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Gene: Ambp (alpha-1-microglobulin/bikunin precursor) Rattus norvegicus

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Symbol:

Ambp

Name:

alpha-1-microglobulin/bikunin precursor

RGD ID:

2102

Description:

Enables serine-type endopeptidase inhibitor activity. Involved in protein catabolic process. Located in cell surface and extracellular space. Biomarker of calcium oxalate nephrolithiasis. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor); INTERACTS WITH 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alpha 1 microglobulin/bikunin; alpha-1 microglobulin/bikunin; ulinastatin; urinary trypsin inhibitor; UTI

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	81,583,621 - 81,593,938 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	81,583,622 - 81,593,850 (-)	Ensembl				GRCr8
mRatBN7.2	5	76,568,094 - 76,578,416 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	76,568,094 - 76,578,331 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	78,967,475 - 78,977,717 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	80,784,609 - 80,794,851 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	80,760,118 - 80,770,360 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	78,975,690 - 78,986,021 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	78,975,678 - 78,985,990 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	83,093,799 - 83,104,019 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	80,119,742 - 80,129,962 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	75,505,542 - 75,515,762 (-)	NCBI		Celera
RGSC_v3.1	5	80,124,854 - 80,135,075 (-)	NCBI
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

adult respiratory distress syndrome (ISO)

asthma (ISO)

Brain Injuries (ISO)

calcium oxalate nephrolithiasis (IEP,ISO)

Chemical and Drug Induced Liver Injury (ISO)

Inflammation (ISO)

kidney failure (ISO)

mood disorder (ISO)

Neoplasm Invasiveness (ISO)

pyelonephritis (ISO)

transitional cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (EXP,ISO)

1,3,5-trinitro-1,3,5-triazinane (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-amino-2-deoxy-D-galactopyranose (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

8-anilinonaphthalene-1-sulfonic acid (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benazepril (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcium silicate (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DAUDA (ISO)

decabromodiphenyl ether (ISO)

deoxynivalenol (ISO)

diarsenic trioxide (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (EXP)

entinostat (ISO)

ferroheme b (ISO)

fulvestrant (ISO)

furan (EXP)

graphite (EXP)

heme b (ISO)

hexadecanoic acid (ISO)

histamine (EXP)

hydroquinone (ISO)

ibuprofen (ISO)

leukotriene C4 (EXP)

lipopolysaccharide (ISO)

losartan (ISO)

mercury dibromide (ISO)

metformin (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosomorpholine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nitrofen (EXP)

Nivalenol (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (EXP,ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

reactive oxygen species (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

trichloroethene (ISO)

Triptolide (EXP)

valproic acid (ISO)

vinclozolin (EXP)

XL147 (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (ISO,ISS)

cellular response to reactive oxygen species (ISO,ISS)

cytochrome c metabolic process (ISO,ISS)

hemoglobin metabolic process (ISO,ISS)

protein catabolic process (IDA)

Cellular Component

cell surface (IBA,IDA)

cytosol (IEA)

endoplasmic reticulum (IEA)

extracellular region (IEA)

extracellular space (IDA,ISO,ISS)

matrix side of mitochondrial inner membrane (ISO)

mitochondrial inner membrane (IEA)

nuclear membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

antioxidant activity (ISO,ISS)

carbohydrate binding (ISO)

chondroitin sulfate binding (ISO,ISS)

collagen fibril binding (ISO,ISS)

heme binding (IEA,ISO,ISS)

