Aldh3a1 (aldehyde dehydrogenase 3 family, member A1) - Rat Genome Database

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Gene: Aldh3a1 (aldehyde dehydrogenase 3 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh3a1
Name: aldehyde dehydrogenase 3 family, member A1
RGD ID: 2088
Description: Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH 1,2,3,7,8-Pentachlorodibenzodioxin; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ahd-c; AHDC; Aldehyde dehydrogenase (Ahd-c); aldehyde dehydrogenase 3A1; aldehyde dehydrogenase class 3; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase family 3 subfamily A1; aldehyde dehydrogenase family 3, member A1; Aldehyde dehydrogenase family 3, subfamily A1; aldehyde dehydrogenase, dimeric NADP-preferring; Aldh; Aldh3; HTC-ALDH; tumor-associated aldehyde dehydrogenase tumor ALDH; tumor-associated aldehyde dehydrogenase, tumor ALDH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,392,464 - 46,402,151 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,392,411 - 46,402,151 (+)EnsemblGRCr8
mRatBN7.21045,892,993 - 45,902,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,892,924 - 45,902,681 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,595,478 - 50,605,184 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,085,870 - 50,095,575 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,589,438 - 45,599,135 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,490,168 - 47,499,855 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)Ensemblrn6Rnor6.0
Rnor_5.01047,265,007 - 47,274,692 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,365,195 - 47,374,880 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1045,146,398 - 45,156,083 (+)NCBICelera
RGSC_v3.11047,378,817 - 47,388,503 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-naphthoquinone  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-hexenal  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenyl acetate  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
Aldophosphamide  (ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzaldehyde  (ISO)
benzene  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[b]fluorene  (ISO)
Benzo[c]fluorene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
benzyl isothiocyanate  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloroethene  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofuran  (EXP)
diethyldithiocarbamic acid  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
drometrizole  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
hexanal  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
MeIQx  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methyl methacrylate  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
Moniliformin  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
non-2-enal  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
oct-2-enal  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
Pf-06840003  (ISO)
phenanthrene  (ISO)
PhIP  (EXP,ISO)
picene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
puromycin  (EXP)
pyrene  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
thiram  (ISO)
trichloroethene  (EXP)
triphenylene  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)
zinc oxide  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IDA,ISO)
endoplasmic reticulum  (ISO)
membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Preliminary characterization of the rat class 3 aldehyde dehydrogenase gene. Asman DC, etal., Adv Exp Med Biol 1993;328:81-6.
2. Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. Boesch JS, etal., J Biol Chem. 1996 Mar 1;271(9):5150-7.
3. The negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: involvement of a single imperfect palindromic glucocorticoid responsive element. Falkner KC, etal., Mol Pharmacol. 1999 Apr;55(4):649-57.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Aldehyde dehydrogenase activity and large vessel disease in diabetes mellitus. A preliminary study. Jerntorp P, etal., Diabetes. 1986 Mar;35(3):291-4.
7. Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase. Jones DE Jr, etal., Proc Natl Acad Sci U S A 1988 Mar;85(6):1782-6.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Kondraganti SR, etal., Toxicol Sci. 2008 Apr;102(2):337-44. Epub 2008 Jan 17.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibition of cytosolic class 3 aldehyde dehydrogenase by antisense oligonucleotides in rat hepatoma cells. Muzio G, etal., Chem Biol Interact. 2001 Jan 30;130-132(1-3):219-25.
12. Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases. Muzio G, etal., Chem Biol Interact. 2003 Feb 1;143-144:37-43.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Acute-phase response to benzopyrene and induction of rat ALDH3A1. Pappas P, etal., Chem Biol Interact. 2003 Feb 1;143-144:55-62.
15. Anti-inflammatory agents and inducibility of hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):457-60.
16. Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):461-7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Aldehyde dehydrogenase 3 gene regulation: studies on constitutive and hypoxia-modulated expression. Reisdorph R and Lindahl R, Chem Biol Interact. 2001 Jan 30;130-132(1-3):227-33.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression. Xiao G, etal., J Biol Chem. 1997 Feb 7;272(6):3238-45.
25. Comparative study of alcohol metabolism in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats fed normal or low levels of dietary protein. Yang SC, etal., J Nutr Sci Vitaminol (Tokyo). 1994 Dec;40(6):547-55.
26. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
Additional References at PubMed
PMID:742739   PMID:1737758   PMID:2091023   PMID:2713359   PMID:3284529   PMID:4015840   PMID:8509394   PMID:9095201   PMID:10376761   PMID:11784860   PMID:12610736   PMID:15489334  
PMID:17530188   PMID:22664934   PMID:25286108   PMID:26674287  


