Atp1b1 (ATPase Na+/K+ transporting subunit beta 1) - Rat Genome Database

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Gene: Atp1b1 (ATPase Na+/K+ transporting subunit beta 1) Rattus norvegicus
Analyze
Symbol: Atp1b1
Name: ATPase Na+/K+ transporting subunit beta 1
RGD ID: 2170
Description: Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Involved in potassium ion transport; response to hypoxia; and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Biomarker of sensorineural hearing loss. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase Na+/K+ transporting beta 1 polypeptide; ATPase, Na+/K+ transporting, beta 1 polypeptide; ATPBS; Na,K-ATPase beta 1 subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81379,319,708 - 79,340,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1379,319,706 - 79,340,549 (-)EnsemblGRCr8
mRatBN7.21376,786,580 - 76,807,096 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,786,578 - 76,807,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,404,955 - 79,425,485 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,708,953 - 80,729,485 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,964,000 - 77,984,560 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,737,161 - 82,757,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)Ensemblrn6Rnor6.0
Rnor_5.01387,621,447 - 87,641,967 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41380,214,056 - 80,234,576 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,517,954 - 76,538,475 (-)NCBICelera
RGSC_v3.11380,228,241 - 80,249,087 (-)NCBI
RH 3.4 Map13485.8RGD
Cytogenetic Map13q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
eugenol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
glafenine  (EXP)
glutathione  (EXP)
haloperidol  (EXP)
heparin  (EXP)
inulin  (ISO)
isoflavones  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrogallol  (ISO)
quartz  (EXP)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (EXP)
sodium dichromate  (ISO)
succimer  (ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,IEA,ISO)
basolateral plasma membrane  (IDA,IEA,ISO)
caveola  (IDA)
intercalated disc  (IEA,ISO)
lateral plasma membrane  (IEA,ISO)
membrane  (IDA,IEA,ISO)
organelle membrane  (IEA,ISO)
plasma membrane  (IEA,ISO)
sarcolemma  (IEA,ISO)
sodium:potassium-exchanging ATPase complex  (IBA,IDA,IEA,ISO)
sperm flagellum  (IEA,ISO)
T-tubule  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. Beguin P, etal., EMBO J 2002 Jul 1;21(13):3264-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
5. Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. Kasai K, etal., Brain Res Mol Brain Res 2003 Jan 31;110(1):38-44.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Li J, etal., Kidney Int. 2004 Sep;66(3):1068-75.
8. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
9. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mercer RW, etal., Mol Cell Biol 1986 Nov;6(11):3884-90.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Identification of the beta-subunit for nongastric H-K-ATPase in rat anterior prostate. Pestov NB, etal., Am J Physiol Cell Physiol. 2004 Jun;286(6):C1229-37. doi: 10.1152/ajpcell.00393.2003. Epub 2004 Jan 28.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. Stoica A, etal., Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
22. Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein. Young RM, etal., J Biol Chem 1987 Apr 5;262(10):4905-10.
