N4bp2l1 (NEDD4 binding protein 2-like 1) - Rat Genome Database

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Gene: N4bp2l1 (NEDD4 binding protein 2-like 1) Rattus norvegicus
Analyze
Symbol: N4bp2l1
Name: NEDD4 binding protein 2-like 1
RGD ID: 1595713
Description: Orthologous to human N4BP2L1 (NEDD4 binding protein 2 like 1); INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498131; NEDD4-binding protein 2-like 1; similar to OTTHUMP00000018227
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,938,199 - 4,965,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,927,142 - 4,963,045 (-)EnsemblGRCr8
mRatBN7.212102,572 - 128,352 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12102,573 - 127,257 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx12671,272 - 695,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,193,509 - 1,217,839 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01293,105 - 117,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.012546,759 - 576,744 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12546,760 - 576,746 (-)Ensemblrn6Rnor6.0
Rnor_5.012533,777 - 558,064 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4124,256,571 - 4,280,941 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,812,217 - 1,836,541 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
GSK-J4  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
N4bp2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,938,199 - 4,965,003 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,927,142 - 4,963,045 (-)EnsemblGRCr8
mRatBN7.212102,572 - 128,352 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12102,573 - 127,257 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx12671,272 - 695,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,193,509 - 1,217,839 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01293,105 - 117,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.012546,759 - 576,744 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12546,760 - 576,746 (-)Ensemblrn6Rnor6.0
Rnor_5.012533,777 - 558,064 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4124,256,571 - 4,280,941 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,812,217 - 1,836,541 (-)NCBICelera
Cytogenetic Map12p12NCBI
N4BP2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381332,400,723 - 32,429,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1332,400,723 - 32,428,311 (-)Ensemblhg38GRCh38
GRCh371332,974,860 - 33,002,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361331,872,860 - 31,900,315 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1314,041,664 - 14,069,106 (-)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1313,786,644 - 13,814,058 (-)NCBIHuRef
CHM1_11332,942,373 - 32,969,852 (-)NCBICHM1_1
T2T-CHM13v2.01331,617,965 - 31,646,859 (-)NCBIT2T-CHM13v2.0
N4bp2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,495,108 - 150,518,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,495,109 - 150,520,653 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385150,571,643 - 150,598,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,571,644 - 150,597,188 (-)Ensemblmm10GRCm38
MGSCv375151,374,218 - 151,397,100 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365150,840,023 - 150,862,879 (-)NCBIMGSCv36mm8
Celera5148,576,168 - 148,598,991 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.55NCBI
N4bp2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543113,437,902 - 13,446,527 (+)Ensembl
ChiLan1.0NW_00495543113,437,902 - 13,446,527 (+)NCBIChiLan1.0ChiLan1.0
N4BP2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21431,967,446 - 31,994,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11323,074,011 - 23,101,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01313,659,603 - 13,689,608 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,094,139 - 32,121,161 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,094,139 - 32,121,161 (-)EnsemblpanPan2panpan1.1
N4BP2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,706,195 - 7,733,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,727,787 - 7,731,647 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha257,729,597 - 7,763,851 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0257,796,072 - 7,830,337 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,796,241 - 7,829,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,696,046 - 7,730,250 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,694,282 - 7,728,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,751,594 - 7,785,824 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
N4bp2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945168,910,415 - 168,933,944 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647227,018,265 - 27,041,208 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647226,996,828 - 27,041,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
N4BP2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl118,857,175 - 8,885,420 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1118,860,777 - 8,889,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
N4BP2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,157,131 - 11,186,330 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605733,166,385 - 33,195,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
N4bp2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247765,472,635 - 5,495,117 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247765,472,541 - 5,495,117 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
N4bp2l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v116125,762 - 149,406 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in N4bp2l1
263 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:219
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000061446
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat

Markers in Region
D12Rat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8124,952,146 - 4,952,371 (+)Marker Load Pipeline
mRatBN7.212116,519 - 116,744 (+)MAPPERmRatBN7.2
Rnor_6.012560,707 - 560,931NCBIRnor6.0
Rnor_5.012547,725 - 547,949UniSTSRnor5.0
RGSC_v3.4124,266,768 - 4,266,993RGDRGSC3.4
RGSC_v3.4124,266,769 - 4,266,993UniSTSRGSC3.4
Celera121,826,165 - 1,826,389UniSTS
RGSC_v3.1124,266,768 - 4,266,993RGD
SHRSP x BN Map122.13UniSTS
SHRSP x BN Map122.13RGD
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 164 91 90 59 92 59 6 354 191 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000085295   ⟹   ENSRNOP00000071776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,938,200 - 4,963,045 (-)Ensembl
mRatBN7.2 Ensembl12102,573 - 127,257 (-)Ensembl
Rnor_6.0 Ensembl12546,760 - 576,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110394   ⟹   ENSRNOP00000082490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,927,142 - 4,963,044 (-)Ensembl
mRatBN7.2 Ensembl12124,296 - 127,257 (-)Ensembl
RefSeq Acc Id: NM_001035222   ⟹   NP_001030299
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,938,199 - 4,962,569 (-)NCBI
mRatBN7.212102,572 - 126,944 (-)NCBI
Rnor_6.012546,759 - 576,744 (-)NCBI
Rnor_5.012533,777 - 558,064 (-)NCBI
RGSC_v3.4124,256,571 - 4,280,941 (+)RGD
Celera121,812,217 - 1,836,541 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089675   ⟹   XP_038945603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,939,691 - 4,962,779 (-)NCBI
mRatBN7.212102,572 - 127,208 (-)NCBI
RefSeq Acc Id: XR_005491660
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,943,520 - 4,965,003 (-)NCBI
mRatBN7.212107,893 - 128,352 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001030299 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945603 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68658 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071776.2
  ENSRNOP00000082490.2
RefSeq Acc Id: NP_001030299   ⟸   NM_001035222
- UniProtKB: B5DEG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071776   ⟸   ENSRNOT00000085295
RefSeq Acc Id: XP_038945603   ⟸   XM_039089675
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000082490   ⟸   ENSRNOT00000110394

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1B7-F1-model_v2 AlphaFold A0A0G2K1B7 1-238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698357
Promoter ID:EPDNEW_R8882
Type:single initiation site
Name:N4bp2l1_1
Description:NEDD4 binding protein 2-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.012576,736 - 576,796EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595713 AgrOrtholog
BioCyc Gene G2FUF-20524 BioCyc
Ensembl Genes ENSRNOG00000059322 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085295.3 UniProtKB/TrEMBL
  ENSRNOT00000110394.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro NEDD4_b_p2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:498131 UniProtKB/TrEMBL
NCBI Gene 498131 ENTREZGENE
PANTHER NEDD4-BINDING PROTEIN 2-LIKE 1 UniProtKB/TrEMBL
  PTHR13308 UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/TrEMBL
PhenoGen N4bp2l1 PhenoGen
RatGTEx ENSRNOG00000059322 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K1B7_RAT UniProtKB/TrEMBL
  A0A8I5ZY12_RAT UniProtKB/TrEMBL
  B5DEG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 N4bp2l1  NEDD4 binding protein 2-like 1  LOC498131  similar to OTTHUMP00000018227  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC498131  similar to OTTHUMP00000018227      Symbol and Name status set to provisional 70820 PROVISIONAL