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Gene: Azgp1 (alpha-2-glycoprotein 1, zinc-binding) Rattus norvegicus

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Symbol:

Azgp1

Name:

alpha-2-glycoprotein 1, zinc-binding

RGD ID:

2187

Description:

Involved in cellular response to insulin stimulus and cellular response to magnesium ion. Predicted to be located in extracellular region. Predicted to be active in external side of plasma membrane and extracellular space. Biomarker of chronic kidney disease; epilepsy; liver disease (multiple); obesity; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

alpha-2 - glycoprotein 1 zinc; alpha-2 - glycoprotein 1, zinc; alpha-2-glycoprotein 1, zinc; MGC124966; ZA2GA; zinc-alpha-2-glycoprotein; Zn - alpha2 - glycoprotein; zn-alpha-2-glycoprotein; zn-alpha-2-GP; Zna2gp

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,044,685 - 22,051,248 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	22,044,751 - 22,053,020 (+)	Ensembl				GRCr8
mRatBN7.2	12	16,930,990 - 16,939,333 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,931,024 - 16,939,091 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	17,761,589 - 17,767,981 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,385,332 - 18,391,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,438,735 - 17,445,127 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,196,565 - 19,203,094 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,196,611 - 19,202,647 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	17,492,913 - 17,498,949 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	18,867,978 - 18,873,945 (+)	NCBI		Celera
RGSC_v3.1	12	17,482,434 - 17,488,471 (+)	NCBI
RH 3.4 Map	12	256.8	RGD
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

adenocarcinoma (ISO)

Cachexia (ISO)

Cardiac Fibrosis (ISO)

chronic kidney disease (IEP,ISO)

colon cancer (ISO)

colorectal cancer (ISO)

epilepsy (IEP)

esophagus squamous cell carcinoma (ISO)

hepatocellular carcinoma (IEP,ISO)

liver cirrhosis (IEP,ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

metabolic dysfunction-associated steatohepatitis (IEP)

metabolic dysfunction-associated steatotic liver disease (IEP)

obesity (IEP,ISO)

oral squamous cell carcinoma (ISO)

polycystic ovary syndrome (ISO)

prostate cancer (ISO)

prostate carcinoma (ISO)

Prostatic Neoplasms (ISO)

rheumatoid arthritis (IEP)

sinusitis (ISO)

stomach carcinoma (ISO)

temporal lobe epilepsy (ISO)

Tubulointerstitial Fibrosis (ISO)

Yin Deficiency (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

allopurinol (EXP)

ammonium chloride (EXP)

antimony(0) (ISO)

aristolochic acid A (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chromium atom (ISO)

cobalt dichloride (EXP)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

coumarin (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

DDE (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzalutamide (ISO)

ethanol (EXP)

fipronil (EXP)

flavonoids (EXP)

fructose (EXP)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

hydroquinone (ISO)

indometacin (ISO)

lead(0) (ISO)

levonorgestrel (ISO)

liraglutide (ISO)

medroxyprogesterone acetate (ISO)

mercury atom (ISO)

mercury(0) (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nickel dichloride (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

ochratoxin A (EXP)

okadaic acid (ISO)

paracetamol (ISO)

paraquat (EXP)

PCB138 (ISO)

phenobarbital (EXP)

potassium dichromate (ISO)

quinolin-8-ol (ISO)

rac-lactic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

testosterone (ISO)

testosterone undecanoate (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent (IBA)

antigen processing and presentation of endogenous peptide antigen via MHC class Ib (IBA)

cell adhesion (ISO,ISS)

cellular response to insulin stimulus (IEP)

cellular response to magnesium ion (IEP)

detection of chemical stimulus involved in sensory perception of bitter taste (ISO)

immune response (IBA)

positive regulation of T cell mediated cytotoxicity (IBA)