Genomics

Comparative Map Data
Aldh3a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,392,464 - 46,402,151 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,392,411 - 46,402,151 (+)EnsemblGRCr8
mRatBN7.21045,892,993 - 45,902,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,892,924 - 45,902,681 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,595,478 - 50,605,184 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,085,870 - 50,095,575 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,589,438 - 45,599,135 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,490,168 - 47,499,855 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)Ensemblrn6Rnor6.0
Rnor_5.01047,265,007 - 47,274,692 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,365,195 - 47,374,880 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1045,146,398 - 45,156,083 (+)NCBICelera
RGSC_v3.11047,378,817 - 47,388,503 (+)NCBI
Cytogenetic Map10q22NCBI
ALDH3A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,737,984 - 19,748,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,737,984 - 19,748,943 (-)Ensemblhg38GRCh38
GRCh371719,641,297 - 19,651,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,581,889 - 19,592,200 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341719,581,891 - 19,592,200NCBI
Celera1717,054,645 - 17,065,094 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1719,020,080 - 19,030,532 (-)NCBIHuRef
CHM1_11719,650,159 - 19,660,608 (-)NCBICHM1_1
T2T-CHM13v2.01719,686,602 - 19,696,916 (-)NCBIT2T-CHM13v2.0
Aldh3a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,099,336 - 61,109,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,098,363 - 61,109,247 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381161,208,510 - 61,218,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,207,537 - 61,218,421 (+)Ensemblmm10GRCm38
MGSCv371161,022,244 - 61,031,920 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361161,024,940 - 61,034,609 (+)NCBIMGSCv36mm8
MGSCv361161,638,438 - 61,648,107 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Aldh3a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546796,140 - 105,738 (+)Ensembl
ChiLan1.0NW_00495546796,140 - 105,738 (+)NCBIChiLan1.0ChiLan1.0
ALDH3A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,728,524 - 54,738,858 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,540,244 - 59,550,581 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,384,740 - 31,395,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,531,830 - 36,539,428 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,531,720 - 36,542,504 (+)EnsemblpanPan2panpan1.1
ALDH3A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,466,237 - 40,474,272 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,466,237 - 40,474,457 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha540,608,116 - 40,616,150 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0540,572,237 - 40,580,273 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,572,237 - 40,580,458 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,543,623 - 40,551,653 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,489,252 - 40,497,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,681,916 - 40,689,952 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh3a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,509,720 - 60,516,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688170,951 - 77,839 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493688171,047 - 77,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH3A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,897,496 - 59,905,897 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11259,895,476 - 59,905,900 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,639,844 - 62,660,135 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH3A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11618,302,145 - 18,312,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1618,302,142 - 18,312,756 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660592,534,705 - 2,545,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Aldh3a1
92 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:118
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000003182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH132563  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81046,401,809 - 46,402,115 (+)Marker Load Pipeline
mRatBN7.21045,902,338 - 45,902,644 (+)MAPPERmRatBN7.2
Rnor_6.01047,499,514 - 47,499,819NCBIRnor6.0
Rnor_5.01047,274,351 - 47,274,656UniSTSRnor5.0
RGSC_v3.41047,374,539 - 47,374,844UniSTSRGSC3.4
Celera1045,155,742 - 45,156,047UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 49 111 39 43 12 31 12 6 195 107 10 90 52 79 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000003182   ⟹   ENSRNOP00000003182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,392,411 - 46,402,151 (+)Ensembl
mRatBN7.2 Ensembl1045,892,924 - 45,902,680 (+)Ensembl
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107161   ⟹   ENSRNOP00000078369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,892,953 - 45,902,681 (+)Ensembl
RefSeq Acc Id: NM_031972   ⟹   NP_114178
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,392,464 - 46,402,151 (+)NCBI
mRatBN7.21045,892,993 - 45,902,680 (+)NCBI
Rnor_6.01047,490,168 - 47,499,855 (+)NCBI
Rnor_5.01047,265,007 - 47,274,692 (+)NCBI
RGSC_v3.41047,365,195 - 47,374,880 (+)RGD
Celera1045,146,398 - 45,156,083 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114178 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40713 (Get FASTA)   NCBI Sequence Viewer  
  AAA40722 (Get FASTA)   NCBI Sequence Viewer  
  AAH70924 (Get FASTA)   NCBI Sequence Viewer  
  EDM04678 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003182
GenBank Protein P11883 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114178   ⟸   NM_031972
- UniProtKB: P11883 (UniProtKB/Swiss-Prot),   A6HF73 (UniProtKB/TrEMBL),   A0A8L2Q0S9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003182   ⟸   ENSRNOT00000003182
Ensembl Acc Id: ENSRNOP00000078369   ⟸   ENSRNOT00000107161
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11883-F1-model_v2 AlphaFold P11883 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697259
Promoter ID:EPDNEW_R7784
Type:single initiation site
Name:Aldh3a1_1
Description:aldehyde dehydrogenase 3 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01047,490,289 - 47,490,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2088 AgrOrtholog
BioCyc Gene G2FUF-24823 BioCyc
Ensembl Genes ENSRNOG00000002331 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003182 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096634 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
  Aldehyde_DH_NAD(P) UniProtKB/Swiss-Prot
KEGG Report rno:25375 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91608 IMAGE-MGC_LOAD
NCBI Gene 25375 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING UniProtKB/Swiss-Prot
  PTHR43570 UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PharmGKB ALDH3A1 RGD
PhenoGen Aldh3a1 PhenoGen
PIRSF ALDH UniProtKB/Swiss-Prot
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002331 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
TIGR TC231508
UniProt A0A8L2Q0S9 ENTREZGENE, UniProtKB/TrEMBL
  A6HF73 ENTREZGENE, UniProtKB/TrEMBL
  AL3A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-12 Aldh3a1  aldehyde dehydrogenase 3 family, member A1  Aldh3a1  aldehyde dehydrogenase family 3, member A1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Aldh3a1  aldehyde dehydrogenase family 3, member A1     Aldehyde dehydrogenase family 3, subfamily A1  Name updated 629478 APPROVED
2001-06-12 Aldh3a1  Aldehyde dehydrogenase family 3, subfamily A1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED
2001-06-12 Aldh3  Aldehyde dehydrogenase class 3      Symbol and Name withdrawn 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease expressed during hepatocarcinogenesis 632185
gene_function has aldehyde dehydrogenase activity in vitro 632185
gene_product member of the aldehyde dehydrogenase family 632185