Atp5if1 (ATP synthase inhibitory factor subunit 1) - Rat Genome Database

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Gene: Atp5if1 (ATP synthase inhibitory factor subunit 1) Rattus norvegicus
Analyze
Symbol: Atp5if1
Name: ATP synthase inhibitory factor subunit 1
RGD ID: 2181
Description: Enables ATPase inhibitor activity. Predicted to be involved in several processes, including mitochondrial depolarization; negative regulation of mitochondrial ATP synthesis coupled proton transport; and positive regulation of metabolic process. Predicted to act upstream of or within positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and reactive oxygen species metabolic process. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP synthase F1 subunit epsilon; ATPase inhibitor; ATPase inhibitor (rat mitochondrial IF1 protein); ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; Atpi; Atpif1; IF(1); IF1; IF1PA; inhibitor of F(1)F(o)-ATPase; LOC362620
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,022,960 - 150,026,677 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,022,960 - 150,026,677 (-)EnsemblGRCr8
mRatBN7.25144,738,950 - 144,742,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,738,950 - 144,742,668 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,438,531 - 147,442,246 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,208,092 - 149,211,807 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,196,912 - 149,200,629 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,719,570 - 150,723,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,719,569 - 150,723,321 (-)Ensemblrn6Rnor6.0
Rnor_5.05154,387,824 - 154,391,541 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,618,307 - 152,622,024 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,165,585 - 143,169,339 (-)NCBICelera
RGSC_v3.15152,628,417 - 152,632,067 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
GSK-J4  (ISO)
hydrazine  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO,ISS)
cytoplasm  (IBA)
mitochondrion  (IBA,IEA,ISO,ISS)
protein-containing complex  (ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interaction cloning of protein kinase C substrates. Chapline C, etal., J Biol Chem 1993 Apr 5;268(10):6858-61.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning and sequence of cDNAs for the import precursors of oligomycin sensitivity conferring protein, ATPase inhibitor protein, and subunit c of H(+)-ATP synthase in rat mitochondria. Higuti T, etal., Biochim Biophys Acta 1993 Mar 20;1172(3):311-4.
5. Regulation of the mitochondrial ATP synthase/ATPase complex: cDNA cloning, sequence, overexpression, and secondary structural characterization of a functional protein inhibitor. Lebowitz MS and Pedersen PL, Arch Biochem Biophys 1993 Feb 15;301(1):64-70.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Isolation of the rat F1-ATPase inhibitor gene and its pseudogenes. Samuel DS, etal., Biochim Biophys Acta 1995 Jun 1;1230(1-2):81-5.
Additional References at PubMed
PMID:12110673   PMID:12477932   PMID:14651853   PMID:15528193   PMID:17042487   PMID:17490602   PMID:18590689   PMID:18614015   PMID:18725417   PMID:19096392   PMID:20180002   PMID:20538613  
PMID:20833797   PMID:21106936   PMID:21412184   PMID:23135403   PMID:24005319   PMID:24380588   PMID:26484591   PMID:29380352   PMID:32005857   PMID:33922643   PMID:36657294   PMID:36881363  


Genomics

Comparative Map Data
Atp5if1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,022,960 - 150,026,677 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,022,960 - 150,026,677 (-)EnsemblGRCr8
mRatBN7.25144,738,950 - 144,742,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,738,950 - 144,742,668 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,438,531 - 147,442,246 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,208,092 - 149,211,807 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,196,912 - 149,200,629 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,719,570 - 150,723,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,719,569 - 150,723,321 (-)Ensemblrn6Rnor6.0
Rnor_5.05154,387,824 - 154,391,541 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,618,307 - 152,622,024 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,165,585 - 143,169,339 (-)NCBICelera
RGSC_v3.15152,628,417 - 152,632,067 (+)NCBI
Cytogenetic Map5q36NCBI
ATP5IF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,236,124 - 28,238,100 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,236,084 - 28,246,906 (+)Ensemblhg38GRCh38
GRCh37128,562,635 - 28,564,611 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,435,198 - 28,437,198 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34128,246,752 - 28,248,751NCBI
Celera126,958,253 - 26,960,253 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,819,368 - 26,821,382 (+)NCBIHuRef
CHM1_1128,678,108 - 28,680,122 (+)NCBICHM1_1
T2T-CHM13v2.0128,077,959 - 28,079,935 (+)NCBIT2T-CHM13v2.0
Atp5if1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,257,870 - 132,262,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,257,866 - 132,260,970 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384132,530,555 - 132,535,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,530,555 - 132,533,659 (-)Ensemblmm10GRCm38
MGSCv374132,086,470 - 132,089,574 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364131,802,635 - 131,805,721 (-)NCBIMGSCv36mm8
Celera4130,690,732 - 130,693,836 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.51NCBI
Atp5if1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,373,001 - 7,375,856 (+)Ensembl
ChiLan1.0NW_0049554527,372,917 - 7,375,072 (+)NCBIChiLan1.0ChiLan1.0
ATP5IF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,616,521 - 198,618,569 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,733,428 - 197,735,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,495,250 - 27,497,255 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,532,091 - 28,534,109 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,532,091 - 28,542,607 (+)EnsemblpanPan2panpan1.1
ATP5IF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,188,562 - 72,191,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,188,266 - 72,191,326 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha268,766,422 - 68,769,200 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,748,757 - 72,751,535 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,748,456 - 72,751,516 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,576,066 - 69,578,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,586,244 - 70,589,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,582,936 - 71,585,714 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp5if1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,571,625 - 46,574,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,396,023 - 12,401,023 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,396,416 - 12,399,760 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5IF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,307,189 - 85,309,215 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1685,307,242 - 85,309,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,045,827 - 79,047,796 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5IF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,567,306 - 104,569,346 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603311,910,192 - 11,912,229 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp5if1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,068,638 - 12,072,190 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476412,068,518 - 12,070,542 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp5if1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1125,704,161 - 25,708,380 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp5if1
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000018038
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018038   ⟹   ENSRNOP00000018038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,022,960 - 150,026,677 (-)Ensembl
mRatBN7.2 Ensembl5144,738,950 - 144,742,668 (-)Ensembl
Rnor_6.0 Ensembl5150,719,569 - 150,723,321 (-)Ensembl
RefSeq Acc Id: NM_012915   ⟹   NP_037047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,022,960 - 150,026,677 (-)NCBI
mRatBN7.25144,738,950 - 144,742,668 (-)NCBI
Rnor_6.05150,719,570 - 150,723,287 (-)NCBI
Rnor_5.05154,387,824 - 154,391,541 (-)NCBI
RGSC_v3.45152,618,307 - 152,622,024 (+)RGD
Celera5143,165,585 - 143,169,339 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037047 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA85094 (Get FASTA)   NCBI Sequence Viewer  
  AAI26066 (Get FASTA)   NCBI Sequence Viewer  
  BAA02424 (Get FASTA)   NCBI Sequence Viewer  
  EDL80639 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018038
  ENSRNOP00000018038.3
GenBank Protein Q03344 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037047   ⟸   NM_012915
- Peptide Label: precursor
- UniProtKB: A0JMZ8 (UniProtKB/Swiss-Prot),   Q03344 (UniProtKB/Swiss-Prot),   A6IST8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018038   ⟸   ENSRNOT00000018038

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03344-F1-model_v2 AlphaFold Q03344 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694098
Promoter ID:EPDNEW_R4622
Type:initiation region
Name:Atp5if1_1
Description:ATP synthase inhibitory factor subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05150,723,264 - 150,723,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2181 AgrOrtholog
BioCyc Gene G2FUF-39684 BioCyc
Ensembl Genes ENSRNOG00000013300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018038 ENTREZGENE
  ENSRNOT00000018038.6 UniProtKB/Swiss-Prot
Gene3D-CATH Single helix bin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7442425 IMAGE-MGC_LOAD
InterPro ATPase_inhibitor_mt UniProtKB/Swiss-Prot
KEGG Report rno:25392 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156492 IMAGE-MGC_LOAD
NCBI Gene 25392 ENTREZGENE
PANTHER ATP SYNTHASE F1 SUBUNIT EPSILON UniProtKB/Swiss-Prot
  ATP SYNTHASE F1 SUBUNIT EPSILON UniProtKB/Swiss-Prot
Pfam IATP UniProtKB/Swiss-Prot
PhenoGen Atp5if1 PhenoGen
RatGTEx ENSRNOG00000013300 RatGTEx
Superfamily-SCOP F1 ATPase inhibitor, IF1, C-terminal domain UniProtKB/Swiss-Prot
UniProt A0JMZ8 ENTREZGENE
  A6IST8 ENTREZGENE, UniProtKB/TrEMBL
  ATIF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JMZ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-13 Atp5if1  ATP synthase inhibitory factor subunit 1  Atpif1  ATPase inhibitory factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-05 Atpif1  ATPase inhibitory factor 1  Atpif1_predicted  ATPase inhibitory factor 1 (predicted)  Data merged from RGD:1304891 737654 APPROVED
2005-12-02 Atpif1  ATPase inhibitory factor 1  Atpi  ATPase inhibitor  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Atpif1_predicted  ATPase inhibitory factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-11-06 Atpi  ATPase inhibitor    ATPase inhibitor (rat mitochondrial IF1 protein)  Name updated 625702 APPROVED
2002-06-10 Atpi  ATPase inhibitor (rat mitochondrial IF1 protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondria 631733
gene_domains has 25 N-terminal amino acids which encode a putative mitochondrial targeting sequence 631733
gene_expression expressed in liver 631733
gene_process a component of the mitochondrial ATP synthase/ATPase complex; inhibits ATP hydrolysis 631733
gene_protein 107 amino acids 631733
gene_transcript contains three exons and two introns 631785