Apoc2 (apolipoprotein C2) - Rat Genome Database

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Gene: Apoc2 (apolipoprotein C2) Rattus norvegicus
Analyze
Symbol: Apoc2
Name: apolipoprotein C2
RGD ID: 2135
Description: Predicted to enable several functions, including identical protein binding activity; lipase activator activity; and phospholipase binding activity. Involved in lipoprotein transport and response to xenobiotic stimulus. Predicted to be located in extracellular space. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Apo-CII; ApoC-II; apolipoprotein C-II; LOC292697; RGD1560725; similar to Apolipoprotein C2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,457,397 - 88,462,365 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,457,396 - 88,463,438 (-)EnsemblGRCr8
mRatBN7.2179,329,429 - 79,334,397 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,329,428 - 79,334,476 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,724,358 - 84,729,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,275,674 - 93,280,670 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,479,464 - 86,484,436 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,589,023 - 80,593,991 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,589,023 - 80,594,136 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,854,610 - 81,859,580 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,979,034 - 78,984,002 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,788,729 - 73,793,701 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-ephedrine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aconitine  (EXP)
amiodarone  (ISO)
amphotericin B  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
fenthion  (ISO)
folic acid  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lithocholic acid  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
pioglitazone  (ISO)
quercetin  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation. Andersson Y, etal., Arterioscler Thromb Vasc Biol. 1999 Jan;19(1):115-21.
2. Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. Baggio G, etal., J Clin Invest. 1986 Feb;77(2):520-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia. Hegele RA, etal., Dis Markers. 1991 Mar-Apr;9(2):73-80.
5. Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney and pancreas transplantation. Hughes TA, etal., Metabolism. 1994 Mar;43(3):333-47.
6. Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Jong MC, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):472-84.
7. Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus. Joven J, etal., Nephron. 1993;64(4):565-9.
8. Serum apolipoproteins in heterozygous familial hypercholesterolemia. Kajinami K, etal., Clin Chim Acta. 1992 Oct 15;211(1-2):93-9.
9. Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids. Kardassis D, etal., Biochem J 2003 Jun 1;372(Pt 2):291-304.
10. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Konemori G, etal., Nippon Ronen Igakkai Zasshi. 1990 Jan;27(1):22-7.
11. Missense mutation Leu72Pro located on the carboxyl terminal amphipathic helix of apolipoprotein C-II causes familial chylomicronemia syndrome. Lam CW, etal., Clin Chim Acta. 2006 Feb;364(1-2):256-9. Epub 2005 Sep 8.
12. Plasma lipids, lipoproteins and apolipoproteins in two kindreds of hypobetalipoproteinemia. Lontie JF, etal., Atherosclerosis. 1990 Aug;83(2-3):187-96.
13. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. Mak PA, etal., J Biol Chem 2002 Aug 30;277(35):31900-8. Epub 2002 May 24.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Abnormal composition of apoproteins C-I, C-II, and C-III in plasma and very-low-density lipoproteins of non-insulin-dependent diabetic Chinese. Pan XR, etal., Clin Chem. 1986 Oct;32(10):1914-20.
17. Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II. Pham CL, etal., Biochemistry 2002 Dec 3;41(48):14313-22.
18. [Allelic variants of apolipoproteins B and CII genes in patients with ischemic heart disease and in healthy persons from the Moscow population]. Pogoda TV, etal., Genetika. 1995 Jul;31(7):1001-9.
19. Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. Pullinger CR, etal., Hum Mol Genet. 1993 Jan;2(1):69-74.
20. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao / [bian ji zhe, Hua xi yi ke da xue xue bao bian wei hui] Ren Y, etal., Hua Xi Yi Ke Da Xue Xue Bao. 2001 Mar;32(1):48-51, 69.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
26. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
27. Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. Windler E and Havel RJ, J Lipid Res. 1985 May;26(5):556-65.
28. Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis. Zouali H, etal., Mult Scler 1999 Apr;5(2):134-6.
29. The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. Zysow BR, etal., Clin Genet. 1994 Jun;45(6):292-7.
Additional References at PubMed
PMID:182536   PMID:270715   PMID:1917954   PMID:8245722   PMID:8889548   PMID:10727238   PMID:11162594   PMID:12477932   PMID:15778093   PMID:15878877   PMID:16682745   PMID:17018885  
PMID:17336988   PMID:23376485   PMID:28229588  


Genomics

Comparative Map Data
Apoc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,457,397 - 88,462,365 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,457,396 - 88,463,438 (-)EnsemblGRCr8
mRatBN7.2179,329,429 - 79,334,397 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,329,428 - 79,334,476 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,724,358 - 84,729,330 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,275,674 - 93,280,670 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,479,464 - 86,484,436 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,589,023 - 80,593,991 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,589,023 - 80,594,136 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,854,610 - 81,859,580 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,979,034 - 78,984,002 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,788,729 - 73,793,701 (-)NCBICelera
Cytogenetic Map1q21NCBI
APOC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,946,051 - 44,949,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,945,709 - 44,949,580 (+)Ensemblhg38GRCh38
GRCh371945,449,308 - 45,452,822 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,141,083 - 50,144,658 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,141,082 - 50,144,657NCBI
Celera1942,253,565 - 42,257,132 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,879,798 - 41,883,381 (+)NCBIHuRef
CHM1_11945,452,071 - 45,455,660 (+)NCBICHM1_1
T2T-CHM13v2.01947,770,875 - 47,774,393 (+)NCBIT2T-CHM13v2.0
Apoc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,405,504 - 19,411,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,405,504 - 19,411,866 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,671,579 - 19,677,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,671,579 - 19,677,941 (-)Ensemblmm10GRCm38
MGSCv37720,256,928 - 20,262,213 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,830,106 - 18,836,463 (-)NCBIMGSCv36mm8
Celera717,077,835 - 17,082,947 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,016,217 - 2,021,830 (+)Ensembl
ChiLan1.0NW_0049555552,019,547 - 2,021,543 (+)NCBIChiLan1.0ChiLan1.0
APOC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,104,521 - 51,108,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,976,612 - 52,980,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,892,954 - 41,896,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,498,109 - 50,501,877 (+)NCBIPanPan1.1PanPan1.1panPan2
APOC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,504,806 - 110,506,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,504,815 - 110,506,961 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1109,985,886 - 109,987,967 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,034,576 - 111,036,727 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,034,585 - 111,036,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,709,344 - 110,711,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,344,763 - 110,346,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,213,632 - 111,215,715 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apoc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,183,204 - 17,184,690 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,531,219 - 1,531,921 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1651,404,219 - 51,406,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,285,954 - 47,288,054 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,406,829 - 38,411,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,409,641 - 38,410,927 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607317,985,436 - 17,990,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,765,481 - 1,769,781 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249071,765,467 - 1,769,786 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Apoc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12170,940,090 - 170,945,166 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apoc2
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:74
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000024800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH139261  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,457,471 - 88,458,161 (+)Marker Load Pipeline
mRatBN7.2179,329,503 - 79,330,193 (+)MAPPERmRatBN7.2
Rnor_6.0180,589,098 - 80,589,787NCBIRnor6.0
Rnor_5.0181,854,687 - 81,855,376UniSTSRnor5.0
RGSC_v3.4178,979,109 - 78,979,798UniSTSRGSC3.4
Celera173,788,804 - 73,789,493UniSTS
RH 3.4 Map1787.0UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 9 32 92 87 86 59 20 59 6 222 71 73 72 62 27 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000024800   ⟹   ENSRNOP00000024800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,457,396 - 88,463,438 (-)Ensembl
mRatBN7.2 Ensembl179,329,428 - 79,334,476 (-)Ensembl
Rnor_6.0 Ensembl180,589,023 - 80,594,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099655   ⟹   ENSRNOP00000083873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,329,776 - 79,334,476 (-)Ensembl
RefSeq Acc Id: NM_001085352   ⟹   NP_001078821
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,457,397 - 88,462,365 (-)NCBI
mRatBN7.2179,329,429 - 79,334,397 (-)NCBI
Rnor_6.0180,589,023 - 80,593,991 (-)NCBI
Rnor_5.0181,854,610 - 81,859,580 (-)NCBI
RGSC_v3.4178,979,034 - 78,984,002 (-)RGD
Celera173,788,729 - 73,793,701 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001078821 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI57807 (Get FASTA)   NCBI Sequence Viewer  
  EDM08174 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024800.4
GenBank Protein G3V8D4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001078821   ⟸   NM_001085352
- Peptide Label: precursor
- UniProtKB: G3V8D4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024800   ⟸   ENSRNOT00000024800
Ensembl Acc Id: ENSRNOP00000083873   ⟸   ENSRNOT00000099655

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8D4-F1-model_v2 AlphaFold G3V8D4 1-97 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689777
Promoter ID:EPDNEW_R301
Type:multiple initiation site
Name:Apoc2_1
Description:apolipoprotein C2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,594,001 - 80,594,061EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2135 AgrOrtholog
BioCyc Gene G2FUF-60491 BioCyc
Ensembl Genes ENSRNOG00000018402 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024800.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1440.10 UniProtKB/Swiss-Prot
InterPro Apo-CII UniProtKB/Swiss-Prot
  ApoC-II_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:292697 UniProtKB/Swiss-Prot
NCBI Gene Apoc2 ENTREZGENE
PANTHER APOLIPOPROTEIN C-II UniProtKB/Swiss-Prot
  PTHR16566 UniProtKB/Swiss-Prot
Pfam Apo-CII UniProtKB/Swiss-Prot
PhenoGen Apoc2 PhenoGen
RatGTEx ENSRNOG00000018402 RatGTEx
UniProt APOC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoc2  apolipoprotein C2  Apoc2  apolipoprotein C-II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-10 Apoc2  apolipoprotein C-II  Apoc2_predicted  apolipoprotein C-II (predicted)  Data merged from RGD:1560725 737654 APPROVED
2006-03-30 Apoc2_predicted  apolipoprotein C-II (predicted)  RGD1560725_predicted  similar to Apolipoprotein C2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560725_predicted  similar to Apolipoprotein C2 (predicted)  LOC292697  similar to Apolipoprotein C2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292697  similar to Apolipoprotein C2      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Apoc2  apolipoprotein C-II    Apolipoprotein C2  Name updated 629478 APPROVED
2002-06-10 Apoc2  Apolipoprotein C2      Symbol and Name status set to approved 70586 APPROVED