Lemd3 (LEM domain containing 3) - Rat Genome Database

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Gene: Lemd3 (LEM domain containing 3) Rattus norvegicus
Analyze
Symbol: Lemd3
Name: LEM domain containing 3
RGD ID: 1596822
Description: Predicted to enable chromatin DNA binding activity. Predicted to be involved in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway and nuclear envelope organization. Predicted to act upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Predicted to be located in nuclear inner membrane. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inner nuclear membrane protein Man1; LOC680066; RGD1561001; similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,300,556 - 58,389,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl758,316,851 - 58,384,707 (-)EnsemblGRCr8
mRatBN7.2756,415,053 - 56,499,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx758,356,363 - 58,404,803 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,559,575 - 60,608,007 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,336,954 - 60,385,385 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,976,671 - 63,045,860 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)Ensemblrn6Rnor6.0
Rnor_5.0762,960,779 - 63,032,159 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4760,232,118 - 60,281,459 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera753,196,837 - 53,246,156 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA,ISO)
nuclear envelope  (IEA,ISO)
nuclear inner membrane  (IEA,ISO)
nuclear membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Familial cutaneous collagenomas resulting from a novel mutation in LEMD3. Hershkovitz D, etal., Br J Dermatol. 2007 Feb;156(2):375-7.
3. Buschke-Ollendorff syndrome associated with hypertrophic scar formation: a possible role for LEMD3 mutation. Korekawa A, etal., Br J Dermatol. 2012 Apr;166(4):900-3. doi: 10.1111/j.1365-2133.2011.10691.x. Epub 2012 Jan 9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Buschke-Ollendorff syndrome: absence of LEMD3 mutation in an affected family. Yadegari M, etal., Arch Dermatol. 2010 Jan;146(1):63-8. doi: 10.1001/archdermatol.2009.320.
10. Buschke-Ollendorff syndrome with striking phenotypic variation resulting from a novel c.2203C>T nonsense mutation in LEMD3. Yuste-Chaves M, etal., Pediatr Dermatol. 2011 Jul-Aug;28(4):447-50. doi: 10.1111/j.1525-1470.2010.01206.x. Epub 2010 Jul 29.
11. Novel and recurrent germline LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis. Zhang Y, etal., Clin Genet. 2009 Jun;75(6):556-61. doi: 10.1111/j.1399-0004.2009.01177.x. Epub 2009 May 5.
Additional References at PubMed
PMID:10671519   PMID:15647271   PMID:16943282   PMID:19720741  


Genomics

Comparative Map Data
Lemd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8758,300,556 - 58,389,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl758,316,851 - 58,384,707 (-)EnsemblGRCr8
mRatBN7.2756,415,053 - 56,499,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx758,356,363 - 58,404,803 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0760,559,575 - 60,608,007 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0760,336,954 - 60,385,385 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,976,671 - 63,045,860 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)Ensemblrn6Rnor6.0
Rnor_5.0762,960,779 - 63,032,159 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4760,232,118 - 60,281,459 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera753,196,837 - 53,246,156 (-)NCBICelera
Cytogenetic Map7q22NCBI
LEMD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,169,583 - 65,248,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,169,342 - 65,248,355 (+)Ensemblhg38GRCh38
GRCh371265,563,363 - 65,642,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,849,638 - 63,928,374 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341263,849,637 - 63,928,374NCBI
Celera1265,228,844 - 65,307,664 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1262,615,007 - 62,693,876 (+)NCBIHuRef
CHM1_11265,530,362 - 65,609,142 (+)NCBICHM1_1
T2T-CHM13v2.01265,148,505 - 65,227,374 (+)NCBIT2T-CHM13v2.0
Lemd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,759,316 - 120,815,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,759,318 - 120,815,237 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810120,923,411 - 120,979,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,923,413 - 120,979,332 (-)Ensemblmm10GRCm38
MGSCv3710120,360,467 - 120,416,386 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610120,326,471 - 120,382,392 (-)NCBIMGSCv36mm8
Celera10123,286,658 - 123,342,549 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1068.88NCBI
LEMD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21029,113,605 - 29,192,854 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11229,110,380 - 29,189,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,668,368 - 23,747,369 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,172,749 - 24,251,533 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,172,749 - 24,252,314 (-)EnsemblpanPan2panpan1.1
LEMD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1107,775,995 - 7,833,895 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl107,777,946 - 7,834,107 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha107,711,419 - 7,784,249 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0107,887,012 - 7,959,867 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl107,887,036 - 7,945,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1107,763,790 - 7,836,639 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,003,513 - 8,063,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,135,524 - 8,208,304 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lemd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,656,254 - 50,724,268 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,385,062 - 3,454,243 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,385,821 - 3,453,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEMD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl529,596,334 - 29,673,875 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1529,596,334 - 29,672,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2532,770,399 - 32,896,622 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEMD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11160,861,671 - 60,945,858 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1160,862,265 - 60,946,040 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037184,811,579 - 184,892,026 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lemd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11198,924,326 - 198,973,869 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lemd3
418 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:147
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000039532
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH132044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,448,198 - 56,448,389 (+)MAPPERmRatBN7.2
Rnor_6.0762,994,859 - 62,995,049NCBIRnor6.0
Rnor_5.0762,977,589 - 62,977,779UniSTSRnor5.0
RGSC_v3.4760,230,641 - 60,230,831UniSTSRGSC3.4
Celera753,195,360 - 53,195,550UniSTS
RH 3.4 Map7500.8UniSTS
Cytogenetic Map7q22UniSTS
RH133682  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8758,334,764 - 58,334,972 (+)Marker Load Pipeline
mRatBN7.2756,449,270 - 56,449,478 (+)MAPPERmRatBN7.2
Rnor_6.0762,995,931 - 62,996,138NCBIRnor6.0
Rnor_5.0762,978,661 - 62,978,868UniSTSRnor5.0
RGSC_v3.4760,231,713 - 60,231,920UniSTSRGSC3.4
Celera753,196,432 - 53,196,639UniSTS
RH 3.4 Map7493.0UniSTS
Cytogenetic Map7q22UniSTS
AW534569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2756,497,773 - 56,497,957 (+)MAPPERmRatBN7.2
Rnor_6.0763,044,488 - 63,044,671NCBIRnor6.0
Rnor_5.0763,027,218 - 63,027,401UniSTSRnor5.0
RGSC_v3.4760,280,219 - 60,280,402UniSTSRGSC3.4
Celera753,244,916 - 53,245,099UniSTS
RH 3.4 Map7493.0UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039532   ⟹   ENSRNOP00000032921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl758,335,170 - 58,384,508 (-)Ensembl
mRatBN7.2 Ensembl756,449,676 - 56,499,014 (-)Ensembl
Rnor_6.0 Ensembl762,996,336 - 63,045,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103155   ⟹   ENSRNOP00000090081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl756,305,448 - 56,502,474 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105233   ⟹   ENSRNOP00000092420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl758,335,170 - 58,384,707 (-)Ensembl
mRatBN7.2 Ensembl756,449,676 - 56,502,474 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154353   ⟹   ENSRNOP00000103948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl758,316,851 - 58,384,707 (-)Ensembl
RefSeq Acc Id: NM_001191000   ⟹   NP_001177929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,335,170 - 58,384,508 (-)NCBI
mRatBN7.2756,449,676 - 56,499,014 (-)NCBI
Rnor_6.0762,996,336 - 63,045,728 (-)NCBI
Rnor_5.0762,960,779 - 63,032,159 (-)NCBI
Celera753,196,837 - 53,246,156 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005486725
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,300,556 - 58,389,485 (-)NCBI
mRatBN7.2756,415,053 - 56,499,047 (-)NCBI
RefSeq Acc Id: XR_010053041
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8758,353,502 - 58,389,485 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001177929 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032921.6
  ENSRNOP00000092420
  ENSRNOP00000092420.1
  ENSRNOP00000103948.1
RefSeq Acc Id: NP_001177929   ⟸   NM_001191000
- UniProtKB: F1LWZ8 (UniProtKB/TrEMBL),   A0A8I6GK62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032921   ⟸   ENSRNOT00000039532
Ensembl Acc Id: ENSRNOP00000090081   ⟸   ENSRNOT00000103155
Ensembl Acc Id: ENSRNOP00000092420   ⟸   ENSRNOT00000105233
Ensembl Acc Id: ENSRNOP00000103948   ⟸   ENSRNOT00000154353
Protein Domains
LEM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWZ8-F1-model_v2 AlphaFold F1LWZ8 1-914 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695223
Promoter ID:EPDNEW_R5748
Type:multiple initiation site
Name:Lemd3_1
Description:LEM domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0763,045,742 - 63,045,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596822 AgrOrtholog
BioCyc Gene G2FUF-33884 BioCyc
Ensembl Genes ENSRNOG00000024027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039532.7 UniProtKB/TrEMBL
  ENSRNOT00000105233 ENTREZGENE
  ENSRNOT00000105233.2 UniProtKB/TrEMBL
  ENSRNOT00000154353.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1180 UniProtKB/TrEMBL
  1.10.720.40 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro INM_ESCRT-Associated UniProtKB/TrEMBL
  Inner-Nucl-membr_MAN1 UniProtKB/TrEMBL
  LEM UniProtKB/TrEMBL
  LEM-like_dom UniProtKB/TrEMBL
  Man1_RRM UniProtKB/TrEMBL
  MAN1_winged_helix_dom UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
KEGG Report rno:680066 UniProtKB/TrEMBL
NCBI Gene 680066 ENTREZGENE
PANTHER INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR13428:SF10 UniProtKB/TrEMBL
Pfam LEM UniProtKB/TrEMBL
  MSC UniProtKB/TrEMBL
PhenoGen Lemd3 PhenoGen
PROSITE LEM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024027 RatGTEx
SMART LEM UniProtKB/TrEMBL
Superfamily-SCOP LEM_like UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6GK62 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L3W3_RAT UniProtKB/TrEMBL
  F1LWZ8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Lemd3  LEM domain containing 3  LOC680066  similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680066  similar to Inner nuclear membrane protein Man1 (LEM domain containing protein 3)      Symbol and Name status set to provisional 70820 PROVISIONAL