Cellular Component

external side of plasma membrane (IBA)

extracellular region (IEA)

extracellular space (IBA,ISO,TAS)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Plasma proteome analysis in diet-induced obesity-prone and obesity-resistant rats.	Choi JW, etal., Proteomics. 2010 Dec;10(24):4386-400. doi: 10.1002/pmic.201000391. Epub 2010 Nov 17.
2.	AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status.	Falvella FS, etal., Oncogene. 2008 Mar 6;27(11):1650-6. doi: 10.1038/sj.onc.1210775. Epub 2007 Aug 27.
3.	Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein.	Fueyo A, etal., Gene 1994 Aug 5;145(2):245-9.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer.	Hale LP, etal., Clin Cancer Res. 2001 Apr;7(4):846-53.
6.	Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches.	Heawchaiyaphum C, etal., J Proteomics. 2018 Feb 20;173:52-61. doi: 10.1016/j.jprot.2017.11.022. Epub 2017 Dec 1.
7.	Decreased expression of AZGP1 is associated with poor prognosis in primary gastric cancer.	Huang CY, etal., PLoS One. 2013 Jul 23;8(7):e69155. doi: 10.1371/journal.pone.0069155. Print 2013.
8.	Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis.	Huang Y, etal., J Transl Med. 2012 May 24;10:106. doi: 10.1186/1479-5876-10-106.
9.	Identification of potential salivary biomarker panels for oral squamous cell carcinoma.	Jain A, etal., Sci Rep. 2021 Feb 9;11(1):3365. doi: 10.1038/s41598-021-82635-0.
10.	Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.	Ji D, etal., Carcinogenesis. 2013 Jun;34(6):1265-72. doi: 10.1093/carcin/bgt056. Epub 2013 Feb 7.
11.	Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation.	Kabil SL and Mahmoud NM, Eur J Pharmacol. 2018 Jun 5;828:135-145. doi: 10.1016/j.ejphar.2018.03.043. Epub 2018 Mar 30.
12.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13.	Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.	Li C, etal., Acta Cir Bras. 2016 Nov;31(11):706-713. doi: 10.1590/S0102-865020160110000001.
14.	The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses.	Liu CM, etal., J Ethnopharmacol. 2018 Oct 28;225:271-278. doi: 10.1016/j.jep.2018.05.001. Epub 2018 May 2.
15.	Neuronal zinc-α2-glycoprotein is decreased in temporal lobe epilepsy in patients and rats.	Liu Y, etal., Neuroscience. 2017 Aug 15;357:56-66. doi: 10.1016/j.neuroscience.2017.05.043. Epub 2017 May 31.
16.	Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis.	Martín AI, etal., J Endocrinol. 2008 Apr;197(1):111-9. doi: 10.1677/JOE-07-0491.
17.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
18.	Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients.	Mracek T, etal., Br J Cancer. 2011 Feb 1;104(3):441-7. doi: 10.1038/sj.bjc.6606083. Epub 2011 Jan 18.
19.	Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes.	Mracek T, etal., J Endocrinol. 2010 Feb;204(2):165-72. doi: 10.1677/JOE-09-0299. Epub 2009 Nov 24.
20.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
21.	White adipose tissue overproduces the lipid-mobilizing factor zinc α2-glycoprotein in chronic kidney disease.	Pelletier CC, etal., Kidney Int. 2013 May;83(5):878-86. doi: 10.1038/ki.2013.9. Epub 2013 Feb 20.
22.	GOA pipeline	RGD automated data pipeline
23.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
24.	Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease.	Sörensen-Zender I, etal., BMC Nephrol. 2013 Jul 12;14:145. doi: 10.1186/1471-2369-14-145.
25.	Zinc-α2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart.	Sörensen-Zender I, etal., J Am Soc Nephrol. 2015 Nov;26(11):2659-68. doi: 10.1681/ASN.2014050485. Epub 2015 Mar 18.
26.	Seizure-induced impairment in neuronal ketogenesis: Role of zinc-α2-glycoprotein in mitochondria.	Tan C, etal., J Cell Mol Med. 2020 Jun;24(12):6833-6845. doi: 10.1111/jcmm.15337. Epub 2020 Apr 27.
27.	Reduction of AZGP1 predicts poor prognosis in esophageal squamous cell carcinoma patients in Northern China.	Tang H, etal., Onco Targets Ther. 2016 Dec 20;10:85-94. doi: 10.2147/OTT.S113932. eCollection 2017.
28.	Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma.	Tian H, etal., Carcinogenesis. 2017 Feb 1;38(2):207-217. doi: 10.1093/carcin/bgw125.
29.	Structure and expression of rat and mouse mRNAs for Zn-alpha 2-glycoprotein.	Ueyama H, etal., J Biochem (Tokyo) 1994 Sep;116(3):677-81.
30.	Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons.	Wei X, etal., Neuroreport. 2019 May 22;30(8):580-585. doi: 10.1097/WNR.0000000000001250.
31.	AZGP1 suppresses epithelial-to-mesenchymal transition and hepatic carcinogenesis by blocking TGFβ1-ERK2 pathways.	Xu MY, etal., Cancer Lett. 2016 May 1;374(2):241-9. doi: 10.1016/j.canlet.2016.02.025. Epub 2016 Feb 20.
32.	Zinc-α-2-glycoprotein: a candidate biomarker for colon cancer diagnosis in Chinese population.	Xue Y, etal., Int J Mol Sci. 2014 Dec 30;16(1):691-703. doi: 10.3390/ijms16010691.
33.	AZGP1 suppresses the process of colorectal cancer after upregulating FASN expression via mTOR signal pathway.	Yu W, etal., Gen Physiol Biophys. 2020 May;39(3):239-248. doi: 10.4149/gpb_2019061.
34.	Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity.	Zhu H, etal., Front Endocrinol (Lausanne). 2018 Apr 26;9:190. doi: 10.3389/fendo.2018.00190. eCollection 2018.