Additional References at PubMed
PMID:1314096   PMID:10636900   PMID:10837135   PMID:11193188   PMID:12754184   PMID:14761885   PMID:15489334   PMID:16269407   PMID:16708288   PMID:16861705   PMID:17606467   PMID:17634366  
PMID:17673438   PMID:18052210   PMID:18075585   PMID:18522992   PMID:18728015   PMID:19542013   PMID:19683723   PMID:19751721   PMID:19764716   PMID:20100892   PMID:20131911   PMID:20444976  
PMID:20458337   PMID:20937802   PMID:21642423   PMID:21705333   PMID:22328500   PMID:22871113   PMID:23376485   PMID:23392350   PMID:23533145   PMID:23954377   PMID:24769233   PMID:27563007  
PMID:28131823   PMID:29476059   PMID:29802248   PMID:30746862   PMID:31686426   PMID:32357304   PMID:33805551  


Genomics

Comparative Map Data
Atp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81379,319,708 - 79,340,226 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1379,319,706 - 79,340,549 (-)EnsemblGRCr8
mRatBN7.21376,786,580 - 76,807,096 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1376,786,578 - 76,807,459 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1379,404,955 - 79,425,485 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01380,708,953 - 80,729,485 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01377,964,000 - 77,984,560 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01382,737,161 - 82,757,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)Ensemblrn6Rnor6.0
Rnor_5.01387,621,447 - 87,641,967 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41380,214,056 - 80,234,576 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1376,517,954 - 76,538,475 (-)NCBICelera
RGSC_v3.11380,228,241 - 80,249,087 (-)NCBI
RH 3.4 Map13485.8RGD
Cytogenetic Map13q23NCBI
ATP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,106,690 - 169,132,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,105,697 - 169,310,992 (+)Ensemblhg38GRCh38
GRCh371169,075,928 - 169,101,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,342,571 - 167,368,584 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341165,807,604 - 165,833,618NCBI
Celera1142,186,000 - 142,212,016 (+)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1140,321,997 - 140,348,078 (+)NCBIHuRef
CHM1_11170,498,009 - 170,524,021 (+)NCBICHM1_1
T2T-CHM13v2.01168,462,171 - 168,488,201 (+)NCBIT2T-CHM13v2.0
Atp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,264,668 - 164,285,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1164,264,678 - 164,285,924 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381164,437,099 - 164,458,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,437,109 - 164,458,355 (-)Ensemblmm10GRCm38
MGSCv371166,367,398 - 166,388,486 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361166,273,942 - 166,295,030 (-)NCBIMGSCv36mm8
Celera1166,878,624 - 166,899,734 (-)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.75NCBI
Atp1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554628,073,679 - 8,094,880 (-)Ensembl
ChiLan1.0NW_0049554628,072,519 - 8,095,311 (-)NCBIChiLan1.0ChiLan1.0
ATP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2180,630,907 - 80,659,587 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1180,299,320 - 80,328,363 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,592,667 - 144,621,052 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,314,700 - 148,343,205 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,314,793 - 148,342,050 (+)EnsemblpanPan2panpan1.1
ATP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1729,464,132 - 29,487,124 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl729,464,132 - 29,487,947 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha728,995,904 - 29,019,080 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0729,266,289 - 29,289,513 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl729,265,440 - 29,289,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1729,114,027 - 29,137,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0729,155,842 - 29,179,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0729,386,814 - 29,410,001 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,591,400 - 99,613,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648117,436,270 - 17,460,348 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648117,438,146 - 17,460,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,911,561 - 81,991,840 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1481,912,543 - 81,937,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,530,583 - 89,550,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.3-q2.1NCBI
ATP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,898,745 - 59,925,166 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2559,895,341 - 59,925,522 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605561,575,309 - 61,602,086 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248267,054,371 - 7,076,919 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248267,058,046 - 7,076,919 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp1b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11043,661,854 - 43,683,122 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp1b1
135 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:385
Count of miRNA genes:223
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000003932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,804,907 - 76,805,053 (+)MAPPERmRatBN7.2
Rnor_6.01382,755,491 - 82,755,638NCBIRnor6.0
Rnor_5.01387,639,777 - 87,639,924UniSTSRnor5.0
RGSC_v3.41380,232,386 - 80,232,533UniSTSRGSC3.4
Celera1376,536,285 - 76,536,432UniSTS
Cytogenetic Map13q23UniSTS
RH132763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,800,031 - 76,800,232 (+)MAPPERmRatBN7.2
Rnor_6.01382,750,613 - 82,750,813NCBIRnor6.0
Rnor_5.01387,634,899 - 87,635,099UniSTSRnor5.0
RGSC_v3.41380,227,508 - 80,227,708UniSTSRGSC3.4
Celera1376,531,407 - 76,531,607UniSTS
RH 3.4 Map13485.8UniSTS
Cytogenetic Map13q23UniSTS
RH94466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21376,787,096 - 76,787,291 (+)MAPPERmRatBN7.2
Rnor_6.01382,737,678 - 82,737,872NCBIRnor6.0
Rnor_5.01387,621,964 - 87,622,158UniSTSRnor5.0
RGSC_v3.41380,214,573 - 80,214,767UniSTSRGSC3.4
Celera1376,518,471 - 76,518,665UniSTS
RH 3.4 Map13485.8UniSTS
Cytogenetic Map13q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003932   ⟹   ENSRNOP00000003932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1379,319,706 - 79,340,549 (-)Ensembl
mRatBN7.2 Ensembl1376,786,581 - 76,807,459 (-)Ensembl
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075948   ⟹   ENSRNOP00000068146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1379,319,706 - 79,328,301 (-)Ensembl
mRatBN7.2 Ensembl1376,786,578 - 76,795,173 (-)Ensembl
Rnor_6.0 Ensembl1382,739,406 - 82,753,438 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1382,738,252 - 82,745,761 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154567   ⟹   ENSRNOP00000111008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1379,319,706 - 79,340,549 (-)Ensembl
RefSeq Acc Id: NM_013113   ⟹   NP_037245
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81379,319,708 - 79,340,226 (-)NCBI
mRatBN7.21376,786,580 - 76,807,096 (-)NCBI
Rnor_6.01382,737,161 - 82,757,681 (-)NCBI
Rnor_5.01387,621,447 - 87,641,967 (-)NCBI
RGSC_v3.41380,214,056 - 80,234,576 (-)RGD
Celera1376,517,954 - 76,538,475 (-)RGD
Sequence:
RefSeq Acc Id: NP_037245   ⟸   NM_013113
- UniProtKB: Q63062 (UniProtKB/Swiss-Prot),   P07340 (UniProtKB/Swiss-Prot),   A6IDE6 (UniProtKB/TrEMBL),   A0A8L2Q0J0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068146   ⟸   ENSRNOT00000075948
Ensembl Acc Id: ENSRNOP00000003932   ⟸   ENSRNOT00000003932
Ensembl Acc Id: ENSRNOP00000111008   ⟸   ENSRNOT00000154567

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07340-F1-model_v2 AlphaFold P07340 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698957
Promoter ID:EPDNEW_R9481
Type:multiple initiation site
Name:Atp1b1_1
Description:ATPase Na+/K+ transporting subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9482  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01382,757,692 - 82,757,752EPDNEW
RGD ID:13698958
Promoter ID:EPDNEW_R9482
Type:multiple initiation site
Name:Atp1b1_2
Description:ATPase Na+/K+ transporting subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9481  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01382,758,044 - 82,758,104EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2170 AgrOrtholog
BioCyc Gene G2FUF-17596 BioCyc
Ensembl Genes ENSRNOG00000002934 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003932 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  2.60.40.1660 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111949 IMAGE-MGC_LOAD
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot
KEGG Report rno:25650 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93649 IMAGE-MGC_LOAD
NCBI Gene 25650 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot
  PTHR11523:SF10 UniProtKB/Swiss-Prot
Pfam Na_K-ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1b1 PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002934 RatGTEx
UniProt A0A096MJI9_RAT UniProtKB/TrEMBL
  A0A8L2Q0J0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M639_RAT UniProtKB/TrEMBL
  A6IDE3_RAT UniProtKB/TrEMBL
  A6IDE4_RAT UniProtKB/TrEMBL
  A6IDE5_RAT UniProtKB/TrEMBL
  A6IDE6 ENTREZGENE, UniProtKB/TrEMBL
  A6IDE7_RAT UniProtKB/TrEMBL
  A6IDE8_RAT UniProtKB/TrEMBL
  AT1B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63062 ENTREZGENE
UniProt Secondary Q63062 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1b1  ATPase Na+/K+ transporting subunit beta 1  Atp1b1  ATPase, Na+/K+ transporting, beta 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Atp1b1  ATPase, Na+/K+ transporting, beta 1 polypeptide    ATPase Na+/K+ transporting beta 1 polypeptide  Name updated 1299863 APPROVED
2002-06-10 Atp1b1  ATPase Na+/K+ transporting beta 1 polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may help maintain the cellular environment of astrocytes subjected to hypoxia/reoxygenation 631759
gene_process may play an important role in Na,K-ATPase structure-function and aid in cellular resistance to cardiac glycosides 632210
gene_regulation may be regulated by FXYD7 in brain 631775
gene_transcript multiple mRNA species exist due to transcription from multiple initiation sites 631776