Adra2c (adrenoceptor alpha 2C) - Rat Genome Database

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Gene: Adra2c (adrenoceptor alpha 2C) Rattus norvegicus
Analyze
Symbol: Adra2c
Name: adrenoceptor alpha 2C
RGD ID: 2058
Description: Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; alpha2-adrenergic receptor activity; and protein dimerization activity. Involved in female pregnancy; negative regulation of uterine smooth muscle contraction; and positive regulation of vasoconstriction. Located in axon terminus and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human ADRA2C (adrenoceptor alpha 2C); INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,695,514 - 79,697,476 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,694,995 - 79,706,656 (-)EnsemblGRCr8
mRatBN7.21475,470,884 - 75,472,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,471,143 - 75,472,846 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,924,216 - 79,926,175 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,165,071 - 81,167,030 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,610,079 - 77,612,038 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,730,307 - 80,732,010 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,730,307 - 80,732,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,422,130 - 81,423,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,107,907 - 81,109,610 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,399,360 - 74,401,063 (-)NCBICelera
RGSC_v3.11481,110,297 - 81,112,001 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methoxyidazoxan  (ISO)
2-phenylethylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dopamine  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fipronil  (ISO)
flavonoids  (EXP)
genistein  (EXP,ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
metoprolol  (ISO)
N,N-diethyl-m-toluamide  (ISO)
naphthalene  (EXP)
nickel atom  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
oxcarbazepine  (EXP)
oxymetazoline  (ISO)
ozone  (EXP)
perfluorooctanoic acid  (EXP)
phenylpropanolamine  (ISO)
progesterone  (ISO)
quercitrin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
synephrine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Xylometazoline  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a rat brain alpha 2B-adrenergic receptor. Flordellis CS, etal., Proc Natl Acad Sci U S A 1991 Feb 1;88(3):1019-23.
2. The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat. Gal A, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):193-200. Epub 2009 May 15.
3. Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat. Gaspar R, etal., Neurochem Int. 2007 Oct;51(5):311-8. Epub 2007 Jul 1.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Postjunctional alpha2C-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity. Jantschak F, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):487-97. Epub 2010 Sep 24.
7. Ultrastructural evidence for prominent postsynaptic localization of alpha2C-adrenergic receptors in catecholaminergic dendrites in the rat nucleus locus coeruleus. Lee A, etal., J Comp Neurol. 1998 May 4;394(2):218-29.
8. Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Axon terminals possessing the alpha 2c-adrenergic receptor in the rat dorsal horn are predominantly excitatory. Olave MJ and Maxwell DJ, Brain Res 2003 Mar 7;965(1-2):269-73.
12. An investigation of neurones that possess the alpha 2C-adrenergic receptor in the rat dorsal horn. Olave MJ and Maxwell DJ, Neuroscience 2002;115(1):31-40.
13. Axon terminals possessing alpha2C-adrenergic receptors densely innervate neurons in the rat lateral spinal nucleus which respond to noxious stimulation. Olave MJ and Maxwell DJ, Neuroscience 2004;126(2):391-403.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Philipp M, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat. Roh DH, etal., Anesth Analg. 2010 Feb 1;110(2):622-9. Epub 2009 Dec 10.
20. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. Small KM, etal., N Engl J Med 2002 Oct 10;347(15):1135-42.
21. alpha(2a) and alpha(2c) adrenoceptors on spinal neurons controlling penile erection. Yaici ED, etal., Neuroscience 2002;114(4):945-60.
Additional References at PubMed
PMID:1645350   PMID:1704314   PMID:14712229   PMID:16605244   PMID:17215105   PMID:19000416   PMID:20607388   PMID:20691504   PMID:20854830   PMID:21518261   PMID:21562737   PMID:22892388  
PMID:25218984   PMID:25407049  


