Aplp2 (amyloid beta precursor like protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Aplp2 (amyloid beta precursor like protein 2) Rattus norvegicus
Analyze
Symbol: Aplp2
Name: amyloid beta precursor like protein 2
RGD ID: 2128
Description: Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to act upstream of or within several processes, including brain development; intracellular copper ion homeostasis; and suckling behavior. Predicted to be located in nucleus. Predicted to be active in spine apparatus. Used to study Alzheimer's disease. Biomarker of neurodegenerative disease. Orthologous to human APLP2 (amyloid beta precursor like protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: amyloid beta (A4) precursor-like protein 2; amyloid beta (A4) precursor-like protein 2-like; amyloid protein homolog; Amyloid protein precursor-like protein 2; amyloid-like protein 2; APLP-2; Apph; CDEBP; LOC100363366; LOC64312; sperm membrane protein (YWK-II); sperm membrane protein YWK-II; WALPLP2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,857,407 - 37,920,487 (-)NCBIGRCr8
mRatBN7.2829,599,230 - 29,662,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx833,668,572 - 33,730,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,962,969 - 32,025,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,830,857 - 29,892,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,298,526 - 32,328,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,323,516 - 32,353,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera831,060,571 - 31,122,969 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP)
bisphenol F  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
genistein  (ISO)
glutathione  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
menadione  (ISO)
methidathion  (ISO)
Methylazoxymethanol acetate  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, etal., Biochem J 1998 Feb 15;330 ( Pt 1):513-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. Sandbrink R, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):167-70.
10. Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression. Shen Y, etal., Eur J Neurosci 2002 Sep;16(5):896-906.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein. Yan YC, etal., Proc Natl Acad Sci U S A 1990 Apr;87(7):2405-8.
Additional References at PubMed
PMID:7702756   PMID:9461064   PMID:10526140   PMID:15208260   PMID:15385965   PMID:15689559   PMID:16193067   PMID:17556541   PMID:17920016   PMID:19199708   PMID:19946888   PMID:22724288  
PMID:25683482   PMID:26890784   PMID:26921470  


Genomics

Comparative Map Data
Aplp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,857,407 - 37,920,487 (-)NCBIGRCr8
mRatBN7.2829,599,230 - 29,662,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx833,668,572 - 33,730,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,962,969 - 32,025,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,830,857 - 29,892,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,298,526 - 32,328,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,323,516 - 32,353,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera831,060,571 - 31,122,969 (-)NCBICelera
Cytogenetic Map8q13NCBI
APLP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,069,894 - 130,144,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,068,147 - 130,144,811 (+)EnsemblGRCh38hg38GRCh38
GRCh3711129,939,789 - 130,014,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,445,011 - 129,519,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411129,445,010 - 129,519,910NCBI
Celera11127,107,986 - 127,182,408 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,891,358 - 125,966,057 (+)NCBIHuRef
CHM1_111129,825,308 - 129,900,554 (+)NCBICHM1_1
T2T-CHM13v2.011130,106,007 - 130,180,474 (+)NCBIT2T-CHM13v2.0
Aplp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39931,060,853 - 31,123,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,060,853 - 31,123,111 (-)EnsemblGRCm39 Ensembl
GRCm38931,149,557 - 31,211,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,149,557 - 31,211,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv37930,957,142 - 31,019,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36930,899,122 - 30,961,380 (-)NCBIMGSCv36mm8
Celera928,408,874 - 28,471,021 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.66NCBI
Aplp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBIChiLan1.0ChiLan1.0
APLP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,749,892 - 130,822,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,860,588 - 131,933,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011124,881,191 - 124,944,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,812,227 - 128,847,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,775,329 - 128,847,482 (+)Ensemblpanpan1.1panPan2
APLP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,704,155 - 4,786,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,705,491 - 4,786,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha54,764,879 - 4,846,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.054,663,992 - 4,746,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,663,992 - 4,746,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,725,302 - 4,807,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,706,890 - 4,788,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,734,652 - 4,816,738 (-)NCBIUU_Cfam_GSD_1.0
Aplp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,172,610 - 112,244,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,205,478 - 2,277,842 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,205,527 - 2,277,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,798,810 - 56,872,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1956,798,781 - 56,871,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2962,965,051 - 63,035,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APLP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,150,296 - 121,224,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,150,291 - 121,224,534 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660434,883,243 - 4,956,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aplp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,490,798 - 4,571,623 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248124,490,798 - 4,571,500 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aplp2
191 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2124
Count of miRNA genes:296
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000070818, ENSRNOT00000074166, ENSRNOT00000074457
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat

Markers in Region
RH127464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,599,411 - 29,599,599 (+)MAPPERmRatBN7.2
Rnor_6.0832,298,708 - 32,298,895NCBIRnor6.0
Rnor_5.0832,323,698 - 32,323,885UniSTSRnor5.0
Celera831,060,753 - 31,060,940UniSTS
RH 3.4 Map8243.8UniSTS
Cytogenetic Map8q13UniSTS
RH142178  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0832,220,143 - 32,220,276UniSTSRnor5.0
RGSC_v3.4830,972,451 - 30,972,584UniSTSRGSC3.4
Celera831,122,808 - 31,122,941UniSTS
Cytogenetic Map8q13UniSTS
MARC_21333-21334:1023126386:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,628,491 - 29,629,431 (+)MAPPERmRatBN7.2
Rnor_6.0832,327,829 - 32,328,768NCBIRnor6.0
Rnor_5.0832,352,646 - 32,353,585UniSTSRnor5.0
RGSC_v3.4830,939,249 - 30,940,188UniSTSRGSC3.4
Celera831,089,619 - 31,090,558UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP497339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA340752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB700594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB795867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM029818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM030557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM041002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM044356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM112636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000070818   ⟹   ENSRNOP00000067835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)Ensembl
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074457   ⟹   ENSRNOP00000067077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl829,599,234 - 29,661,839 (-)Ensembl
Rnor_6.0 Ensembl832,299,770 - 32,328,819 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097481   ⟹   ENSRNOP00000081588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)Ensembl
RefSeq Acc Id: NM_012906   ⟹   NP_037038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,031 (-)NCBI
mRatBN7.2829,599,230 - 29,661,855 (-)NCBI
Rnor_6.0832,298,526 - 32,328,821 (-)NCBI
Rnor_5.0832,323,516 - 32,353,638 (-)NCBI
Celera831,060,571 - 31,122,969 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022520   ⟹   NP_071965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,031 (-)NCBI
mRatBN7.2829,599,230 - 29,661,855 (-)NCBI
Rnor_6.0832,298,526 - 32,328,821 (-)NCBI
Rnor_5.0832,323,516 - 32,353,638 (-)NCBI
Celera831,060,571 - 31,122,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082083   ⟹   XP_038938011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,487 (-)NCBI
mRatBN7.2829,599,230 - 29,662,311 (-)NCBI
RefSeq Acc Id: XM_039082084   ⟹   XP_038938012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,857,407 - 37,920,487 (-)NCBI
mRatBN7.2829,599,230 - 29,662,311 (-)NCBI
RefSeq Acc Id: NP_071965   ⟸   NM_022520
- Peptide Label: isoform 2 precursor
- UniProtKB: P15943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_037038   ⟸   NM_012906
- Peptide Label: isoform 1 precursor
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A6JYG2 (UniProtKB/TrEMBL),   M0RDX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067835   ⟸   ENSRNOT00000070818
RefSeq Acc Id: ENSRNOP00000067077   ⟸   ENSRNOT00000074457
RefSeq Acc Id: XP_038938012   ⟸   XM_039082084
- Peptide Label: isoform X2
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A6JYG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938011   ⟸   XM_039082083
- Peptide Label: isoform X1
- UniProtKB: P15943 (UniProtKB/Swiss-Prot),   A0A8I5ZSU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081588   ⟸   ENSRNOT00000097481
Protein Domains
BPTI/Kunitz inhibitor   E1   E2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15943-F1-model_v2 AlphaFold P15943 1-765 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2128 AgrOrtholog
BioCyc Gene G2FUF-31262 BioCyc
Ensembl Genes ENSRNOG00000047179 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070818 ENTREZGENE
  ENSRNOT00000070818.4 UniProtKB/TrEMBL
  ENSRNOT00000074457 ENTREZGENE
  ENSRNOT00000074457.4 UniProtKB/TrEMBL
  ENSRNOT00000097481 ENTREZGENE
  ENSRNOT00000097481.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64312 UniProtKB/TrEMBL
NCBI Gene Aplp2 ENTREZGENE
PANTHER AMYLOID-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aplp2 PhenoGen
PRINTS AMYLOIDA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BASICPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_INTRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPTI_KUNITZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047179 RatGTEx
SMART A4_EXTRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF109843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56491 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57362 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF89811 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216661
UniProt A0A8I5ZSU5 ENTREZGENE, UniProtKB/TrEMBL
  A6JYG1 ENTREZGENE, UniProtKB/TrEMBL
  A6JYG2 ENTREZGENE, UniProtKB/TrEMBL
  APLP2_RAT UniProtKB/Swiss-Prot
  M0RBX7_RAT UniProtKB/TrEMBL
  M0RDX2 ENTREZGENE, UniProtKB/TrEMBL
  P15943 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Aplp2  amyloid beta precursor like protein 2  Aplp2  amyloid beta (A4) precursor-like protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Aplp2  amyloid beta (A4) precursor-like protein 2  LOC100363366  amyloid beta (A4) precursor-like protein 2-like  Data merged from RGD:2323177 737654 PROVISIONAL
2010-05-06 LOC100363366  amyloid beta (A4) precursor-like protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-04-26 Aplp2  amyloid beta (A4) precursor-like protein 2  LOC64312  sperm membrane protein (YWK-II)  Data merged from RGD:708562 737654 APPROVED
2003-04-09 Aplp2  amyloid beta (A4) precursor-like protein 2    Amyloid protein precursor-like protein 2  Name updated 629478 APPROVED
2002-06-10 Aplp2  Amyloid protein precursor-like protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization putative sperm membrane protein with homology to the amyloid A4 transmembrane-cytoplasmic domain 634653
gene_domains contains an RKR sequence that may represent a membrane cytoplasmic junction 634653