Ap1b1 (adaptor related protein complex 1 subunit beta 1) - Rat Genome Database

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Gene: Ap1b1 (adaptor related protein complex 1 subunit beta 1) Rattus norvegicus
Analyze
Symbol: Ap1b1
Name: adaptor related protein complex 1 subunit beta 1
RGD ID: 2064
Description: Enables protein serine/threonine kinase binding activity. Involved in clathrin coat assembly. Predicted to be located in Golgi apparatus and clathrin-coated vesicle membrane. Predicted to be part of clathrin coat. Predicted to be active in synaptic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-tert-Octylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter-related protein complex 1 subunit beta-1; adaptor protein complex AP-1 subunit beta-1; adaptor protein complex AP-1, beta 1 subunit; adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex 1, beta 1 subunit; adaptor-related protein complex AP-1 beta 1 subunit; Adtb1; AP-1 complex subunit beta-1; beta-1-adaptin; beta-adaptin 1; beta1-adaptin; clathrin assembly protein complex 1 beta large chain; golgi adaptor HA1/AP1 adaptin beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ap1b1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,093,529 - 84,144,835 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,093,559 - 84,144,892 (+)EnsemblGRCr8
mRatBN7.21479,879,482 - 79,930,778 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,879,533 - 79,930,778 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,281,794 - 84,333,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,521,871 - 85,573,146 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,971,168 - 82,022,449 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,230,652 - 85,281,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,230,648 - 85,281,803 (+)Ensemblrn6Rnor6.0
Rnor_5.01485,927,665 - 85,959,253 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,663,840 - 85,695,487 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,770,483 - 78,821,787 (+)NCBICelera
RGSC_v3.11485,682,982 - 85,714,630 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
furfural  (ISO)
genistein  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
starch  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
2. The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. Gallusser A and Kirchhausen T, EMBO J. 1993 Dec 15;12(13):5237-44.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. Kirchhausen T, etal., Proc Natl Acad Sci U S A 1989 Apr;86(8):2612-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7987321   PMID:16025302   PMID:17825088   PMID:18072934   PMID:19199090   PMID:19628795   PMID:21307259   PMID:21700703   PMID:25807483   PMID:26316108   PMID:28131823   PMID:29476059  
PMID:30053369  


Genomics

Comparative Map Data
Ap1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,093,529 - 84,144,835 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,093,559 - 84,144,892 (+)EnsemblGRCr8
mRatBN7.21479,879,482 - 79,930,778 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,879,533 - 79,930,778 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,281,794 - 84,333,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,521,871 - 85,573,146 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,971,168 - 82,022,449 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,230,652 - 85,281,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,230,648 - 85,281,803 (+)Ensemblrn6Rnor6.0
Rnor_5.01485,927,665 - 85,959,253 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,663,840 - 85,695,487 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,770,483 - 78,821,787 (+)NCBICelera
RGSC_v3.11485,682,982 - 85,714,630 (+)NCBI
Cytogenetic Map14q21NCBI
AP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,327,680 - 29,388,570 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,327,680 - 29,388,612 (-)Ensemblhg38GRCh38
GRCh372229,723,669 - 29,784,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,053,669 - 28,114,569 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342228,048,222 - 28,109,123NCBI
Celera2213,523,525 - 13,584,427 (-)NCBICelera
Cytogenetic Map22q12.2ENTREZGENE
HuRef2212,687,908 - 12,748,805 (-)NCBIHuRef
CHM1_12229,683,069 - 29,743,967 (-)NCBICHM1_1
T2T-CHM13v2.02229,791,092 - 29,851,977 (-)NCBIT2T-CHM13v2.0
Ap1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,897,320 - 4,992,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,936,824 - 4,992,791 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38114,947,320 - 5,042,794 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,986,824 - 5,042,791 (+)Ensemblmm10GRCm38
MGSCv37114,886,908 - 4,942,732 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36114,886,908 - 4,942,732 (+)NCBIMGSCv36mm8
Celera115,484,717 - 5,540,177 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.15NCBI
Ap1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,632,053 - 3,686,046 (-)Ensembl
ChiLan1.0NW_0049554553,632,053 - 3,686,007 (-)NCBIChiLan1.0ChiLan1.0
AP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,311,384 - 39,371,820 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,012,016 - 42,072,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,383,036 - 10,443,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,189,831 - 28,291,808 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,189,831 - 28,285,007 (-)EnsemblpanPan2panpan1.1
AP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,632,970 - 22,715,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,630,670 - 22,689,996 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2622,504,815 - 22,561,619 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02623,007,105 - 23,063,883 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,909,397 - 23,101,375 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,716,272 - 22,773,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,979,414 - 23,036,219 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,044,435 - 23,101,614 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,474,816 - 112,527,032 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,341,242 - 3,395,957 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,343,675 - 3,395,877 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,469,430 - 46,520,153 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11446,469,462 - 46,520,175 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,434,365 - 49,485,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,195,981 - 12,259,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,195,755 - 12,259,272 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045113,891,188 - 113,953,947 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,704,477 - 5,755,321 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247475,703,647 - 5,755,344 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ap1b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11173,962,157 - 74,014,149 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ap1b1
321 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:102
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000057407
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat

Markers in Region
Y07919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,929,960 - 79,930,064 (+)MAPPERmRatBN7.2
Rnor_6.01485,280,989 - 85,281,092NCBIRnor6.0
Rnor_5.01485,958,610 - 85,958,713UniSTSRnor5.0
RGSC_v3.41485,694,844 - 85,694,947UniSTSRGSC3.4
Celera1478,820,970 - 78,821,073UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000057407   ⟹   ENSRNOP00000054218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,093,559 - 84,144,658 (+)Ensembl
mRatBN7.2 Ensembl1479,879,533 - 79,930,592 (+)Ensembl
Rnor_6.0 Ensembl1485,250,042 - 85,281,630 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089866   ⟹   ENSRNOP00000072388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,093,572 - 84,144,892 (+)Ensembl
mRatBN7.2 Ensembl1479,898,950 - 79,930,778 (+)Ensembl
Rnor_6.0 Ensembl1485,230,648 - 85,281,803 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110241   ⟹   ENSRNOP00000095773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,115,348 - 84,144,835 (+)Ensembl
mRatBN7.2 Ensembl1479,901,291 - 79,930,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115824   ⟹   ENSRNOP00000096766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,117,725 - 84,142,564 (+)Ensembl
mRatBN7.2 Ensembl1479,903,668 - 79,928,507 (+)Ensembl
RefSeq Acc Id: NM_001308298   ⟹   NP_001295227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,572 - 84,144,835 (+)NCBI
mRatBN7.21479,879,515 - 79,930,778 (+)NCBI
Rnor_6.01485,230,652 - 85,281,806 (+)NCBI
Celera1478,770,483 - 78,821,787 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091797   ⟹   XP_038947725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,548 - 84,144,661 (+)NCBI
mRatBN7.21479,879,484 - 79,930,604 (+)NCBI
RefSeq Acc Id: XM_063273008   ⟹   XP_063129078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,548 - 84,144,661 (+)NCBI
RefSeq Acc Id: XM_063273009   ⟹   XP_063129079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,535 - 84,144,661 (+)NCBI
RefSeq Acc Id: XM_063273010   ⟹   XP_063129080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,529 - 84,144,661 (+)NCBI
RefSeq Acc Id: XM_063273011   ⟹   XP_063129081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,093,549 - 84,144,661 (+)NCBI
RefSeq Acc Id: NP_001295227   ⟸   NM_001308298
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   A0A0G2K2V2 (UniProtKB/TrEMBL),   A6IKJ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054218   ⟸   ENSRNOT00000057407
Ensembl Acc Id: ENSRNOP00000072388   ⟸   ENSRNOT00000089866
RefSeq Acc Id: XP_038947725   ⟸   XM_039091797
- Peptide Label: isoform X2
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   G3V9N8 (UniProtKB/TrEMBL),   A6IKJ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096766   ⟸   ENSRNOT00000115824
Ensembl Acc Id: ENSRNOP00000095773   ⟸   ENSRNOT00000110241
RefSeq Acc Id: XP_063129080   ⟸   XM_063273010
- Peptide Label: isoform X2
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   A6IKJ6 (UniProtKB/TrEMBL),   G3V9N8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129079   ⟸   XM_063273009
- Peptide Label: isoform X1
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   A0A0G2K2V2 (UniProtKB/TrEMBL),   A6IKJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129078   ⟸   XM_063273008
- Peptide Label: isoform X1
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   A0A0G2K2V2 (UniProtKB/TrEMBL),   A6IKJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129081   ⟸   XM_063273011
- Peptide Label: isoform X2
- UniProtKB: P52303 (UniProtKB/Swiss-Prot),   A6IKJ6 (UniProtKB/TrEMBL),   G3V9N8 (UniProtKB/TrEMBL)
Protein Domains
Beta-adaptin appendage C-terminal subdomain   Clathrin adaptor alpha/beta/gamma-adaptin appendage

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52303-F1-model_v2 AlphaFold P52303 1-949 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699452
Promoter ID:EPDNEW_R9976
Type:multiple initiation site
Name:Ap1b1_1
Description:adaptor-related protein complex 1, beta 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,230,639 - 85,230,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2064 AgrOrtholog
BioCyc Gene G2FUF-15156 BioCyc
Ensembl Genes ENSRNOG00000008786 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000057407 ENTREZGENE
  ENSRNOT00000089866 ENTREZGENE
  ENSRNOT00000115824 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
  2.60.40.1150 UniProtKB/Swiss-Prot
  3.30.310.10 UniProtKB/Swiss-Prot
InterPro AP_beta UniProtKB/Swiss-Prot
  AP_complex_bsu_1_2_4 UniProtKB/Swiss-Prot
  ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  B-adaptin_app_sub_C UniProtKB/Swiss-Prot
  Clathrin/coatomer_adapt-like_N UniProtKB/Swiss-Prot
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/Swiss-Prot
  Clathrin_app_Ig-like_sf UniProtKB/Swiss-Prot
  Clathrin_b-adaptin_app_Ig-like UniProtKB/Swiss-Prot
  Coatomer/calthrin_app_sub_C UniProtKB/Swiss-Prot
  TBP_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 29663 ENTREZGENE
PANTHER PTHR11134 UniProtKB/Swiss-Prot
Pfam Adaptin_N UniProtKB/Swiss-Prot
  Alpha_adaptinC2 UniProtKB/Swiss-Prot
  B2-adapt-app_C UniProtKB/Swiss-Prot
PhenoGen Ap1b1 PhenoGen
PIRSF AP_complex_beta UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008786 RatGTEx
SMART Alpha_adaptinC2 UniProtKB/Swiss-Prot
  B2-adapt-app_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF49348 UniProtKB/Swiss-Prot
  SSF55711 UniProtKB/Swiss-Prot
TIGR TC218103
UniProt A0A0G2K2V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AM50_RAT UniProtKB/TrEMBL
  A0A8I6AT57_RAT UniProtKB/TrEMBL
  A6IKJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6IKJ6 ENTREZGENE, UniProtKB/TrEMBL
  A6IKJ7_RAT UniProtKB/TrEMBL
  AP1B1_RAT UniProtKB/Swiss-Prot
  G3V9N8 ENTREZGENE, UniProtKB/TrEMBL
  P52303 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap1b1  adaptor related protein complex 1 subunit beta 1  Ap1b1  adaptor-related protein complex 1, beta 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ap1b1  adaptor-related protein complex 1, beta 1 subunit  Ap1b1  adaptor protein complex AP-1, beta 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ap1b1  adaptor protein complex AP-1, beta 1 subunit      Symbol and Name status set to approved 70586 APPROVED
2001-01-13 Ap1b1  Adaptor protein complex AP-1, beta 1 subunit      Symbol and name updated to reflect Human and Mouse nomenclature 61478 APPROVED
2000-11-11 Adtb1  Adaptor-related protein complex AP-1, beta 1 subunit      Symbol and name withdrawn 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may be associated with clathrin coated vesicles 70660
gene_expression expressed in brain 70660
gene_function may interact with receptors in clathrin coated vesicles 70660