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Gene: Add2 (adducin 2) Rattus norvegicus

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Symbol:

Add2

Name:

adducin 2

RGD ID:

2042

Description:

Predicted to enable several functions, including cytoskeletal anchor activity; cytoskeletal protein binding activity; and protein dimerization activity. Predicted to be a structural constituent of cytoskeleton. Involved in monoatomic ion transport. Is active in glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

adducin 2 (beta); adducin 2, beta; adducin beta; Adducin, beta; adducin-63; beta adducin; beta-ADD; beta-adducin; erythrocyte adducin subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADD2 (adducin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Add2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Add2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADD2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADD2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Add2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADD2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADD2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Add2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Add2 (adducin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Add2 (adducin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADD2 (adducin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	add2 (adducin 2 (beta))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	add-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	add-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	hts	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	add2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	add2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Is Marker For:

Strains: MHS/N

Candidate Gene For:

Bp116

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	120,001,977 - 120,101,090 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	120,002,054 - 120,101,091 (+)	Ensembl				GRCr8
mRatBN7.2	4	118,444,594 - 118,538,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	118,497,416 - 118,538,505 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	123,971,536 - 124,012,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	119,746,277 - 119,787,417 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	118,370,290 - 118,411,423 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	117,691,294 - 117,887,556 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	117,743,710 - 117,882,464 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	182,417,932 - 182,454,565 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	120,221,140 - 120,275,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	107,471,489 - 107,504,523 (+)	NCBI		Celera
RGSC_v3.1	4	120,465,620 - 120,510,931 (+)	NCBI
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary spherocytosis type 1 (ISS)

hypertension (IDA,ISO)

IgA glomerulonephritis (ISO)

proteinuria (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2-butoxyethanol (ISO)

3,3',5-triiodo-L-thyronine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

Butylbenzyl phthalate (EXP)

cadmium dichloride (EXP)

carbonyl sulfide (EXP)

chlorpyrifos (ISO)

chromium(6+) (ISO)

copper atom (EXP)

copper(0) (EXP)

daidzein (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

FR900359 (ISO)

genistein (ISO)

glycitein (ISO)

graphite (EXP)

ivermectin (ISO)

ketamine (EXP)

manganese(II) chloride (EXP)

methamphetamine (EXP)

nitrofen (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

Theaflavin 3,3'-digallate (ISO)

thiram (ISO)

titanium dioxide (EXP)

toluene (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

actin filament bundle assembly (IEA,ISO)

barbed-end actin filament capping (IBA,IEA,ISO)

hemopoiesis (ISO)

leukocyte migration (IEA,ISO)

leukocyte tethering or rolling (IEA,ISO)

monoatomic ion transport (IMP)

protein-containing complex assembly (IEA,ISO,ISS)

synapse assembly (IEA,ISO)

Cellular Component

cytoplasmic vesicle (IEA,ISO,ISS)

cytoskeleton (IBA,IEA)

F-actin capping protein complex (IEA,ISO)

glutamatergic synapse (IDA)

membrane (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

plasma membrane raft (IEA,ISO)

postsynapse (IDA)

postsynaptic density (IBA,IEA,ISO)

Molecular Function

actin binding (IEA,ISO)

actin filament binding (IBA,IEA,ISO)

calmodulin binding (IEA)

cytoskeletal anchor activity (IEA,ISO)

protein binding (ISO)

protein dimerization activity (IEA,ISO)

protein heterodimerization activity (IEA,ISO)

protein homodimerization activity (IEA,ISO)

protein kinase binding (IEA,ISO)

spectrin binding (IEA,ISO)

structural constituent of cytoskeleton (IEA,ISO,NAS)

References

References - curated

#	Reference Title	Reference Citation
1.	The genetic association database.	Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2.	alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy.	Ferrandi M, etal., J Mol Med (Berl). 2010 Feb;88(2):203-17. Epub 2009 Oct 17.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Polymorphisms in four candidate genes in young patients with essential hypertension.	Marcun Varda N, etal., Acta Paediatr. 2006 Mar;95(3):353-8.
6.	Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.	Matsuoka Y, etal., J Cell Biol. 1998 Jul 27;142(2):485-97.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.	Muro AF, etal., Blood 2000 Jun 15;95(12):3978-85.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13.	Molecular cloning of an adducin-like protein: evidence of a polymorphism in the normotensive and hypertensive rats of the Milan strain.	Tripodi G, etal., Biochem Biophys Res Commun 1991 Jun 28;177(3):939-47.
14.	Characterisation and chromosomal localisation of the rat alpha- and beta-adducin-encoding genes.	Tripodi G, etal., Gene 1995 Dec 12;166(2):307-11.
15.	[Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population].	Valencia DM, etal., Biomedica. 2013 Oct-Dec;33(4):598-614.

Additional References at PubMed

PMID:3693401	PMID:7642559	PMID:8626479	PMID:8889548	PMID:10485892	PMID:10602987	PMID:12646192	PMID:15528469	PMID:16414955	PMID:17114649	PMID:18347014	PMID:18634768
PMID:19292454	PMID:21150638	PMID:21435558	PMID:25425738	PMID:26639316	PMID:28131823	PMID:29476059	PMID:30053369

Genomics

Comparative Map Data

Add2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	120,001,977 - 120,101,090 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	120,002,054 - 120,101,091 (+)	Ensembl				GRCr8
mRatBN7.2	4	118,444,594 - 118,538,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	118,497,416 - 118,538,505 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	123,971,536 - 124,012,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	119,746,277 - 119,787,417 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	118,370,290 - 118,411,423 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	117,691,294 - 117,887,556 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	117,743,710 - 117,882,464 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	182,417,932 - 182,454,565 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	120,221,140 - 120,275,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	107,471,489 - 107,504,523 (+)	NCBI		Celera
RGSC_v3.1	4	120,465,620 - 120,510,931 (+)	NCBI
Cytogenetic Map	4	q34	NCBI

ADD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	70,656,784 - 70,768,200 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	70,607,618 - 70,768,499 (-)	Ensembl			hg38	GRCh38
GRCh37	2	70,883,916 - 70,995,332 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	70,742,770 - 70,848,837 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	70,800,919 - 70,906,984	NCBI
Celera	2	70,739,895 - 70,846,052 (-)	NCBI		Celera
Cytogenetic Map	2	p13.3	NCBI
HuRef	2	70,626,283 - 70,732,257 (-)	NCBI		HuRef
CHM1_1	2	70,818,535 - 70,924,705 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	70,667,847 - 70,779,251 (-)	NCBI		T2T-CHM13v2.0

Add2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	86,005,663 - 86,101,391 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	86,005,663 - 86,101,391 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	86,028,681 - 86,124,409 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	86,028,681 - 86,124,409 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	86,028,078 - 86,069,549 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	86,043,718 - 86,085,189 (+)	NCBI		MGSCv36	mm8
Celera	6	88,013,744 - 88,055,678 (+)	NCBI		Celera
Cytogenetic Map	6	C3- D1	NCBI
cM Map	6	37.55	NCBI

Add2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	14,411,124 - 14,517,813 (+)	Ensembl
ChiLan1.0	NW_004955424	14,411,279 - 14,517,813 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	55,621,219 - 55,732,515 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	55,625,166 - 55,736,459 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	70,724,454 - 70,831,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	71,839,470 - 71,944,537 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	71,839,470 - 71,895,106 (-)	Ensembl			panPan2	panpan1.1

ADD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	69,056,367 - 69,098,775 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	69,057,267 - 69,098,521 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	68,939,411 - 69,031,911 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	70,074,115 - 70,166,872 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	70,077,064 - 70,166,770 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	69,792,050 - 69,885,391 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	70,054,471 - 70,147,033 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	70,356,179 - 70,411,965 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Add2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	13,599,879 - 13,714,530 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	14,862,531 - 14,971,329 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	14,856,764 - 14,971,161 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	71,730,003 - 71,840,861 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	71,729,882 - 71,845,761 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	75,131,802 - 75,191,268 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	36,343,978 - 36,450,685 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	36,344,022 - 36,449,315 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	75,565,751 - 75,677,689 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Add2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	2,674,620 - 2,726,587 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624762	2,619,371 - 2,726,586 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Add2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	60,203,871 - 60,238,746 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Add2
600 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	66
Count of miRNA genes:	52
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000021491
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	96731383	141731383	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	86583980	149763391	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	92406430	137406430	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	117737142	152833657	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	78687630	123687630	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	86058928	131411333	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	84349032	129349032	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	82336765	127336765	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	113634167	149763391	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	88883695	133883695	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	103834277	148834277	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	86583980	131583980	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	88883695	133883695	Rat

Markers in Region

D4Got91

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	118,509,866 - 118,510,108 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	117,848,346 - 117,848,588	NCBI	Rnor6.0
Rnor_6.0	4	117,853,932 - 117,854,171	NCBI	Rnor6.0
Rnor_5.0	4	182,420,290 - 182,420,532	UniSTS	Rnor5.0
Rnor_5.0	4	182,425,876 - 182,426,115	UniSTS	Rnor5.0
RGSC_v3.4	4	120,240,909 - 120,241,146	UniSTS	RGSC3.4
RGSC_v3.4	4	120,246,489 - 120,246,729	RGD	RGSC3.4
RGSC_v3.4	4	120,240,908 - 120,241,146	RGD	RGSC3.4
RGSC_v3.4	4	120,246,490 - 120,246,729	UniSTS	RGSC3.4
Celera	4	107,483,238 - 107,483,479	UniSTS
RGSC_v3.1	4	120,490,971 - 120,491,210	RGD
RH 3.4 Map	4	696.1	RGD
RH 3.4 Map	4	696.1	UniSTS
Cytogenetic Map	4	q34	UniSTS

Related Rat Strains

The following Strains have been annotated to Add2

MHS/N

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	11	64	146	90	89	59	78	59	6	322	173	11	122	70	84	30	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF130338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY226987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE121149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ231568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY315967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV762188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021491 ⟹ ENSRNOP00000021491

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	120,002,054 - 120,101,091 (+)	Ensembl
mRatBN7.2 Ensembl	4	118,497,416 - 118,538,505 (+)	Ensembl
Rnor_6.0 Ensembl	4	117,743,710 - 117,882,464 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081173 ⟹ ENSRNOP00000073973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	120,054,878 - 120,087,116 (+)	Ensembl
mRatBN7.2 Ensembl	4	118,497,416 - 118,529,658 (+)	Ensembl
Rnor_6.0 Ensembl	4	117,744,075 - 117,873,700 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095410 ⟹ ENSRNOP00000085131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	120,002,054 - 120,101,091 (+)	Ensembl
mRatBN7.2 Ensembl	4	118,497,416 - 118,538,505 (+)	Ensembl

RefSeq Acc Id:

NM_001109880 ⟹ NP_001103350

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	120,054,878 - 120,095,961 (+)	NCBI
mRatBN7.2	4	118,497,416 - 118,538,505 (+)	NCBI
Rnor_6.0	4	117,744,075 - 117,882,427 (+)	NCBI
Rnor_5.0	4	182,417,932 - 182,454,565 (+)	NCBI
RGSC_v3.4	4	120,221,140 - 120,275,351 (+)	RGD
Celera	4	107,471,489 - 107,504,523 (+)	NCBI

Sequence:

show sequence

AGGCCACAGGCACTGCCTCCTTCATTTGTGGGAGTCTACAAGGATGGAGGATAGTTCCCACCCG
GCTGTGTGAAGTGTGGCTGTGCCAGCCCTCCTAGTTGTGAAGACCTGGCACTGAGGACAGAGAC
TGGACAGGCCTGGTTCATCCTACTGGGTTCCGGGAGTGGACTGAAGCCTTAGCAGGAGCATGAG
TGAGGACACGGTCCCCGAGGCAGCCTCACCGCCACCCTCTCAGGGGCAGCACTACTTTGACCGG
TTCTCTGAGGATGACCCTGAATACTTGCGACTTCGCAACCGTGCAGCTGACCTGCGACAAGACT
TCAACCTGATGGAGCAGAAGAAACGGGTCACCATGATCCTGCAGAGCCCTTCTTTCAGGGAGGA
GCTGGAAGGCCTCATCCAGGAACAGATGAAGAAGGGTAACAACTCCTCCAACATCTGGGCCCTC
CGACAGATCGCGGACTTCATGGCCAGCACCTCCCACGCAGTCTTCCCAGCTTCCTCCATGAACT
TCTCCATGATGACACCCATCAATGACCTCCACACTGCCGACTCCCTGAACCTGGCCAAGGGGGA
GAGGCTTATGCGGTGCAAGATCAGCAGTGTCTACCGTCTTCTGGACCTCTATGGCTGGGCGCAG
CTCAGCGACACCTATGTCACGCTGAGAGTGAGCAAGGAGCAGGACCACTTCCTGATCAGCCCCA
AAGGGGTTTCCTGCAGTGAGGTCACGGCATCCAGCCTGATTAAGGTGAACATTCTAGGAGAGGT
CGTGGAGAAGGGCAGCAGTTGCTTCCCAGTGGACACCACCGGCTTCAGTCTGCACTCAGCCATC
TATGCGGCCAGGCCGGACGTGCGGTGTGCCATCCACCTGCACACGCCTGCCACAGCAGCGGTGT
CAGCTATGAAGTGTGGCCTCCTGCCTGTCTCCCATAATGCCCTGCTGGTGGGGGACATGGCCTA
CTATGACTTCAATGGGGAAATGGAGCAGGAAGCTGATCGAATCAACTTGCAGAAGTGCCTTGGA
CCCACCTGCAAGATTCTGGTGCTAAGAAACCATGGTATGGTCGCCCTGGGTGACACCGTGGAGG
AAGCTTTCTACAAGGTCTTCCACCTGCAGGCTGCGTGTGAGGTACAGGTGTCGGCTCTGTCCAG
CGCTGGGGGGACCGAGAACCTCATCCTCCTGGAGCAAGAGAAACACCGTCCGCATGAGGTGGGC
TCTGTGCAGTGGGCCGGCAGCACCTTTGGGCCCATGCAGAAGAGCCGGCTGGGAGAGCATGAAT
TTGAAGCCCTCATGAGGATGCTCGACAACTTAGGCTACAGAACAGGCTATACGTACCGCCACCC
CTTCGTCCAAGAGAAAACCAAACACAAAAGTGAAGTGGAGATCCCAGCCACGGTCACTGCCTTT
GTGTTCGAAGAGGATGGTGTCCCAGTCCCTGCTCTGCGCCAGCACGCCCAAAAGCAGCAGAAGG
AAAAGACCCGCTGGCTTAACACTCCCAACACCTACCTGAGGGTGAATGTGGCCGACGAGGTGCA
GAGGAACATGGGCAGTCCCCGACCGAAGACCACGTGGATGAAGGCTGATGAAGTGGAAAAGTCC
AGCAGCGGCATGCCCATACGGATTGAAAACCCAAACCAATTTGTGCCTCTCTACACTGACCCCC
AAGAAGTGCTGGACATGAGGAACAAGATTCGAGAACAAAACCGACAAGATATAAAGTCAGCCGG
GCCTCAGTCTCAGCTCTTGGCCAGCGTCATCGCCGAGAAGAGCCGGAGTCCGTCTACAGAGAGC
CAGCTGGCGTCCAAGGGCGATGCAGATACCAAAGATGAATTGGAGGAGACGGTGCCCAACCCCT
TCAGCCAACTCACTGACCAGGAGCTGGAGGAGTACAAGAAGGAGGTGGAAAGGAAGAAGCTAGA
ACAGGAGCAAGAAGGGGAGAAGGACGCAGCCACAGAGGAGCCTGGTTCACCTGTAAAGTCCACA
CCTGCGTCTCCTGTGCAGAGCCCAACGAGGGCAGGGACCAAGAGTCCAGCGGTCTCTCCTTCCA
AGGCTTCAGAGGATGCCAAGAAGACAGAAGTCAGCGAAGCCAACACAGAGCCTGAGCCAGAGAA
ACCAGAAGGGGTGGTGGTGAATGGGAAGGAGGAGGAGCCGAGTGTGGAAGAGGTCCTCAGCAAA
GGACCGGGCCAGATGACTACCAATGCTGACACTGATGGCGACAGTTACAAGGACAAAACCGAGT
CAGTTACCAGTGGCCCCTTGTCCCCAGAGGGCTCGCCCTCTAAGTCACCCTCCAAAAAGAAAAA
GAAATTCCGAACCCCCTCCTTCCTGAAGAAGAGCAAGAAGAAGGAGAAGGTGGAATCCTGATTA
GTGGCTCAGTGGGTCCTGATGCATCCCTGCCCTCCTTCCTTACCTTCTCCCAACTCTGACCCTG
AAGCCAGGGCCAAGGAGGGCAAGAGGAGATCCTGGGATCACACTCAGAGGGGAACTTAGAGCCT
GCCTTCCCAGAGCAGCCAGGTGTCTTG

hide sequence

RefSeq Acc Id:

NM_012491 ⟹ NP_036623

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	120,054,878 - 120,087,117 (+)	NCBI
mRatBN7.2	4	118,497,416 - 118,529,659 (+)	NCBI
Rnor_6.0	4	117,744,075 - 117,873,701 (+)	NCBI
Rnor_5.0	4	182,417,932 - 182,454,565 (+)	NCBI
RGSC_v3.4	4	120,221,140 - 120,275,351 (+)	RGD
Celera	4	107,471,489 - 107,503,009 (+)	NCBI

Sequence:

show sequence

AGGCCACAGGCACTGCCTCCTTCATTTGTGGGAGTCTACAAGGATGGAGGATAGTTCCCACCCG
GCTGTGTGAAGTGTGGCTGTGCCAGCCCTCCTAGTTGTGAAGACCTGGCACTGAGGACAGAGAC
TGGACAGGCCTGGTTCATCCTACTGGGTTCCGGGAGTGGACTGAAGCCTTAGCAGGAGCATGAG
TGAGGACACGGTCCCCGAGGCAGCCTCACCGCCACCCTCTCAGGGGCAGCACTACTTTGACCGG
TTCTCTGAGGATGACCCTGAATACTTGCGACTTCGCAACCGTGCAGCTGACCTGCGACAAGACT
TCAACCTGATGGAGCAGAAGAAACGGGTCACCATGATCCTGCAGAGCCCTTCTTTCAGGGAGGA
GCTGGAAGGCCTCATCCAGGAACAGATGAAGAAGGGTAACAACTCCTCCAACATCTGGGCCCTC
CGACAGATCGCGGACTTCATGGCCAGCACCTCCCACGCAGTCTTCCCAGCTTCCTCCATGAACT
TCTCCATGATGACACCCATCAATGACCTCCACACTGCCGACTCCCTGAACCTGGCCAAGGGGGA
GAGGCTTATGCGGTGCAAGATCAGCAGTGTCTACCGTCTTCTGGACCTCTATGGCTGGGCGCAG
CTCAGCGACACCTATGTCACGCTGAGAGTGAGCAAGGAGCAGGACCACTTCCTGATCAGCCCCA
AAGGGGTTTCCTGCAGTGAGGTCACGGCATCCAGCCTGATTAAGGTGAACATTCTAGGAGAGGT
CGTGGAGAAGGGCAGCAGTTGCTTCCCAGTGGACACCACCGGCTTCAGTCTGCACTCAGCCATC
TATGCGGCCAGGCCGGACGTGCGGTGTGCCATCCACCTGCACACGCCTGCCACAGCAGCGGTGT
CAGCTATGAAGTGTGGCCTCCTGCCTGTCTCCCATAATGCCCTGCTGGTGGGGGACATGGCCTA
CTATGACTTCAATGGGGAAATGGAGCAGGAAGCTGATCGAATCAACTTGCAGAAGTGCCTTGGA
CCCACCTGCAAGATTCTGGTGCTAAGAAACCATGGTATGGTCGCCCTGGGTGACACCGTGGAGG
AAGCTTTCTACAAGGTCTTCCACCTGCAGGCTGCGTGTGAGGTACAGGTGTCGGCTCTGTCCAG
CGCTGGGGGGACCGAGAACCTCATCCTCCTGGAGCAAGAGAAACACCGTCCGCATGAGGTGGGC
TCTGTGCAGTGGGCCGGCAGCACCTTTGGGCCCATGCAGAAGAGCCGGCTGGGAGAGCATGAAT
TTGAAGCCCTCATGAGGATGCTCGACAACTTAGGCTACAGAACAGGCTATACGTACCGCCACCC
CTTCGTCCAAGAGAAAACCAAACACAAAAGTGAAGTGGAGATCCCAGCCACGGTCACTGCCTTT
GTGTTCGAAGAGGATGGTGTCCCAGTCCCTGCTCTGCGCCAGCACGCCCAAAAGCAGCAGAAGG
AAAAGACCCGCTGGCTTAACACTCCCAACACCTACCTGAGGGTGAATGTGGCCGACGAGGTGCA
GAGGAACATGGGCAGTCCCCGACCGAAGACCACGTGGATGAAGGCTGATGAAGTGGAAAAGTCC
AGCAGCGGCATGCCCATACGGATTGAAAACCCAAACCAATTTGTGCCTCTCTACACTGACCCCC
AAGAAGTGCTGGACATGAGGAACAAGATTCGAGAACAAAACCGACAAGATATAAAGTCAGCCGG
GCCTCAGTCTCAGCTCTTGGCCAGCGTCATCGCCGAGAAGAGCCGGAGTCCGGTACAGCAGAGA
CTGCCCCCAACTGAAGGGGAAGCTTATCAGACTCCTGGGGCTGGGCAGGGGACCCCTGAGTCCT
CAGGCCCACTCACCCCATGACCTTAGGTGCTGGGCTCTTGCTGCACAGTGAAGGGCCACCACAC
AGGTGGCTGTGAGGTCCAGGGAGGACAATGTTGGCTCACTCCTGGGTGCACCAGATAGGGAGCA
ACAAGGAGCATCTGTTCATAGGAAGGCTTCTGGCCAGCCCCACACCTCCCGCCATGAGACTCCA
CGAGGCCCTCTCTCAGTGTCCTGCTGAATTCTGGTGGCCCAAGTGTTTCTGACCCCTGGTTTGG
ATGTAGCATCATCAGGATACAGGGAGGGGGTTGTGGCTAGGACTGCTGTGCTATGGGGTGGGAA
GGGTAAAAAGTAGCCATACAAACGTAGTTAGCATTAGAAAGCATGACGTCACTGTTTCTGTGTT
TGAGGGGATGGCATCTTGTCTAGGGCTTAGGAGCAGATGGCATTGCAATTCTGCCTTGCGTGGC
ATCATGGCTGTTCATGGCTTGTGGCAAAGGGTGTGACACTTTCCTAGACAATGGCTAATGGGAC
GTGCCAGGGCCCATCACTCTCTGCAGAGCATGTTAACGTGATATGGCTGCAGATCAGGCAGCTG
CAGGCTGCACCCTCACATCTGCTTCCTGACCTCCCCCAGCTCAGCCAAGTCAGTGAACTCTGAG
CATGCCATAGAATCAAGGTTAGAAATGACCCGTGATCCCAGGGGGATGAGAGATGAGCACAGGG
CAGGACTGTCGTTCAGCAGCTCTGTCCTTCACAGCAGGAGTTCTCAGTGGAGTCCCTCATCCTC
CTTGGGGTCTATCTTAGACTCCCCTTTGACTCTGAAACCCGTTGAAATAAGCCTATTGTTGCTT
CTGTATGAGTGCAGCCCATAAGTGGTGACCAGAAACCATGGTTGCTCTGGGCTCACCTCCCTGA
GATCTCACTCTGTTCTCCTCCTCCGATAGTAAGTGATGCCTTCTGATAGGCCACAGTGAGGAAA
CTGACTTAGGGAAAGGACAGAAGGGTCTGGGTTCAGTCCTCTCTTGAGCAAGAGGGACCAGATG
ATTCAGAGCCAGGGATTCAACTGAGGTGCAGAGCAGAGGTTCTGTCAGTGCCCCTGCCAGGGCC
TCAGGGCCTGGCCTCTTGGTCACCATGACTCCAGGATTCACTGCTTGGACTGAGAATGCTGAAG
GCCCTGTATCTTATTGTTTTAATGCTGTGTGCTGAGGCTGCTCTTGAGGGACCTGGGGGAAGGC
AGTGGGGGAGAGGGCTGGGGAGGGGCAGCAGGGGAGAGGGCTGGCATGCTGCTTGCTCTAGCCA
ATGCTATGCTTGCTAGACTTTGTCTGACTAAATTTGGGCCACCAAATGTATGCACAGTCATGGC
TTGGAAGTGTCCGTAGATGGGAATGCAATAAAGGTATGTCTTCTGCTTGGGAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_063285470 ⟹ XP_063141540

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	120,001,977 - 120,101,090 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001103350	(Get FASTA)	NCBI Sequence Viewer
	NP_036623	(Get FASTA)	NCBI Sequence Viewer
	XP_063141540	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40679	(Get FASTA)	NCBI Sequence Viewer
	AAF31764	(Get FASTA)	NCBI Sequence Viewer
	AAO66430	(Get FASTA)	NCBI Sequence Viewer
	EDL91218	(Get FASTA)	NCBI Sequence Viewer
	EDL91219	(Get FASTA)	NCBI Sequence Viewer
	EDL91220	(Get FASTA)	NCBI Sequence Viewer
	EDL91221	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021491
	ENSRNOP00000073973
	ENSRNOP00000073973.1
GenBank Protein	Q05764	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036623 ⟸ NM_012491
- Peptide Label:	isoform b
- UniProtKB:	A6IAV2 (UniProtKB/TrEMBL), A6IAV0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEDTVPEAASPPPSQGQHYFDRFSEDDPEYLRLRNRAADLRQDFNLMEQKKRVTMILQSPSFR EELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVFPASSMNFSMMTPINDLHTADSLNLAK GERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILG EVVEKGSSCFPVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDM AYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSAL SSAGGTENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYR HPFVQEKTKHKSEVEIPATVTAFVFEEDGVPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADE VQRNMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLDMRNKIREQNRQDIKS AGPQSQLLASVIAEKSRSPVQQRLPPTEGEAYQTPGAGQGTPESSGPLTP hide sequence

RefSeq Acc Id:	NP_001103350 ⟸ NM_001109880
- Peptide Label:	isoform a
- UniProtKB:	Q05764 (UniProtKB/Swiss-Prot), F8WFS9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEDTVPEAASPPPSQGQHYFDRFSEDDPEYLRLRNRAADLRQDFNLMEQKKRVTMILQSPSFR EELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVFPASSMNFSMMTPINDLHTADSLNLAK GERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILG EVVEKGSSCFPVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDM AYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSAL SSAGGTENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYR HPFVQEKTKHKSEVEIPATVTAFVFEEDGVPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADE VQRNMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLDMRNKIREQNRQDIKS AGPQSQLLASVIAEKSRSPSTESQLASKGDADTKDELEETVPNPFSQLTDQELEEYKKEVERKK LEQEQEGEKDAATEEPGSPVKSTPASPVQSPTRAGTKSPAVSPSKASEDAKKTEVSEANTEPEP EKPEGVVVNGKEEEPSVEEVLSKGPGQMTTNADTDGDSYKDKTESVTSGPLSPEGSPSKSPSKK KKKFRTPSFLKKSKKKEKVES hide sequence

Ensembl Acc Id:

ENSRNOP00000021491 ⟸ ENSRNOT00000021491

Ensembl Acc Id:

ENSRNOP00000073973 ⟸ ENSRNOT00000081173

Ensembl Acc Id:

ENSRNOP00000085131 ⟸ ENSRNOT00000095410

RefSeq Acc Id:	XP_063141540 ⟸ XM_063285470
- Peptide Label:	isoform X1
- UniProtKB:	Q05764 (UniProtKB/Swiss-Prot), F8WFS9 (UniProtKB/TrEMBL)

Protein Domains

Class II aldolase/adducin N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q05764-F1-model_v2	AlphaFold	Q05764	1-725	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693202

Promoter ID:

EPDNEW_R3726

Type:

single initiation site

Name:

Add2_1

Description:

adducin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	117,744,065 - 117,744,125	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2042	AgrOrtholog
BioCyc Gene	G2FUF-43909	BioCyc
Ensembl Genes	ENSRNOG00000015903	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021491	ENTREZGENE
	ENSRNOT00000081173	ENTREZGENE
	ENSRNOT00000081173.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.225.10	UniProtKB/Swiss-Prot
InterPro	Aldolase-II_Adducin_sf	UniProtKB/Swiss-Prot
	Aldolase_II/adducin_N	UniProtKB/Swiss-Prot
	Aldolase_II/adducin_N_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:24171	UniProtKB/Swiss-Prot
NCBI Gene	24171	ENTREZGENE
PANTHER	ADDUCIN	UniProtKB/Swiss-Prot
	PTHR10672:SF6	UniProtKB/Swiss-Prot
Pfam	Aldolase_II	UniProtKB/Swiss-Prot
PhenoGen	Add2	PhenoGen
RatGTEx	ENSRNOG00000015903	RatGTEx
SMART	Aldolase_II	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53639	UniProtKB/Swiss-Prot
TIGR	TC216666
UniProt	A0A8I6A2L7_RAT	UniProtKB/TrEMBL
	A6IAV0	ENTREZGENE, UniProtKB/TrEMBL
	A6IAV1_RAT	UniProtKB/TrEMBL
	A6IAV2	ENTREZGENE, UniProtKB/TrEMBL
	A6IAV3_RAT	UniProtKB/TrEMBL
	ADDB_RAT	UniProtKB/Swiss-Prot
	F8WFS9	ENTREZGENE, UniProtKB/TrEMBL
	Q05764	ENTREZGENE
	Q80UA1_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Add2	adducin 2	Add2	adducin 2 (beta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Add2	adducin 2 (beta)		adducin 2, beta	Name updated	1299863	APPROVED
2002-11-06	Add2	adducin 2, beta		Adducin, beta	Name updated	625702	APPROVED
2002-06-10	Add2	Adducin, beta			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the cytoskeleton	631736
gene_disease	Gln to Arg substitution is associated with altered ion transport and blood pressure variation in the Milan hypertensive strain (MHS)	631712
gene_function	interacts with other proteins of the membrane cytoskeleton	631736
gene_physical_interaction	forms a heterodimer with alpha adducin (Add1)	631736
gene_process	plays a role in membrane ion transport	631712
gene_process	plays a role in membrane ion transport	631736
gene_protein	63 kDa protein	631712
gene_protein	63 kDa protein	631736

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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