BTG2 (BTG anti-proliferation factor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: BTG2 (BTG anti-proliferation factor 2) Homo sapiens
Analyze
Symbol: BTG2
Name: BTG anti-proliferation factor 2
RGD ID: 69157
HGNC Page HGNC:1131
Description: Predicted to enable transcription corepressor activity. Involved in negative regulation of cell population proliferation; negative regulation of translation; and neuron projection development. Acts upstream of or within DNA damage response and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Located in extracellular exosome. Biomarker of breast cancer; prostate carcinoma in situ; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: APRO1; B-cell translocation gene 2; b-cell translocation gene 2, anti-proliferative; BTG family member 2; BTG family, member 2; MGC126063; MGC126064; nerve growth factor-inducible anti-proliferative; NGF-inducible anti-proliferative protein PC3; PC3; pheochromacytoma cell-3; TIS21
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,305,519 - 203,309,602 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,305,491 - 203,309,602 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,274,647 - 203,278,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,541,287 - 201,545,353 (+)NCBINCBI36Build 36hg18NCBI36
Build 341200,006,320 - 200,010,384NCBI
Celera1176,403,938 - 176,408,003 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,439,723 - 174,443,788 (+)NCBIHuRef
CHM1_11204,697,045 - 204,701,100 (+)NCBICHM1_1
T2T-CHM13v2.01202,568,370 - 202,572,442 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (EXP)
(-)-demecolcine  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
15-acetyldeoxynivalenol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (ISO)
2-arachidonoylglycerol  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitrofluorene  (ISO)
2-nitropropane  (ISO)
2-palmitoylglycerol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (EXP)
6-O-methylguanine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
adefovir pivoxil  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-phellandrene  (EXP)
alvocidib  (ISO)
AM-251  (ISO)
ammonium chloride  (ISO)
antimonite  (EXP)
antimycin A  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Brevetoxin B  (EXP)
bromoacetate  (EXP)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chloroacetaldehyde  (EXP)
chloroform  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
DDE  (EXP)
DDT  (ISO)
delphinidin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (EXP)
diuron  (EXP)
divanadium pentaoxide  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP,ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fentin chloride  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxyurea  (EXP)
ifosfamide  (EXP)
indometacin  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leptomycin B  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
melatonin  (ISO)
melphalan  (EXP)
menadione  (EXP,ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP,ISO)
methylisothiazolinone  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myristicin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
progesterone  (ISO)
propanal  (EXP)
quercetin  (EXP)
quinomethionate  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sotorasib  (EXP)
succimer  (ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
trametinib  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
tungsten  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord. Carmel JB, etal., Exp Neurol. 2004 Jan;185(1):81-96.
2. Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis. Ficazzola MA, etal., Carcinogenesis. 2001 Aug;22(8):1271-9.
3. Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats. Fiedler F, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):562-5.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Immediate early gene induction after neonatal hypoxia-ischemia. Gubits RM, etal., Brain Res Mol Brain Res. 1993 May;18(3):228-38.
6. Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Kawakubo H, etal., Cancer Res. 2006 Jul 15;66(14):7075-82.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Simkhovich BZ, etal., Cardiovasc Res. 2003 Aug 1;59(2):450-9.
9. Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma. Struckmann K, etal., Cancer Res. 2004 Mar 1;64(5):1632-8.
Additional References at PubMed
PMID:1713584   PMID:8663146   PMID:8891336   PMID:8944033   PMID:9712883   PMID:9828097   PMID:10200315   PMID:10341341   PMID:10617598   PMID:10669755   PMID:11136725   PMID:11237868  
PMID:11267995   PMID:11377414   PMID:11429045   PMID:11814693   PMID:11856371   PMID:11930152   PMID:11989967   PMID:12135500   PMID:12360398   PMID:12477932   PMID:12771185   PMID:15056715  
PMID:15378000   PMID:15489334   PMID:15542835   PMID:15741235   PMID:15788397   PMID:16418486   PMID:16710414   PMID:16782888   PMID:16997058   PMID:17353931   PMID:17371797   PMID:18029348  
PMID:18196550   PMID:18288394   PMID:18337750   PMID:18393292   PMID:18773938   PMID:18840609   PMID:18854154   PMID:18974182   PMID:19056867   PMID:19117054   PMID:19203451   PMID:19468252  
PMID:19546886   PMID:19615363   PMID:19728149   PMID:20020054   PMID:20398657   PMID:20553615   PMID:20569234   PMID:21120602   PMID:21172304   PMID:21873635   PMID:22266859   PMID:22392501  
PMID:22493435   PMID:22562501   PMID:22614007   PMID:22975506   PMID:23089312   PMID:23236473   PMID:23299537   PMID:23857284   PMID:23876794   PMID:23907596   PMID:23917204   PMID:24047462  
PMID:24162774   PMID:24308156   PMID:24440351   PMID:24698107   PMID:24780075   PMID:24821435   PMID:24981574   PMID:25284287   PMID:25405282   PMID:25416956   PMID:25576360   PMID:25626081  
PMID:26151427   PMID:26394836   PMID:26722427   PMID:26818199   PMID:26912148   PMID:26925784   PMID:27208501   PMID:27409164   PMID:27510158   PMID:27613090   PMID:27932314   PMID:28611215  
PMID:29098552   PMID:29239139   PMID:29310680   PMID:29352138   PMID:29395067   PMID:29441724   PMID:29472702   PMID:29656435   PMID:29808317   PMID:30912184   PMID:31138781   PMID:31603257  
PMID:31721211   PMID:31819167   PMID:31924214   PMID:31959200   PMID:31992359   PMID:32296183   PMID:32409840   PMID:32513696   PMID:32746503   PMID:33025678   PMID:33334784   PMID:33844600  
PMID:34082648   PMID:34337864   PMID:34557203   PMID:34699325   PMID:34852712   PMID:35239148   PMID:35388633   PMID:35640718   PMID:35730068   PMID:35880434   PMID:36314369   PMID:37257243  
PMID:37269593   PMID:37894995   PMID:38329343  


Genomics

Comparative Map Data
BTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,305,519 - 203,309,602 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,305,491 - 203,309,602 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,274,647 - 203,278,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,541,287 - 201,545,353 (+)NCBINCBI36Build 36hg18NCBI36
Build 341200,006,320 - 200,010,384NCBI
Celera1176,403,938 - 176,408,003 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,439,723 - 174,443,788 (+)NCBIHuRef
CHM1_11204,697,045 - 204,701,100 (+)NCBICHM1_1
T2T-CHM13v2.01202,568,370 - 202,572,442 (+)NCBIT2T-CHM13v2.0
Btg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,002,603 - 134,006,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,002,908 - 134,006,858 (-)EnsemblGRCm39 Ensembl
GRCm381134,074,865 - 134,079,155 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,075,170 - 134,079,120 (-)EnsemblGRCm38mm10GRCm38
MGSCv371135,971,442 - 135,975,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,891,276 - 135,895,566 (-)NCBIMGSCv36mm8
Celera1136,692,103 - 136,696,393 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.1NCBI
Btg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,083,931 - 48,087,690 (-)NCBIGRCr8
mRatBN7.21345,531,881 - 45,535,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,531,925 - 45,535,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,140,195 - 48,143,949 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,428,246 - 49,432,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,692,987 - 46,696,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,913,185 - 50,916,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,966,299 - 55,970,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,026,986 - 47,030,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,041,028 - 47,044,788 (-)NCBI
Celera1345,860,186 - 45,864,450 (-)NCBICelera
Cytogenetic Map13q13NCBI
Btg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,303,175 - 39,308,778 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,303,221 - 39,307,308 (+)NCBIChiLan1.0ChiLan1.0
BTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,068,366 - 46,072,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,035,354 - 46,039,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,907,317 - 178,911,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,201,297 - 183,205,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,201,297 - 183,205,404 (+)Ensemblpanpan1.1panPan2
BTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13870,921 - 75,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3870,452 - 72,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38161,110 - 165,136 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03867,926 - 71,934 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3867,702 - 71,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13860,447 - 64,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.038454,515 - 458,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.038668,563 - 672,594 (+)NCBIUU_Cfam_GSD_1.0
Btg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,075,888 - 72,079,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,309,658 - 1,314,515 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,310,525 - 1,314,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,031,832 - 64,035,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,033,853 - 64,037,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,327,454 - 70,331,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q21-q25NCBI
BTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,032,404 - 26,036,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,034,632 - 26,036,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,808,911 - 26,813,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,540,602 - 7,545,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,541,335 - 7,545,412 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BTG2
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
NM_006763.3(BTG2):c.421G>A (p.Val141Met) single nucleotide variant not provided [RCV000210751] Chr1:203307382 [GRCh38]
Chr1:203276510 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
NM_006763.3(BTG2):c.400C>T (p.Leu134Phe) single nucleotide variant Inborn genetic diseases [RCV003244875] Chr1:203307361 [GRCh38]
Chr1:203276489 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NC_000001.10:g.(?_200522516)_(206945780_?)dup duplication Epilepsy, familial adult myoclonic, 5 [RCV003116306] Chr1:200522516..206945780 [GRCh37]
Chr1:1q32.1
uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2
uncertain significance|no classifications from unflagged records
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44
pathogenic
NM_006763.3(BTG2):c.433C>G (p.Arg145Gly) single nucleotide variant Inborn genetic diseases [RCV002778240] Chr1:203307394 [GRCh38]
Chr1:203276522 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3
pathogenic
NM_006763.3(BTG2):c.94G>C (p.Glu32Gln) single nucleotide variant Inborn genetic diseases [RCV002950482] Chr1:203305700 [GRCh38]
Chr1:203274828 [GRCh37]
Chr1:1q32.1
uncertain significance
NM_006763.3(BTG2):c.266A>G (p.Gln89Arg) single nucleotide variant Inborn genetic diseases [RCV002850656] Chr1:203307227 [GRCh38]
Chr1:203276355 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q31.3-32.1(chr1:197216705-203683110)x1 copy number loss not specified [RCV003986384] Chr1:197216705..203683110 [GRCh37]
Chr1:1q31.3-32.1
likely pathogenic
GRCh37/hg19 1q32.1(chr1:199373229-204335027)x3 copy number gain not specified [RCV003986684] Chr1:199373229..204335027 [GRCh37]
Chr1:1q32.1
likely pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//GFP reporter assay//Western blot//LuFunctional MTI19546886
MIR21hsa-miR-21-5pMirecordsexternal_info{changed}NA19546886
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA22614007
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA19546886
MIR32hsa-miR-32-5pOncomiRDBexternal_infoNANA22266859

Predicted Target Of
Summary Value
Count of predictions:1943
Count of miRNA genes:731
Interacting mature miRNAs:850
Transcripts:ENST00000290551, ENST00000475157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
BTG2_75  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,278,110 - 203,278,893UniSTSGRCh37
Build 361201,544,733 - 201,545,516RGDNCBI36
Celera1176,407,383 - 176,408,166RGD
HuRef1174,443,168 - 174,443,951UniSTS
SHGC-4213  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,278,354 - 203,278,683UniSTSGRCh37
Build 361201,544,977 - 201,545,306RGDNCBI36
Celera1176,407,627 - 176,407,956RGD
Cytogenetic Map1q32UniSTS
HuRef1174,443,412 - 174,443,741UniSTS
TNG Radiation Hybrid Map133547.0UniSTS
GeneMap99-G3 RH Map17767.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 161 107 27 15 107 70 30 11 41 6 21 105
Medium 2259 2851 1516 448 1899 286 4195 2103 3578 394 1299 1526 174 1 1183 2683 6 2
Low 19 33 181 175 36 178 55 24 119 13 118 77 1
Below cutoff 2 1 1 1 6 1 1 4

Sequence


RefSeq Acc Id: ENST00000290551   ⟹   ENSP00000290551
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,305,519 - 203,309,602 (+)Ensembl
RefSeq Acc Id: ENST00000475157   ⟹   ENSP00000433553
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,305,491 - 203,309,569 (+)Ensembl
RefSeq Acc Id: NM_006763   ⟹   NP_006754
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,305,519 - 203,309,602 (+)NCBI
GRCh371203,274,664 - 203,278,730 (+)ENTREZGENE
Build 361201,541,287 - 201,545,353 (+)NCBI Archive
HuRef1174,439,723 - 174,443,788 (+)ENTREZGENE
CHM1_11204,697,045 - 204,701,100 (+)NCBI
T2T-CHM13v2.01202,568,370 - 202,572,442 (+)NCBI
Sequence:
RefSeq Acc Id: NP_006754   ⟸   NM_006763
- UniProtKB: Q3KR25 (UniProtKB/Swiss-Prot),   A0A024R986 (UniProtKB/Swiss-Prot),   Q5VUT0 (UniProtKB/Swiss-Prot),   P78543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000433553   ⟸   ENST00000475157
RefSeq Acc Id: ENSP00000290551   ⟸   ENST00000290551

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P78543-F1-model_v2 AlphaFold P78543 1-158 view protein structure

Promoters
RGD ID:6784731
Promoter ID:HG_KWN:6902
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000087168,   OTTHUMT00000087169,   OTTHUMT00000087170,   OTTHUMT00000098780,   OTTHUMT00000098781,   UC009XAO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361201,539,436 - 201,541,997 (+)MPROMDB
RGD ID:6858630
Promoter ID:EPDNEW_H2480
Type:initiation region
Name:BTG2_1
Description:BTG anti-proliferation factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,305,519 - 203,305,579EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1131 AgrOrtholog
COSMIC BTG2 COSMIC
Ensembl Genes ENSG00000159388 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000290551 ENTREZGENE
  ENST00000290551.5 UniProtKB/Swiss-Prot
  ENST00000475157.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.640.90 UniProtKB/Swiss-Prot
GTEx ENSG00000159388 GTEx
HGNC ID HGNC:1131 ENTREZGENE
Human Proteome Map BTG2 Human Proteome Map
InterPro Anti_prolifrtn UniProtKB/Swiss-Prot
  BTG UniProtKB/Swiss-Prot
  BTG-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:7832 UniProtKB/Swiss-Prot
NCBI Gene 7832 ENTREZGENE
OMIM 601597 OMIM
PANTHER PTHR22978 UniProtKB/Swiss-Prot
  PTHR22978:SF29 UniProtKB/Swiss-Prot
Pfam BTG UniProtKB/Swiss-Prot
PharmGKB PA25451 PharmGKB
PRINTS ANTIPRLFBTG1 UniProtKB/Swiss-Prot
PROSITE BTG_1 UniProtKB/Swiss-Prot
  BTG_2 UniProtKB/Swiss-Prot
SMART btg1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF160696 UniProtKB/Swiss-Prot
UniProt A0A024R986 ENTREZGENE
  BTG2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q3KR25 ENTREZGENE
  Q5VUT0 ENTREZGENE
UniProt Secondary A0A024R986 UniProtKB/Swiss-Prot
  Q3KR25 UniProtKB/Swiss-Prot
  Q5VUT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-12 BTG2  BTG anti-proliferation factor 2  BTG2  BTG family member 2  Symbol and/or name change 5135510 APPROVED
2015-11-24 BTG2  BTG family member 2  BTG2  BTG family, member 2  Symbol and/or name change 5135510 APPROVED