 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095350   ⟹   ENSRNOP00000089211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,662,732 - 131,676,072 (+)Ensembl
mRatBN7.2 Ensembl7129,783,674 - 129,797,074 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097309   ⟹   ENSRNOP00000087593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,666,249 - 131,676,072 (+)Ensembl
mRatBN7.2 Ensembl7129,784,776 - 129,797,074 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102945   ⟹   ENSRNOP00000082583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,664,324 - 131,676,085 (+)Ensembl
mRatBN7.2 Ensembl7129,787,539 - 129,797,074 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125873   ⟹   ENSRNOP00000105119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,666,249 - 131,676,072 (+)Ensembl
RefSeq Acc Id: NM_012828   ⟹   NP_036960
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,666,551 - 131,676,085 (+)NCBI
mRatBN7.27129,787,540 - 129,797,074 (+)NCBI
Rnor_6.07140,315,369 - 140,324,902 (+)NCBI
Rnor_5.0X114,814,959 - 114,828,180 (+)NCBI
RGSC_v3.47137,384,752 - 137,394,283 (+)RGD
Celera7126,277,809 - 126,287,303 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257329   ⟹   XP_006257391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,663,810 - 131,676,072 (+)NCBI
mRatBN7.27129,784,799 - 129,797,061 (+)NCBI
Rnor_6.07140,312,627 - 140,324,889 (+)NCBI
Rnor_5.0X114,814,959 - 114,828,180 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594673   ⟹   XP_017450162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,663,873 - 131,676,072 (+)NCBI
mRatBN7.27129,784,824 - 129,797,061 (+)NCBI
Rnor_6.07140,312,652 - 140,324,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078460   ⟹   XP_038934388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,663,864 - 131,673,582 (+)NCBI
mRatBN7.27129,784,824 - 129,794,474 (+)NCBI
RefSeq Acc Id: XM_063263026   ⟹   XP_063119096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,672,212 - 131,676,072 (+)NCBI
RefSeq Acc Id: NP_036960   ⟸   NM_012828
- UniProtKB: P54287 (UniProtKB/Swiss-Prot),   A6KC95 (UniProtKB/TrEMBL),   A0A8I6GH08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257391   ⟸   XM_006257329
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GH08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450162   ⟸   XM_017594673
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A832 (UniProtKB/TrEMBL),   A0A8I6GH08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073026   ⟸   ENSRNOT00000081206
RefSeq Acc Id: XP_038934388   ⟸   XM_039078460
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000082583   ⟸   ENSRNOT00000102945
Ensembl Acc Id: ENSRNOP00000087593   ⟸   ENSRNOT00000097309
Ensembl Acc Id: ENSRNOP00000089211   ⟸   ENSRNOT00000095350
RefSeq Acc Id: XP_063119096   ⟸   XM_063263026
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000105119   ⟸   ENSRNOT00000125873
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54287-F1-model_v2 AlphaFold P54287 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695627
Promoter ID:EPDNEW_R6152
Type:multiple initiation site
Name:Cacnb3_1
Description:calcium voltage-gated channel auxiliary subunit beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07140,315,335 - 140,315,395EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2248 AgrOrtholog
BioCyc Gene G2FUF-32124 BioCyc
Ensembl Genes ENSRNOG00000054274 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081206.2 UniProtKB/Swiss-Prot
  ENSRNOT00000095350 ENTREZGENE
  ENSRNOT00000097309 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro CAB1-4_N_A-dom UniProtKB/Swiss-Prot
  CACNB3_SH3 UniProtKB/Swiss-Prot
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  VDCC_L_b3su UniProtKB/Swiss-Prot
  VDCC_L_bsu UniProtKB/Swiss-Prot
KEGG Report rno:25297 UniProtKB/Swiss-Prot
NCBI Gene 25297 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  VGCC_beta4Aa_N UniProtKB/Swiss-Prot
PhenoGen Cacnb3 PhenoGen
PRINTS LCACHANNELB UniProtKB/Swiss-Prot
  LCACHANNELB3 UniProtKB/Swiss-Prot
PROSITE SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054274 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC219369
UniProt A0A8I5ZTS4_RAT UniProtKB/TrEMBL
  A0A8I6A832 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GH08 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LU88_RAT UniProtKB/TrEMBL
  A6KC95 ENTREZGENE, UniProtKB/TrEMBL
  CACB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacnb3  calcium voltage-gated channel auxiliary subunit beta 3  Cacnb3  calcium channel, voltage-dependent, beta 3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Cacnb3  calcium channel, voltage-dependent, beta 3 subunit     Calcium channel subunit beta 3  Name updated 629478 APPROVED
2002-06-10 Cacnb3  Calcium channel subunit beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in neuronal tissues, with the highest levels being found in the cerebellum 634680
gene_function interacts with alpha 1 subunits and increases functional alpha 1 activity 634680