Gnl3l (G protein nucleolar 3 like) - Rat Genome Database

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Gene: Gnl3l (G protein nucleolar 3 like) Rattus norvegicus
Analyze
Symbol: Gnl3l
Name: G protein nucleolar 3 like
RGD ID: 1600217
Description: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,404,324 - 23,437,501 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX23,404,324 - 23,439,315 (-)EnsemblGRCr8
mRatBN7.2X19,961,277 - 19,994,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,958,603 - 19,994,508 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX17,399,883 - 17,432,684 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X22,690,900 - 22,723,701 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,490,522 - 20,523,699 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X20,037,558 - 20,070,505 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX20,034,882 - 20,070,578 (-)Ensemblrn6Rnor6.0
Rnor_5.0X20,782,438 - 20,819,550 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X40,301,219 - 40,334,396 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX20,218,772 - 20,251,971 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetamide  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
indometacin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (IBA,IEA,ISO)
telomerase holoenzyme complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:18082603   PMID:19487455   PMID:19946888   PMID:22641345   PMID:22658674   PMID:25931508  


Genomics

Comparative Map Data
Gnl3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X23,404,324 - 23,437,501 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX23,404,324 - 23,439,315 (-)EnsemblGRCr8
mRatBN7.2X19,961,277 - 19,994,454 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX19,958,603 - 19,994,508 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX17,399,883 - 17,432,684 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X22,690,900 - 22,723,701 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X20,490,522 - 20,523,699 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X20,037,558 - 20,070,505 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX20,034,882 - 20,070,578 (-)Ensemblrn6Rnor6.0
Rnor_5.0X20,782,438 - 20,819,550 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X40,301,219 - 40,334,396 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX20,218,772 - 20,251,971 (-)NCBICelera
Cytogenetic MapXq12NCBI
GNL3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,530,219 - 54,645,854 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX54,529,900 - 54,621,565 (+)Ensemblhg38GRCh38
GRCh37X54,556,652 - 54,593,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,573,369 - 54,608,698 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X54,439,762 - 54,474,737NCBI
CeleraX58,389,207 - 58,426,283 (+)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX51,606,400 - 51,643,319 (+)NCBIHuRef
CHM1_1X54,547,228 - 54,584,316 (+)NCBICHM1_1
T2T-CHM13v2.0X53,821,079 - 53,936,915 (+)NCBIT2T-CHM13v2.0
Gnl3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X149,766,129 - 149,800,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX149,766,137 - 149,800,318 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X150,983,133 - 151,017,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX150,983,141 - 151,017,322 (-)Ensemblmm10GRCm38
MGSCv37X147,417,676 - 147,451,865 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X146,323,857 - 146,357,964 (-)NCBIMGSCv36mm8
CeleraX133,387,729 - 133,422,241 (+)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Gnl3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554751,792,268 - 1,854,288 (+)Ensembl
ChiLan1.0NW_0049554751,792,268 - 1,849,601 (+)NCBIChiLan1.0ChiLan1.0
GNL3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X55,914,661 - 56,010,500 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X55,922,390 - 56,014,108 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X46,733,431 - 46,825,139 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X54,966,098 - 55,057,466 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX54,966,121 - 55,002,925 (+)EnsemblpanPan2panpan1.1
GNL3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X46,270,162 - 46,296,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX46,189,870 - 46,296,966 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX37,662,545 - 37,689,357 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X46,594,979 - 46,621,792 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX46,594,730 - 46,624,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,092,970 - 46,119,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X46,543,140 - 46,569,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X46,610,450 - 46,637,264 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnl3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,084,141 - 39,117,404 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367511,423,804 - 1,459,998 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367511,423,822 - 1,457,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNL3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX47,256,505 - 47,284,520 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X47,256,467 - 47,284,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X53,113,296 - 53,141,321 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNL3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X50,650,512 - 50,684,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX50,666,794 - 50,684,649 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660864,610,907 - 4,644,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnl3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249092,400,899 - 2,448,493 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249092,401,242 - 2,524,409 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gnl3l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X12,364,682 - 12,395,931 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gnl3l
273 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003397
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
RH140481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X19,958,843 - 19,958,982 (+)MAPPERmRatBN7.2
Rnor_6.0X20,035,125 - 20,035,263NCBIRnor6.0
Rnor_5.0X20,782,682 - 20,782,820UniSTSRnor5.0
RGSC_v3.4X40,298,786 - 40,298,924UniSTSRGSC3.4
CeleraX20,216,339 - 20,216,477UniSTS
Cytogenetic MapXq14-q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003397   ⟹   ENSRNOP00000003397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX23,404,324 - 23,439,315 (-)Ensembl
mRatBN7.2 EnsemblX19,958,603 - 19,994,508 (-)Ensembl
Rnor_6.0 EnsemblX20,034,882 - 20,070,578 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093602   ⟹   ENSRNOP00000076269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX20,037,557 - 20,070,537 (-)Ensembl
RefSeq Acc Id: NM_001081958   ⟹   NP_001075427
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X23,404,324 - 23,437,501 (-)NCBI
mRatBN7.2X19,961,277 - 19,994,454 (-)NCBI
Rnor_6.0X20,037,558 - 20,070,505 (-)NCBI
Rnor_5.0X20,782,438 - 20,819,550 (-)NCBI
RGSC_v3.4X40,301,219 - 40,334,396 (-)RGD
CeleraX20,218,772 - 20,251,971 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001075427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003397
  ENSRNOP00000003397.9
RefSeq Acc Id: NP_001075427   ⟸   NM_001081958
- UniProtKB: D3ZMZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076269   ⟸   ENSRNOT00000093602
Ensembl Acc Id: ENSRNOP00000003397   ⟸   ENSRNOT00000003397

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMZ9-F1-model_v2 AlphaFold D3ZMZ9 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701763
Promoter ID:EPDNEW_R12287
Type:initiation region
Name:Gnl3l_1
Description:G protein nucleolar 3 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X20,070,557 - 20,070,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1600217 AgrOrtholog
BioCyc Gene G2FUF-2782 BioCyc
Ensembl Genes ENSRNOG00000002509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003397 ENTREZGENE
  ENSRNOT00000003397.10 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1580.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro G_CP_dom UniProtKB/TrEMBL
  GTP-bd_ortho_bundle UniProtKB/TrEMBL
  GTP1_OBG UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  TRAFAC_YlqF/YawG_RiboMat UniProtKB/TrEMBL
NCBI Gene 100034253 ENTREZGENE
PANTHER GTP-BINDING PROTEIN-RELATED UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3-LIKE PROTEIN UniProtKB/TrEMBL
Pfam MMR_HSR1 UniProtKB/TrEMBL
PhenoGen Gnl3l PhenoGen
PRINTS GTP1OBG UniProtKB/TrEMBL
PROSITE G_CP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002509 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt D3ZMZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnl3l  G protein nucleolar 3 like  Gnl3l  guanine nucleotide binding protein-like 3 (nucleolar)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-03-03 Gnl3l  guanine nucleotide binding protein-like 3 (nucleolar)-like      Symbol and Name status set to provisional 70820 PROVISIONAL