Fcgr2al1 (Fc gamma receptor 2A like 1) - Rat Genome Database

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Gene: Fcgr2al1 (Fc gamma receptor 2A like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fcgr2al1 (Ensembl: Fcgr2a)
Name: Fc gamma receptor 2A like 1 (Ensembl:Fc gamma receptor 2A)
RGD ID: 1594388
Description: Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc gamma receptor IIa).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fc gamma receptor II beta; Fc-gamma RIIIB-alpha; Fc-gamma RIIIC-alpha; Fc-gamma RIIID-alpha; LOC100911825; LOC498276; low affinity immunoglobulin gamma Fc region receptor III-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,835,616 - 85,846,011 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1385,855,437 - 85,864,394 (-)EnsemblGRCr8
GRCr8 Ensembl1385,835,966 - 85,844,705 (-)EnsemblGRCr8
mRatBN7.21383,302,874 - 83,315,744 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,280,790 - 83,484,920 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1385,922,810 - 85,933,312 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,216,303 - 87,226,805 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,454,248 - 84,464,760 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1385,203,563 - 85,213,959 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1385,414,664 - 85,425,060 (-)NCBILyon_Normotensive
Lyon_Hypertensive1385,354,161 - 85,364,559 (-)NCBILyon_Hypertensive
F344_StmMcwi1385,409,795 - 85,420,192 (-)NCBIF344_StmMcwi
Rnor_6.01391,168,972 - 91,181,937 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,146,876 - 91,229,066 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,687,142 - 95,697,538 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41386,920,631 - 86,931,027 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1338,983,318 - 38,985,592 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
IgG binding  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1692135   PMID:1710249   PMID:12477932  


Genomics

Variants

.
Variants in Fcgr2al1
57 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH128796  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01348,941,261 - 48,941,447NCBIRnor5.0
Rnor_5.01395,706,985 - 95,707,171NCBIRnor5.0
Rnor_5.01393,944,549 - 93,944,735NCBIRnor5.0
RGSC_v3.41386,940,475 - 86,940,660UniSTSRGSC3.4
Celera1338,985,385 - 38,985,570UniSTS
Celera1382,933,414 - 82,933,825UniSTS
RH 3.4 Map13560.7UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 44 67 138 95 11 43 36 32 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000047349   ⟹   ENSRNOP00000039989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,302,898 - 83,331,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071728   ⟹   ENSRNOP00000064241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,302,898 - 83,331,645 (-)Ensembl
Rnor_6.0 Ensembl1391,146,876 - 91,228,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071897   ⟹   ENSRNOP00000067309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,855,437 - 85,864,394 (-)Ensembl
mRatBN7.2 Ensembl1383,322,700 - 83,336,082 (-)Ensembl
Rnor_6.0 Ensembl1391,188,847 - 91,229,066 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073643   ⟹   ENSRNOP00000064819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,302,881 - 83,331,645 (-)Ensembl
Rnor_6.0 Ensembl1391,219,843 - 91,228,935 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084881   ⟹   ENSRNOP00000069409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,835,966 - 85,844,705 (-)Ensembl
mRatBN7.2 Ensembl1383,280,790 - 83,484,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091821   ⟹   ENSRNOP00000075678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,302,882 - 83,313,295 (-)Ensembl
Rnor_6.0 Ensembl1391,146,997 - 91,160,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096032   ⟹   ENSRNOP00000090763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1385,855,437 - 85,864,394 (-)Ensembl
mRatBN7.2 Ensembl1383,322,703 - 83,337,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097851   ⟹   ENSRNOP00000092014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,280,812 - 83,317,119 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111130   ⟹   ENSRNOP00000083026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,280,790 - 83,484,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111401   ⟹   ENSRNOP00000084073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,281,210 - 83,336,134 (-)Ensembl
RefSeq Acc Id: NM_001135992   ⟹   NP_001129464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,835,616 - 85,846,011 (-)NCBI
mRatBN7.21383,302,882 - 83,313,278 (-)NCBI
Dahl_SR_JrHsd1385,203,563 - 85,213,959 (-)NCBI
Lyon_Normotensive1385,414,664 - 85,425,060 (-)NCBI
Lyon_Hypertensive1385,354,161 - 85,364,559 (-)NCBI
F344_StmMcwi1385,409,795 - 85,420,192 (-)NCBI
Rnor_6.01391,168,977 - 91,179,373 (-)NCBI
Rnor_5.01395,687,142 - 95,697,538 (-)NCBI
RGSC_v3.41386,920,631 - 86,931,027 (-)RGD
Celera1338,983,318 - 38,985,592 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001430400   ⟹   NP_001417329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd1385,203,563 - 85,212,621 (-)NCBI
Lyon_Normotensive1385,414,664 - 85,423,722 (-)NCBI
Lyon_Hypertensive1385,354,161 - 85,363,221 (-)NCBI
F344_StmMcwi1385,409,795 - 85,418,854 (-)NCBI
RefSeq Acc Id: XM_039090977   ⟹   XP_038946905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,835,616 - 85,844,754 (-)NCBI
mRatBN7.21383,302,874 - 83,312,013 (-)NCBI
RefSeq Acc Id: XM_039090979   ⟹   XP_038946907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,836,325 - 85,844,748 (-)NCBI
mRatBN7.21383,303,584 - 83,312,006 (-)NCBI
RefSeq Acc Id: XM_039090980   ⟹   XP_038946908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,835,616 - 85,844,744 (-)NCBI
mRatBN7.21383,302,874 - 83,312,001 (-)NCBI
RefSeq Acc Id: XM_063272543   ⟹   XP_063128613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,835,616 - 85,844,736 (-)NCBI
RefSeq Acc Id: NP_001129464   ⟸   NM_001135992
- UniProtKB: B0K007 (UniProtKB/TrEMBL),   M0R4F7 (UniProtKB/TrEMBL),   A0A096MIU6 (UniProtKB/TrEMBL),   A0A0G2KB71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064819   ⟸   ENSRNOT00000073643
Ensembl Acc Id: ENSRNOP00000067309   ⟸   ENSRNOT00000071897
Ensembl Acc Id: ENSRNOP00000064241   ⟸   ENSRNOT00000071728
Ensembl Acc Id: ENSRNOP00000075678   ⟸   ENSRNOT00000091821
RefSeq Acc Id: XP_038946905   ⟸   XM_039090977
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KB71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946908   ⟸   XM_039090980
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946907   ⟸   XM_039090979
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000090763   ⟸   ENSRNOT00000096032
Ensembl Acc Id: ENSRNOP00000039989   ⟸   ENSRNOT00000047349
Ensembl Acc Id: ENSRNOP00000092014   ⟸   ENSRNOT00000097851
Ensembl Acc Id: ENSRNOP00000083026   ⟸   ENSRNOT00000111130
Ensembl Acc Id: ENSRNOP00000084073   ⟸   ENSRNOT00000111401
Ensembl Acc Id: ENSRNOP00000069409   ⟸   ENSRNOT00000084881
RefSeq Acc Id: XP_063128613   ⟸   XM_063272543
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001417329   ⟸   NM_001430400
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27645-F1-model_v2 AlphaFold P27645 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594388 AgrOrtholog
BioCyc Gene G2FUF-17447 BioCyc
Ensembl Genes ENSRNOG00000046663 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000058500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071897.4 UniProtKB/TrEMBL
  ENSRNOT00000084881 ENTREZGENE
  ENSRNOT00000084881.3 UniProtKB/TrEMBL
  ENSRNOT00000096032.2 UniProtKB/TrEMBL
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7459664 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_Fc_receptor UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
KEGG Report rno:498276 UniProtKB/TrEMBL
MGC_CLONE MGC:188666 IMAGE-MGC_LOAD
NCBI Gene 498276 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/TrEMBL
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
PhenoGen Fcgr2al1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046663 RatGTEx
  ENSRNOG00000058500 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
UniProt A0A096MIU6 ENTREZGENE
  A0A0G2KB71 ENTREZGENE
  A0A8I6GJ50_RAT UniProtKB/TrEMBL
  A0ABZ3NNM9_RAT UniProtKB/TrEMBL
  B0K007 ENTREZGENE, UniProtKB/TrEMBL
  M0R4F7 ENTREZGENE
  M0RCJ0_RAT UniProtKB/TrEMBL
UniProt Secondary A0A096MIU6 UniProtKB/TrEMBL
  M0R4F7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Fcgr2al1  Fc gamma receptor 2A like 1  LOC498276  Fc gamma receptor II beta  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC498276  Fc gamma receptor II beta  LOC100911825  low affinity immunoglobulin gamma Fc region receptor III-like  Data merged from RGD:6490558 737654 PROVISIONAL
2012-07-05 LOC100911825  low affinity immunoglobulin gamma Fc region receptor III-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC498276  Fc gamma receptor II beta      Symbol and Name status set to provisional 70820 PROVISIONAL