Additional References at PubMed

PMID:8647453	PMID:9813179	PMID:12477932	PMID:16502470	PMID:19199708	PMID:21630459	PMID:22664934	PMID:23376485	PMID:23533145	PMID:23580065	PMID:24248522	PMID:27068509
PMID:27559042	PMID:29566716	PMID:39105875

Genomics

Comparative Map Data

Azgp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,044,685 - 22,051,248 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	22,044,751 - 22,053,020 (+)	Ensembl				GRCr8
mRatBN7.2	12	16,930,990 - 16,939,333 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,931,024 - 16,939,091 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	17,761,589 - 17,767,981 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,385,332 - 18,391,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,438,735 - 17,445,127 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,196,565 - 19,203,094 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,196,611 - 19,202,647 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	17,492,913 - 17,498,949 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	18,867,978 - 18,873,945 (+)	NCBI		Celera
RGSC_v3.1	12	17,482,434 - 17,488,471 (+)	NCBI
RH 3.4 Map	12	256.8	RGD
Cytogenetic Map	12	q11	NCBI

AZGP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	99,966,730 - 99,976,031 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	99,966,720 - 99,976,066 (-)	Ensembl			hg38	GRCh38
GRCh37	7	99,564,353 - 99,573,654 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,402,286 - 99,411,623 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	99,209,002 - 99,218,338	NCBI
Celera	7	94,298,908 - 94,308,290 (-)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,200,047 - 94,209,434 (-)	NCBI		HuRef
CHM1_1	7	99,494,515 - 99,503,901 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,206,237 - 101,220,128 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	98,924,486 - 98,933,868 (-)	NCBI

Azgp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	137,979,783 - 137,988,495 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	137,979,782 - 137,988,495 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	137,981,521 - 137,990,233 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	137,981,520 - 137,990,233 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	138,422,749 - 138,431,461 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,211,348 - 138,220,018 (+)	NCBI		MGSCv36	mm8
Celera	5	134,967,149 - 134,978,633 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.92	NCBI

Azgp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	899,798 - 912,272 (-)	Ensembl
ChiLan1.0	NW_004955573	902,153 - 910,481 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100980965
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	117,883,884 - 117,897,021 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,148,518 - 166,161,655 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	91,999,717 - 92,009,066 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,432,782 - 105,442,219 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,432,782 - 105,442,219 (-)	Ensembl			panPan2	panpan1.1

