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Gene: Mad1l1 (mitotic arrest deficient 1 like 1) Rattus norvegicus

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Symbol:

Mad1l1

Name:

mitotic arrest deficient 1 like 1

RGD ID:

1596881

Description:

Predicted to enable identical protein binding activity and kinetochore binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; regulation of metaphase plate congression; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within negative regulation of T cell proliferation; regulation of mitotic cell cycle phase transition; and thymus development. Predicted to be located in cytoplasm; mitotic spindle pole; and nucleus. Predicted to be part of MAD1 complex; mitotic spindle assembly checkpoint MAD1-MAD2 complex; and nuclear pore nuclear basket. Predicted to be active in kinetochore; mitotic spindle; and nuclear envelope. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC680006; MAD1 mitotic arrest deficient like 1; MAD1 mitotic arrest deficient-like 1; MAD1 mitotic arrest deficient-like 1 (yeast); mitotic arrest deficient 1-like 1; mitotic spindle assembly checkpoint protein MAD1; similar to Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAD1L1 (mitotic arrest deficient 1 like 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mad1l1 (MAD1 mitotic arrest deficient 1-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mad1l1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAD1L1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAD1L1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mad1l1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MAD1L1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAD1L1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mad1l1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mad1l1 (mitotic arrest deficient 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAD1L1 (mitotic arrest deficient 1 like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mad1l1 (MAD1 mitotic arrest deficient 1-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mad1l1 (mitotic arrest deficient 1 like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAD1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	MAD1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Mad1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdf-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	mdf-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mad1l1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mad1l1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	19,434,782 - 19,744,574 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	19,434,746 - 19,744,567 (+)	Ensembl				GRCr8
mRatBN7.2	12	14,320,892 - 14,630,750 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	14,320,892 - 14,630,703 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	15,128,699 - 15,439,478 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	15,752,197 - 16,062,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	14,778,908 - 15,089,705 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	16,410,083 - 16,721,232 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	16,410,083 - 16,719,824 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	18,402,692 - 18,711,591 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	14,793,899 - 15,107,476 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	16,079,638 - 16,388,296 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Familial Prostate Cancer (ISO)

juvenile rheumatoid arthritis (ISO)

lymphoma (ISO)

mosaic variegated aneuploidy syndrome 1 (ISO)

mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition (ISO)

prostate cancer (ISO)

Prostate Cancer, Somatic (ISO)

Prostatic Neoplasms (ISO)

Testicular Germ Cell Tumor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

genistein (ISO)

ivermectin (ISO)

melatonin (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

N,N-diethyl-m-toluamide (EXP)

Nor-9-carboxy-delta9-THC (ISO)

O-methyleugenol (EXP,ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

phenobarbital (EXP,ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

promethazine (EXP)

quercetin (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chromate (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

topotecan (EXP)

trametinib (ISO)

triadimefon (EXP)

triclosan (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (IBA)

cell division (IEA)

deactivation of mitotic spindle assembly checkpoint (ISO)

mitotic spindle assembly checkpoint signaling (IBA,IEA,ISO)

negative regulation of T cell proliferation (ISO)

positive regulation of mitotic cell cycle spindle assembly checkpoint (IEA,ISO)

regulation of metaphase plate congression (IEA,ISO)

regulation of mitotic cell cycle phase transition (ISO)

thymus development (ISO)

Cellular Component

cytoplasm (IEA,ISO)

kinetochore (IBA,IEA,ISO)

MAD1 complex (ISO)

mitotic spindle (IBA,IEA,ISO)

mitotic spindle assembly checkpoint MAD1-MAD2 complex (ISO)

mitotic spindle pole (IEA,ISO)

nuclear envelope (IBA,IEA,ISO)

nuclear membrane (IEA,ISO)

nuclear pore nuclear basket (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

spindle pole (IEA,ISO)

Molecular Function

kinetochore binding (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9130602	PMID:11313860	PMID:16189514	PMID:17363900	PMID:17504913	PMID:17938250	PMID:18981471	PMID:20133940	PMID:21558374	PMID:22351768	PMID:22493223	PMID:27107012

Genomics

Comparative Map Data

Mad1l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	19,434,782 - 19,744,574 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	19,434,746 - 19,744,567 (+)	Ensembl				GRCr8
mRatBN7.2	12	14,320,892 - 14,630,750 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	14,320,892 - 14,630,703 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	15,128,699 - 15,439,478 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	15,752,197 - 16,062,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	14,778,908 - 15,089,705 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	16,410,083 - 16,721,232 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	16,410,083 - 16,719,824 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	18,402,692 - 18,711,591 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	14,793,899 - 15,107,476 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	16,079,638 - 16,388,296 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

MAD1L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	1,815,795 - 2,232,945 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	1,815,787 - 2,233,243 (-)	Ensembl			hg38	GRCh38
GRCh37	7	1,855,431 - 2,272,580 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	1,821,954 - 2,239,109 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	1,628,673 - 2,043,593	NCBI
Celera	7	1,824,029 - 2,242,272 (-)	NCBI		Celera
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	1,775,090 - 2,191,874 (-)	NCBI		HuRef
CHM1_1	7	1,855,013 - 2,272,150 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	1,928,871 - 2,346,389 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	1,908,333 - 2,321,257 (-)	NCBI

Mad1l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	139,994,444 - 140,307,346 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	139,994,444 - 140,307,307 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	140,008,689 - 140,321,608 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	140,008,689 - 140,321,552 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	140,484,643 - 140,797,506 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	140,261,163 - 140,574,024 (-)	NCBI		MGSCv36	mm8
Celera	5	137,065,976 - 137,380,304 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	78.82	NCBI

Mad1l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	9,340,681 - 9,672,134 (-)	Ensembl
ChiLan1.0	NW_004955460	9,340,728 - 9,672,478 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAD1L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	6,773,465 - 7,199,146 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	55,098,168 - 55,523,724 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	2,070,299 - 2,502,471 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	2,187,104 - 2,604,168 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	2,187,104 - 2,601,328 (-)	Ensembl			panPan2	panpan1.1

MAD1L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	14,889,126 - 15,236,194 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	14,882,875 - 15,236,192 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	16,351,128 - 16,704,460 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	15,015,423 - 15,362,579 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	15,014,693 - 15,362,577 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	14,818,674 - 15,165,656 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	14,745,470 - 15,092,432 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	15,033,169 - 15,380,211 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mad1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	143,053,218 - 143,167,762 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936754	1,842,588 - 1,957,116 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAD1L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	1,236,076 - 1,559,041 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	1,236,066 - 1,559,346 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	1,859,406 - 1,883,565 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAD1L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	19,358,942 - 19,768,079 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	19,359,233 - 19,768,078 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	1,956,015 - 2,370,489 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mad1l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	27,174,354 - 27,523,492 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	27,174,450 - 27,523,366 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mad1l1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	12,874,290 - 13,182,424 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mad1l1
4404 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	130
Count of miRNA genes:	100
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000001709
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

D12Got30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	14,463,967 - 14,464,125 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	16,553,097 - 16,553,251	NCBI	Rnor6.0
Rnor_5.0	12	18,544,968 - 18,545,122	UniSTS	Rnor5.0
RGSC_v3.4	12	14,940,432 - 14,940,590	RGD	RGSC3.4
RGSC_v3.4	12	14,940,433 - 14,940,590	UniSTS	RGSC3.4
Celera	12	16,222,308 - 16,222,465	UniSTS
RGSC_v3.1	12	14,970,361 - 14,970,518	RGD
RH 3.4 Map	12	224.9	UniSTS
RH 3.4 Map	12	224.9	RGD
RH 2.0 Map	12	168.7	RGD
Cytogenetic Map	12	q11	UniSTS

RH130878

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	14,630,527 - 14,630,680 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	16,719,649 - 16,719,801	NCBI	Rnor6.0
Rnor_5.0	12	18,711,416 - 18,711,568	UniSTS	Rnor5.0
RGSC_v3.4	12	15,107,301 - 15,107,453	UniSTS	RGSC3.4
Celera	12	16,388,121 - 16,388,273	UniSTS
RH 3.4 Map	12	239.1	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001709 ⟹ ENSRNOP00000001709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	19,434,917 - 19,725,946 (+)	Ensembl
mRatBN7.2 Ensembl	12	14,320,892 - 14,630,703 (+)	Ensembl
Rnor_6.0 Ensembl	12	16,410,083 - 16,719,824 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114435 ⟹ ENSRNOP00000087168

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	19,434,746 - 19,744,567 (+)	Ensembl
mRatBN7.2 Ensembl	12	14,321,013 - 14,630,703 (+)	Ensembl

RefSeq Acc Id:

NM_001109387 ⟹ NP_001102857

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	19,434,782 - 19,744,574 (+)	NCBI
mRatBN7.2	12	14,320,892 - 14,630,703 (+)	NCBI
Rnor_6.0	12	16,410,083 - 16,719,824 (+)	NCBI
Rnor_5.0	12	18,402,692 - 18,711,591 (+)	NCBI
RGSC_v3.4	12	14,793,899 - 15,107,476 (+)	RGD
Celera	12	16,079,638 - 16,388,296 (+)	RGD

Sequence:

show sequence

GGGAGATCTGAGCCGCTGCTGCAGCACTCGGCTCCTCAACTCGGGAGGGTGACCATGGAAGACC
TTGGGGAGAACACCACAGTCCTGTCCACCCTGAGATCTCTCAACAACTTCATTTCTCAGCGAAT
GGAGGGAGCATCAGGCTTGGATGTGTCCACATCTGCCTCAGGGTCCCTACAGAAGCAGTATGAA
CAGAACATGCAGCTGGAGGAGAGAGCAGAGCAGATCCGTTCAAAGTCCTACCTCATCCAGGTGG
AGCGGGAGAAGATGCAGATGGAGCTGAGCCACAAGAGGGCTCGGGTGGAGCTGGAGAGAGCGGC
CAGCACCAATGCCAGGAACTATGAGCGCGAGGTGGATCGCAACCAGGAACTCCTGGCACGCATT
CGGCAGCTCCAGGAGCGTGAGGCCGCAGCAGAAGAGAAGATGCGGGAGCAGCTGGAGCGCCACA
GGCTGTGCAAGCAGAGCCTGGACGCTGCCAGTCAGCAGCTGCGGGAACGAGAGGATGGCCTGGC
TGCAGCCAGGGAGACGATTAGTTCATTGAAGGGGCGAGTCTCCGAGCTGCAGTTGAGTGCGATG
GACCAGAAGGTACAGGTCAAGCGCCTGGAGTCTGAGAAGCAGGAGCTGAAGGAGCAGCTGGAAC
TGCAGCAGCGGAAATGGCAGGAGGCAAATCAGAAGATCCAGGAGCTACAGGCCAGTCAAGAAGA
GAGAACTGACCAGGAGCAGAAGATTAAGGACCTGGAGCAGAAGCTGTGTCTGCAAGAGCAGGAT
GCAGCTGTGGTGAAGAGCATGAAATCTGAGCTGTTGCGACTGCCTCGGATGGAGCGTGAGCTAA
AGAGGCTGCGTGAGGAGAACACTCATCTAAGGGAGATGAGGGAGACCAATGGGCTGCTCACAGA
GGAGCTGGAAGGTCTGCAGAGGAAGCTGGGCCGCCAGGAGAAGATGCAGGAAGCTCTGGTTGAT
CTGGAGTTGGAGAAGGAGAAGCTGCTTGCAAAGCTGCAGAGCTGGGAGAAACTGGACCAGACCA
TGGGCTTGAATCTCAGGACTCCAGAGGACCTTTCGAGGTTCGTGATTGAGCTGCAGCAGCGAGA
GCTGGCGCTGAAGGAGAAGAATAGCAGCATCACCAGCAGTGCCCGGGGTCTGGAGAAGGCCCAG
CAGCAGCTCCAGGATGAGGTCCGGCAGGTCAATGCACAGCTGCTGGAAGAGAGGAAGAAGAGGG
AGACACATGAGGCACTTGCCCGAAGGCTCCAGAAGCGCAATGCATTGCTGACCAAGGAGCGAGA
CGGCATGCGCGCCATCCTGGGATCCTACGACAGTGAGCTGACCCAAGCTGAGTACTCGCCCCAG
CTTACACAGCGCATGTGGGAGGCTGAGGACATGGTTCAGAAGGTGCATGCCCACAGCTCAGAGA
TGGAGGCTCAGCTGTCTCAGGCCCTGGAAGAGCTTGGGGTTCAGAAGCAGAGAGCTGACACGCT
GGAGATGGAGTTGAAGATGCTGAGGGCCCAGACAAGCTCAGCCGAAGCCAGCTTCCCATTCTGC
AAAGAGGAGGTGGATGCACTCAGGTTGAAGGTGGAGGAGCTGGAGGGTGAGCGGAGCCGTCTGG
AACAGGAAAAGCAGGCTCTGGAGATGCAGATGGAGAGACTAACCCTACAGGGTGACTACAACCA
GAGTCGAACCAAAGTGCTACACATGAGCCTGAACCCGGCTAGCATGGCCAGGCAGCGCCAGCGT
GAGGACCATGACCGGCTGCAGGAGGAATGCGAGCGCTTACGGGGACTTGTGCATGCCCTAGAGA
GAGGCGGTCCCATCCCTGCTGACCTGGAGGCTGCCTCCAGCCTGCCCTCATCCAAGGAGGTGGC
AGAGCTGCGGAAGCAGGTAGAAAGCGCTGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTCCAG
ACCAAGATCCAGGAGTTCCGCAAGGTTTGCTACACACTGACCGGCTACCAGATTGACGTGACCA
CTGAGAGCCAATACCGCCTCACCTCCCGATATGCTGAGCACCAGACTGACTGCCTCATCTTCAA
GGCCACAGGACCCTCGGGCTCCAAAATGCAGCTGCTGGAGACGGAGTTCTCCCGTTCAGTGCCT
GAGCTCATTGAGCTGCACCTGCTGCAGCAGGACAGCATCCCTGCCTTCCTCAGCGCGCTCACCA
TAGAGCTGTTCAGCCGCCAGACCTCTGTCTAGCCTCTTCCCATGAGCATCCACGCCTACAGCCA
CTGGACCTCGGCCTAGCCTATACCTGCAGCGTCTCACATGCAACCCTCAGACCTTGGCCTAGCT
CTTGGTCTTCCAGACAGTTACCCACATGTCCCCAAACCCCTTTGCTACCCATAGCTGCATCATG
TCACAAACACCATTCTTGTCCCTGGCCAGCAGGAGCAAGCTGCTGGGGATGACCAAGCCAGATC
ACACCCCACCATTCTCCTCTCCTCCCCACCCCATCGAGTTCTAGGGCTGTACTGTCCCAAGGTG
TGCCCGTACCGGCCCATGTGCTGGTTGCTTATGTCACTTTGGTGGCCAGACTGTGGCCTGCGTC
CACAGTCCCAGCCTGATGAAATAAAGTGCTACATTTATCTTCCCTCCCGGGA

hide sequence

RefSeq Acc Id:

XM_017598453 ⟹ XP_017453942

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	19,455,411 - 19,744,565 (+)	NCBI
mRatBN7.2	12	14,341,507 - 14,630,750 (+)	NCBI
Rnor_6.0	12	16,430,280 - 16,721,232 (+)	NCBI

Sequence:

show sequence

TCAGTCTGTGCAGCTTCCTATACTAAGCAGGGGTGGAGGCAGTCCTGTCACTCACAGACCTTCC
TGCCTAGAGGATGCATGCTGATTGTCTCGTGGATGCCAGGCCCTGTGCTGGCTCCTTGGGAGGC
CAAGTGAGTACTCAAGTGCTCAAGTGTCCCAGTGATGAAGACCCACAAGAAATCCACGGGAAAA
GGCTAACACAGAGGACTGCAATCTAGGGTTAGAGAGGTGTGCATAGGATACAACTGTGAGCCTA
GCCTGTTGAGGCTGAGATGAGAGGATCATGAGTTTGAGACCAGGTATTCCATGAAGTAGGTTTA
GAGGGGGTAGAGCATGGCTGAGCTAGGTCACCAGGCCAGGGCTGTTGATTTAAGTTCAGCCTCC
TTTATTACAGTGAATGTCGTTGGAGAGGTGGTGCCTTGAGCTTCCTTCCATGGTTTCCTGTTGT
CTTTAGTGTGATAACCAGTCCCAGGAAGGAGGACCTGGAGCAGAAGCTGTGTCTGCAAGAGCAG
GATGCAGCTGTGGTGAAGAGCATGAAATCTGAGCTGTTGCGACTGCCTCGGATGGAGCGTGAGC
TAAAGAGGCTGCGTGAGGAGAACACTCATCTAAGGGAGATGAGGGAGACCAATGGGCTGCTCAC
AGAGGAGCTGGAAGGTCTGCAGAGGAAGCTGGGCCGCCAGGAGAAGATGCAGGAAGCTCTGGTT
GATCTGGAGTTGGAGAAGGAGAAGCTGCTTGCAAAGCTGCAGAGCTGGGAGAAACTGGACCAGA
CCATGGGCTTGAATCTCAGGACTCCAGAGGACCTTTCGAGGTTCGTGATTGAGCTGCAGCAGCG
AGAGCTGGCGCTGAAGGAGAAGAATAGCAGCATCACCAGCAGTGCCCGGGGTCTGGAGAAGGCC
CAGCAGCAGCTCCAGGATGAGGTCCGGCAGGTCAATGCACAGCTGCTGGAAGAGAGGAAGAAGA
GGGAGACACATGAGGCACTTGCCCGAAGGCTCCAGAAGCGCAATGCATTGCTGACCAAGGAGCG
AGACGGCATGCGCGCCATCCTGGGATCCTACGACAGTGAGCTGACCCAAGCTGAGTACTCGCCC
CAGCTTACACAGCGCATGTGGGAGGCTGAGGACATGGTTCAGAAGGTGCATGCCCACAGCTCAG
AGATGGAGGCTCAGCTGTCTCAGGCCCTGGAAGAGCTTGGGGTTCAGAAGCAGAGAGCTGACAC
GCTGGAGATGGAGTTGAAGATGCTGAGGGCCCAGACAAGCTCAGCCGAAGCCAGCTTCCCATTC
TGCAAAGAGGAGGTGGATGCACTCAGGTTGAAGGTGGAGGAGCTGGAGGGTGAGCGGAGCCGTC
TGGAACAGGAAAAGCAGGCTCTGGAGATGCAGATGGAGAGACTAACCCTACAGGGTGACTACAA
CCAGAGTCGAACCAAAGTGCTACACATGAGCCTGAACCCGGCTAGCATGGCCAGGCAGCGCCAG
CGTGAGGACCATGACCGGCTGCAGGAGGAATGCGAGCGCTTACGGGGACTTGTGCATGCCCTAG
AGAGAGGCGGTCCCATCCCTGCTGACCTGGAGGCTGCCTCCAGCCTGCCCTCATCCAAGGAGGT
GGCAGAGCTGCGGAAGCAGGTAGAAAGCGCTGAGCTGAAGAACCAGCGGCTCAAGGAGGTTTTC
CAGACCAAGATCCAGGAGTTCCGCAAGGTTTGCTACACACTGACCGGCTACCAGATTGACGTGA
