Clec4g (C-type lectin domain family 4, member G) - Rat Genome Database

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Gene: Clec4g (C-type lectin domain family 4, member G) Rattus norvegicus
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Symbol: Clec4g
Name: C-type lectin domain family 4, member G
RGD ID: 1597482
Description: Predicted to enable several functions, including exogenous protein binding activity; monosaccharide binding activity; and pattern recognition receptor activity. Predicted to be involved in immune response; positive regulation of viral life cycle; and symbiont entry into host cell. Predicted to act upstream of or within negative regulation of T cell mediated immunity; negative regulation of alpha-beta T cell proliferation; and negative regulation of immature T cell proliferation in thymus. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4G (C-type lectin domain family 4 member G); INTERACTS WITH bisphenol A; indole-3-methanol; paraquat.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-type lectin domain family 4 member G; LOC689004; RGD1562320; similar to C-type lectin domain family 4, member g
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,578,266 - 6,582,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,578,258 - 6,582,894 (-)EnsemblGRCr8
mRatBN7.2121,780,370 - 1,785,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,780,371 - 1,784,985 (-)EnsemblmRatBN7.2
Rnor_6.0122,273,649 - 2,278,594 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,273,941 - 2,277,169 (-)Ensemblrn6Rnor6.0
Rnor_5.0124,434,464 - 4,439,027 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,412,875 - 2,416,940 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,635,478 - 3,641,645 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18697825   PMID:19632227   PMID:23487419  


Genomics

Comparative Map Data
Clec4g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,578,266 - 6,582,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,578,258 - 6,582,894 (-)EnsemblGRCr8
mRatBN7.2121,780,370 - 1,785,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,780,371 - 1,784,985 (-)EnsemblmRatBN7.2
Rnor_6.0122,273,649 - 2,278,594 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,273,941 - 2,277,169 (-)Ensemblrn6Rnor6.0
Rnor_5.0124,434,464 - 4,439,027 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,412,875 - 2,416,940 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,635,478 - 3,641,645 (-)NCBICelera
Cytogenetic Map12p12NCBI
CLEC4G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,728,957 - 7,732,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,728,957 - 7,733,906 (-)Ensemblhg38GRCh38
GRCh37197,793,843 - 7,796,996 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,699,850 - 7,703,005 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34197,699,851 - 7,703,006NCBI
Celera197,664,968 - 7,668,182 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,463,587 - 7,466,801 (-)NCBIHuRef
CHM1_1197,793,562 - 7,796,776 (-)NCBICHM1_1
T2T-CHM13v2.0197,729,985 - 7,733,138 (-)NCBIT2T-CHM13v2.0
Clec4g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,757,066 - 3,770,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,757,064 - 3,770,651 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3883,707,066 - 3,720,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,707,064 - 3,720,651 (-)Ensemblmm10GRCm38
MGSCv3783,716,071 - 3,720,651 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3683,716,077 - 3,720,651 (-)NCBIMGSCv36mm8
Celera83,946,232 - 3,950,812 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Clec4g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,571,288 - 1,575,979 (+)Ensembl
ChiLan1.0NW_0049555631,571,374 - 1,574,901 (+)NCBIChiLan1.0ChiLan1.0
CLEC4G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,397,121 - 12,401,902 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,514,375 - 11,518,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,015,848 - 7,019,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,870,550 - 7,873,699 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,870,730 - 7,873,631 (-)EnsemblpanPan2panpan1.1
CLEC4G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,476,162 - 52,480,341 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,476,200 - 52,479,930 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,279,523 - 52,283,613 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,005,016 - 53,009,106 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,005,022 - 53,009,242 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,208,486 - 52,218,901 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,652,069 - 52,656,165 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,883,279 - 52,887,375 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clec4g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,094,033 - 213,097,594 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,738,182 - 4,740,750 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,737,278 - 4,740,750 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC4G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,433,421 - 71,436,567 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1271,433,406 - 71,436,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,967,726 - 71,970,446 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233812
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,206,303 - 7,211,213 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,206,712 - 7,209,431 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081636,814 - 640,084 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clec4g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828773,569 - 778,615 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624828775,114 - 778,526 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Clec4g
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1161,641,745 - 1,646,187 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clec4g
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000061719
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 2 60 41 74 78 51 35 51 6 195 113 2 24 22 60 27 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000078078   ⟹   ENSRNOP00000068921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,578,258 - 6,582,894 (-)Ensembl
mRatBN7.2 Ensembl121,780,371 - 1,784,985 (-)Ensembl
Rnor_6.0 Ensembl122,273,941 - 2,277,169 (-)Ensembl
RefSeq Acc Id: XM_039089898   ⟹   XP_038945826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,578,266 - 6,582,913 (-)NCBI
mRatBN7.2121,780,370 - 1,785,027 (-)NCBI
RefSeq Acc Id: XM_039089899   ⟹   XP_038945827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,578,266 - 6,582,913 (-)NCBI
mRatBN7.2121,780,370 - 1,785,027 (-)NCBI
RefSeq Acc Id: XM_063271727   ⟹   XP_063127797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,578,266 - 6,582,883 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038945826 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068921
  ENSRNOP00000068921.2
Ensembl Acc Id: ENSRNOP00000068921   ⟸   ENSRNOT00000078078
RefSeq Acc Id: XP_038945827   ⟸   XM_039089899
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945826   ⟸   XM_039089898
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127797   ⟸   XM_063271727
- Peptide Label: isoform X3
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU13-F1-model_v2 AlphaFold A0A0G2JU13 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597482 AgrOrtholog
BioCyc Gene G2FUF-20380 BioCyc
Ensembl Genes ENSRNOG00000054013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078078 ENTREZGENE
  ENSRNOT00000078078.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  C-type_lectin/snaclec_domain UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/TrEMBL
  CD209-like_CTLD UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
NCBI Gene 689004 ENTREZGENE
PANTHER MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
PhenoGen Clec4g PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054013 RatGTEx
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
UniProt A0A0G2JU13 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Clec4g  C-type lectin domain family 4, member G  LOC689004  similar to C-type lectin domain family 4, member g  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689004  similar to C-type lectin domain family 4, member g      Symbol and Name status set to provisional 70820 PROVISIONAL