AZGP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,622,991 - 9,629,154 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,622,992 - 9,629,154 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	11,261,385 - 11,267,549 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	9,560,452 - 9,566,604 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,560,452 - 9,566,605 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,409,423 - 9,415,561 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	9,389,742 - 9,395,878 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,568,881 - 9,575,021 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Azgp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,922,347 - 133,930,595 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	105,956 - 114,190 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	105,983 - 113,475 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AZGP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	7,867,521 - 7,874,857 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	7,121,544 - 7,129,596 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AZGP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	13,104,262 - 13,120,329 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	13,104,323 - 13,120,363 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	3,149,715 - 3,159,344 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Azgp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	17,054,221 - 17,063,226 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	17,054,221 - 17,062,420 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Azgp1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	15,433,631 - 15,439,786 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Azgp1
60 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	273
Count of miRNA genes:	178
Interacting mature miRNAs:	224
Transcripts:	ENSRNOT00000001801
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	20139028	26430640	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

D12Hmgc1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	22,046,647 - 22,046,818 (+)	Marker Load Pipeline
mRatBN7.2	12	16,932,935 - 16,933,106 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	19,198,497 - 19,198,667	NCBI	Rnor6.0
Rnor_5.0	12	21,257,572 - 21,257,742	UniSTS	Rnor5.0
RGSC_v3.4	12	17,494,799 - 17,494,969	UniSTS	RGSC3.4
Celera	12	18,869,861 - 18,870,031	UniSTS
RH 3.4 Map	12	254.4	UniSTS
RH 3.4 Map	12	254.4	RGD
Cytogenetic Map	12	q11	UniSTS

RH94525

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	16,936,912 - 16,937,085 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	19,202,474 - 19,202,646	NCBI	Rnor6.0
Rnor_5.0	12	21,261,549 - 21,261,721	UniSTS	Rnor5.0
RGSC_v3.4	12	17,498,776 - 17,498,948	UniSTS	RGSC3.4
Celera	12	18,873,838 - 18,874,010	UniSTS
RH 3.4 Map	12	256.8	UniSTS
Cytogenetic Map	12	q11	UniSTS

RH138481

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	16,937,303 - 16,937,471 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	19,202,865 - 19,203,032	NCBI	Rnor6.0
Rnor_5.0	12	21,261,940 - 21,262,107	UniSTS	Rnor5.0
RGSC_v3.4	12	17,499,167 - 17,499,334	UniSTS	RGSC3.4
Celera	12	18,874,229 - 18,874,396	UniSTS
RH 3.4 Map	12	254.4	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	22	71	87	86	55	39	55	6	233	87	5	51	67	65	31	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D21058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X75309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X86178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001801 ⟹ ENSRNOP00000001801

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	22,044,751 - 22,053,020 (+)	Ensembl
mRatBN7.2 Ensembl	12	16,931,053 - 16,937,090 (+)	Ensembl
Rnor_6.0 Ensembl	12	19,196,611 - 19,202,647 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096300 ⟹ ENSRNOP00000082549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	22,045,459 - 22,053,020 (+)	Ensembl
mRatBN7.2 Ensembl	12	16,931,745 - 16,939,091 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102149 ⟹ ENSRNOP00000088478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	22,044,754 - 22,052,803 (+)	Ensembl
mRatBN7.2 Ensembl	12	16,931,024 - 16,939,091 (+)	Ensembl

RefSeq Acc Id:

NM_012826 ⟹ NP_036958

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	22,044,757 - 22,050,732 (+)	NCBI
mRatBN7.2	12	16,931,043 - 16,937,020 (+)	NCBI
Rnor_6.0	12	19,196,606 - 19,202,581 (+)	NCBI
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI
RGSC_v3.4	12	17,492,913 - 17,498,949 (+)	RGD
Celera	12	18,867,978 - 18,873,945 (+)	NCBI

Sequence:

show sequence

CTGGGCACTACAGTAGCAATGGTGCCTGTCCTGTTGTCCCTGCCTCTCCTTCTGGGTCCTGCAG
TCCTTCAGGAGACTGGGTCTTATTCTCTGATCTTCCTCTACACCGGGTTGTCCAGGCCCAGCAA
AGGCCTTCTGAGGTTTCAAGCCACCGCATTTCTCAACGATCAGGCCTTCTTCCACTACAACAGC
AACAGTGGGAAGGCAGAGCCCGTGGAACCCTGGAGCCATGTGGAAGGAATGGAGGACTGGGAGA
AGGAAAGCCAGCTTCAGAGAGCCAGGGAGGAGATCTTCCTCGTGACCCTGAAAGACATCATGGA
CTATTACGAGGACAGTACAGGGTCTCACACCTTTCAGGGAATGTTTGGTTGTGAGATCACAAAT
AACAGAAGTAGTGGAGCAGTCTGGAGGTATGCCTACGATGGAGAAGATTTCATCGAATTCAACA
AGGAAATCCCAGCCTGGATCCCCTTAGACCCAGCAGCCGCAAACACCAAGCTGAAGTGGGAGGC
AGAAAAGGTCTATGTGCAGCGAGCCAAGGCATACCTAGAGGAGGAGTGTCCTACAATGCTGAAG
AAGTACCTGACCTACAGTAGATCTCACCTGGACCGAACAGATCCTCCCACTGTGAAAATCACCA
GCCGTGTGGCCCCAGGAAGAAACAGAATATTCAGATGTCTGGCCTATGACTTCTACCCACAAAG
AATTAGTCTGCACTGGAACCAGGCCAGCAAGAAGCTGGCATCTGAACCAGAAAGAGGTGTTTTT
CCCAATGGAAATGGCACTTACCTCTCCTGGATGGAGGTGGAAGTCCCCCCACAGAACAGAGACC
CCTTTGTCTGCCACATAGAACACAAGGGGCTATCCCAATCTCTCTCAGTGCAGTGGGATGAGAA
AAGTAAAGTCTGAAAACAGTGCTGTATCTCAGCCTCAGAAAGGTTACCCTCTCTGCCGGATATG
AGAGAGTTGAACTTCAGAAGTCACTGTCACCAGCAAGCCCGCAAGTCTCCAAGGAATGGGTGTG
GGCCCAGAAGATTTGAATACCAAGCACCGAGTTCACTCTCAAAGTCAAATCAATCACCTTGCCT
TGTAAAACTCCTCCTCAATTAATCTGTAAGCCCTTGCAATTACCTTCACGCCCAGCACAGCACA
GAAAGGCATTTTAAACTCTGAGATGCTACAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006249003 ⟹ XP_006249065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	22,044,685 - 22,051,248 (+)	NCBI
mRatBN7.2	12	16,930,990 - 16,939,333 (+)	NCBI
Rnor_6.0	12	19,196,565 - 19,203,094 (+)	NCBI
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI

Sequence:

show sequence

GCCTCAAGGCAAGAGCCTCGTTTCCTGTGTAGACTGTCCACCTGGGCACTACAGTAGCAATGGT
GCCTGTCCTGTTGTCCCTGCCTCTCCTTCTGGGTCCTGCAGTCCTTCAGGAGACTGGGTCTTAT
TCTCTGATCTTCCTCTACACCGGGTTGTCCAGGCCCAGCAAAGGCCTTCTGAGGTTTCAAGCCA
CCGCATTTCTCAACGATCAGGCCTTCTTCCACTACAACAGCAACAGTGGGAAGGCAGAGCCCGT
GGAACCCTGGAGCCATGTGGAAGGAATGGAGGACTGGGAGAAGGAAAGCCAGCTTCAGAGAGCC
AGGGAGGAGATCTTCCTCGTGACCCTGAAAGACATCATGGACTATTACGAGGACAGTACAGTTC
CTTCCTACACAGGCACCAGTGACATTTCATCTCCATACCCTGACCCCCTTGAGAGGGAATCAGA
TTCAACACGACCCAAGTGGAGAGCAGAATTCTCAAGTGGAGAGAAGAATTCTCATTCATTCAAC
AAAACAGGGTCTCACACCTTTCAGGGAATGTTTGGTTGTGAGATCACAAATAACAGAAGTAGTG
GAGCAGTCTGGAGGTATGCCTACGATGGAGAAGATTTCATCGAATTCAACAAGGAAATCCCAGC
CTGGATCCCCTTAGACCCAGCAGCCGCAAACACCAAGCTGAAGTGGGAGGCAGAAAAGGTCTAT
GTGCAGCGAGCCAAGGCATACCTAGAGGAGGAGTGTCCTACAATGCTGAAGAAGTACCTGACCT
ACAGTAGATCTCACCTGGACCGAACAGATCCTCCCACTGTGAAAATCACCAGCCGTGTGGCCCC
AGGAAGAAACAGAATATTCAGATGTCTGGCCTATGACTTCTACCCACAAAGAATTAGTCTGCAC
TGGAACCAGGCCAGCAAGAAGCTGGCATCTGAACCAGAAAGAGGTGTTTTTCCCAATGGAAATG
GCACTTACCTCTCCTGGATGGAGGTGGAAGTCCCCCCACAGAACAGAGACCCCTTTGTCTGCCA
CATAGAACACAAGGGGCTATCCCAATCTCTCTCAGTGCAGTGGGATGAGAAAAGTAAAGTCTGA
AAACAGTGCTGTATCTCAGCCTCAGAAAGGTTACCCTCTCTGCCGGATATGAGAGAGTTGAACT
TCAGAAGTCACTGTCACCAGCAAGCCCGCAAGTCTCCAAGGAATGGGTGTGGGCCCAGAAGATT
TGAATACCAAGCACCGAGTTCACTCTCAAAGTCAAATCAATCACCTTGCCTTGTAAAACTCCTC
CTCAATTAATCTGTAAGCCCTTGCAATTACCTTCACGCCCAGCACAGCACAGAAAGGCATTTTA
AACTCTGAGATGCTACAGAAGTGTGAGTTGATTTTATCATGTATACTGCCCCGACATACTTGAT
TCATGGGAATGTCTCCATATTCAATCAAAGACGGTGTCCTAGTTTCATTTCTGATGCTGTAAGA
AAATATCCCAAACAAAAGCGACTTCAACAGAGAAGAGGTTTGTCAGGCTTATCTTTCCAGGTCT
CTGTTGTACGACTCTACTCTTGGGAACATGAGAACAGGCATCTACTCACCTCAGCTAGGGAACC
AACAGCAGATCAAAGGATGAACACCACCAAAGTCCAGCTCAGTGAACTGAGTCCAGGTTGGTGA
ACTGTAATTCTTGTGGGGTTCTCTTATGTACCTTTTGTGCCCAAATAACTGCAGGGTATTTCTG
TGCCCACTCTAGCCCATGCTGTCTCCCAGATAGATGACACAGAGACCTGATTTTTTATTGACAA
AATAAAGGCACTAAGCTGGGCAGGTTCTGAGCTATTCGAACCCTCGAAGGCTGCCTATTTCCCA
GCCACGTGGTCCTTTACCATC

hide sequence

RefSeq Acc Id:

XM_006249004 ⟹ XP_006249066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	22,044,685 - 22,051,248 (+)	NCBI
mRatBN7.2	12	16,930,990 - 16,939,333 (+)	NCBI
Rnor_6.0	12	19,196,565 - 19,203,094 (+)	NCBI
Rnor_5.0	12	21,255,645 - 21,262,122 (+)	NCBI

Sequence:

show sequence

GCCTCAAGGCAAGAGCCTCGTTTCCTGTGTAGACTGTCCACCTGGGCACTACAGTAGCAATGGT
GCCTGTCCTGTTGTCCCTGCCTCTCCTTCTGGGTCCTGCAGTCCTTCAGGAGACTGGGTCTTAT
TCTCTGATCTTCCTCTACACCGGGTTGTCCAGGCCCAGCAAAGGCCTTCTGAGGTTTCAAGCCA
CCGCATTTCTCAACGATCAGGCCTTCTTCCACTACAACAGCAACAGTGGGAAGGCAGAGCCCGT
GGAACCCTGGAGCCATGTGGAAGGAATGGAGGACTGGGAGAAGGAAAGCCAGCTTCAGAGAGCC
AGGGAGGAGATCTTCCTCGTGACCCTGAAAGACATCATGGACTATTACGAGGACAGTACAGGCA
CCAGTGACATTTCATCTCCATACCCTGACCCCCTTGAGAGGGAATCAGATTCAACACGACCCAA
GTGGAGAGCAGAATTCTCAAGTGGAGAGAAGAATTCTCATTCATTCAACAAAACAGGGTCTCAC
ACCTTTCAGGGAATGTTTGGTTGTGAGATCACAAATAACAGAAGTAGTGGAGCAGTCTGGAGGT
ATGCCTACGATGGAGAAGATTTCATCGAATTCAACAAGGAAATCCCAGCCTGGATCCCCTTAGA
CCCAGCAGCCGCAAACACCAAGCTGAAGTGGGAGGCAGAAAAGGTCTATGTGCAGCGAGCCAAG
GCATACCTAGAGGAGGAGTGTCCTACAATGCTGAAGAAGTACCTGACCTACAGTAGATCTCACC
TGGACCGAACAGATCCTCCCACTGTGAAAATCACCAGCCGTGTGGCCCCAGGAAGAAACAGAAT
ATTCAGATGTCTGGCCTATGACTTCTACCCACAAAGAATTAGTCTGCACTGGAACCAGGCCAGC
AAGAAGCTGGCATCTGAACCAGAAAGAGGTGTTTTTCCCAATGGAAATGGCACTTACCTCTCCT
GGATGGAGGTGGAAGTCCCCCCACAGAACAGAGACCCCTTTGTCTGCCACATAGAACACAAGGG
GCTATCCCAATCTCTCTCAGTGCAGTGGGATGAGAAAAGTAAAGTCTGAAAACAGTGCTGTATC
TCAGCCTCAGAAAGGTTACCCTCTCTGCCGGATATGAGAGAGTTGAACTTCAGAAGTCACTGTC
ACCAGCAAGCCCGCAAGTCTCCAAGGAATGGGTGTGGGCCCAGAAGATTTGAATACCAAGCACC
GAGTTCACTCTCAAAGTCAAATCAATCACCTTGCCTTGTAAAACTCCTCCTCAATTAATCTGTA
AGCCCTTGCAATTACCTTCACGCCCAGCACAGCACAGAAAGGCATTTTAAACTCTGAGATGCTA
CAGAAGTGTGAGTTGATTTTATCATGTATACTGCCCCGACATACTTGATTCATGGGAATGTCTC
CATATTCAATCAAAGACGGTGTCCTAGTTTCATTTCTGATGCTGTAAGAAAATATCCCAAACAA
AAGCGACTTCAACAGAGAAGAGGTTTGTCAGGCTTATCTTTCCAGGTCTCTGTTGTACGACTCT
ACTCTTGGGAACATGAGAACAGGCATCTACTCACCTCAGCTAGGGAACCAACAGCAGATCAAAG
GATGAACACCACCAAAGTCCAGCTCAGTGAACTGAGTCCAGGTTGGTGAACTGTAATTCTTGTG
GGGTTCTCTTATGTACCTTTTGTGCCCAAATAACTGCAGGGTATTTCTGTGCCCACTCTAGCCC
ATGCTGTCTCCCAGATAGATGACACAGAGACCTGATTTTTTATTGACAAAATAAAGGCACTAAG
CTGGGCAGGTTCTGAGCTATTCGAACCCTCGAAGGCTGCCTATTTCCCAGCCACGTGGTCCTTT
ACCATC

hide sequence

Protein Sequences


Protein RefSeqs	NP_036958	(Get FASTA)	NCBI Sequence Viewer
	XP_006249065	(Get FASTA)	NCBI Sequence Viewer
	XP_006249066	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05823	(Get FASTA)	NCBI Sequence Viewer
	BAA04637	(Get FASTA)	NCBI Sequence Viewer
	CAA53057	(Get FASTA)	NCBI Sequence Viewer
	EDL83887	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001801
	ENSRNOP00000088478
GenBank Protein	Q63678	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036958 ⟸ NM_012826
- Peptide Label:	precursor
- UniProtKB:	Q63678 (UniProtKB/Swiss-Prot), Q63523 (UniProtKB/Swiss-Prot), Q3B8R6 (UniProtKB/TrEMBL), A6KSS1 (UniProtKB/TrEMBL), A0A8I6A9I2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQATAFLNDQAFFHYNSNSGKAE PVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTGSHTFQGMFGCEITNNRSSGA VWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYS RSHLDRTDPPTVKITSRVAPGRNRIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGT YLSWMEVEVPPQNRDPFVCHIEHKGLSQSLSVQWDEKSKV hide sequence

