Iho1 (interactor of HORMAD1 1) - Rat Genome Database

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Gene: Iho1 (interactor of HORMAD1 1) Rattus norvegicus
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Symbol: Iho1
Name: interactor of HORMAD1 1
RGD ID: 1596869
Description: Predicted to be involved in several processes, including meiosis I cell cycle process; regulation of homologous chromosome segregation; and spermatogenesis. Predicted to be active in condensed nuclear chromosome. Orthologous to human IHO1 (interactor of HORMAD1 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ccdc36; coiled-coil domain containing 36; coiled-coil domain-containing protein 36; hypothetical protein LOC680018; hypothetical protein LOC686631; interactor of HORMAD1 protein 1; LOC680018
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,969,099 - 118,005,724 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,971,077 - 118,003,482 (-)EnsemblGRCr8
mRatBN7.28109,091,134 - 109,126,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)EnsemblmRatBN7.2
Rnor_6.08117,182,484 - 117,215,390 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)Ensemblrn6Rnor6.0
Rnor_5.08116,531,078 - 116,559,700 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera8108,394,590 - 108,425,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27723721  


Genomics

Comparative Map Data
Iho1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,969,099 - 118,005,724 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,971,077 - 118,003,482 (-)EnsemblGRCr8
mRatBN7.28109,091,134 - 109,126,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)EnsemblmRatBN7.2
Rnor_6.08117,182,484 - 117,215,390 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)Ensemblrn6Rnor6.0
Rnor_5.08116,531,078 - 116,559,700 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera8108,394,590 - 108,425,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
IHO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,191,309 - 49,258,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,198,428 - 49,258,106 (+)Ensemblhg38GRCh38
GRCh37349,235,861 - 49,295,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,210,865 - 49,270,160 (+)NCBIBuild 36Build 36hg18NCBI36
Celera349,193,717 - 49,258,916 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,293,567 - 49,352,860 (+)NCBIHuRef
CHM1_1349,188,591 - 49,248,327 (+)NCBICHM1_1
T2T-CHM13v2.0349,219,377 - 49,286,187 (+)NCBIT2T-CHM13v2.0
Iho1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,280,691 - 108,309,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,280,810 - 108,305,683 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389108,403,492 - 108,431,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,403,611 - 108,428,484 (-)Ensemblmm10GRCm38
MGSCv379108,305,952 - 108,330,813 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369108,261,591 - 108,294,188 (-)NCBIMGSCv36mm8
Celera9108,012,831 - 108,037,747 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.32NCBI
Iho1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,198,316 - 1,226,875 (+)NCBIChiLan1.0ChiLan1.0
IHO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,169,837 - 49,248,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,174,605 - 49,240,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,122,120 - 49,181,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,217,333 - 50,260,487 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,239,250 - 50,259,890 (+)EnsemblpanPan2panpan1.1
IHO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,964,629 - 40,006,726 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,965,480 - 39,990,756 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2039,882,962 - 39,925,161 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02040,321,654 - 40,363,853 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,321,646 - 40,350,915 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,688,399 - 39,730,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,092,252 - 40,134,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,371,900 - 40,414,505 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Iho1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,109,471 - 64,172,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529889,423 - 929,929 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936529905,692 - 929,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IHO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,802,948 - 31,837,912 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11331,802,963 - 31,836,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,060,241 - 35,067,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IHO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,593,516 - 10,653,519 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,373,695 - 156,435,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iho1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,215,447 - 3,239,060 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247303,208,648 - 3,249,281 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Iho1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1899,733,574 - 99,755,073 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Iho1
805 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000071189
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 7 60 128 53 52 25 35 25 6 232 124 10 108 67 92 27 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000071189   ⟹   ENSRNOP00000065793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,971,077 - 118,003,482 (-)Ensembl
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)Ensembl
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)Ensembl
RefSeq Acc Id: XM_001055346   ⟹   XP_001055346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,969,099 - 118,005,724 (-)NCBI
mRatBN7.28109,091,134 - 109,126,386 (-)NCBI
Rnor_6.08117,182,484 - 117,215,390 (-)NCBI
Rnor_5.08116,531,078 - 116,559,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266465   ⟹   XP_063122535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,969,099 - 117,985,667 (-)NCBI
RefSeq Acc Id: XM_063266467   ⟹   XP_063122537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,969,099 - 118,005,720 (-)NCBI
RefSeq Acc Id: XM_063266468   ⟹   XP_063122538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,969,099 - 118,005,719 (-)NCBI
Protein Sequences
Protein RefSeqs XP_001055346 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122535 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122537 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122538 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77175 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065793
  ENSRNOP00000065793.1
RefSeq Acc Id: XP_001055346   ⟸   XM_001055346
- Peptide Label: isoform X1
- UniProtKB: M0R8J7 (UniProtKB/TrEMBL),   A6I352 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065793   ⟸   ENSRNOT00000071189
RefSeq Acc Id: XP_063122537   ⟸   XM_063266467
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122538   ⟸   XM_063266468
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122535   ⟸   XM_063266465
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8J7-F1-model_v2 AlphaFold M0R8J7 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596869 AgrOrtholog
BioCyc Gene G2FUF-29144 BioCyc
Ensembl Genes ENSRNOG00000048919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071189 ENTREZGENE
  ENSRNOT00000071189.3 UniProtKB/TrEMBL
InterPro DUF4700 UniProtKB/TrEMBL
KEGG Report rno:680018 UniProtKB/TrEMBL
NCBI Gene 680018 ENTREZGENE
PANTHER INTERACTOR OF HORMAD1 PROTEIN 1 UniProtKB/TrEMBL
  PTHR35662 UniProtKB/TrEMBL
Pfam DUF4700 UniProtKB/TrEMBL
PhenoGen Iho1 PhenoGen
RatGTEx ENSRNOG00000048919 RatGTEx
UniProt A6I352 ENTREZGENE, UniProtKB/TrEMBL
  M0R8J7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Iho1  interactor of HORMAD1 1  Ccdc36  coiled-coil domain containing 36  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Ccdc36  coiled-coil domain containing 36  LOC686631  hypothetical protein LOC686631  Data merged from RGD:1595017 1643240 APPROVED
2008-03-05 Ccdc36  coiled-coil domain containing 36  LOC680018  hypothetical protein LOC680018  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680018  hypothetical protein LOC680018      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686631  hypothetical protein LOC686631      Symbol and Name status set to provisional 70820 PROVISIONAL