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Gene: Chml (CHM like Rab escort protein) Rattus norvegicus

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Symbol:

Chml

Name:

CHM like Rab escort protein

RGD ID:

1596201

Description:

Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHML (CHM like Rab escort protein); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CHM like, Rab escort protein 2; choroideremia-like; choroideremia-like (Rab escort protein 2); LOC689102; rab proteins geranylgeranyltransferase component A 2; similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CHML (CHM like Rab escort protein)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Chml (choroideremia-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Chml (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CHML (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CHML (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Chml (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CHML (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CHML (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Chml (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Chml (CHM like Rab escort protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CHML (CHM like Rab escort protein)	Alliance	DIOPT (HGNC)
Homo sapiens (human):	CHML (CHM like Rab escort protein)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Chml (choroideremia-like)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chm (CHM Rab escort protein)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MRS6	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Rep	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rep-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	chm	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	90,141,880 - 90,152,097 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	90,131,514 - 90,151,265 (-)	Ensembl				GRCr8
mRatBN7.2	13	87,609,647 - 87,619,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	87,589,298 - 87,619,862 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	90,113,464 - 90,115,329 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	91,513,723 - 91,515,588 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	88,692,863 - 88,694,728 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	93,740,759 - 93,742,624 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	98,205,028 - 98,206,893 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	91,420,770 - 91,422,635 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	87,212,029 - 87,213,894 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

manganese(II) chloride (EXP)

methyl methanesulfonate (ISO)

miconazole (ISO)

naled (ISO)

nitrofen (EXP)

perfluorohexanesulfonic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

torcetrapib (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular protein transport (IEA)

protein geranylgeranylation (ISO)

protein targeting to membrane (IBA)

small GTPase-mediated signal transduction (IEA)

vesicle-mediated transport (IBA)

Cellular Component

cytoplasm (IEA)

cytosol (IBA,IEA,ISO)

nucleoplasm (ISO)

nucleus (IBA)

Rab-protein geranylgeranyltransferase complex (IBA,IEA,ISO)

Molecular Function

GDP-dissociation inhibitor activity (IEA)

GTPase activator activity (IEA)

small GTPase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Developmental aspects of automatic word processing: language lateralization of early ERP components in children, young adults and middle-aged subjects.	Spironelli C and Angrilli A, Biol Psychol. 2009 Jan;80(1):35-45. Epub 2008 Feb 7.

Additional References at PubMed

PMID:12356470	PMID:15186776

Genomics

Comparative Map Data

Chml
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	90,141,880 - 90,152,097 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	90,131,514 - 90,151,265 (-)	Ensembl				GRCr8
mRatBN7.2	13	87,609,647 - 87,619,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	87,589,298 - 87,619,862 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	90,113,464 - 90,115,329 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	91,513,723 - 91,515,588 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	88,692,863 - 88,694,728 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	93,740,759 - 93,742,624 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	98,205,028 - 98,206,893 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	91,420,770 - 91,422,635 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	87,212,029 - 87,213,894 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

CHML
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	241,628,851 - 241,640,369 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	241,628,851 - 241,640,369 (-)	Ensembl			hg38	GRCh38
GRCh37	1	241,792,153 - 241,803,671 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	239,858,789 - 239,865,855 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	238,118,203 - 238,125,273	NCBI
Celera	1	215,047,269 - 215,054,335 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI
HuRef	1	212,250,224 - 212,257,290 (-)	NCBI		HuRef
CHM1_1	1	243,064,835 - 243,071,901 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	241,040,328 - 241,051,843 (-)	NCBI		T2T-CHM13v2.0

Chml
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	175,509,803 - 175,520,198 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	175,509,803 - 175,520,467 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	175,682,237 - 175,688,353 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	175,682,237 - 175,692,901 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	177,612,368 - 177,618,484 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	177,523,163 - 177,525,028 (-)	NCBI		MGSCv36	mm8
Celera	1	182,767,895 - 182,774,011 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	81.7	NCBI

Chml
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955406	10,455,367 - 10,461,934 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHML
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	7,511,348 - 7,518,257 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	7,734,966 - 7,741,875 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	217,191,065 - 217,202,578 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	222,171,842 - 222,182,951 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

CHML
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	33,027,051 - 33,040,711 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	32,504,522 - 32,513,774 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	32,853,744 - 32,862,999 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	32,860,224 - 32,867,701 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	32,688,279 - 32,697,533 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	32,712,648 - 32,721,906 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	32,960,620 - 32,969,892 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Chml
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	45,903,365 - 45,909,195 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936526	8,833,921 - 8,844,484 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHML
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	11,835,582 - 11,845,804 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	11,835,472 - 11,845,833 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	14,057,719 - 14,062,929 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHML
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	78,712,003 - 78,714,842 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	80,845,319 - 80,848,158 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chml
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624771	11,981,078 - 11,987,379 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Chml
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	54,210,492 - 54,216,573 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Chml
122 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
1302791	Stl29	Serum triglyceride level QTL 29	3.3	0.0011	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	13	89333129	92500981	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	48	66	137	94	11	47	36	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000111169 ⟹ ENSRNOP00000088776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	90,144,452 - 90,147,733 (-)	Ensembl
mRatBN7.2 Ensembl	13	87,589,298 - 87,619,862 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126537 ⟹ ENSRNOP00000105045

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	90,131,514 - 90,148,029 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000130403 ⟹ ENSRNOP00000100506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	90,144,132 - 90,151,265 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142738 ⟹ ENSRNOP00000108481

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	90,142,088 - 90,149,104 (-)	Ensembl

RefSeq Acc Id:

NM_001109524 ⟹ NP_001102994

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	90,141,880 - 90,152,097 (-)	NCBI
mRatBN7.2	13	87,609,647 - 87,619,868 (-)	NCBI
Rnor_6.0	13	93,740,759 - 93,742,624 (-)	NCBI
Rnor_5.0	13	98,205,028 - 98,206,893 (-)	NCBI
RGSC_v3.4	13	91,420,770 - 91,422,635 (-)	RGD
Celera	13	87,212,029 - 87,213,894 (-)	RGD

Sequence:

show sequence

ATGGCGGACAAACTTCCCACAGAGTTTGATGTGGTTATAATAGGGACTGGTTTGCCTGAGTCCA
TCCTGGCAGCTGCATGTTCAAGAAGTGGACAGAGAGTTCTGCACGTTGACTCAAGGAGTTACTA
TGGAGGGAATTGGGCGAGTTTCAGCTTTACAGGTTTGCTGTCGTGGCTGAAGGACTATCAACAG
AACCATGACAGCGAGGGAGACGTGACTGGCACATGGCAAGACCTGATCGATGAAACCGAAGAAG
CCATCGCTCTTTGCAAGAAGGACGAAACTATTCAGCACACGGAAGTCTTCTGTTATGCTAGTCA
AGATGTGGAAGATAGCATGCAAGAGACCGACCCTCTGCAGAAAAGTCCCTCCCCAGAGGCATCT
GCTACTCCGGCGGACTCTCTGGATACTGCAAGCTTGCCCAAAGAAAGGCACTCAGAAGACTGTA
CAAGCTACGAGGCGCCTTCTAGACGTACAGAGGGAAGTGATGGAGCAGTTTCACTCTCCTCCGC
TGATGCACAGGACTCACTGGAGAAAGAAAAGTTCTGTGGAGATGAAACCGGGATGCACACAGTT
TCAGATGGAGAAGAAGGTGAACACAAACTTGCTGCAGAAGACAACGTAGGACAACCAAAGAGAA
ATACGATTACTTACTCGCAGATGGTCAAGGAGAGCCGGACATTCAACATTGACTTGGTATCAAA
GCTGCTGTATTCTCAAGGCTCACTGATCGATCTTCTAATCAAATCAAACGTTAGTCGTTATGCA
GAGTTTAAGAATGTTACTAGGATCCTTGCATTTCGGGAAGGGAAGGTAGAACAGGTGCCTTGCT
CCAGAGCAGATGTGTTTAACAGTAAAGAGCTCACTATGGTTGAGAAGAGAATGCTAATGAAGTT
TCTCACGTTCTGTTTAGACTACGAGCAACATTCAGATGAATACCAAGATTTCAAACAATGTTCA
TTTTCTGACTACTTAAAAACTAAAAAGCTAACGCCTAACCTCCAACACTTCATACTCCACTCAA
TTGCAATGTCGTCAGACTCATCCTGCACTACATTAGATGGCCTTCAAGCAACAAAGAACTTCCT
TCGGTGTCTTGGACGGTTTGGCAACACTCCCTTTATATTCCCTTTATACGGCCAAGGAGAAATT
CCCCAGTGTTTCTGCAGGATGTGCGCAGTTTTTGGTGGAGTCTATTGCCTTCGCCATAAGGTAC
AATGTCTTGTAGTTGACAGAGACTCTGGAAGATGTAAAGGAATCATAGATGGCTTTGGGCAGAG
AATAAGTGCCAACTATTTTATCGTGGAGGACAGTTACCTTTCTAAGGAAATGTGTTCAAACATT
CAGTATAAGCAGATCTCAAGGGCAGTGCTTATCACAGATCAGTCCATCCTGAAGACTGATTCAG
ACCAGCAGATTTCCATTTTGGTAGTGCCTCCTCTGGAGCCGGGAACTGCTTCGGTTCGGGTCAT
GGAATTATGTTCCTCAACCATGACATGCATGAAGGACAGCTATCTGGTCCACTTGACCTGTTTC
TCTTCAAAAACAGCCCGAGAAGACTTGGAACCCGTGGTGAAGCAGTTATTCATCCCTTTTGCAG
AAGCAGAAGCAGACAAAGAGGAACTCAGAAAACCAAGACTTTTGTGGGCCCTTTATTTTAATAT
GAGAGATTCCTCAGGGGTGAGCCGAAGCTCATACTGTAGCTTACCTTCCAATGTATACATCTGC
TCTGGTCCTGACTGTGGACTGGGGAATGAGCATGCAGTCAAGCAAGCGGAAACACTGTTCCAGG
AGATCTTTCCCAGTGAAGAGTTCTGCCCTCCTCCACCAAACCCTGAAGACATTATCTTTGAAGC
GGAGGGTTAG

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Protein Sequences


Protein RefSeqs	NP_001102994	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94772	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000088776.1
	ENSRNOP00000100506.1
	ENSRNOP00000105045.1
	ENSRNOP00000108481
	ENSRNOP00000108481.1

RefSeq Acc Id:

NP_001102994 ⟸ NM_001109524

- UniProtKB:

A0A8I6AAJ7 (UniProtKB/TrEMBL), A6JGB6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLLSWLKDYQQ
NHDSEGDVTGTWQDLIDETEEAIALCKKDETIQHTEVFCYASQDVEDSMQETDPLQKSPSPEAS
ATPADSLDTASLPKERHSEDCTSYEAPSRRTEGSDGAVSLSSADAQDSLEKEKFCGDETGMHTV
SDGEEGEHKLAAEDNVGQPKRNTITYSQMVKESRTFNIDLVSKLLYSQGSLIDLLIKSNVSRYA
EFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLDYEQHSDEYQDFKQCS
FSDYLKTKKLTPNLQHFILHSIAMSSDSSCTTLDGLQATKNFLRCLGRFGNTPFIFPLYGQGEI
PQCFCRMCAVFGGVYCLRHKVQCLVVDRDSGRCKGIIDGFGQRISANYFIVEDSYLSKEMCSNI
QYKQISRAVLITDQSILKTDSDQQISILVVPPLEPGTASVRVMELCSSTMTCMKDSYLVHLTCF
SSKTAREDLEPVVKQLFIPFAEAEADKEELRKPRLLWALYFNMRDSSGVSRSSYCSLPSNVYIC
SGPDCGLGNEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEAEG

hide sequence

Ensembl Acc Id:

ENSRNOP00000088776 ⟸ ENSRNOT00000111169

Ensembl Acc Id:

ENSRNOP00000105045 ⟸ ENSRNOT00000126537

Ensembl Acc Id:

ENSRNOP00000100506 ⟸ ENSRNOT00000130403

Ensembl Acc Id:

ENSRNOP00000108481 ⟸ ENSRNOT00000142738

Protein Domains

RAE1/2

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1596201	AgrOrtholog
BioCyc Gene	G2FUF-17229	BioCyc
Ensembl Genes	ENSRNOG00000067369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000111169.2	UniProtKB/TrEMBL
	ENSRNOT00000126537.1	UniProtKB/TrEMBL
	ENSRNOT00000130403.1	UniProtKB/TrEMBL
	ENSRNOT00000142738	ENTREZGENE
	ENSRNOT00000142738.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.50.60	UniProtKB/TrEMBL
	Guanine Nucleotide Dissociation Inhibitor, domain 1	UniProtKB/TrEMBL
	Guanine Nucleotide Dissociation Inhibitor, domain 2	UniProtKB/TrEMBL
InterPro	FAD/NAD-bd_sf	UniProtKB/TrEMBL
	GDP_dissociation_inhibitor	UniProtKB/TrEMBL
	Rab_escort	UniProtKB/TrEMBL
	RAE1_2_domI_C	UniProtKB/TrEMBL
KEGG Report	rno:689102	UniProtKB/TrEMBL
NCBI Gene	689102	ENTREZGENE
PANTHER	PTHR11787	UniProtKB/TrEMBL
	RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2	UniProtKB/TrEMBL
Pfam	GDI	UniProtKB/TrEMBL
	RAE1_2_domI_C	UniProtKB/TrEMBL
PhenoGen	Chml	PhenoGen
PIRSF	Rab_ger_ger_transf_A_euk	UniProtKB/TrEMBL
PRINTS	RABESCORT	UniProtKB/TrEMBL
	RABGDIREP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000067369	RatGTEx
Superfamily-SCOP	FAD-linked reductases, C-terminal domain	UniProtKB/TrEMBL
	SSF51905	UniProtKB/TrEMBL
UniProt	A0A8I6AAJ7	ENTREZGENE, UniProtKB/TrEMBL
	A6JGB6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Chml	CHM like Rab escort protein	Chml	CHM like, Rab escort protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-02-07	Chml	CHM like, Rab escort protein 2	Chml	choroideremia-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-09	Chml	choroideremia-like	Chml	choroideremia-like (Rab escort protein 2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Chml	choroideremia-like (Rab escort protein 2)	Chml	choroideremia-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-07-08	Chml	choroideremia-like	LOC682080	similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)	Data merged from RGD:1588087	1643240	APPROVED
2008-03-06	Chml	choroideremia-like	LOC689102	similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC689102	similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682080	similar to Rab proteins geranylgeranyltransferase component A 2 (Rab escort protein 2) (REP-2) (Choroideraemia-like protein)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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