RefSeq Acc Id:	XP_006249065 ⟸ XM_006249003
- Peptide Label:	isoform X1
- UniProtKB:	Q63678 (UniProtKB/Swiss-Prot), Q63523 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQATAFLNDQAFFHYNSNSGKAE PVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTVPSYTGTSDISSPYPDPLERE SDSTRPKWRAEFSSGEKNSHSFNKTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEI PAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRV APGRNRIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFV CHIEHKGLSQSLSVQWDEKSKV hide sequence

RefSeq Acc Id:	XP_006249066 ⟸ XM_006249004
- Peptide Label:	isoform X2
- UniProtKB:	Q63678 (UniProtKB/Swiss-Prot), Q63523 (UniProtKB/Swiss-Prot), F7F110 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQATAFLNDQAFFHYNSNSGKAE PVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTGTSDISSPYPDPLERESDSTR PKWRAEFSSGEKNSHSFNKTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIP LDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRVAPGRN RIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFVCHIEH KGLSQSLSVQWDEKSKV hide sequence

Ensembl Acc Id:

ENSRNOP00000001801 ⟸ ENSRNOT00000001801

Ensembl Acc Id:

ENSRNOP00000088478 ⟸ ENSRNOT00000102149

Ensembl Acc Id:

ENSRNOP00000082549 ⟸ ENSRNOT00000096300

Protein Domains

Ig-like Ig-like C1-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63678-F1-model_v2	AlphaFold	Q63678	1-296	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698489

Promoter ID:

EPDNEW_R9014

Type:

initiation region

Name:

Azgp1_1

Description:

alpha-2-glycoprotein 1, zinc-binding

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	19,196,605 - 19,196,665	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2187	AgrOrtholog
BioCyc Gene	G2FUF-19829	BioCyc
Ensembl Genes	ENSRNOG00000001333	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000001801	ENTREZGENE
	ENSRNOT00000102149	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	3.30.500.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7371444	IMAGE-MGC_LOAD
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_C1-set	UniProtKB/Swiss-Prot
	MHC_class-I_related	UniProtKB/Swiss-Prot
	MHC_I-like_Ag-recog	UniProtKB/Swiss-Prot
	MHC_I-like_Ag-recog_sf	UniProtKB/Swiss-Prot
	MHC_I/II-like_Ag-recog	UniProtKB/Swiss-Prot
	MHC_I_a_a1/a2	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124966	IMAGE-MGC_LOAD
NCBI Gene	25294	ENTREZGENE
PANTHER	MHC CLASS I-RELATED	UniProtKB/Swiss-Prot
	ZINC-ALPHA-2-GLYCOPROTEIN	UniProtKB/Swiss-Prot
Pfam	C1-set	UniProtKB/Swiss-Prot
	MHC_I	UniProtKB/Swiss-Prot
PhenoGen	Azgp1	PhenoGen
PRINTS	MHCCLASSI	UniProtKB/Swiss-Prot
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001333	RatGTEx
SMART	IGc1	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
	SSF54452	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZXF5_RAT	UniProtKB/TrEMBL
	A0A8I6A9I2	ENTREZGENE, UniProtKB/TrEMBL
	A0ABZ3NNF9_RAT	UniProtKB/TrEMBL
	A6KSS1	ENTREZGENE, UniProtKB/TrEMBL
	F7F110	ENTREZGENE
	Q3B8R6	ENTREZGENE
	Q63523	ENTREZGENE
	Q63678	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q63523	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-25	Azgp1	alpha-2-glycoprotein 1, zinc-binding	Azgp1	alpha-2-glycoprotein 1, zinc	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Azgp1	alpha-2-glycoprotein 1, zinc		alpha-2 - glycoprotein 1, zinc	Name updated	625702	APPROVED
2001-07-23	Azgp1	alpha-2 - glycoprotein 1, zinc			Name updated to reflect Human and Mouse nomenclature	67952	APPROVED
2001-07-23	Azgp1	Zn - alpha2 - glycoprotein			Name withdrawn	67952	WITHDRAWN

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to plasma	631730
gene_expression	expressed at high level in liver, expressed at low level in submandibular gland, lung, kidney, and stomach	631730
gene_expression	not expressed in prostate, mammary gland, intestine, pancreas, ovary, uterus, thyroid, placenta, spleen, brain and heart	631786
gene_homology	has 60% identity with human protein	631730
gene_protein	293 amino acids	631730

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD