RGD Reference Report - Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop preeclampsia later in pregnancy: implications for screening. - Rat Genome Database

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Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop preeclampsia later in pregnancy: implications for screening.

Authors: Farina, A  Morano, D  Arcelli, D  De Sanctis, P  Sekizawa, A  Purwosunu, Y  Zucchini, C  Simonazzi, G  Okai, T  Rizzo, N 
Citation: Farina A, etal., Prenat Diagn. 2009 Nov;29(11):1038-44.
RGD ID: 5147993
Pubmed: PMID:19731222   (View Abstract at PubMed)
DOI: DOI:10.1002/pd.2344   (Journal Full-text)

OBJECTIVES: To determine the gene expression profile in chorionic villous samples (CVS) of women destined to develop preeclampsia. METHOD: cDNA microarray technology was employed. Ten singleton fetuses of women who subsequently developed preeclampsia where compared with a pool of 50 controls. The mRNA expression of some of the genes previously found to be up- or down-regulated were validated by RT-PCR in peripheral blood from 23 pregnant women at term affected with preeclampsia and 23 controls. RESULTS: Altered expression was found among several genes including those involved in invasion of human trophoblasts (Titin), in inflammatory stress (Lactotransferrin), endothelial aberration (Claudin 6), angiogenesis (Vasohibin 1), blood pressure control (Adducin 1). Also the peripheral blood from preeclampsia patients showed significant differences for all the genes studied. CONCLUSION: CVS show an aberrant gene profile prior to preeclampsia onset that may be predictive of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pre-eclampsia  IEP 5147993mRNA:increased expression:bloodRGD 
pre-eclampsia  ISOADD1 (Homo sapiens)5147993; 5147993mRNA:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Add1  (adducin 1)

Genes (Mus musculus)
Add1  (adducin 1)

Genes (Homo sapiens)
ADD1  (adducin 1)


Additional Information