CCACTGAGAGCCAATACCGCCTCACCTCCCGATATGCTGAGCACCAGACTGACTGCCTCATCTT
CAAGGCCACAGGACCCTCGGGCTCCAAAATGCAGCTGCTGGAGACGGAGTTCTCCCGTTCAGTG
CCTGAGCTCATTGAGCTGCACCTGCTGCAGCAGGACAGCATCCCTGCCTTCCTCAGCGCGCTCA
CCATAGAGCTGTTCAGCCGCCAGACCTCTGTCTAGCCTCTTCCCATGAGCATCCACGCCTACAG
CCACTGGACCTCGGCCTAGCCTATACCTGCAGCGTCTCACATGCAACCCTCAGACCTTGGCCTA
GCTCTTGGTCTTCCAGACAGTTACCCACATGTCCCCAAACCCCTTTGCTACCCATAGCTGCATC
ATGTCACAAACACCATTCTTGTCCCTGGCCAGCAGGAGCAAGCTGCTGGGGATGACCAAGCCAG
ATCACACCCCACCATTCTCCTCTCCTCCCCACCCCATCGAGTTCTAGGGCTGTACTGTCCCAAG
GTGTGCCCGTACCGGCCCATGTGCTGGTTGCTTATGTCACTTTGGTGGCCAGACTGTGGCCTGC
GTCCACAGTCCCAGCCTGATGAAATAAAGTGCTACATTTATCTTCCCTCCCGGGACTGTGGCCA
AGGCTGTTCAGGCCTCACCACTGTGCTATGCTTCCCAACACCTGGCAGGTCTGTTCATACACGC
AGCCGAAAGGGACAGGCAGATGGGGTTGGAATGCTAGTGTCCCATCCCTCTGAGCCTGGGTGTC
TCATTCCCTGCCTTGGTTTCTTCCCTGCCTGCCCCTCCCCAAACCCCCGTGCGAGGCCTCTGAG
TCCAGTGGGTGAGCCTCCCTTGCTAGCTCCCCCTGCAAGGGGCCTCACCAAGCCCAGCCATCCA
TACCACTGCAAGTGTCCTGATTAACAGGTTTTCTTAGGCAGAGGTGGAGAGGTGAGGGCCTGAG
TTGGGGATGTATGTGTCTGGGCACCTGATCATGTGTCCCTCATGTGTTGATGACCTGTCACCTG
AGTGTATCATAGCCTCCTCACATGCCTTCAAGAAAATGGAAGTGAGACAGCCTGCTGGGAACGC
TCAGGCTTGGGCCAGAGAAAATTTTACTTGTGGCAGCCCCAGGCTTACACCAGCTCGTCACTGG
GCCCCCACTGATAAATGGGTCTTAAGCTGCTAATGACTCACTTTAAGGGATTAGTGGCATGGTG
ACAAGCGTCACAGCCAGGAGGTAACAGGATTTGCTATGTCCAGGCCTCCAGCTCCCCTACCAGG
GGACCCCTGCTGCCCCCACCTCCTCCCATCGAGCTCAGCTGGAGCAACTAGTTCTGCCATGACT
GAGTTCTTTATTGCCTTGTCCTTTGTTGCCTGGTGCAAGGCCCTCTGGGATATACAGATTGTGG
GTATTTCTCCAGCTCCTGGCCCATCCCAGGGACCTCCAGGCTGTTCCCAGGCAGGAATGAACAG
CCTCCCAGGGCACCCTCAGAATCCCCCAGCAGCCAGCGGGGACTGGTTGCACCCAGCTCTCTGC
TCGCTCTCTTCCATGTCAAGCTGGCCTTCCAGCTGGGTGGCATCAGGCTACAGGTTAGGGATGA
AGGGGTCCTGCTCCAGTCAGCTGTGGGTCTGGACTCAAACCCAGCTCTCCAAGCTACCTGGCTT
CAGAGTCATATGAATGGTCCTTCCTGCGGTGCTTATGTGTGCTTGCGATCTGAGTAGTACTTCT
GCCCAGAAAAGGATGTGCCCACCCAACACACACACACATACAGAGGGGTAGGGAGGAGACACCA
AGTGGGAGCAAGGAGCCCCGGCGAGGCCTATATTTATACCCGCTTTCTGGTTAACTGTACAACT
TGAATATCATTAAAGCAAAACGAATAAACCTCCAAAGAGACAGGAGGTGAGGGAAGGAGAGCCC
CTCCCCTGGCTCCCAGCCAGCCTCCAGCCTGGTGGGCGGACCTGCACACCTCGTGTGTGGATGG
GTGAGAGTGCCCAGGTTTGTTTCGTCAGATTCTGTACAGGAGTTTTTAATAACTG

hide sequence

RefSeq Acc Id:

XM_063271650 ⟹ XP_063127720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	19,434,877 - 19,744,565 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102857	(Get FASTA)	NCBI Sequence Viewer
	XP_017453942	(Get FASTA)	NCBI Sequence Viewer
	XP_063127720	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89740	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001709.5
	ENSRNOP00000087168
	ENSRNOP00000087168.2

RefSeq Acc Id:

NP_001102857 ⟸ NM_001109387

- UniProtKB:

D3ZIV3 (UniProtKB/TrEMBL), A6K1T2 (UniProtKB/TrEMBL), A0A8I6A596 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDLGENTTVLSTLRSLNNFISQRMEGASGLDVSTSASGSLQKQYEQNMQLEERAEQIRSKSYL
IQVEREKMQMELSHKRARVELERAASTNARNYEREVDRNQELLARIRQLQEREAAAEEKMREQL
ERHRLCKQSLDAASQQLREREDGLAAARETISSLKGRVSELQLSAMDQKVQVKRLESEKQELKE
QLELQQRKWQEANQKIQELQASQEERTDQEQKIKDLEQKLCLQEQDAAVVKSMKSELLRLPRME
RELKRLREENTHLREMRETNGLLTEELEGLQRKLGRQEKMQEALVDLELEKEKLLAKLQSWEKL
DQTMGLNLRTPEDLSRFVIELQQRELALKEKNSSITSSARGLEKAQQQLQDEVRQVNAQLLEER
KKRETHEALARRLQKRNALLTKERDGMRAILGSYDSELTQAEYSPQLTQRMWEAEDMVQKVHAH
SSEMEAQLSQALEELGVQKQRADTLEMELKMLRAQTSSAEASFPFCKEEVDALRLKVEELEGER
SRLEQEKQALEMQMERLTLQGDYNQSRTKVLHMSLNPASMARQRQREDHDRLQEECERLRGLVH
ALERGGPIPADLEAASSLPSSKEVAELRKQVESAELKNQRLKEVFQTKIQEFRKVCYTLTGYQI
DVTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFSRSVPELIELHLLQQDSIPAFLS
ALTIELFSRQTSV

hide sequence

RefSeq Acc Id:

XP_017453942 ⟸ XM_017598453

- Peptide Label:

isoform X2

- Sequence:

show sequence

MKSELLRLPRMERELKRLREENTHLREMRETNGLLTEELEGLQRKLGRQEKMQEALVDLELEKE
KLLAKLQSWEKLDQTMGLNLRTPEDLSRFVIELQQRELALKEKNSSITSSARGLEKAQQQLQDE
VRQVNAQLLEERKKRETHEALARRLQKRNALLTKERDGMRAILGSYDSELTQAEYSPQLTQRMW
EAEDMVQKVHAHSSEMEAQLSQALEELGVQKQRADTLEMELKMLRAQTSSAEASFPFCKEEVDA
LRLKVEELEGERSRLEQEKQALEMQMERLTLQGDYNQSRTKVLHMSLNPASMARQRQREDHDRL
QEECERLRGLVHALERGGPIPADLEAASSLPSSKEVAELRKQVESAELKNQRLKEVFQTKIQEF
RKVCYTLTGYQIDVTTESQYRLTSRYAEHQTDCLIFKATGPSGSKMQLLETEFSRSVPELIELH
LLQQDSIPAFLSALTIELFSRQTSV

hide sequence

Ensembl Acc Id:

ENSRNOP00000001709 ⟸ ENSRNOT00000001709

Ensembl Acc Id:

ENSRNOP00000087168 ⟸ ENSRNOT00000114435

RefSeq Acc Id:	XP_063127720 ⟸ XM_063271650
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A596 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZIV3-F1-model_v2	AlphaFold	D3ZIV3	1-717	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698458

Promoter ID:

EPDNEW_R8983

Type:

initiation region

Name:

Mad1l1_1

Description:

mitotic arrest deficient 1 like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	16,410,086 - 16,410,146	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1596881	AgrOrtholog
BioCyc Gene	G2FUF-19910	BioCyc
Ensembl Genes	ENSRNOG00000001265	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001709.7	UniProtKB/TrEMBL
	ENSRNOT00000114435	ENTREZGENE
	ENSRNOT00000114435.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	3.30.457.60	UniProtKB/TrEMBL
	6.10.250.90	UniProtKB/TrEMBL
InterPro	MAD	UniProtKB/TrEMBL
KEGG Report	rno:680006	UniProtKB/TrEMBL
NCBI Gene	680006	ENTREZGENE
PANTHER	MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1	UniProtKB/TrEMBL
	PTHR23168	UniProtKB/TrEMBL
Pfam	MAD	UniProtKB/TrEMBL
PhenoGen	Mad1l1	PhenoGen
RatGTEx	ENSRNOG00000001265	RatGTEx
Superfamily-SCOP	Mitotic arrest deficient-like 1, Mad1	UniProtKB/TrEMBL
UniProt	A0A8I6A596	ENTREZGENE, UniProtKB/TrEMBL
	A6K1T2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZIV3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-28	Mad1l1	mitotic arrest deficient 1 like 1	Mad1l1	MAD1 mitotic arrest deficient like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-04-20	Mad1l1	MAD1 mitotic arrest deficient like 1	Mad1l1	MAD1 mitotic arrest deficient-like 1 (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Mad1l1	MAD1 mitotic arrest deficient-like 1 (yeast)	Mad1l1	mitotic arrest deficient 1-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-07-08	Mad1l1	mitotic arrest deficient 1-like 1	LOC686419	similar to Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1)	Data merged from RGD:1597665	1643240	APPROVED
2008-03-05	Mad1l1	mitotic arrest deficient 1-like 1	LOC680006	similar to Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC680006	similar to Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC686419	similar to Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)