Kpna7 (karyopherin subunit alpha 7) - Rat Genome Database

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Gene: Kpna7 (karyopherin subunit alpha 7) Rattus norvegicus
Analyze
Symbol: Kpna7
Name: karyopherin subunit alpha 7
RGD ID: 1594749
Description: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within blastocyst development and regulation of gene expression. Predicted to be located in female germ cell nucleus and spindle. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleus. Orthologous to human KPNA7 (karyopherin subunit alpha 7); INTERACTS WITH atrazine; bisphenol A; lidocaine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin subunit alpha-8; karyopherin alpha 7; LOC690504; similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,690,124 - 14,728,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,686,886 - 14,726,604 (+)EnsemblGRCr8
mRatBN7.2129,576,378 - 9,635,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,576,378 - 9,612,833 (+)EnsemblmRatBN7.2
Rnor_6.01211,347,631 - 11,378,810 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,347,643 - 11,384,349 (+)Ensemblrn6Rnor6.0
Rnor_5.01213,415,221 - 13,450,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,891,128 - 9,922,325 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1211,380,844 - 11,411,786 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20699224  


Genomics

Comparative Map Data
Kpna7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,690,124 - 14,728,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,686,886 - 14,726,604 (+)EnsemblGRCr8
mRatBN7.2129,576,378 - 9,635,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,576,378 - 9,612,833 (+)EnsemblmRatBN7.2
Rnor_6.01211,347,631 - 11,378,810 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,347,643 - 11,384,349 (+)Ensemblrn6Rnor6.0
Rnor_5.01213,415,221 - 13,450,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,891,128 - 9,922,325 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1211,380,844 - 11,411,786 (+)NCBICelera
Cytogenetic Map12p11NCBI
KPNA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,145,804 - 99,219,419 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,173,572 - 99,250,075 (-)Ensemblhg38GRCh38
GRCh37798,771,195 - 98,805,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,609,133 - 98,643,088 (-)NCBIBuild 36Build 36hg18NCBI36
Celera793,500,798 - 93,534,654 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,403,840 - 93,437,801 (-)NCBIHuRef
CHM1_1798,701,508 - 98,735,324 (-)NCBICHM1_1
T2T-CHM13v2.07100,406,814 - 100,455,185 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,127,179 - 98,161,076 (-)NCBI
Kpna7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395144,920,537 - 144,946,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5144,920,329 - 145,020,840 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385144,983,727 - 145,009,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5144,983,519 - 145,084,030 (-)Ensemblmm10GRCm38
MGSCv375145,744,613 - 145,770,505 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365145,237,271 - 145,263,163 (-)NCBIMGSCv36mm8
Celera5141,974,903 - 142,000,999 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map584.91NCBI
Kpna7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546014,901,207 - 14,924,746 (-)Ensembl
ChiLan1.0NW_00495546014,901,350 - 14,931,209 (-)NCBIChiLan1.0ChiLan1.0
KPNA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,026,123 - 117,062,475 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,290,048 - 165,327,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,141,586 - 91,177,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17104,645,887 - 104,680,585 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,645,887 - 104,680,568 (-)EnsemblpanPan2panpan1.1
KPNA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,344,320 - 10,363,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,329,617 - 10,363,624 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha611,953,716 - 11,991,208 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0610,327,456 - 10,365,181 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,344,530 - 10,363,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,197,342 - 10,235,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,175,616 - 10,213,769 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,409,583 - 10,447,333 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kpna7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,425,481 - 138,449,724 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367501,498,637 - 1,519,759 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367501,496,735 - 1,519,759 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,167,385 - 6,200,982 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.136,167,382 - 6,201,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,330,984 - 6,364,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KPNA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,957,818 - 13,989,778 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,958,285 - 13,989,633 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660702,307,484 - 2,341,171 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,648,640 - 32,671,427 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474032,645,262 - 32,771,840 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kpna7
275 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000038175, ENSRNOT00000073712
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)121186960016966542Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
10 8 30 17 4 4 3 4 1 39 24 17 1 40 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000038175   ⟹   ENSRNOP00000038662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1211,347,643 - 11,378,462 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075986   ⟹   ENSRNOP00000068379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,688,895 - 14,726,604 (+)Ensembl
mRatBN7.2 Ensembl129,576,378 - 9,612,833 (+)Ensembl
Rnor_6.0 Ensembl1211,347,643 - 11,384,349 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165682   ⟹   ENSRNOP00000111133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,686,886 - 14,726,604 (+)Ensembl
RefSeq Acc Id: XM_063271923   ⟹   XP_063127993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,690,124 - 14,728,478 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063127993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068379
  ENSRNOP00000068379.2
  ENSRNOP00000111133.1
Ensembl Acc Id: ENSRNOP00000068379   ⟸   ENSRNOT00000075986
Ensembl Acc Id: ENSRNOP00000038662   ⟸   ENSRNOT00000038175
RefSeq Acc Id: XP_063127993   ⟸   XM_063271923
- UniProtKB: A0A096MK49 (UniProtKB/TrEMBL),   A6K1G5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111133   ⟸   ENSRNOT00000165682

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MK49-F1-model_v2 AlphaFold A0A096MK49 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594749 AgrOrtholog
BioCyc Gene G2FUF-20050 BioCyc
Ensembl Genes ENSRNOG00000042296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075986 ENTREZGENE
  ENSRNOT00000075986.4 UniProtKB/TrEMBL
  ENSRNOT00000165682.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.690 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Importin-a_IBB UniProtKB/TrEMBL
  Importin-a_IBB_sf UniProtKB/TrEMBL
  Importing_su_alpha UniProtKB/TrEMBL
NCBI Gene 690504 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
  Arm_3 UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
PhenoGen Kpna7 PhenoGen
PIRSF Importin_alpha UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
  IBB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042296 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A096MK49 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJR5_RAT UniProtKB/TrEMBL
  A6K1G5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpna7  karyopherin subunit alpha 7  Kpna7  karyopherin alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Kpna7  karyopherin alpha 7  LOC684620  similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1)  Data merged from RGD:1587952 1643240 APPROVED
2010-04-23 Kpna7  karyopherin alpha 7  LOC690504  similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690504  similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684620  similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1)      Symbol and Name status set to provisional 70820 PROVISIONAL