IgA binding (IEA,ISO,ISS)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (ISO,ISS)

peptidase inhibitor activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO,ISS)

serine-type endopeptidase inhibitor activity (IBA,IDA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Urine protein markers distinguish stone-forming from non-stone-forming relatives of calcium stone formers.	Bergsland KJ, etal., Am J Physiol Renal Physiol. 2006 Sep;291(3):F530-6. Epub 2006 Apr 18.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells.	Grewal JS, etal., Biochem J. 2005 May 1;387(Pt 3):609-16.
5.	Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes.	Ito K, etal., Injury. 2005 Mar;36(3):387-94.
6.	Kunitz-type protease inhibitor found in rat mast cells. Purification, properties, and amino acid sequence.	Kido H, etal., J Biol Chem. 1988 Dec 5;263(34):18104-7.
7.	Purification, characterization, and relation to bikunin of rat urinary trypsin inhibitors.	Kurata A, etal., J Protein Chem. 2000 Nov;19(8):693-8.
8.	Rat alpha 1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor.	Lindqvist A, etal., Biochim Biophys Acta 1992 Feb 28;1130(1):63-7.
9.	Urinary excretion of low molecular weight proteins in patients with pure monoclonal light chain proteinuria.	Madalena L, etal., J Nephrol. 2007 Nov-Dec;20(6):683-8.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Protective effect of human ulinastatin against gentamicin-induced acute renal failure in rats.	Nakakuki M, etal., Can J Physiol Pharmacol. 1996 Jan;74(1):104-11.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	[Evaluation of inflammatory and renal injury markers in youngest children with pyelonephritis].	Puczko-Michalczuk A, etal., Pol Merkur Lekarski. 2008 Dec;25(150):451-4.
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Significant elevation of urinary trypsin inhibitor in patients with brain contusion--a preliminary report.	Sakai K, etal., J Clin Neurosci. 2003 Nov;10(6):677-9.
18.	Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients.	Vyssoulis GP, etal., Am J Hypertens. 2007 Sep;20(9):1016-21.
19.	Increased serum concentration of urinary trypsin inhibitor with asthma exacerbation.	Yasui K, etal., Eur Respir J. 2003 Nov;22(5):739-42.

Additional References at PubMed

PMID:2429963	PMID:7508921	PMID:7519849	PMID:11877257	PMID:11883904	PMID:12477932	PMID:12817471	PMID:15489334	PMID:16502470	PMID:19056867	PMID:22516433	PMID:23376485
PMID:23533145	PMID:27559042

Genomics

Comparative Map Data

Ambp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	81,583,621 - 81,593,938 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	81,583,622 - 81,593,850 (-)	Ensembl				GRCr8
mRatBN7.2	5	76,568,094 - 76,578,416 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	76,568,094 - 76,578,331 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	78,967,475 - 78,977,717 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	80,784,609 - 80,794,851 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	80,760,118 - 80,770,360 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	78,975,690 - 78,986,021 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	78,975,678 - 78,985,990 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	83,093,799 - 83,104,019 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	80,119,742 - 80,129,962 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	75,505,542 - 75,515,762 (-)	NCBI		Celera
RGSC_v3.1	5	80,124,854 - 80,135,075 (-)	NCBI
Cytogenetic Map	5	q24	NCBI

AMBP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	114,060,127 - 114,078,300 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	114,060,127 - 114,080,970 (-)	Ensembl			hg38	GRCh38
GRCh37	9	116,822,407 - 116,840,580 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	115,862,228 - 115,880,536 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	113,901,963 - 113,920,269	NCBI
Celera	9	87,469,703 - 87,488,044 (-)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI
HuRef	9	86,428,731 - 86,447,071 (-)	NCBI		HuRef
CHM1_1	9	116,968,857 - 116,987,201 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	126,258,798 - 126,276,960 (-)	NCBI		T2T-CHM13v2.0

Ambp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	63,061,512 - 63,072,409 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	63,061,512 - 63,073,036 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	63,143,275 - 63,154,172 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	63,143,275 - 63,154,799 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	62,804,313 - 62,815,176 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	62,629,640 - 62,640,503 (-)	NCBI		MGSCv36	mm8
Celera	4	61,799,977 - 61,810,839 (-)	NCBI		Celera
Cytogenetic Map	4	B3	NCBI
cM Map	4	33.96	NCBI

Ambp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	13,478,552 - 13,492,327 (+)	Ensembl
ChiLan1.0	NW_004955419	13,478,904 - 13,492,329 (+)	NCBI	ChiLan1.0	ChiLan1.0