Genomics

Comparative Map Data
Adra2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,695,514 - 79,697,476 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,694,995 - 79,706,656 (-)EnsemblGRCr8
mRatBN7.21475,470,884 - 75,472,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,471,143 - 75,472,846 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,924,216 - 79,926,175 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,165,071 - 81,167,030 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,610,079 - 77,612,038 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,730,307 - 80,732,010 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,730,307 - 80,732,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01481,422,130 - 81,423,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,107,907 - 81,109,610 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1474,399,360 - 74,401,063 (-)NCBICelera
RGSC_v3.11481,110,297 - 81,112,001 (-)NCBI
Cytogenetic Map14q21NCBI
ADRA2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,766,385 - 3,768,526 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,766,348 - 3,768,526 (+)Ensemblhg38GRCh38
GRCh3743,768,112 - 3,770,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,738,094 - 3,740,051 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3443,804,398 - 3,807,217NCBI
Celera43,671,112 - 3,673,097 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,705,412 - 3,707,390 (+)NCBIHuRef
CHM1_143,766,238 - 3,768,183 (+)NCBICHM1_1
T2T-CHM13v2.043,765,283 - 3,767,445 (+)NCBIT2T-CHM13v2.0
Adra2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,435,910 - 35,439,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,435,663 - 35,439,107 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,278,566 - 35,281,763 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,278,319 - 35,281,763 (+)Ensemblmm10GRCm38
MGSCv37535,621,215 - 35,624,412 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36535,595,575 - 35,598,742 (+)NCBIMGSCv36mm8
Celera532,753,998 - 32,757,254 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.09NCBI
ADRA2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v234,099,781 - 4,102,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan144,033,469 - 4,035,654 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,904,346 - 3,906,577 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,894,575 - 3,897,018 (+)NCBIPanPan1.1PanPan1.1panPan2
ADRA2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,608,632 - 60,648,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,646,132 - 60,647,722 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,296,546 - 63,298,547 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0361,121,798 - 61,123,799 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,122,360 - 61,123,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,615,963 - 60,617,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0360,821,563 - 60,823,566 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,177,369 - 61,179,380 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ADRA2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,320,226 - 2,321,608 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.182,320,125 - 2,322,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.282,048,614 - 2,050,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12744,950,928 - 44,953,245 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2744,951,457 - 44,952,827 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660511,297,830 - 1,299,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,300,347 - 24,301,693 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475524,299,985 - 24,301,824 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adra2c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,792,228 - 69,794,766 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adra2c
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:88
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000012322
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
D14Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81479,694,125 - 79,694,414 (+)Marker Load Pipeline
mRatBN7.21475,469,493 - 75,470,354 (+)MAPPERmRatBN7.2
mRatBN7.21475,469,752 - 75,469,784 (+)MAPPERmRatBN7.2
mRatBN7.21475,469,493 - 75,469,784 (+)MAPPERmRatBN7.2
Rnor_6.01480,728,059 - 80,728,347NCBIRnor6.0
Rnor_6.01480,728,059 - 80,728,948NCBIRnor6.0
Rnor_5.01481,419,882 - 81,420,771UniSTSRnor5.0
Rnor_5.01481,419,882 - 81,420,170UniSTSRnor5.0
RGSC_v3.41481,106,260 - 81,106,548UniSTSRGSC3.4
RGSC_v3.41481,106,259 - 81,106,548RGDRGSC3.4
Celera1474,397,716 - 74,398,002UniSTS
RGSC_v3.11481,108,650 - 81,108,939RGD
Cytogenetic Map14q21UniSTS
RH131895  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81479,695,555 - 79,695,762 (+)Marker Load Pipeline
mRatBN7.21475,470,925 - 75,471,132 (+)MAPPERmRatBN7.2
Rnor_6.01480,730,090 - 80,730,296NCBIRnor6.0
Rnor_5.01481,421,913 - 81,422,119UniSTSRnor5.0
RGSC_v3.41481,107,690 - 81,107,896UniSTSRGSC3.4
Celera1474,399,143 - 74,399,349UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 9 26 134 43 37 17 20 17 6 172 69 4 119 69 77 20 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000012322   ⟹   ENSRNOP00000012322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,471,143 - 75,472,846 (-)Ensembl
Rnor_6.0 Ensembl1480,730,307 - 80,732,010 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156401   ⟹   ENSRNOP00000108688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,694,995 - 79,706,656 (-)Ensembl
RefSeq Acc Id: NM_138506   ⟹   NP_612515
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,695,514 - 79,697,476 (-)NCBI
mRatBN7.21475,470,884 - 75,472,846 (-)NCBI
Rnor_6.01480,730,307 - 80,732,010 (-)NCBI
Rnor_5.01481,422,130 - 81,423,833 (-)NCBI
RGSC_v3.41481,107,907 - 81,109,610 (-)RGD
Celera1474,399,360 - 74,401,063 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_612515 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40634 (Get FASTA)   NCBI Sequence Viewer  
  AAA42033 (Get FASTA)   NCBI Sequence Viewer  
  BAA00700 (Get FASTA)   NCBI Sequence Viewer  
  CAA40861 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012322.1
  ENSRNOP00000108688
GenBank Protein P22086 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_612515   ⟸   NM_138506
- UniProtKB: P22086 (UniProtKB/Swiss-Prot),   A6IK05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012322   ⟸   ENSRNOT00000012322
Ensembl Acc Id: ENSRNOP00000108688   ⟸   ENSRNOT00000156401
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22086-F1-model_v2 AlphaFold P22086 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2058 AgrOrtholog
BioCyc Gene G2FUF-15316 BioCyc
Ensembl Genes ENSRNOG00000009299 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000084818 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012322.4 UniProtKB/Swiss-Prot
  ENSRNOT00000156401 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA2C_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:24175 UniProtKB/Swiss-Prot
NCBI Gene 24175 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR24248:SF25 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRA2C RGD
PhenoGen Adra2c PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA2CR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009299 RatGTEx
  ENSRNOG00000084818 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6IK05 ENTREZGENE, UniProtKB/TrEMBL
  ADA2C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra2c  adrenoceptor alpha 2C  Adra2c  adrenergic, alpha-2C-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Adra2c  adrenergic, alpha-2C-, receptor  Adra2c  adrenergic receptor, alpha 2c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adra2c  adrenergic receptor, alpha 2c    Adrenergic, alpha2C-, receptor class I  Name updated 625702 APPROVED
2002-06-10 Adra2c  Adrenergic, alpha2C-, receptor class I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein detected in spinal cord neurons 631768
gene_function may mediate noradrenaline action 632213
gene_process may mediate penile erection 631768