RGD Reference Report - Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. - Rat Genome Database

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Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues.

Authors: Sandbrink, R  Masters, CL  Beyreuther, K 
Citation: Sandbrink R, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):167-70.
RGD ID: 734582
Pubmed: PMID:8086458   (View Abstract at PubMed)

We present the cDNA sequence of the rat amyloid precursor-like protein 2 (APLP2) comprising the complete coding sequence of 765 amino acid residues. By alternative splicing of two exons, transcripts encoding for 753, 709 and 697 amino acids are also generated. The derived amino acid sequence displays a sequence identity to human APLP2 of approx. 92% and to murine CDEI binding protein of approx. 95%, but differs from both by a deletion of 2 amino acids and an insertion of 4 amino acids within the acidic domain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IDA 734582 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aplp2  (amyloid beta precursor like protein 2)

Objects referenced in this article
Gene APLP2 amyloid beta precursor like protein 2 Homo sapiens
Gene Aplp2 amyloid beta precursor-like protein 2 Mus musculus

Additional Information