Fam72a (family with sequence similarity 72, member A) - Rat Genome Database

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Gene: Fam72a (family with sequence similarity 72, member A) Rattus norvegicus
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Symbol: Fam72a
Name: family with sequence similarity 72, member A
RGD ID: 1598023
Description: Acts upstream of or within positive regulation of apoptotic process. Located in cytosol and membrane. Orthologous to several human genes including FAM72A (family with sequence similarity 72 member A); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dpr4-related protein; hypothetical protein LOC681249; LOC681249
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,519,940 - 45,531,322 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,519,818 - 45,531,324 (+)EnsemblGRCr8
mRatBN7.21342,967,701 - 42,979,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,967,578 - 42,984,208 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,578,609 - 45,589,164 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,866,731 - 46,877,284 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,130,633 - 44,141,187 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,288,071 - 48,298,604 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,287,873 - 48,298,664 (+)Ensemblrn6Rnor6.0
Rnor_5.01353,363,989 - 53,374,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41344,453,797 - 44,469,514 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1343,313,802 - 43,323,924 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,IEA)
membrane  (IDA)
mitochondrion  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. Nehar S, etal., FEBS Lett. 2009 Oct 6;583(19):3247-53. doi: 10.1016/j.febslet.2009.09.018. Epub 2009 Sep 13.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fam72a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,519,940 - 45,531,322 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,519,818 - 45,531,324 (+)EnsemblGRCr8
mRatBN7.21342,967,701 - 42,979,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,967,578 - 42,984,208 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,578,609 - 45,589,164 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,866,731 - 46,877,284 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,130,633 - 44,141,187 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,288,071 - 48,298,604 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,287,873 - 48,298,664 (+)Ensemblrn6Rnor6.0
Rnor_5.01353,363,989 - 53,374,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41344,453,797 - 44,469,514 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1343,313,802 - 43,323,924 (+)NCBICelera
Cytogenetic Map13q13NCBI
FAM72A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,186,179 - 206,205,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,186,179 - 206,204,414 (-)Ensemblhg38GRCh38
GRCh371206,135,557 - 206,155,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,299,717 - 204,321,779 (+)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map1q32.1NCBI
CHM1_11207,631,795 - 207,647,958 (-)NCBICHM1_1
T2T-CHM13v2.01205,450,361 - 205,469,960 (-)NCBIT2T-CHM13v2.0
Fam72a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,454,336 - 131,466,773 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,455,641 - 131,467,610 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381131,526,598 - 131,539,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,527,903 - 131,539,872 (+)Ensemblmm10GRCm38
MGSCv371133,424,566 - 133,436,449 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361133,355,533 - 133,367,418 (+)NCBIMGSCv36mm8
Celera1134,140,340 - 134,152,215 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.99NCBI
Fam72a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,786,953 - 41,801,049 (-)Ensembl
ChiLan1.0NW_00495540641,788,278 - 41,801,141 (-)NCBIChiLan1.0ChiLan1.0
FAM72A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2143,167,400 - 43,185,573 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1143,132,982 - 43,151,097 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,792,764 - 181,811,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,075,381 - 186,094,057 (-)NCBIPanPan1.1PanPan1.1panPan2
FAM72A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,495,180 - 2,505,313 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,587,156 - 2,597,889 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0382,492,061 - 2,502,802 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,492,058 - 2,502,714 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,485,733 - 2,496,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,878,293 - 2,889,028 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,078,832 - 3,089,556 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam72a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,098,282 - 69,116,272 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365576,339,076 - 6,355,586 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365576,339,076 - 6,355,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM72A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1966,824,251 - 66,839,780 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,077,782 - 73,085,565 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM72A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12523,147,233 - 23,185,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605523,846,115 - 23,865,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam72a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248075,169,178 - 5,184,597 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam72a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1104,288,739 - 4,300,811 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fam72a
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:112
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000068223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 65 165 91 90 59 85 59 6 333 181 11 144 72 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000068223   ⟹   ENSRNOP00000061509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,519,818 - 45,531,324 (+)Ensembl
mRatBN7.2 Ensembl1342,967,578 - 42,984,208 (+)Ensembl
Rnor_6.0 Ensembl1348,287,873 - 48,298,664 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134861   ⟹   ENSRNOP00000112479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,519,818 - 45,527,636 (+)Ensembl
RefSeq Acc Id: NM_001081451   ⟹   NP_001074920
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,519,940 - 45,531,322 (+)NCBI
mRatBN7.21342,967,701 - 42,979,083 (+)NCBI
Rnor_6.01348,288,071 - 48,298,604 (+)NCBI
Rnor_5.01353,363,989 - 53,374,272 (+)NCBI
RGSC_v3.41344,453,797 - 44,469,514 (+)RGD
Celera1343,313,802 - 43,323,924 (+)RGD
Sequence:
RefSeq Acc Id: XM_063272602   ⟹   XP_063128672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,520,648 - 45,531,322 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001074920 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128672 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1KXW8 (Get FASTA)   NCBI Sequence Viewer  
  AAS82862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061509
RefSeq Acc Id: NP_001074920   ⟸   NM_001081451
- UniProtKB: A1KXW8 (UniProtKB/Swiss-Prot),   D4A3G3 (UniProtKB/TrEMBL),   A6IC20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061509   ⟸   ENSRNOT00000068223
RefSeq Acc Id: XP_063128672   ⟸   XM_063272602
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000112479   ⟸   ENSRNOT00000134861

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1KXW8-F1-model_v2 AlphaFold A1KXW8 1-149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598023 AgrOrtholog
BioCyc Gene G2FUF-18346 BioCyc
Ensembl Genes ENSRNOG00000042747 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068223 ENTREZGENE
InterPro FAM72 UniProtKB/Swiss-Prot
KEGG Report rno:681249 UniProtKB/Swiss-Prot
NCBI Gene 681249 ENTREZGENE
PANTHER PROTEIN FAM72A-RELATED UniProtKB/Swiss-Prot
  PTHR31841 UniProtKB/Swiss-Prot
Pfam FAM72 UniProtKB/Swiss-Prot
PhenoGen Fam72a PhenoGen
RatGTEx ENSRNOG00000042747 RatGTEx
UniProt A0ABK0M0N4_RAT UniProtKB/TrEMBL
  A1KXW8 ENTREZGENE
  A6IC20 ENTREZGENE, UniProtKB/TrEMBL
  D4A3G3 ENTREZGENE, UniProtKB/TrEMBL
  FA72A_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Fam72a  family with sequence similarity 72, member A  LOC681249  hypothetical protein LOC681249  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681249  hypothetical protein LOC681249      Symbol and Name status set to provisional 70820 PROVISIONAL