4933405O20Rikl (RIKEN cDNA 4933405O20 gene like) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: 4933405O20Rikl (RIKEN cDNA 4933405O20 gene like) Rattus norvegicus
Analyze
Symbol: 4933405O20Rikl (Ensembl: LOC103690168)
Name: RIKEN cDNA 4933405O20 gene like (Ensembl:probable isocitrate dehydrogenase)
RGD ID: 1642415
Description: Predicted to enable magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be active in mitochondrion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC100125384; isocitric dehydrogenase subunit gamma 2; LOC100125384; LOC100909825; MGC116152; NAD(+)-specific ICDH subunit gamma 2; probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial-like
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81109,436,262 - 109,437,732 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21100,300,241 - 100,301,711 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1105,656,387 - 105,657,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01114,128,315 - 114,129,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01107,450,582 - 107,452,052 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01105,935,449 - 105,936,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,405,002 - 106,406,469 (+)Ensemblrn6Rnor6.0
Rnor_5.01107,446,703 - 107,448,173 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41100,482,038 - 100,483,508 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera194,486,862 - 94,488,332 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
4933405O20Rikl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81109,436,262 - 109,437,732 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21100,300,241 - 100,301,711 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1105,656,387 - 105,657,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01114,128,315 - 114,129,785 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01107,450,582 - 107,452,052 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01105,935,449 - 105,936,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,405,002 - 106,406,469 (+)Ensemblrn6Rnor6.0
Rnor_5.01107,446,703 - 107,448,173 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41100,482,038 - 100,483,508 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera194,486,862 - 94,488,332 (+)NCBICelera
Cytogenetic Map1q22NCBI
AC099730.1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381121,283,781 - 21,284,939 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1121,283,779 - 21,284,955 (+)Ensemblhg38GRCh38
GRCh371121,305,327 - 21,306,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11p15.1NCBI
HuRef1120,988,119 - 20,989,277 (+)NCBIHuRef
CHM1_11121,305,178 - 21,306,336 (+)NCBICHM1_1
T2T-CHM13v2.01121,404,440 - 21,405,598 (+)NCBIT2T-CHM13v2.0
4933405O20Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39750,248,938 - 50,250,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl750,248,938 - 50,250,278 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38750,599,190 - 50,600,528 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl750,599,190 - 50,600,530 (+)Ensemblmm10GRCm38
MGSCv37757,854,560 - 57,855,898 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36750,467,209 - 50,468,547 (+)NCBIMGSCv36mm8
Celera746,011,952 - 46,013,290 (+)NCBICelera
Cytogenetic Map7B4NCBI
cM Map732.53NCBI

Variants

.
Variants in 4933405O20Rikl
11 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 4 27 9 17 5 2 5 22 8 26 2 30 12 6 6

Sequence


RefSeq Acc Id: NM_001103363   ⟹   NP_001096833
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81109,436,262 - 109,437,732 (+)NCBI
mRatBN7.21100,300,241 - 100,301,711 (+)NCBI
Rnor_6.01105,935,449 - 105,936,919 (+)NCBI
Rnor_5.01107,446,703 - 107,448,173 (+)NCBI
RGSC_v3.41100,482,038 - 100,483,508 (+)RGD
Celera194,486,862 - 94,488,332 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001096833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98006 (Get FASTA)   NCBI Sequence Viewer  
  AAI05849 (Get FASTA)   NCBI Sequence Viewer  
  EDM07215 (Get FASTA)   NCBI Sequence Viewer  
  Q4QQT5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001096833   ⟸   NM_001103363
- UniProtKB: Q4QQT5 (UniProtKB/Swiss-Prot),   Q3B8Q8 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Isopropylmalate dehydrogenase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QQT5-F1-model_v2 AlphaFold Q4QQT5 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1642415 AgrOrtholog
BioCyc Gene G2FUF-59551 BioCyc
Ensembl Genes ENSRNOG00000045720 Ensembl
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7453927 IMAGE-MGC_LOAD
  IMAGE:7456480 IMAGE-MGC_LOAD
InterPro Isocitrate_DH_NAD UniProtKB/Swiss-Prot
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:100125384 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116152 IMAGE-MGC_LOAD
  MGC:125272 IMAGE-MGC_LOAD
NCBI Gene 100125384 ENTREZGENE
PANTHER DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE UniProtKB/Swiss-Prot
  ISOCITRATE DEHYDROGENASE [NAD] GAMMA 2, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam Iso_dh UniProtKB/Swiss-Prot
PhenoGen 4933405O20Rikl PhenoGen
RatGTEx ENSRNOG00000045720 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot
UniProt IDHG2_RAT UniProtKB/Swiss-Prot
  Q3B8Q8 ENTREZGENE, UniProtKB/TrEMBL
  Q4QQT5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 4933405O20Rikl  RIKEN cDNA 4933405O20 gene like  LOC100125384  hypothetical protein LOC100125384  Symbol and Name Changed 1299863 APPROVED
2015-07-29 LOC100125384  hypothetical protein LOC100125384  LOC100909825  probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial-like  Data merged from RGD:6501685 737654 PROVISIONAL
2012-07-05 LOC100909825  probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-09-15 LOC100125384  hypothetical protein LOC100125384      Symbol and Name status set to provisional 70820 PROVISIONAL