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Gene: Zc3h12d (zinc finger CCCH type containing 12D) Rattus norvegicus

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Symbol:

Zc3h12d

Name:

zinc finger CCCH type containing 12D

RGD ID:

1597152

Description:

Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in 3'-UTR-mediated mRNA destabilization; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of cell growth. Predicted to act upstream of or within mRNA catabolic process and negative regulation of T cell proliferation. Predicted to be located in P-body and nucleoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12D (zinc finger CCCH-type containing 12D); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC308266; probable ribonuclease ZC3H12D; similar to zinc finger CCCH-type containing 12D

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	4,131,674 - 4,169,192 (+)	NCBI		GRCr8
mRatBN7.2	1	2,313,110 - 2,348,820 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	2,314,324 - 2,348,819 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	1,964,214 - 1,998,661 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	7,964,619 - 7,999,064 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	2,246,326 - 2,280,771 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	1,937,620 - 1,972,919 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,938,419 - 1,972,918 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	3,634,641 - 3,669,534 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	2,507,365 - 2,541,861 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	863,044 - 897,549 (+)	NCBI		Celera
Cytogenetic Map	1	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

15-acetyldeoxynivalenol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cyclosporin A (ISO)

endosulfan (EXP)

fenthion (ISO)

fulvestrant (ISO)

furan (EXP)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

rotenone (ISO)

serpentine asbestos (ISO)

testosterone (EXP)

thioacetamide (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

3'-UTR-mediated mRNA destabilization (ISO)

mRNA catabolic process (ISO)

negative regulation of cell growth (ISO)

negative regulation of G1/S transition of mitotic cell cycle (ISO)

negative regulation of T cell proliferation (ISO)

T cell proliferation (ISO)

Cellular Component

cytoplasm (ISO)

cytoplasmic ribonucleoprotein granule (IBA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

P-body (ISO)

Molecular Function

mRNA binding (IBA)

protein binding (ISO)

RNA endonuclease activity (IBA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19531561	PMID:24415781	PMID:24721400	PMID:26134560

Genomics

Comparative Map Data

Zc3h12d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	4,131,674 - 4,169,192 (+)	NCBI		GRCr8
mRatBN7.2	1	2,313,110 - 2,348,820 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	2,314,324 - 2,348,819 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	1,964,214 - 1,998,661 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	7,964,619 - 7,999,064 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	2,246,326 - 2,280,771 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	1,937,620 - 1,972,919 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,938,419 - 1,972,918 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	3,634,641 - 3,669,534 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	2,507,365 - 2,541,861 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	863,044 - 897,549 (+)	NCBI		Celera
Cytogenetic Map	1	p13	NCBI

ZC3H12D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	149,446,795 - 149,485,014 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	149,446,795 - 149,485,014 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	149,767,931 - 149,806,150 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	149,812,571 - 149,847,723 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	150,503,861 - 150,541,240 (-)	NCBI		Celera
Cytogenetic Map	6	q25.1	NCBI
HuRef	6	147,335,524 - 147,372,891 (-)	NCBI		HuRef
CHM1_1	6	150,033,515 - 150,070,897 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	150,646,494 - 150,684,730 (-)	NCBI		T2T-CHM13v2.0

Zc3h12d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	7,708,087 - 7,746,161 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	7,708,234 - 7,746,160 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	7,832,323 - 7,870,397 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	7,832,470 - 7,870,396 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	7,552,268 - 7,590,195 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	7,522,660 - 7,560,586 (+)	NCBI		MGSCv36	mm8
Celera	10	7,711,148 - 7,749,061 (+)	NCBI		Celera
Cytogenetic Map	10	A1	NCBI
cM Map	10	2.44	NCBI

Zc3h12d
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	11,768,812 - 11,785,230 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	11,761,099 - 11,787,508 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZC3H12D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	169,474,368 - 169,510,614 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	167,365,292 - 167,404,189 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	147,266,039 - 147,304,289 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	151,973,996 - 152,010,309 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	151,974,485 - 151,999,898 (-)	Ensembl	panpan1.1		panPan2

