Garem2 (GRB2 associated regulator of MAPK1 subtype 2) - Rat Genome Database

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Gene: Garem2 (GRB2 associated regulator of MAPK1 subtype 2) Rattus norvegicus
Analyze
Symbol: Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
RGD ID: 1597138
Description: Predicted to act upstream of or within several processes, including cognition; neuron projection extension; and social behavior. Orthologous to human GAREM2 (GRB2 associated regulator of MAPK1 subtype 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam59b; family with sequence similarity 59, member B; Gareml; GRB2 associated regulator of MAPK1, member 2; GRB2 associated, regulator of MAPK1-like; GRB2-associated and regulator of MAPK protein 2; GRB2-associated and regulator of MAPK protein-like; hypothetical LOC362801; LOC362801
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,949,877 - 31,961,591 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,949,877 - 31,961,790 (-)EnsemblGRCr8
mRatBN7.2626,228,965 - 26,255,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,230,048 - 26,241,762 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx626,522,683 - 26,534,395 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,838,563 - 26,850,275 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,316,987 - 26,328,707 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,631,364 - 27,643,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,631,364 - 27,643,076 (-)Ensemblrn6Rnor6.0
Rnor_5.0637,442,035 - 37,453,747 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera625,706,997 - 25,718,643 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23376485  


Genomics

Comparative Map Data
Garem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,949,877 - 31,961,591 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,949,877 - 31,961,790 (-)EnsemblGRCr8
mRatBN7.2626,228,965 - 26,255,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,230,048 - 26,241,762 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx626,522,683 - 26,534,395 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,838,563 - 26,850,275 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,316,987 - 26,328,707 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,631,364 - 27,643,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,631,364 - 27,643,076 (-)Ensemblrn6Rnor6.0
Rnor_5.0637,442,035 - 37,453,747 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera625,706,997 - 25,718,643 (-)NCBICelera
Cytogenetic Map6q14NCBI
GAREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,173,088 - 26,204,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,173,088 - 26,189,663 (+)Ensemblhg38GRCh38
GRCh37226,395,957 - 26,412,532 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,248,519 - 26,266,169 (+)NCBIBuild 36Build 36hg18NCBI36
Celera226,236,190 - 26,252,761 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,135,335 - 26,148,315 (+)NCBIHuRef
CHM1_1226,325,865 - 26,342,455 (+)NCBICHM1_1
T2T-CHM13v2.0226,208,391 - 26,239,634 (+)NCBIT2T-CHM13v2.0
Garem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,310,194 - 30,323,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,310,159 - 30,323,376 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38530,105,196 - 30,118,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,105,161 - 30,118,378 (+)Ensemblmm10GRCm38
MGSCv37530,431,736 - 30,444,920 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36530,435,989 - 30,449,769 (+)NCBIMGSCv36mm8
Celera527,622,719 - 27,635,917 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.92NCBI
Garem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,171,714 - 8,181,052 (+)Ensembl
ChiLan1.0NW_0049554698,170,914 - 8,182,193 (+)NCBIChiLan1.0ChiLan1.0
GAREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,328,914 - 100,345,547 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,332,883 - 100,349,515 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,168,328 - 26,184,967 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,262,295 - 26,278,789 (+)NCBIPanPan1.1PanPan1.1panPan2
GAREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,291,845 - 20,306,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,291,599 - 20,304,814 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1720,187,030 - 20,201,761 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01720,614,033 - 20,628,768 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,613,745 - 20,627,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,300,650 - 20,315,404 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,310,380 - 20,325,137 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,358,375 - 20,373,108 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Garem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,598,087 - 64,613,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,225,853 - 6,241,478 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,227,183 - 6,241,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,800,719 - 112,805,740 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13112,799,350 - 112,817,583 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,784,588 - 119,802,837 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,469,614 - 81,486,103 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,471,013 - 81,485,979 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604530,671,411 - 30,687,961 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Garem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,324,155 - 8,336,773 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247388,324,097 - 8,337,274 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Garem2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1723,920,142 - 23,932,891 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Garem2
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:64
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000074348
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 66 162 75 74 43 83 43 6 326 182 11 140 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074348   ⟹   ENSRNOP00000066748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,949,877 - 31,961,790 (-)Ensembl
mRatBN7.2 Ensembl626,230,048 - 26,241,762 (-)Ensembl
Rnor_6.0 Ensembl627,631,364 - 27,643,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157274   ⟹   ENSRNOP00000101887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,949,877 - 31,961,790 (-)Ensembl
RefSeq Acc Id: NM_001191874   ⟹   NP_001178803
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,949,877 - 31,961,591 (-)NCBI
mRatBN7.2626,230,048 - 26,241,762 (-)NCBI
Rnor_6.0627,631,364 - 27,643,076 (-)NCBI
Rnor_5.0637,442,035 - 37,453,747 (-)NCBI
Celera625,706,997 - 25,718,643 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178803 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066748
  ENSRNOP00000066748.1
  ENSRNOP00000101887.1
RefSeq Acc Id: NP_001178803   ⟸   NM_001191874
- UniProtKB: M0RB26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066748   ⟸   ENSRNOT00000074348
Ensembl Acc Id: ENSRNOP00000101887   ⟸   ENSRNOT00000157274
Protein Domains
CABIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RB26-F1-model_v2 AlphaFold M0RB26 1-879 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597138 AgrOrtholog
BioCyc Gene G2FUF-38301 BioCyc
Ensembl Genes ENSRNOG00000048004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074348 ENTREZGENE
  ENSRNOT00000074348.3 UniProtKB/TrEMBL
  ENSRNOT00000157274.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
InterPro CABIT_dom UniProtKB/TrEMBL
  GAREM UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
KEGG Report rno:362801 UniProtKB/TrEMBL
NCBI Gene 362801 ENTREZGENE
PANTHER GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 2 UniProtKB/TrEMBL
  GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam CABIT UniProtKB/TrEMBL
PhenoGen Garem2 PhenoGen
RatGTEx ENSRNOG00000048004 RatGTEx
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
UniProt A0ABK0LG65_RAT UniProtKB/TrEMBL
  M0RB26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-14 Garem2  GRB2 associated regulator of MAPK1 subtype 2  Garem2  GRB2 associated regulator of MAPK1, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Garem2  GRB2 associated regulator of MAPK1, member 2  Gareml  GRB2 associated, regulator of MAPK1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-12-10 Gareml  GRB2 associated, regulator of MAPK1-like  Fam59b  family with sequence similarity 59, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Fam59b  family with sequence similarity 59, member B  LOC362801  hypothetical LOC362801  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC362801  hypothetical LOC362801      Symbol and Name status set to provisional 70820 PROVISIONAL