Aplp2 (amyloid beta precursor like protein 2) - Rat Genome Database

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Gene: Aplp2 (amyloid beta precursor like protein 2) Rattus norvegicus
Analyze
Symbol: Aplp2
Name: amyloid beta precursor like protein 2
RGD ID: 2128
Description: Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to act upstream of or within several processes, including brain development; intracellular copper ion homeostasis; and suckling behavior. Predicted to be located in nucleus. Predicted to be active in spine apparatus. Used to study Alzheimer's disease. Biomarker of neurodegenerative disease. Orthologous to human APLP2 (amyloid beta precursor like protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: amyloid beta (A4) precursor-like protein 2; amyloid beta (A4) precursor-like protein 2-like; amyloid protein homolog; Amyloid protein precursor-like protein 2; amyloid-like protein 2; APLP-2; Apph; CDEBP; LOC100363366; LOC64312; sperm membrane protein (YWK-II); sperm membrane protein YWK-II; WALPLP2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,857,407 - 37,920,487 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,857,407 - 37,920,031 (-)EnsemblGRCr8
mRatBN7.2829,599,230 - 29,662,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx833,668,572 - 33,730,720 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,962,969 - 32,025,119 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,830,857 - 29,892,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,298,526 - 32,328,821 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)Ensemblrn6Rnor6.0
Rnor_5.0832,323,516 - 32,353,638 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera831,060,571 - 31,122,969 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
genistein  (ISO)
glutathione  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
menadione  (ISO)
methidathion  (ISO)
Methylazoxymethanol acetate  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nivalenol  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, etal., Biochem J 1998 Feb 15;330 ( Pt 1):513-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. Sandbrink R, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):167-70.
10. Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression. Shen Y, etal., Eur J Neurosci 2002 Sep;16(5):896-906.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein. Yan YC, etal., Proc Natl Acad Sci U S A 1990 Apr;87(7):2405-8.
Additional References at PubMed
PMID:7702756   PMID:9461064   PMID:10526140   PMID:15208260   PMID:15385965   PMID:15689559   PMID:16193067   PMID:17556541   PMID:17920016   PMID:19199708   PMID:19946888   PMID:22724288  
PMID:25683482   PMID:26890784   PMID:26921470  


Genomics

Comparative Map Data
Aplp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,857,407 - 37,920,487 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,857,407 - 37,920,031 (-)EnsemblGRCr8
mRatBN7.2829,599,230 - 29,662,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx833,668,572 - 33,730,720 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,962,969 - 32,025,119 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,830,857 - 29,892,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,298,526 - 32,328,821 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)Ensemblrn6Rnor6.0
Rnor_5.0832,323,516 - 32,353,638 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera831,060,571 - 31,122,969 (-)NCBICelera
Cytogenetic Map8q13NCBI
APLP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,069,894 - 130,144,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,068,147 - 130,144,811 (+)Ensemblhg38GRCh38
GRCh3711129,939,789 - 130,014,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,445,011 - 129,519,910 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411129,445,010 - 129,519,910NCBI
Celera11127,107,986 - 127,182,408 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,891,358 - 125,966,057 (+)NCBIHuRef
CHM1_111129,825,308 - 129,900,554 (+)NCBICHM1_1
T2T-CHM13v2.011130,106,007 - 130,180,474 (+)NCBIT2T-CHM13v2.0
Aplp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39931,060,853 - 31,123,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,060,853 - 31,123,111 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38931,149,557 - 31,211,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,149,557 - 31,211,815 (-)Ensemblmm10GRCm38
MGSCv37930,957,142 - 31,019,400 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36930,899,122 - 30,961,380 (-)NCBIMGSCv36mm8
Celera928,408,874 - 28,471,021 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.66NCBI
Aplp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)Ensembl
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBIChiLan1.0ChiLan1.0
APLP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,749,892 - 130,822,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,860,588 - 131,933,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011124,881,191 - 124,944,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,812,227 - 128,847,482 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,775,329 - 128,847,482 (+)EnsemblpanPan2panpan1.1
APLP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,704,155 - 4,786,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,705,491 - 4,786,079 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha54,764,879 - 4,846,709 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.054,663,992 - 4,746,091 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,663,992 - 4,746,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,725,302 - 4,807,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,706,890 - 4,788,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,734,652 - 4,816,738 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aplp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,172,610 - 112,244,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,205,478 - 2,277,842 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,205,527 - 2,277,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,798,810 - 56,872,642 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1956,798,781 - 56,871,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2962,965,051 - 63,035,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APLP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,150,296 - 121,224,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,150,291 - 121,224,534 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660434,883,243 - 4,956,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aplp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,490,798 - 4,571,623 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248124,490,798 - 4,571,500 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aplp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1826,882,316 - 26,943,478 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aplp2
499 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2124
Count of miRNA genes:296
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000070818, ENSRNOT00000074166, ENSRNOT00000074457
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH127464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,599,411 - 29,599,599 (+)MAPPERmRatBN7.2
Rnor_6.0832,298,708 - 32,298,895NCBIRnor6.0
Rnor_5.0832,323,698 - 32,323,885UniSTSRnor5.0
Celera831,060,753 - 31,060,940UniSTS
RH 3.4 Map8243.8UniSTS
Cytogenetic Map8q13UniSTS
RH142178  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0832,220,143 - 32,220,276UniSTSRnor5.0
RGSC_v3.4830,972,451 - 30,972,584UniSTSRGSC3.4
Celera831,122,808 - 31,122,941UniSTS
Cytogenetic Map8q13UniSTS
MARC_21333-21334:1023126386:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8837,886,667 - 37,887,607 (+)Marker Load Pipeline
mRatBN7.2829,628,491 - 29,629,431 (+)MAPPERmRatBN7.2
Rnor_6.0832,327,829 - 32,328,768NCBIRnor6.0
Rnor_5.0832,352,646 - 32,353,585UniSTSRnor5.0
RGSC_v3.4830,939,249 - 30,940,188UniSTSRGSC3.4
Celera831,089,619 - 31,090,558UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP497339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA340752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB700594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB795867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM029818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM030557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM041002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM044356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM112636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000070818   ⟹   ENSRNOP00000067835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,857,407 - 37,920,031 (-)Ensembl
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)Ensembl
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074457   ⟹   ENSRNOP00000067077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,857,407 - 37,920,031 (-)Ensembl
mRatBN7.2 Ensembl829,599,234 - 29,661,839 (-)Ensembl
Rnor_6.0 Ensembl832,299,770 - 32,328,819 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097481   ⟹   ENSRNOP00000081588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,857,407 - 37,920,031 (-)Ensembl
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)Ensembl
RefSeq Acc Id: NM_012906   ⟹   NP_037038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,031 (-)NCBI
mRatBN7.2829,599,230 - 29,661,855 (-)NCBI
Rnor_6.0832,298,526 - 32,328,821 (-)NCBI
Rnor_5.0832,323,516 - 32,353,638 (-)NCBI
Celera831,060,571 - 31,122,969 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022520   ⟹   NP_071965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,031 (-)NCBI
mRatBN7.2829,599,230 - 29,661,855 (-)NCBI
Rnor_6.0832,298,526 - 32,328,821 (-)NCBI
Rnor_5.0832,323,516 - 32,353,638 (-)NCBI
Celera831,060,571 - 31,122,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082083   ⟹   XP_038938011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,487 (-)NCBI
mRatBN7.2829,599,230 - 29,662,311 (-)NCBI
RefSeq Acc Id: XM_039082084   ⟹   XP_038938012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,487 (-)NCBI
mRatBN7.2829,599,230 - 29,662,311 (-)NCBI
RefSeq Acc Id: NP_071965   ⟸   NM_022520
- Peptide Label: isoform 2 precursor
- UniProtKB: P15943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_037038   ⟸   NM_012906
- Peptide Label: isoform 1 precursor
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A6JYG2 (UniProtKB/TrEMBL),   M0RDX2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067835   ⟸   ENSRNOT00000070818
Ensembl Acc Id: ENSRNOP00000067077   ⟸   ENSRNOT00000074457
RefSeq Acc Id: XP_038938012   ⟸   XM_039082084
- Peptide Label: isoform X2
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A6JYG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938011   ⟸   XM_039082083
- Peptide Label: isoform X1
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A0A8I5ZSU5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081588   ⟸   ENSRNOT00000097481
Protein Domains
BPTI/Kunitz inhibitor   E1   E2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15943-F1-model_v2 AlphaFold P15943 1-765 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2128 AgrOrtholog
BioCyc Gene G2FUF-31262 BioCyc
Ensembl Genes ENSRNOG00000047179 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000070818 ENTREZGENE
  ENSRNOT00000074457 ENTREZGENE
  ENSRNOT00000097481 ENTREZGENE
Gene3D-CATH 1.20.120.770 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.1490.140 UniProtKB/Swiss-Prot
  3.90.570.10 UniProtKB/Swiss-Prot
  4.10.410.10 UniProtKB/Swiss-Prot
  6.10.250.1670 UniProtKB/Swiss-Prot
InterPro Amyloid_Cu-bd_sf UniProtKB/Swiss-Prot
  Amyloid_glyco UniProtKB/Swiss-Prot
  Amyloid_glyco_Cu-bd UniProtKB/Swiss-Prot
  Amyloid_glyco_E2_domain UniProtKB/Swiss-Prot
  Amyloid_glyco_extra UniProtKB/Swiss-Prot
  Amyloid_glyco_heparin-bd UniProtKB/Swiss-Prot
  Amyloid_glyco_heparin-bd_sf UniProtKB/Swiss-Prot
  Amyloid_glyco_intracell_CS UniProtKB/Swiss-Prot
  APP_amyloid_C UniProtKB/Swiss-Prot
  APP_CUBD_CS UniProtKB/Swiss-Prot
  E2_sf UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot
NCBI Gene Aplp2 ENTREZGENE
PANTHER AMYLOID-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR23103 UniProtKB/Swiss-Prot
Pfam APP_amyloid UniProtKB/Swiss-Prot
  APP_Cu_bd UniProtKB/Swiss-Prot
  APP_E2 UniProtKB/Swiss-Prot
  APP_N UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
PhenoGen Aplp2 PhenoGen
PRINTS AMYLOIDA4 UniProtKB/Swiss-Prot
  BASICPTASE UniProtKB/Swiss-Prot
PROSITE APP_CUBD UniProtKB/Swiss-Prot
  APP_E1 UniProtKB/Swiss-Prot
  APP_E2 UniProtKB/Swiss-Prot
  APP_INTRA UniProtKB/Swiss-Prot
  BPTI_KUNITZ_1 UniProtKB/Swiss-Prot
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047179 RatGTEx
SMART A4_EXTRA UniProtKB/Swiss-Prot
  SM00131 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109843 UniProtKB/Swiss-Prot
  SSF56491 UniProtKB/Swiss-Prot
  SSF57362 UniProtKB/Swiss-Prot
  SSF89811 UniProtKB/Swiss-Prot
TIGR TC216661
UniProt A0A8I5ZSU5 ENTREZGENE, UniProtKB/TrEMBL
  A6JYG1 ENTREZGENE, UniProtKB/TrEMBL
  A6JYG2 ENTREZGENE, UniProtKB/TrEMBL
  APLP2_RAT UniProtKB/Swiss-Prot
  M0RBX7_RAT UniProtKB/TrEMBL
  M0RDX2 ENTREZGENE, UniProtKB/TrEMBL
  P15943 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Aplp2  amyloid beta precursor like protein 2  Aplp2  amyloid beta (A4) precursor-like protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Aplp2  amyloid beta (A4) precursor-like protein 2  LOC100363366  amyloid beta (A4) precursor-like protein 2-like  Data merged from RGD:2323177 737654 PROVISIONAL
2010-05-06 LOC100363366  amyloid beta (A4) precursor-like protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-04-26 Aplp2  amyloid beta (A4) precursor-like protein 2  LOC64312  sperm membrane protein (YWK-II)  Data merged from RGD:708562 737654 APPROVED
2003-04-09 Aplp2  amyloid beta (A4) precursor-like protein 2    Amyloid protein precursor-like protein 2  Name updated 629478 APPROVED
2002-06-10 Aplp2  Amyloid protein precursor-like protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization putative sperm membrane protein with homology to the amyloid A4 transmembrane-cytoplasmic domain 634653
gene_domains contains an RKR sequence that may represent a membrane cytoplasmic junction 634653