ZC3H12D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	40,249,856 - 40,279,344 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	40,259,705 - 40,279,888 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	41,087,019 - 41,112,742 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	40,429,790 - 40,455,566 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	40,431,812 - 40,459,442 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	40,306,086 - 40,331,843 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	40,171,027 - 40,196,784 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	40,511,853 - 40,537,572 (-)	NCBI		UU_Cfam_GSD_1.0

Zc3h12d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	135,202,865 - 135,228,936 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	2,455,728 - 2,472,328 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	2,454,889 - 2,472,392 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZC3H12D
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	16,465,252 - 16,498,971 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	16,463,532 - 16,498,974 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	18,783,708 - 18,819,632 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZC3H12D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	22,152,938 - 22,195,470 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	22,158,259 - 22,194,514 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	198,177,140 - 198,214,289 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zc3h12d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624785	8,588,480 - 8,613,199 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zc3h12d
187 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	222
Count of miRNA genes:	153
Interacting mature miRNAs:	188
Transcripts:	ENSRNOT00000065646
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600360	Mcs16	Mammary carcinoma susceptibility QTL 16	2.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	2244390	43433040	Rat
2298546	Neuinf4	Neuroinflammation QTL 4	5.1		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	1	1	28736750	Rat
2313090	Bmd69	Bone mineral density QTL 69	4.4	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	1	32356093	Rat
1578650	Bmd6	Bone mineral density QTL 6	12.2		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	1	509108	43284926	Rat
1354647	Despr8	Despair related QTL 8		0.0000341	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	1	24744506	Rat
1578651	Bmd7	Bone mineral density QTL 7	14.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	1	509108	43284926	Rat
1578669	Bss9	Bone structure and strength QTL 9	6.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	1	509108	43284926	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
2313070	Bss52	Bone structure and strength QTL 52	4.4	0.0001	body length (VT:0001256)	body length (CMO:0000013)	1	1	32356093	Rat
2313053	Bss51	Bone structure and strength QTL 51	3.8	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	1	32356093	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat

Markers in Region

BQ196677

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	4,168,728 - 4,168,908 (+)	Marker Load Pipeline
mRatBN7.2	1	2,348,356 - 2,348,536 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	1,972,456 - 1,972,635	NCBI	Rnor6.0
Rnor_5.0	1	3,669,071 - 3,669,250	UniSTS	Rnor5.0
RGSC_v3.4	1	2,541,399 - 2,541,578	UniSTS	RGSC3.4
Celera	1	897,087 - 897,266	UniSTS
RH 3.4 Map	1	14.6	UniSTS
Cytogenetic Map	1	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006227616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000065646 ⟹ ENSRNOP00000059263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	2,314,324 - 2,348,819 (+)	Ensembl
Rnor_6.0 Ensembl	1	1,938,419 - 1,972,918 (+)	Ensembl

RefSeq Acc Id:

NM_001107469 ⟹ NP_001100939

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	4,134,697 - 4,169,191 (+)	NCBI
mRatBN7.2	1	2,314,324 - 2,348,819 (+)	NCBI
Rnor_6.0	1	1,938,419 - 1,972,918 (+)	NCBI
Rnor_5.0	1	3,634,641 - 3,669,534 (+)	NCBI
RGSC_v3.4	1	2,507,365 - 2,541,861 (+)	RGD
Celera	1	863,044 - 897,549 (+)	RGD

Sequence:

show sequence

GCGAGCACTCCCTAGTTGAAAAGAGAGGGTCAGTGTGAAGGCTCAGGCAGCTGGGCCAAGTCTG
CTGGGAGAGCACGAGGGACACACCTGCTGCTCATGCCAGTGCAGCTCTGCCAGGAGGAAGCTCG
GGGCAGGAGCCGGGCCAAGCAACAGTTGGCACGATATGGAGCGTCGGGGCAAGATGGAATTTTT
CCAGAAACTGGGCTACAGCCAGGAGGACGTGGTCAGGGTGCTGGGCAAACTGGGTGACGGTGCC
TTGGTCAATGACGTGCTGCAAGAGTTGATCCAGACCGGCAGCCGCCCAAAGGCCCAGGAGGATC
CAGCCAATGGCACCGGGATAGTGCTCATGCCTCGGGGATGCTGCGGGGTTCGAGACTCTGCCCA
GCAGGGCCTGGGACTAGGCCTAGAAGAGGCTGGCGGAGATCCAGCCAGCTTCCTGCGGCCCATA
GTGATCGATGGCAGCAATGTGGCTATGAGTCATGGAAATAAAGAAGCCTTCTCTTGCCGGGGAA
TTCGTCTGGCCGTGGACTGGTTCAGGGACAGAGGACACACCTACATCAAGGTTTTTGTCCCATC
TTGGAGAAAAGAGCCATCAAGGTCTGATACCCCTATCAGAGAACAGCACGTGTTGGAGGAACTG
GAGCGACAGGCTGTGCTGGTGTACACCCCATCCCGCAAGGTGAACGGCAAGCGAGTGGTCTGCT
ACGACGATCGCTACATCGTGAAGCTGGCCTATGAGAAGGATGGCGTCATTGTCTCCAATGACAA
CTACCGGGACCTGCAGAATGAGAACCCGGAGTGGAAATGGTTCATTGAGCAGCGGCTACTCATG
TTCTCCTTTGTAAATGACAGGTTCATGCCTCCTGATGACCCCCTCGGCCGTCGAGGACCAACAC
TAAGCAATTTCCTAAGCAAGAAGCCAAGGCCCCCAGAGCCATCCTGGCAGCACTGTCCCTATGG
CAAGAAATGCACCTACGGGGTCAAGTGCAGATTCTACCACCCGGAGAGACCACACCAAGGGCAG
CTGCCGGTGGCAGACGAACTCCGTGCCAAGACGCGGGCTTGGCCGGGTGGTGGCGCCGGGGAGT
CGCGGCCACCGAGCGCCCGGAGCCGTCCCGGAGCAGCCCGGCCGCTTCCCCTGGAGCCCGGCGC
TCACAACCCCACGCCGGCCCCGCAGCCCGCGGCCCTGACAGCCCTGAACCAGAGCTTCGCTCGG
CTGACCTTCAGCGATACTGCGGCCAGTGGCGTCGTGTCCCTGTCGCGTGGGCCTGACCGGATGC
CCACGAGTGGTCCCACGTCCTGGGCCTCGCCATCCCTTCGCGCGGGCAGCGTTGCCACCCAAGG
GTCGCCGGGTCTGCGGTGCCTCCGGACTCCGAACAGCCTGCTCTCTCCGGGCGATCTCGGGTCC
CCAATCTGCCCACAGTCCCAGCCATCGGACAGACACTGTTCCAGGGGCATGCACAGTGACCTGC
CTCCCCAGCGCAGACCGCCGGAAGACCCGTGGGCCTTCCTGCCCAGCTCCTATGGTTATTTGAA
TCACTCGGTTTGGGCTGAGTCGGCTTGGAGCGAGAACACCTTTGGAAGACCTTCGGGGTCAGCA
CAATCCACCATCAACAGTGGGGGAACTCGCGCTTCACTCTGCAGCGCCTTCCCATCTGACCGAG
AGGACCCTGTTATGGCCTCGGATCCTGTGCTCTCAGACGTGGCCCTGCGCACCCTCCTGCAGAG
ATCCCAAAAGACTGGTGCTCCGTTGGGGGATCCTTAGGGGACAGGTTCATAACACTGCAAGGGG
TGGTGGCCCAGGCTTGACTCTCTGCTTGGGTAGGTGGGATACAAGATGCTTGTTAATTTGGATG
TGTCCCTGCAGTTGAACGACATTTTTTAAAGGTGGTCTCGGTGGGAGCTTTCTCAATCCTCAGT
GGTGGATACCGGTGGGGATCTTGGGGATGCTCTCTGAAGCCAGGGTCTGCTTCATGAGCAGGAT
GATTTCTGATGTATTTGGAAGGCTTTGTCCAGAGCACATCTAAATCCGGTTCTAACTAGCATCC
AAAAATGTTTCAGCTGGTCATCACCGCTAGCCAAGGTGATTGGCCTGAGTTTGACATAAACTCT
TGGAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAGAATTCTAG
AAAACCAGGAGAACTTAACATGTCGTTGTAGTTGAAAGATTGAAAAAGGCTGGTAAGTCAGTCT
TGACTTTTGTGGTGTCAAATGATGTATAACACATGTTCAGGTGACACAGGAAGGAAGGAAGGTA
TTGCTGTCTGGAGTTTTCAAGTCACTATTGCTAATCTCACTCATAGGGGAAACTCAGCCTTGTG
TAAATTTTACTGTGGGGTTGTCCCAGGGGAACTTGATCCTACGGGTCTCCTCCCTGGGTTTTTA
TTCTTTTTGTACATACATACCATATTACCGAAACATCACAACACACACGCACACGTACACGCAC
ACAACCTTGCTCAAGACTCAGCCTGGCTTTTTTTTTTTTTTTTTAAATCAGCCTTCCTTTGTGT
GATTCTACAAAATTTAAACTGCACCTTATAGAGATAGGATTTCAATCTACCCACCACCCCCTTA
AAAAACAACAACAACAACAACAACTCAGCAGTCAACAACAATCCAGGTTGGTCAGCATAGAGTT
GGATTCTGGTAGAGGTTTATTGCAACTTTACTTAGCTGTGTCTTCTAGATAACTTCTGCTCTGG
GTTTTGTGGGGAGGAGAGGCTCATTCATTCACAAGGGACAAGAAATGATACAGTGTTGCTGGGG
CATGGGCCCAGCATTCTGAGGGAACCCAGCATCTGTAGGCTGCACCCACATGTTCCAGTTACAA
CGGCAGCCTGCCAGGTTGTAACTCATTTGTTCCTGAGGGACTTAGTAGTTCATTTGGTCAGAGA
GAGTCAGAAGGGACCTGCCAATGGGACCTGTTTGCCAAAGCCTCCGAGTTCCTGCAGTGTGGTA
GGCACATTTGGGAAACACCCCTTCATTGCCTCAGGGAAAATGCCGTTGCAGTATTCATGGTAAA
CTTGACTCCTTGGCACCAGGGTAGCCATATGGCTTCCTGGAAGTCCTCCCTCTTTTAAAACCAC
CTTCTTAGCATGGCTTCTTGTGGATCTGTTCCTCACACCCTTTTCAAAACGTATGCTATTCTCA
GACTGTTGCTTCTTATCTTGAGTCCCTGTCCTGAAGAGGGTTTGCTCTTTCTAGATCTTTTGAA
GTTTTTCCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTCTTTT
CATAGGACTCTTAGAGCCGCTGTTTGATTCCCTGGTCTTGTCCCCTGCTTCAAATCAATCCATT
GCGAATTTACAGTTGGAAATGTTTAAACTGCTTCCTATGAAGACAAGTTTGAGTTTTAGTAAGC
TGTAAAGCTATTTTATTTGGTTCACTGTGATTAAGAAAAAAGGGAAGGAAAAAAAGAGGTGTGT
GTGTGTAGGGGAAAGAAACAACACATCTCAGATGTAATCACCTTTGGAAAATTCCAAAGTCTTA
GTATGTCCTTGTGACACAAAACGGTGGATGAGAGACATAAATGAACTGTCCCTAGTTGCATAGC
TGTTAACCATGCTCCAAAAATAAACCACCTTTTCCACACCTGA

hide sequence

RefSeq Acc Id:

XM_006227616 ⟹ XP_006227678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	4,131,674 - 4,169,192 (+)	NCBI
mRatBN7.2	1	2,313,110 - 2,348,820 (+)	NCBI
Rnor_6.0	1	1,937,620 - 1,972,919 (+)	NCBI
Rnor_5.0	1	3,634,641 - 3,669,534 (+)	NCBI

Sequence:

show sequence

CAGTGCAAACAGGAGGACCTGAGTTCTAATCTCCACCATCCAGGCAAAAGCCAGACCATTCTTA
CTTCCTCAGAACCAAATCCTGTGTTCAAAACTCAGCTTAACTCCCTGACTACATCCTTGAGCAA
GTCATTGTTAGGGGTGTACAGAAATCCGAGTCTGCTCTCTGTATAGTGGCGGAATGGTGCGCTG
TGTAGGCCTGGGATCAGACTTGACCTCCTCAGTTAGAGAGAGCTGTCTCTCACTCTACGTAGAC
AACAGTAAAGAGAGCCGTGGAGCCCTTTTCCCACAGAGGTTCATTACTTGTTGGGACTCCTGGT
TTTGTGAATAACTGGCAGAATCCTCCCTGCCCAACCTCCAGGTGCAACTTGTAGCGTCTTTGTC
CTTTCTCCGCTTCCTTCTGACAGTCTGTGGTCGTTTTTTATAGCTGAGCATTAACTTCCCCTAG
GAGCATCTTCAAGCAGATGGGCTTCCCAGGCACCAGGAGTGGGAACTTAGCAGCTGTTCTCACC
CTCTGGATCCAGGGTGCTTTTTCCACTTGAACTCCTGGCCGTCCCGGGAGGAGGCGCGATTGTT
TTGCATGGTGGCTGTACTTTGATTCCGTTGACTGGGGCGGAGGCGTGAACTTCCTACCCCTCAC
TGCTTTCTTCCTTTTCTTTTTAACACAGAGAGTAAGGACCTTTTGCAGCTGAACACGACTAGTG
GCAGGAAGTGGAGCACAGGCATGGATCAGCTTCTAGCAGGGGTGTGGCCTGGGCTTTCTGCCCT
CCTCTGATTCCAGCAACTCCTGAGGGACTGAGCGAGCACTCCCTAGTTGAAAAGAGAGGGTCAG
TGTGAAGGCTCAGGCAGCTGGGCCAAGTCTGCTGGGAGAGCACGAGGGACACACCTGCTGGTGA
GTGCTTGCTGCCCCGCTATCAGTTAACGTGGCAGGCACAGTGCAGACTTCAGTCAAGGGCATGG
GCGAAGGGCATGTTTGAGACAGGTGTGTGAGTGAGGACTGCGCTGAACGCTCTGGTTTCTCACA
CCTGAGAAGCTCTGCTAGGTGTTCAAATTACGGAAATACGCTCATGCCAGTGCAGCTCTGCCAG
GAGGAAGCTCGGGGCAGGAGCCGGGCCAAGCAACAGTTGGCACGATATGGAGCGTCGGGGCAAG
ATGGAATTTTTCCAGAAACTGGGCTACAGCCAGGAGGACGTGGTCAGGGTGCTGGGCAAACTGG
GTGACGGTGCCTTGGTCAATGACGTGCTGCAAGAGTTGATCCAGACCGGCAGCCGCCCAAAGGC
CCAGGAGGATCCAGCCAATGGCACCGGGATAGTGCTCATGCCTCGGGGATGCTGCGGGGTTCGA
GACTCTGCCCAGCAGGGCCTGGGACTAGGCCTAGAAGAGGCTGGCGGAGATCCAGCCAGCTTCC
TGCGGCCCATAGTGATCGATGGCAGCAATGTGGCTATGAGTCATGGAAATAAAGAAGCCTTCTC
TTGCCGGGGAATTCGTCTGGCCGTGGACTGGTTCAGGGACAGAGGACACACCTACATCAAGGTT
TTTGTCCCATCTTGGAGAAAAGAGCCATCAAGGTCTGATACCCCTATCAGAGAACAGCACGTGT
TGGAGGAACTGGAGCGACAGGCTGTGCTGGTGTACACCCCATCCCGCAAGGTGAACGGCAAGCG
AGTGGTCTGCTACGACGATCGCTACATCGTGAAGCTGGCCTATGAGAAGGATGGCGTCATTGTC
TCCAATGACAACTACCGGGACCTGCAGAATGAGAACCCGGAGTGGAAATGGTTCATTGAGCAGC
GGCTACTCATGTTCTCCTTTGTAAATGACAGGTTCATGCCTCCTGATGACCCCCTCGGCCGTCG
AGGACCAACACTAAGCAATTTCCTAAGCAAGAAGCCAAGGCCCCCAGAGCCATCCTGGCAGCAC
TGTCCCTATGGCAAGAAATGCACCTACGGGGTCAAGTGCAGATTCTACCACCCGGAGAGACCAC
ACCAAGGGCAGCTGCCGGTGGCAGACGAACTCCGTGCCAAGACGCGGGCTTGGCCGGGTGGTGG
CGCCGGGGAGTCGCGGCCACCGAGCGCCCGGAGCCGTCCCGGAGCAGCCCGGCCGCTTCCCCTG
GAGCCCGGCGCTCACAACCCCACGCCGGCCCCGCAGCCCGCGGCCCTGACAGCCCTGAACCAGA
GCTTCGCTCGGCTGACCTTCAGCGATACTGCGGCCAGTGGCGTCGTGTCCCTGTCGCGTGGGCC
TGACCGGATGCCCACGAGTGGTCCCACGTCCTGGGCCTCGCCATCCCTTCGCGCGGGCAGCGTT
GCCACCCAAGGGTCGCCGGGTCTGCGGTGCCTCCGGACTCCGAACAGCCTGCTCTCTCCGGGCG
ATCTCGGGTCCCCAATCTGCCCACAGTCCCAGCCATCGGACAGACACTGTTCCAGGGGCATGCA
CAGTGACCTGCCTCCCCAGCGCAGACCGCCGGAAGACCCGTGGGCCTTCCTGCCCAGCTCCTAT
GGTTATTTGAATCACTCGGTTTGGGCTGAGTCGGCTTGGAGCGAGAACACCTTTGGAAGACCTT
CGGGGTCAGCACAATCCACCATCAACAGTGGGGGAACTCGCGCTTCACTCTGCAGCGCCTTCCC
ATCTGACCGAGAGGACCCTGTTATGGCCTCGGATCCTGTGCTCTCAGACGTGGCCCTGCGCACC
CTCCTGCAGAGATCCCAAAAGACTGGTGCTCCGTTGGGGGATCCTTAGGGGACAGGTTCATAAC
ACTGCAAGGGGTGGTGGCCCAGGCTTGACTCTCTGCTTGGGTAGGTGGGATACAAGATGCTTGT
TAATTTGGATGTGTCCCTGCAGTTGAACGACATTTTTTAAAGGTGGTCTCGGTGGGAGCTTTCT
CAATCCTCAGTGGTGGATACCGGTGGGGATCTTGGGGATGCTCTCTGAAGCCAGGGTCTGCTTC
ATGAGCAGGATGATTTCTGATGTATTTGGAAGGCTTTGTCCAGAGCACATCTAAATCCGGTTCT
AACTAGCATCCAAAAATGTTTCAGCTGGTCATCACCGCTAGCCAAGGTGATTGGCCTGAGTTTG
ACATAAACTCTTGGAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTT
TAGAATTCTAGAAAACCAGGAGAACTTAACATGTCGTTGTAGTTGAAAGATTGAAAAAGGCTGG
TAAGTCAGTCTTGACTTTTGTGGTGTCAAATGATGTATAACACATGTTCAGGTGACACAGGAAG
GAAGGAAGGTATTGCTGTCTGGAGTTTTCAAGTCACTATTGCTAATCTCACTCATAGGGGAAAC
TCAGCCTTGTGTAAATTTTACTGTGGGGTTGTCCCAGGGGAACTTGATCCTACGGGTCTCCTCC
CTGGGTTTTTATTCTTTTTGTACATACATACCATATTACCGAAACATCACAACACACACGCACA
CGTACACGCACACAACCTTGCTCAAGACTCAGCCTGGCTTTTTTTTTTTTTTTTTAAATCAGCC
TTCCTTTGTGTGATTCTACAAAATTTAAACTGCACCTTATAGAGATAGGATTTCAATCTACCCA
CCACCCCCTTAAAAAACAACAACAACAACAACAACTCAGCAGTCAACAACAATCCAGGTTGGTC
AGCATAGAGTTGGATTCTGGTAGAGGTTTATTGCAACTTTACTTAGCTGTGTCTTCTAGATAAC
TTCTGCTCTGGGTTTTGTGGGGAGGAGAGGCTCATTCATTCACAAGGGACAAGAAATGATACAG
TGTTGCTGGGGCATGGGCCCAGCATTCTGAGGGAACCCAGCATCTGTAGGCTGCACCCACATGT
TCCAGTTACAACGGCAGCCTGCCAGGTTGTAACTCATTTGTTCCTGAGGGACTTAGTAGTTCAT
TTGGTCAGAGAGAGTCAGAAGGGACCTGCCAATGGGACCTGTTTGCCAAAGCCTCCGAGTTCCT
GCAGTGTGGTAGGCACATTTGGGAAACACCCCTTCATTGCCTCAGGGAAAATGCCGTTGCAGTA
TTCATGGTAAACTTGACTCCTTGGCACCAGGGTAGCCATATGGCTTCCTGGAAGTCCTCCCTCT
TTTAAAACCACCTTCTTAGCATGGCTTCTTGTGGATCTGTTCCTCACACCCTTTTCAAAACGTA
TGCTATTCTCAGACTGTTGCTTCTTATCTTGAGTCCCTGTCCTGAAGAGGGTTTGCTCTTTCTA
GATCTTTTGAAGTTTTTCCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTTCTTTTCATAGGACTCTTAGAGCCGCTGTTTGATTCCCTGGTCTTGTCCCCTGCTTCAA
ATCAATCCATTGCGAATTTACAGTTGGAAATGTTTAAACTGCTTCCTATGAAGACAAGTTTGAG
TTTTAGTAAGCTGTAAAGCTATTTTATTTGGTTCACTGTGATTAAGAAAAAAGGGAAGGAAAAA
AAGAGGTGTGTGTGTGTAGGGGAAAGAAACAACACATCTCAGATGTAATCACCTTTGGAAAATT
CCAAAGTCTTAGTATGTCCTTGTGACACAAAACGGTGGATGAGAGACATAAATGAACTGTCCCT
AGTTGCATAGCTGTTAACCATGCTCCAAAAATAAACCACCTTTTCCACACCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100939	(Get FASTA)	NCBI Sequence Viewer
	XP_006227678	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL93693	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059263.1

RefSeq Acc Id:

NP_001100939 ⟸ NM_001107469

- UniProtKB:

D4A0I4 (UniProtKB/TrEMBL), A6JP21 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERRGKMEFFQKLGYSQEDVVRVLGKLGDGALVNDVLQELIQTGSRPKAQEDPANGTGIVLMPR
GCCGVRDSAQQGLGLGLEEAGGDPASFLRPIVIDGSNVAMSHGNKEAFSCRGIRLAVDWFRDRG
HTYIKVFVPSWRKEPSRSDTPIREQHVLEELERQAVLVYTPSRKVNGKRVVCYDDRYIVKLAYE
KDGVIVSNDNYRDLQNENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRRGPTLSNFLSKKPRPP
EPSWQHCPYGKKCTYGVKCRFYHPERPHQGQLPVADELRAKTRAWPGGGAGESRPPSARSRPGA
ARPLPLEPGAHNPTPAPQPAALTALNQSFARLTFSDTAASGVVSLSRGPDRMPTSGPTSWASPS
LRAGSVATQGSPGLRCLRTPNSLLSPGDLGSPICPQSQPSDRHCSRGMHSDLPPQRRPPEDPWA
FLPSSYGYLNHSVWAESAWSENTFGRPSGSAQSTINSGGTRASLCSAFPSDREDPVMASDPVLS
DVALRTLLQRSQKTGAPLGDP

hide sequence

RefSeq Acc Id:	XP_006227678 ⟸ XM_006227616
- Peptide Label:	isoform X1
- UniProtKB:	D4A0I4 (UniProtKB/TrEMBL), A6JP21 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERRGKMEFFQKLGYSQEDVVRVLGKLGDGALVNDVLQELIQTGSRPKAQEDPANGTGIVLMPR GCCGVRDSAQQGLGLGLEEAGGDPASFLRPIVIDGSNVAMSHGNKEAFSCRGIRLAVDWFRDRG HTYIKVFVPSWRKEPSRSDTPIREQHVLEELERQAVLVYTPSRKVNGKRVVCYDDRYIVKLAYE KDGVIVSNDNYRDLQNENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRRGPTLSNFLSKKPRPP EPSWQHCPYGKKCTYGVKCRFYHPERPHQGQLPVADELRAKTRAWPGGGAGESRPPSARSRPGA ARPLPLEPGAHNPTPAPQPAALTALNQSFARLTFSDTAASGVVSLSRGPDRMPTSGPTSWASPS LRAGSVATQGSPGLRCLRTPNSLLSPGDLGSPICPQSQPSDRHCSRGMHSDLPPQRRPPEDPWA FLPSSYGYLNHSVWAESAWSENTFGRPSGSAQSTINSGGTRASLCSAFPSDREDPVMASDPVLS DVALRTLLQRSQKTGAPLGDP hide sequence

Ensembl Acc Id:

ENSRNOP00000059263 ⟸ ENSRNOT00000065646

Protein Domains

C3H1-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A0I4-F1-model_v2	AlphaFold	D4A0I4	1-533	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1597152	AgrOrtholog
BioCyc Gene	G2FUF-62444	BioCyc
Ensembl Genes	ENSRNOG00000016041	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065646.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.11980	UniProtKB/TrEMBL
InterPro	Rege-1_UBA-like	UniProtKB/TrEMBL
	RNase_Zc3h12	UniProtKB/TrEMBL
	ZC3H12/N4BP1_RNase_Reg	UniProtKB/TrEMBL
	Znf_CCCH	UniProtKB/TrEMBL
KEGG Report	rno:308266	UniProtKB/TrEMBL
NCBI Gene	308266	ENTREZGENE
PANTHER	N4BP1-RELATED	UniProtKB/TrEMBL
	RIBONUCLEASE ZC3H12D-RELATED	UniProtKB/TrEMBL
Pfam	RNase_Zc3h12a	UniProtKB/TrEMBL
	UBA_6	UniProtKB/TrEMBL
PhenoGen	Zc3h12d	PhenoGen
PROSITE	ZF_C3H1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016041	RatGTEx
UniProt	A6JP21	ENTREZGENE, UniProtKB/TrEMBL
	D4A0I4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Zc3h12d	zinc finger CCCH type containing 12D	LOC308266	similar to zinc finger CCCH-type containing 12D	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC308266	similar to zinc finger CCCH-type containing 12D			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD