Add1 (adducin 1) - Rat Genome Database

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Gene: Add1 (adducin 1) Rattus norvegicus
Analyze
Symbol: Add1
Name: adducin 1
RGD ID: 2041
Description: Enables T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Located in dendritic spine and perinuclear region of cytoplasm. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adducin 1 (alpha); adducin 1, alpha; alpha-ADD; alpha-adducin; erythrocyte adducin subunit alpha; MGC124621
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   MHS/N
QTLs:   Bp59  
Candidate Gene For: Bp59
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,333,242 - 80,401,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)EnsemblGRCr8
mRatBN7.21476,108,643 - 76,167,267 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,561,417 - 80,619,806 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,802,070 - 81,860,453 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,247,298 - 78,305,694 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,367,466 - 81,426,610 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)Ensemblrn6Rnor6.0
Rnor_5.01482,054,922 - 82,114,066 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,750,430 - 81,808,919 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1475,033,169 - 75,091,638 (-)NCBICelera
RGSC_v3.11481,754,353 - 81,784,555 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methylmercury(1+)  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
pyrethrins  (EXP)
pyrogallol  (ISO)
quercetin  (ISO)
sarin  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sulindac  (EXP)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Association between the alpha-adducin Gly460Trp polymorphism and systolic blood pressure in familial combined hyperlipidemia. Beeks E, etal., Am J Hypertens. 2001 Dec;14(12):1185-90.
3. The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein alpha-adducin. Bianchi MG, etal., Neuroscience. 2010 Aug 25;169(2):584-95. Epub 2010 May 20.
4. Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection. Bunker-Wiersma HE, etal., Pediatr Crit Care Med. 2008 Sep;9(5):517-23.
5. Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism. Cappuzzello C, etal., Cardiovasc Res. 2007 Aug 1;75(3):608-17. Epub 2007 May 4.
6. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Cusi D, etal., Lancet. 1997 May 10;349(9062):1353-7.
7. 35H, a sequence isolated as a protein kinase C binding protein, is a novel member of the adducin family. Dong L, etal., J Biol Chem 1995 Oct 27;270(43):25534-40.
8. Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop preeclampsia later in pregnancy: implications for screening. Farina A, etal., Prenat Diagn. 2009 Nov;29(11):1038-44.
9. alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy. Ferrandi M, etal., J Mol Med (Berl). 2010 Feb;88(2):203-17. Epub 2009 Oct 17.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling. Lu Q, etal., Mol Immunol. 2004 Jun;41(4):435-47.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Spatial and sub-cellular localization of the membrane cytoskeleton-associated protein alpha-adducin in the rat brain. Seidel B, etal., Brain Res. 1995 Nov 27;700(1-2):13-24.
18. Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. Shaw GM, etal., Am J Med Genet A. 2005 Sep 15;138(1):21-6.
19. Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis. Torfs CP, etal., Birth Defects Res A Clin Mol Teratol. 2006 Oct;76(10):723-30.
20. alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption. Torielli L, etal., Am J Physiol Renal Physiol. 2008 Aug;295(2):F478-87. Epub 2008 Jun 4.
21. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Tripodi G, etal., Biochem Biophys Res Commun 2004 Nov 12;324(2):562-8.
22. Characterisation and chromosomal localisation of the rat alpha- and beta-adducin-encoding genes. Tripodi G, etal., Gene 1995 Dec 12;166(2):307-11.
23. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. Tripodi G, etal., J Clin Invest. 1996 Jun 15;97(12):2815-22.
24. Alpha-adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk. van Rijn MJ, etal., Stroke. 2006 Dec;37(12):2930-4. Epub 2006 Nov 2.
25. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
26. Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis. Zee RY, etal., J Thromb Haemost. 2006 Feb;4(2):341-8.
Additional References at PubMed
PMID:3693401   PMID:7642559   PMID:8626479   PMID:10485892   PMID:12477932   PMID:16289097   PMID:16641100   PMID:18723693   PMID:21423176   PMID:21451595   PMID:22658674   PMID:25468996  
PMID:25978380   PMID:29476059  


Genomics

Comparative Map Data
Add1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,333,242 - 80,401,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)EnsemblGRCr8
mRatBN7.21476,108,643 - 76,167,267 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1480,561,417 - 80,619,806 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,802,070 - 81,860,453 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,247,298 - 78,305,694 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,367,466 - 81,426,610 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)Ensemblrn6Rnor6.0
Rnor_5.01482,054,922 - 82,114,066 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41481,750,430 - 81,808,919 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1475,033,169 - 75,091,638 (-)NCBICelera
RGSC_v3.11481,754,353 - 81,784,555 (-)NCBI
Cytogenetic Map14q21NCBI
ADD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,843,844 - 2,930,062 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,843,576 - 2,930,082 (+)Ensemblhg38GRCh38
GRCh3742,845,571 - 2,931,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,815,382 - 2,901,587 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3442,882,589 - 2,968,794NCBI
Celera42,756,785 - 2,842,980 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,784,038 - 2,870,206 (+)NCBIHuRef
CHM1_142,843,557 - 2,929,744 (+)NCBICHM1_1
T2T-CHM13v2.042,842,299 - 2,928,525 (+)NCBIT2T-CHM13v2.0
Add1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,731,008 - 34,789,652 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,731,008 - 34,789,652 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38534,573,664 - 34,632,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,573,664 - 34,632,308 (+)Ensemblmm10GRCm38
MGSCv37534,916,363 - 34,974,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36534,890,669 - 34,949,165 (+)NCBIMGSCv36mm8
Celera532,044,658 - 32,103,240 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.9NCBI
Add1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,783,814 - 1,815,917 (+)Ensembl
ChiLan1.0NW_0049555141,784,302 - 1,812,845 (+)NCBIChiLan1.0ChiLan1.0
ADD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,179,400 - 3,265,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,115,339 - 3,201,629 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,986,301 - 3,072,590 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,889,073 - 2,975,012 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,920,781 - 2,975,012 (+)EnsemblpanPan2panpan1.1
ADD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,356,643 - 61,443,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,358,162 - 61,474,830 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha363,940,255 - 64,027,099 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0361,832,145 - 61,919,366 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,832,162 - 61,919,940 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,323,682 - 61,410,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,528,369 - 61,615,629 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,887,972 - 61,975,241 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Add1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,993,417 - 67,064,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,691,951 - 20,766,152 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,695,109 - 20,766,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,627,062 - 1,710,650 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.181,627,146 - 1,710,653 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,208,520 - 1,292,568 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,811,611 - 45,901,277 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,813,496 - 45,900,778 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660512,167,948 - 2,256,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Add1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,854,742 - 24,928,006 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475524,854,742 - 24,927,912 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Add1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11170,424,625 - 70,482,454 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Add1
449 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:608
Count of miRNA genes:255
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000018073, ENSRNOT00000018340
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH127695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,108,737 - 76,108,918 (+)MAPPERmRatBN7.2
Rnor_6.01481,367,561 - 81,367,741NCBIRnor6.0
Rnor_5.01482,055,017 - 82,055,197UniSTSRnor5.0
RGSC_v3.41481,750,525 - 81,750,705UniSTSRGSC3.4
Celera1475,033,264 - 75,033,444UniSTS
RH 3.4 Map14489.48UniSTS
Cytogenetic Map14q21UniSTS
BF397471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,158,943 - 76,159,087 (+)MAPPERmRatBN7.2
Rnor_6.01481,418,008 - 81,418,151NCBIRnor6.0
Rnor_5.01482,105,464 - 82,105,607UniSTSRnor5.0
RGSC_v3.41481,800,722 - 81,800,865UniSTSRGSC3.4
Celera1475,083,447 - 75,083,590UniSTS
RH 3.4 Map14483.48UniSTS
Cytogenetic Map14q21UniSTS


Related Rat Strains
The following Strains have been annotated to Add1
MHS/N    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001437183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC107657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z49081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z49082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018073   ⟹   ENSRNOP00000018072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)Ensembl
mRatBN7.2 Ensembl1476,108,656 - 76,167,172 (-)Ensembl
Rnor_6.0 Ensembl1481,367,468 - 81,426,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000018340   ⟹   ENSRNOP00000018340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)Ensembl
mRatBN7.2 Ensembl1476,108,663 - 76,140,405 (-)Ensembl
Rnor_6.0 Ensembl1481,369,146 - 81,399,353 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098266   ⟹   ENSRNOP00000094525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)Ensembl
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100756   ⟹   ENSRNOP00000077285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,333,244 - 80,391,732 (-)Ensembl
mRatBN7.2 Ensembl1476,108,654 - 76,167,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137819   ⟹   ENSRNOP00000103804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1480,334,120 - 80,391,732 (-)Ensembl
RefSeq Acc Id: NM_016990   ⟹   NP_058686
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,732 (-)NCBI
mRatBN7.21476,108,643 - 76,167,141 (-)NCBI
Rnor_6.01481,367,466 - 81,426,496 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
RGSC_v3.41481,750,430 - 81,808,919 (-)RGD
Celera1475,033,169 - 75,091,638 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251159   ⟹   XP_006251221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,108,643 - 76,167,267 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251160   ⟹   XP_006251222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,108,660 - 76,167,266 (-)NCBI
Rnor_6.01481,368,854 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251161   ⟹   XP_006251223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,108,643 - 76,167,266 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251165   ⟹   XP_006251227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,110,504 - 76,167,266 (-)NCBI
Rnor_6.01481,369,065 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251167   ⟹   XP_006251229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,336,379 - 80,391,830 (-)NCBI
mRatBN7.21476,111,780 - 76,167,266 (-)NCBI
Rnor_6.01481,370,603 - 81,426,610 (-)NCBI
Rnor_5.01482,054,922 - 82,114,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599064   ⟹   XP_017454553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,108,643 - 76,167,267 (-)NCBI
Rnor_6.01481,367,466 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599065   ⟹   XP_017454554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,110,504 - 76,167,267 (-)NCBI
Rnor_6.01481,369,065 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599066   ⟹   XP_017454555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,110,382 - 76,167,267 (-)NCBI
Rnor_6.01481,369,256 - 81,426,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091605   ⟹   XP_038947533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,111,780 - 76,167,267 (-)NCBI
RefSeq Acc Id: XM_039091606   ⟹   XP_038947534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,336,379 - 80,391,830 (-)NCBI
mRatBN7.21476,111,780 - 76,167,267 (-)NCBI
RefSeq Acc Id: XM_039091609   ⟹   XP_038947537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,111,780 - 76,167,266 (-)NCBI
RefSeq Acc Id: XM_039091611   ⟹   XP_038947539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
mRatBN7.21476,108,652 - 76,167,179 (-)NCBI
RefSeq Acc Id: XM_063272840   ⟹   XP_063128910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,401,641 (-)NCBI
RefSeq Acc Id: XM_063272841   ⟹   XP_063128911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272842   ⟹   XP_063128912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272843   ⟹   XP_063128913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272844   ⟹   XP_063128914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272845   ⟹   XP_063128915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272846   ⟹   XP_063128916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,336,379 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272847   ⟹   XP_063128917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272848   ⟹   XP_063128918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272849   ⟹   XP_063128919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,333,242 - 80,391,830 (-)NCBI
RefSeq Acc Id: XM_063272850   ⟹   XP_063128920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,336,379 - 80,391,830 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001424112 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424113 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424114 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424115 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424116 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424117 (Get FASTA)   NCBI Sequence Viewer  
  NP_058686 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251221 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251222 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251223 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251227 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251229 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454553 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454554 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454555 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947533 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947534 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947537 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947539 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128910 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128911 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128912 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128913 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128914 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128915 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128916 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128917 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128918 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128919 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128920 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07658 (Get FASTA)   NCBI Sequence Viewer  
  CAA58690 (Get FASTA)   NCBI Sequence Viewer  
  CAA88906 (Get FASTA)   NCBI Sequence Viewer  
  CAA88907 (Get FASTA)   NCBI Sequence Viewer  
  EDM00089 (Get FASTA)   NCBI Sequence Viewer  
  EDM00090 (Get FASTA)   NCBI Sequence Viewer  
  EDM00091 (Get FASTA)   NCBI Sequence Viewer  
  EDM00092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018072
  ENSRNOP00000018340
  ENSRNOP00000077285
  ENSRNOP00000094525
  ENSRNOP00000103804
GenBank Protein Q63028 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058686   ⟸   NM_016990
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   A6IK25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251223   ⟸   XM_006251161
- Peptide Label: isoform X4
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251221   ⟸   XM_006251159
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006251222   ⟸   XM_006251160
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006251227   ⟸   XM_006251165
- Peptide Label: isoform X11
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   A0A8I5Y1E2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251229   ⟸   XM_006251167
- Peptide Label: isoform X17
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   A0A8I6ALT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454553   ⟸   XM_017599064
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454554   ⟸   XM_017599065
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017454555   ⟸   XM_017599066
- Peptide Label: isoform X8
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018340   ⟸   ENSRNOT00000018340
Ensembl Acc Id: ENSRNOP00000018072   ⟸   ENSRNOT00000018073
RefSeq Acc Id: XP_038947539   ⟸   XM_039091611
- Peptide Label: isoform X20
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   A6IK28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947534   ⟸   XM_039091606
- Peptide Label: isoform X9
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038947533   ⟸   XM_039091605
- Peptide Label: isoform X7
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038947537   ⟸   XM_039091609
- Peptide Label: isoform X14
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000094525   ⟸   ENSRNOT00000098266
Ensembl Acc Id: ENSRNOP00000077285   ⟸   ENSRNOT00000100756
RefSeq Acc Id: XP_063128910   ⟸   XM_063272840
- Peptide Label: isoform X1
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128919   ⟸   XM_063272849
- Peptide Label: isoform X21
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128913   ⟸   XM_063272843
- Peptide Label: isoform X12
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128911   ⟸   XM_063272841
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128917   ⟸   XM_063272847
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063128918   ⟸   XM_063272848
- Peptide Label: isoform X19
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128912   ⟸   XM_063272842
- Peptide Label: isoform X10
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128915   ⟸   XM_063272845
- Peptide Label: isoform X15
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128914   ⟸   XM_063272844
- Peptide Label: isoform X13
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   A0A8I5Y1E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128920   ⟸   XM_063272850
- Peptide Label: isoform X22
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128916   ⟸   XM_063272846
- Peptide Label: isoform X16
- UniProtKB: Q64722 (UniProtKB/Swiss-Prot),   Q3B7D4 (UniProtKB/Swiss-Prot),   Q63028 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000103804   ⟸   ENSRNOT00000137819
Protein Domains
Class II aldolase/adducin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63028-F1-model_v2 AlphaFold Q63028 1-735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699398
Promoter ID:EPDNEW_R9923
Type:initiation region
Name:Add1_1
Description:adducin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,426,518 - 81,426,578EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2041 AgrOrtholog
BioCyc Gene G2FUF-15297 BioCyc
Ensembl Genes ENSRNOG00000013039 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018073 ENTREZGENE
  ENSRNOT00000018340 ENTREZGENE
  ENSRNOT00000098266 ENTREZGENE
  ENSRNOT00000100756 ENTREZGENE
  ENSRNOT00000137819 ENTREZGENE
Gene3D-CATH 3.40.225.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7935564 IMAGE-MGC_LOAD
InterPro Aldolase-II_Adducin_sf UniProtKB/Swiss-Prot
  Aldolase_II/adducin_N UniProtKB/Swiss-Prot
  Aldolase_II/adducin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:24170 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124621 IMAGE-MGC_LOAD
NCBI Gene 24170 ENTREZGENE
PANTHER ADDUCIN UniProtKB/Swiss-Prot
  PTHR10672:SF4 UniProtKB/Swiss-Prot
Pfam Aldolase_II UniProtKB/Swiss-Prot
PharmGKB ADD1 RGD
PhenoGen Add1 PhenoGen
RatGTEx ENSRNOG00000013039 RatGTEx
SMART Aldolase_II UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53639 UniProtKB/Swiss-Prot
UniProt A0A0G2JSM7_RAT UniProtKB/TrEMBL
  A0A8I5Y1E2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALT1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRD9_RAT UniProtKB/TrEMBL
  A6IK25 ENTREZGENE, UniProtKB/TrEMBL
  A6IK27_RAT UniProtKB/TrEMBL
  A6IK28 ENTREZGENE, UniProtKB/TrEMBL
  ADDA_RAT UniProtKB/Swiss-Prot
  D3ZZ99 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7D4 ENTREZGENE
  Q63028 ENTREZGENE
  Q64722 ENTREZGENE
UniProt Secondary Q3B7D4 UniProtKB/Swiss-Prot
  Q64722 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Add1  adducin 1  Add1  adducin 1 (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Add1  adducin 1 (alpha)    adducin 1, alpha  Name updated 1299863 APPROVED
2002-11-06 Add1  adducin 1, alpha    Adducin 1, alpha  Name updated 625702 APPROVED
2002-06-10 Add1  Adducin 1, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoskeleton 631736
gene_disease variation in the heteromeric ADD protein is associated with blood pressure variation in the Milan hypertensive strain (MHS) 631736
gene_expression expressed in spleen and kidney 631736
gene_function interacts with other proteins of the membrane cytoskeleton 631736
gene_homology has 91% amino acid identity with human ADD1 631736
gene_physical_interaction forms a heterodimer with beta adducin (Add2) 631736
gene_process does not appear to affect heart rate 1302895
gene_process association with blood pressure strongly indicated by fine mapping of reciprocal congenic strains derived from MNS (hypertensicve) and MHS (normnotensive) rats 1302895
gene_process may play a role in ion transport and signal transduction 631736
gene_protein contains 735 amino acid sequence 631736
gene_transcript has splice variants containing alternatively spliced exons 631736