Aqp7 (aquaporin 7) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Aqp7 (aquaporin 7) Rattus norvegicus
Analyze
Symbol: Aqp7
Name: aquaporin 7
RGD ID: 2145
Description: Enables glycerol channel activity; urea channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; urea transport; and water transport. Located in brush border membrane. Part of ribonucleoprotein complex. Orthologous to several human genes including AQP7 (aquaporin 7); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; water transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AQP-7; aquaglyceroporin-7; aquaporin-7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,968,495 - 60,982,618 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,967,558 - 60,982,618 (-)EnsemblGRCr8
mRatBN7.2556,171,649 - 56,186,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,172,519 - 56,186,642 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,138,736 - 58,152,556 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,957,884 - 59,971,702 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,952,637 - 59,966,600 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,358,297 - 57,372,332 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,358,327 - 57,372,239 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,888,637 - 61,902,549 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,433,731 - 58,447,853 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,784,415 - 54,798,541 (-)NCBICelera
RGSC_v3.1558,433,909 - 58,448,032 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP,ISO)
clofibrate  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dipentyl phthalate  (EXP)
diprotium oxide  (EXP)
disodium selenite  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
fenofibrate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
glycerol  (EXP,ISO)
hydrogen cyanide  (ISO)
indometacin  (EXP,ISO)
L-methionine  (ISO)
lycopene  (ISO)
mercaptoethanol  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP)
methylmercury chloride  (EXP)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
Phenylamil  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urea  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
water  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis. Calamita G, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):619-25.
2. Adipose tissue expression of the glycerol channel Aquaporin-7 gene is altered in severe obesity but not in Type 2 diabetes. Ceperuelo-Mallafre V, etal., J Clin Endocrinol Metab. 2007 Jun 12;.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis. Hardin JA, etal., Cell Tissue Res. 2004 Nov;318(2):313-23. Epub 2004 Aug 27.
6. Cellular localization of aquaporin 7 in the rat kidney. Ishibashi K, etal., Exp Nephrol. 2000 Jul-Oct;8(4-5):252-7.
7. Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. Ishibashi K, etal., J Biol Chem 1997 Aug 15;272(33):20782-6.
8. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
9. Increased AQP7 abundance in skeletal muscle from obese men with type 2 diabetes. Lebeck J, etal., Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E367-E373. doi: 10.1152/ajpendo.00468.2017. Epub 2018 May 21.
10. The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Lee DH, etal., Metabolism. 2005 Oct;54(10):1282-9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis. Suzuki-Toyota F, etal., Cell Tissue Res. 1999 Feb;295(2):279-85.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10510269   PMID:10564231   PMID:11001937   PMID:11034202  
PMID:11076974   PMID:11573934   PMID:11952783   PMID:12084581   PMID:12192003   PMID:14701836   PMID:15489334   PMID:15595681   PMID:15943587   PMID:15948717   PMID:15998844   PMID:16596446  
PMID:17178220   PMID:18059526   PMID:18202181   PMID:18501347   PMID:18511455   PMID:18718702   PMID:18762715   PMID:19180911   PMID:19585522   PMID:21251984   PMID:21321634   PMID:25643985  
PMID:30420639   PMID:32735865   PMID:33506920   PMID:36834823  


Genomics

Comparative Map Data
Aqp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,968,495 - 60,982,618 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,967,558 - 60,982,618 (-)EnsemblGRCr8
mRatBN7.2556,171,649 - 56,186,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,172,519 - 56,186,642 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,138,736 - 58,152,556 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,957,884 - 59,971,702 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,952,637 - 59,966,600 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,358,297 - 57,372,332 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,358,327 - 57,372,239 (-)Ensemblrn6Rnor6.0
Rnor_5.0561,888,637 - 61,902,549 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,433,731 - 58,447,853 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,784,415 - 54,798,541 (-)NCBICelera
RGSC_v3.1558,433,909 - 58,448,032 (-)NCBI
Cytogenetic Map5q22NCBI
AQP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,383,191 - 33,402,568 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,383,179 - 33,402,682 (-)Ensemblhg38GRCh38
GRCh37933,383,189 - 33,402,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,374,948 - 33,392,517 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34933,374,947 - 33,392,517NCBI
Celera933,315,070 - 33,332,637 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,341,505 - 33,358,953 (-)NCBIHuRef
CHM1_1933,384,744 - 33,402,308 (-)NCBICHM1_1
T2T-CHM13v2.0933,401,795 - 33,421,171 (-)NCBIT2T-CHM13v2.0
Aqp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,033,074 - 41,048,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,033,074 - 41,048,139 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38441,033,074 - 41,048,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,033,074 - 41,048,139 (-)Ensemblmm10GRCm38
MGSCv37440,980,107 - 40,995,169 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36441,221,748 - 41,236,641 (-)NCBIMGSCv36mm8
Celera440,693,722 - 40,709,136 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.83NCBI
Aqp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554722,286,547 - 2,298,953 (+)Ensembl
ChiLan1.0NW_0049554722,283,426 - 2,297,251 (+)NCBIChiLan1.0ChiLan1.0
AQP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,201,225 - 91,220,849 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,207,167 - 91,226,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,160,982 - 33,180,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1933,971,842 - 33,983,454 (-)NCBIPanPan1.1PanPan1.1panPan2
AQP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,474,007 - 50,488,191 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,104,054 - 49,118,284 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01151,414,635 - 51,428,870 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,413,367 - 51,428,758 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,078,662 - 50,092,894 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,945,887 - 49,960,128 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,710,993 - 50,725,230 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aqp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,351,053 - 165,367,563 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,899,304 - 1,901,163 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,898,635 - 1,915,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11033,098,746 - 33,130,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,361,028 - 37,376,629 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AQP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11246,866,519 - 46,886,525 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,758,462 - 43,777,506 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473638,130,992 - 38,148,444 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aqp7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,127,798 - 117,141,913 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aqp7
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000012975
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH133701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,172,545 - 56,172,737 (+)MAPPERmRatBN7.2
Rnor_6.0557,358,354 - 57,358,545NCBIRnor6.0
Rnor_5.0561,888,664 - 61,888,855UniSTSRnor5.0
RGSC_v3.4558,433,758 - 58,433,949UniSTSRGSC3.4
Celera554,784,442 - 54,784,633UniSTS
Cytogenetic Map5q22UniSTS
RH142180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,172,526 - 56,172,699 (+)MAPPERmRatBN7.2
Rnor_6.0557,358,335 - 57,358,507NCBIRnor6.0
Rnor_5.0561,888,645 - 61,888,817UniSTSRnor5.0
RGSC_v3.4558,433,739 - 58,433,911UniSTSRGSC3.4
Celera554,784,423 - 54,784,595UniSTS
Cytogenetic Map5q22UniSTS
Aqp7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0557,359,094 - 57,360,228NCBIRnor6.0
Rnor_5.0561,889,404 - 61,890,538UniSTSRnor5.0
RGSC_v3.4558,434,498 - 58,435,842UniSTSRGSC3.4
Celera554,785,182 - 54,786,526UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 12 62 68 90 87 58 24 58 6 276 118 10 42 81 79 29

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB000507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY120935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012975   ⟹   ENSRNOP00000012974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,967,558 - 60,982,618 (-)Ensembl
mRatBN7.2 Ensembl556,172,519 - 56,186,642 (-)Ensembl
Rnor_6.0 Ensembl557,358,327 - 57,372,239 (-)Ensembl
RefSeq Acc Id: NM_019157   ⟹   NP_062030
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,968,496 - 60,982,618 (-)NCBI
mRatBN7.2556,172,519 - 56,186,642 (-)NCBI
Rnor_6.0557,358,327 - 57,372,239 (-)NCBI
Rnor_5.0561,888,637 - 61,902,549 (-)NCBI
RGSC_v3.4558,433,731 - 58,447,853 (-)RGD
Celera554,784,415 - 54,798,541 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109352   ⟹   XP_038965280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,968,495 - 60,980,935 (-)NCBI
mRatBN7.2556,171,649 - 56,184,699 (-)NCBI
RefSeq Acc Id: NP_062030   ⟸   NM_019157
- UniProtKB: Q8K3F5 (UniProtKB/Swiss-Prot),   P56403 (UniProtKB/Swiss-Prot),   A6IIT3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012974   ⟸   ENSRNOT00000012975
RefSeq Acc Id: XP_038965280   ⟸   XM_039109352
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56403-F1-model_v2 AlphaFold P56403 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693642
Promoter ID:EPDNEW_R4166
Type:initiation region
Name:Aqp7_1
Description:aquaporin 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0557,372,270 - 57,372,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2145 AgrOrtholog
BioCyc Gene G2FUF-41581 BioCyc
Ensembl Genes ENSRNOG00000009686 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012975.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104684 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot
  MIP UniProtKB/Swiss-Prot
  MIP/Aquaporin UniProtKB/Swiss-Prot
KEGG Report rno:29171 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91424 IMAGE-MGC_LOAD
NCBI Gene 29171 ENTREZGENE
PANTHER AQUAPORIN OR AQUAGLYCEROPORIN RELATED UniProtKB/Swiss-Prot
  PTHR43829:SF15 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot
PhenoGen Aqp7 PhenoGen
PRINTS AQUAPORIN7 UniProtKB/Swiss-Prot
  MINTRINSICP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009686 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot
TIGR TC207921
UniProt A6IIT3 ENTREZGENE, UniProtKB/TrEMBL
  A6IIT4_RAT UniProtKB/TrEMBL
  A6IIT5_RAT UniProtKB/TrEMBL
  AQP7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K3F5 ENTREZGENE
UniProt Secondary Q8K3F5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp7  aquaporin 7      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis at postnatal day 45, expression increases through day 90 and remains high in the adult 634665
gene_function forms an aquaporin water channel 634665
gene_process may play a role in regulation of fluid homeostasis during testis development and spermatogenesis 634665