AMBP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	25,296,801 - 25,317,823 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	25,299,162 - 25,320,209 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	85,157,680 - 85,176,253 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	113,525,136 - 113,543,680 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	113,525,835 - 113,543,422 (-)	Ensembl			panPan2	panpan1.1

AMBP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	68,338,644 - 68,353,366 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	68,338,389 - 68,351,994 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	66,741,500 - 66,756,216 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	69,461,851 - 69,476,622 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	69,461,782 - 69,475,427 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	67,978,768 - 67,993,416 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	68,009,752 - 68,024,455 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	68,747,753 - 68,762,492 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ambp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	183,631,164 - 183,643,649 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936487	3,399,792 - 3,412,088 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMBP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	254,683,891 - 254,703,225 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	254,683,885 - 254,703,220 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	285,710,963 - 285,725,500 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	1	q	NCBI

AMBP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	25,508,516 - 25,526,821 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	25,508,682 - 25,527,016 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666035	17,294,343 - 17,312,444 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ambp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	21,047,303 - 21,068,076 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	21,047,576 - 21,064,698 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ambp
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	90,412,817 - 90,424,373 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ambp
91 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	58
Count of miRNA genes:	55
Interacting mature miRNAs:	58
Transcripts:	ENSRNOT00000009248
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	73779642	103472210	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	65089051	103648916	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	64589016	93503770	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	64589016	91762830	Rat

Markers in Region

Ambp

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	81,588,374 - 81,589,123 (+)	Marker Load Pipeline
mRatBN7.2	5	76,572,847 - 76,573,596 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	78,980,444 - 78,981,191	NCBI	Rnor6.0
Rnor_5.0	5	83,098,537 - 83,099,284	UniSTS	Rnor5.0
RGSC_v3.4	5	80,124,480 - 80,125,227	UniSTS	RGSC3.4
Celera	5	75,510,280 - 75,511,027	UniSTS
Cytogenetic Map	5	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
16	9	23	67	85	84	59	40	59	5	244	80	1	51	81	78	25

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S87544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009248 ⟹ ENSRNOP00000009248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	81,583,622 - 81,593,850 (-)	Ensembl
mRatBN7.2 Ensembl	5	76,568,094 - 76,578,331 (-)	Ensembl
Rnor_6.0 Ensembl	5	78,975,678 - 78,985,990 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104037 ⟹ ENSRNOP00000082240

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	76,568,094 - 76,578,331 (-)	Ensembl

RefSeq Acc Id:

NM_012901 ⟹ NP_037033

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	81,583,637 - 81,593,857 (-)	NCBI
mRatBN7.2	5	76,568,110 - 76,578,331 (-)	NCBI
Rnor_6.0	5	78,975,706 - 78,985,926 (-)	NCBI
Rnor_5.0	5	83,093,799 - 83,104,019 (-)	NCBI
RGSC_v3.4	5	80,119,742 - 80,129,962 (-)	RGD
Celera	5	75,505,542 - 75,515,762 (-)	RGD

Sequence:

show sequence

GAATTCCGGACTGCAGAGCCATGCAGGGTCTCGGGGCCCTGTTCTTGTTGCTGACTGCCTGCCT
CACTTTGAAGGCTGACAATGTGCCAACACTGCCAGATATCCAGGTTCAGGAGAACTTCAATGAG
GCCCGGATCTATGGAAAATGGTTCAACCTGGCGGTGGGCTCCACCTGCCCGTGGCTGAGGCGGA
TTAAGAACAAGATGAGCGTGAGCACACTGGTGCTGCAGGAGGGGGCGACAGAAGCCGAGATCAG
CGTGACCAGTACTCAATGGCGGAAAGGTGTCTGCGAGGAGATCTCCGGGGTGTATCAGAAGACA
GACATTGACGGAAAGTTCCTTTACCACAAATCCAAATGGAATGCAACCTTGGAATCTTATGTGG
TCCACACCAACTATGACGAATATGCCATTTTCCTTACCAAGAAGTTCAGCCACCGCCACGGACC
CACCATCACTGCCAAGCTCTATGGCCGGGAACCACAGCTGAGGGACAGCCTTCTGCAGGAGTTC
AGGGAGGTGGCCCTGAGTGTGGGCATCCCTGAGAACTCCATTGTTTTTATGGCCGACAGAGGAG
AATGTGTCCCTGGGGATCGGGAGGTAGAGTCCACTTCATTTGCAAGAGCCCGGCGGGCAGTGCT
GCCCCAAGAGAATGAAGGGTCAGGGAGTGAGCCACTCATAACTGGGACCCTCAAGAAAGAAGAC
TCCTGCCAGCTGAACTACTCAGAAGGTCCCTGCCTGGGGATGCAGCAGAAGTATTACTACAATG
GCGCCTCCATGGCCTGCGAGACCTTCCAGTATGGCGGCTGCCTAGGCAATGGTAACAACTTCGC
CTCCGAGAAGGAATGCCTGCAGACGTGCCGGACCATAGCGGCCTGCAATCTCCCCATAGTCCAA
GGCCCCTGCCGAGCCTTTGCAGAACTCTGGGCATTTGATGCAGCGCAAGGGAAGTGCATCCAAT
TCATCTATGGGGGCTGCAAAGGCAACGGCAACAAGTTCTACTCTGAGAAGGAGTGCAAGGAGTA
CTGTGGAGTCCCTGGTGATGGGTACGAGGAGCTAACACGCAGTTGAAGGAGCCGGTCTGCAAGC
CAGAGGGTAGCCACGGTCCGTCACTGAGCAGTCCAGCTTAGATGATCTGGACCCAATAAAACAA
GGCGGAATTC

hide sequence

RefSeq Acc Id:

XM_008763759 ⟹ XP_008761981

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	81,583,621 - 81,593,938 (-)	NCBI
mRatBN7.2	5	76,568,094 - 76,578,416 (-)	NCBI
Rnor_6.0	5	78,975,690 - 78,986,021 (-)	NCBI

Sequence:

show sequence

GCCTCCGGCCCTTTCCCCAGCTTTAGCTTGTAGCTGCCCCTGGCAGGGAGTTAGTCCCTGTTCC
CACACCAAGCTGTGAGACATCAAAGGCCAAAGACTGCAGAGCCATGCAGGGTCTCGGGGCCCTG
TTCTTGTTGCTGACTGCCTGCCTCACTTTGAAGGCTGACAATGTGCCAACACTGCCAGATATCC
AGGTTCAGGAGAACTTCAATGAGGCCCGGATCTATGGAAAATGGTTCAACCTGGCGGTGGGCTC
CACCTGCCCGTGGCTGAGGCGGATTAAGAACAAGATGAGCGTGAGCACGCTGGTGCTGCAGGAG
GGGGCGACAGAAGCCGAGATCAGCGTGACCAGTACTCAATGGCGGAAAGGTGTCTGCGAGGAGA
TCTCCGGGGTGTATCAGAAGACAGACATTGACGGAAAGTTCCTTTACCACAAATCCAAATGGAA
TGCAACCTTGGAATCTTATGTGGTCCACACCAACTATGACGAATATGCCATTTTCCTTACCAAG
AAGTTCAGCCACCGCCACGGACCCACCATCACTGCCAAGCTCTATGGCCGGGAACCACAGCTGA
GGGACAGCCTTCTGCAGGAGTTCAGGGAGGTGGCCCTGAGTGTGGGCATCCCTGAGAACTCCAT
TGTTTTTATGGCCGACAGAGGAGAATGTGTCCCTGGGGATCGGGAGGTAGAGTCCACTTCATTT
GCAAGAGCCCGGCGGGCAGTGCTGCCCCAAGAGAATGAAGGGTCAGGGAGTGAGCCACTCATAA
CTGGGACCCTCAAGAAAGAAGACTCCTGCCAGCTCAACTACTCAGAAGGTCCCTGCCTGGGGAT
GCAGCAGAAGTATTACTACAATGGCGCCTCCATGGCCTGCGAGACCTTCCAATATGGCGGCTGC
CTAGGCAATGGTAACAACTTCGCCTCCGAGAAGGAATGCCTGCAGACGTGCCGGACCATAGCGG
CCTGCAATCTCCCCATAGTCCAAGGCCCCTGCCGAGCCTTTGCAGAACTCTGGGCATTTGATGC
AGCGCAAGGGAAGTGCATCCAATTCATCTATGGGGGCTGCAAAGGCAACGGCAACAAGTTCTAC
TCTGAGAAGGAGTGCAAGGAGTACTGTGGAGTCCCTGGTGATGCCAAAGGACCCATTCTGAGTC
GCTCTGTGTCTGCAGGGTACGAGGAGCTAACACGCAGTTGAAGGAGCCGGTCTGCAAGCCAGAG
GGTAGCCACGGTCCGTCACTGTGCAGTCCAGCTTAGATGATCTGGACCCAATAAAACAAGCTGT
CATTTCCTAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001416262	(Get FASTA)	NCBI Sequence Viewer
	NP_037033	(Get FASTA)	NCBI Sequence Viewer
	XP_008761981	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41596	(Get FASTA)	NCBI Sequence Viewer
	AAB21782	(Get FASTA)	NCBI Sequence Viewer
	AAH88166	(Get FASTA)	NCBI Sequence Viewer
	EDM10533	(Get FASTA)	NCBI Sequence Viewer
	EDM10534	(Get FASTA)	NCBI Sequence Viewer
	EDM10535	(Get FASTA)	NCBI Sequence Viewer
	EDM10536	(Get FASTA)	NCBI Sequence Viewer
	EDM10537	(Get FASTA)	NCBI Sequence Viewer
	EDM10538	(Get FASTA)	NCBI Sequence Viewer
	EDM10539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009248
GenBank Protein	Q64240	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037033 ⟸ NM_012901
- Peptide Label:	precursor
- UniProtKB:	P19603 (UniProtKB/Swiss-Prot), Q63336 (UniProtKB/Swiss-Prot), Q64240 (UniProtKB/Swiss-Prot), A6J7X0 (UniProtKB/TrEMBL), A0A8I5ZUK6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQGLGALFLLLTACLTLKADNVPTLPDIQVQENFNEARIYGKWFNLAVGSTCPWLRRIKNKMSV STLVLQEGATEAEISVTSTQWRKGVCEEISGVYQKTDIDGKFLYHKSKWNATLESYVVHTNYDE YAIFLTKKFSHRHGPTITAKLYGREPQLRDSLLQEFREVALSVGIPENSIVFMADRGECVPGDR EVESTSFARARRAVLPQENEGSGSEPLITGTLKKEDSCQLNYSEGPCLGMQQKYYYNGASMACE TFQYGGCLGNGNNFASEKECLQTCRTIAACNLPIVQGPCRAFAELWAFDAAQGKCIQFIYGGCK GNGNKFYSEKECKEYCGVPGDGYEELTRS hide sequence

RefSeq Acc Id:

XP_008761981 ⟸ XM_008763759

- Peptide Label:

isoform X1

- Sequence:

show sequence

MQGLGALFLLLTACLTLKADNVPTLPDIQVQENFNEARIYGKWFNLAVGSTCPWLRRIKNKMSV
STLVLQEGATEAEISVTSTQWRKGVCEEISGVYQKTDIDGKFLYHKSKWNATLESYVVHTNYDE
YAIFLTKKFSHRHGPTITAKLYGREPQLRDSLLQEFREVALSVGIPENSIVFMADRGECVPGDR
EVESTSFARARRAVLPQENEGSGSEPLITGTLKKEDSCQLNYSEGPCLGMQQKYYYNGASMACE
TFQYGGCLGNGNNFASEKECLQTCRTIAACNLPIVQGPCRAFAELWAFDAAQGKCIQFIYGGCK
GNGNKFYSEKECKEYCGVPGDAKGPILSRSVSAGYEELTRS

hide sequence

Ensembl Acc Id:

ENSRNOP00000009248 ⟸ ENSRNOT00000009248

Ensembl Acc Id:

ENSRNOP00000082240 ⟸ ENSRNOT00000104037

Protein Domains

BPTI/Kunitz inhibitor Lipocalin/cytosolic fatty-acid binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q64240-F1-model_v2	AlphaFold	Q64240	1-349	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693798

Promoter ID:

EPDNEW_R4323

Type:

initiation region

Name:

Ambp_1

Description:

alpha-1-microglobulin/bikunin precursor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	78,985,969 - 78,986,029	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2102	AgrOrtholog
BioCyc Gene	G2FUF-41076	BioCyc
Ensembl Genes	ENSRNOG00000006889	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000009248	ENTREZGENE
Gene3D-CATH	2.40.128.20	UniProtKB/Swiss-Prot
	4.10.410.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7368246	IMAGE-MGC_LOAD
InterPro	A1-microglobln	UniProtKB/Swiss-Prot
	AMBP	UniProtKB/Swiss-Prot
	Calycin	UniProtKB/Swiss-Prot
	Kunitz_BPTI	UniProtKB/Swiss-Prot
	Kunitz_BPTI_sf	UniProtKB/Swiss-Prot
	Lipocalin_CS	UniProtKB/Swiss-Prot
	Lipocln_cytosolic_FA-bd_dom	UniProtKB/Swiss-Prot
	Prtase_inh_Kunz-CS	UniProtKB/Swiss-Prot
KEGG Report	rno:25377	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108765	IMAGE-MGC_LOAD
NCBI Gene	25377	ENTREZGENE
PANTHER	PROTEIN AMBP	UniProtKB/Swiss-Prot
	PTHR46676	UniProtKB/Swiss-Prot
Pfam	Kunitz_BPTI	UniProtKB/Swiss-Prot
	Lipocalin	UniProtKB/Swiss-Prot
PhenoGen	Ambp	PhenoGen
PRINTS	A1MCGLOBULIN	UniProtKB/Swiss-Prot
	BASICPTASE	UniProtKB/Swiss-Prot
	LIPOCALIN	UniProtKB/Swiss-Prot
PROSITE	BPTI_KUNITZ_1	UniProtKB/Swiss-Prot
	BPTI_KUNITZ_2	UniProtKB/Swiss-Prot
	LIPOCALIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000006889	RatGTEx
SMART	SM00131	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50814	UniProtKB/Swiss-Prot
	SSF57362	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZUK6	ENTREZGENE
	A0A8L2Q3T3	ENTREZGENE, UniProtKB/TrEMBL
	A6J7W8_RAT	UniProtKB/TrEMBL
	A6J7W9_RAT	UniProtKB/TrEMBL
	A6J7X0	ENTREZGENE, UniProtKB/TrEMBL
	A6J7X1_RAT	UniProtKB/TrEMBL
	A6J7X2_RAT	UniProtKB/TrEMBL
	A6J7X3_RAT	UniProtKB/TrEMBL
	A6J7X4_RAT	UniProtKB/TrEMBL
	AMBP_RAT	UniProtKB/Swiss-Prot
	P19603	ENTREZGENE
	Q63336	ENTREZGENE
	Q64240	ENTREZGENE
UniProt Secondary	P19603	UniProtKB/Swiss-Prot
	Q63336	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Ambp	alpha-1-microglobulin/bikunin precursor	Ambp	alpha 1 microglobulin/bikunin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ambp	Alpha-1 microglobulin/bikunin			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to microsomes	632200
gene_expression	expressed in liver	632200
gene_process	may be involved in regulation of immune response	632200
gene_protein	polyprotein sequence encodes alpha 1-microglobulin and bikunin	632200

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD