PALD1 (phosphatase domain containing paladin 1) - Rat Genome Database

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Gene: PALD1 (phosphatase domain containing paladin 1) Homo sapiens
Analyze
Symbol: PALD1
Name: phosphatase domain containing paladin 1
RGD ID: 1346451
HGNC Page HGNC:23530
Description: Predicted to enable protein tyrosine phosphatase activity. Located in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIAA1274; paladin; PALD; palladin; phosphatase domain containing, paladin 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,458,485 - 70,568,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,478,767 - 70,668,754 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,238,523 - 72,328,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,908,570 - 71,998,211 (+)NCBINCBI36Build 36hg18NCBI36
Celera1065,519,663 - 65,609,972 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,232,415 - 66,321,733 (+)NCBIHuRef
CHM1_11072,520,781 - 72,610,384 (+)NCBICHM1_1
T2T-CHM13v2.01071,327,903 - 71,438,184 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10574462   PMID:12477932   PMID:14702039   PMID:15146197   PMID:19240061   PMID:19727444   PMID:21873635   PMID:21903422   PMID:22354871   PMID:26186194   PMID:26638075   PMID:27173435  
PMID:28514442   PMID:29133847   PMID:29395067   PMID:30021884   PMID:30258100   PMID:30833792   PMID:31177093   PMID:31871319   PMID:32788342   PMID:32877691   PMID:33916271   PMID:33961781  
PMID:34079125   PMID:34597346   PMID:34672954   PMID:35439318   PMID:35563538   PMID:35748872   PMID:36215168   PMID:37149695   PMID:37774976   PMID:37827155  


Genomics

Comparative Map Data
PALD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,458,485 - 70,568,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,478,767 - 70,668,754 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,238,523 - 72,328,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,908,570 - 71,998,211 (+)NCBINCBI36Build 36hg18NCBI36
Celera1065,519,663 - 65,609,972 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,232,415 - 66,321,733 (+)NCBIHuRef
CHM1_11072,520,781 - 72,610,384 (+)NCBICHM1_1
T2T-CHM13v2.01071,327,903 - 71,438,184 (+)NCBIT2T-CHM13v2.0
Pald1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,155,435 - 61,219,325 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,155,435 - 61,219,309 (-)EnsemblGRCm39 Ensembl
GRCm381061,319,656 - 61,383,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,319,656 - 61,383,530 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,782,405 - 60,846,271 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,715,019 - 60,751,393 (-)NCBIMGSCv36mm8
Celera1062,421,081 - 62,485,225 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.19NCBI
Pald1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,812,650 - 29,877,733 (-)NCBIGRCr8
mRatBN7.22029,269,814 - 29,334,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,270,193 - 29,334,858 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,285,805 - 30,322,376 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,672,104 - 29,708,676 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,414,560 - 30,451,136 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,938,901 - 30,983,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,938,901 - 30,975,472 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,729,253 - 32,773,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,682,111 - 28,718,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,697,549 - 28,732,515 (-)NCBI
Celera2030,703,172 - 30,739,743 (-)NCBICelera
Cytogenetic Map20q11NCBI
Pald1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,720,562 - 20,785,492 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,721,328 - 20,799,090 (-)NCBIChiLan1.0ChiLan1.0
PALD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,631,839 - 82,725,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,637,160 - 82,730,870 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,951,864 - 67,042,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,477,815 - 69,569,130 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,478,636 - 69,569,130 (+)Ensemblpanpan1.1panPan2
PALD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,404,353 - 21,481,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,403,926 - 21,479,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,519,082 - 21,613,509 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,661,824 - 21,755,171 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,679,389 - 21,755,168 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,576,396 - 21,650,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,764,604 - 21,858,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,116,118 - 22,210,521 (+)NCBIUU_Cfam_GSD_1.0
Pald1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,583,775 - 59,641,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,078,071 - 8,111,111 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,076,500 - 8,156,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PALD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,401,018 - 73,483,354 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,400,988 - 73,484,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PALD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,722,357 - 60,835,496 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604821,447,816 - 21,557,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pald1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,605,913 - 4,661,299 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,591,504 - 4,661,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PALD1
52 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q22.1(chr10:70036168-70522664)x3 copy number gain See cases [RCV000051139] Chr10:70036168..70522664 [GRCh38]
Chr10:71795924..72282420 [GRCh37]
Chr10:71465930..71952426 [NCBI36]
Chr10:10q22.1		 uncertain significance
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2		 pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2		 pathogenic
NM_014431.2:c.451C>T single nucleotide variant Malignant melanoma [RCV000069016] Chr10:70530051 [GRCh38]
Chr10:72289807 [GRCh37]
Chr10:71959813 [NCBI36]
Chr10:10q22.1		 not provided
NM_014431.2:c.1280G>A single nucleotide variant Malignant melanoma [RCV000069017] Chr10:70537863 [GRCh38]
Chr10:72297619 [GRCh37]
Chr10:71967625 [NCBI36]
Chr10:10q22.1		 not provided
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2		 pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3		 pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2		 pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_014431.3(PALD1):c.1068G>C (p.Gln356His) single nucleotide variant not specified [RCV004298141] Chr10:70534470 [GRCh38]
Chr10:72294226 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
NM_014431.3(PALD1):c.2455G>C (p.Glu819Gln) single nucleotide variant not specified [RCV004310919] Chr10:70566617 [GRCh38]
Chr10:72326373 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.1234G>A (p.Gly412Ser) single nucleotide variant not specified [RCV004288633] Chr10:70537817 [GRCh38]
Chr10:72297573 [GRCh37]
Chr10:10q22.1		 likely benign
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
NC_000010.10:g.(?_72179670)_(72360658_?)dup duplication Visceral heterotaxy 5, autosomal [RCV000707791] Chr10:70419914..70600902 [GRCh38]
Chr10:72179670..72360658 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_014431.3(PALD1):c.1485C>T (p.Leu495=) single nucleotide variant not provided [RCV000971778] Chr10:70538924 [GRCh38]
Chr10:72298680 [GRCh37]
Chr10:10q22.1		 benign
NM_014431.3(PALD1):c.186-6C>A single nucleotide variant not provided [RCV000947261] Chr10:70529223 [GRCh38]
Chr10:72288979 [GRCh37]
Chr10:10q22.1		 benign
NM_014431.3(PALD1):c.2455G>A (p.Glu819Lys) single nucleotide variant not specified [RCV004289549] Chr10:70566617 [GRCh38]
Chr10:72326373 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.32C>T (p.Thr11Met) single nucleotide variant not specified [RCV004321405] Chr10:70525983 [GRCh38]
Chr10:72285739 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.895C>T (p.Arg299Cys) single nucleotide variant not provided [RCV000891269] Chr10:70533946 [GRCh38]
Chr10:72293702 [GRCh37]
Chr10:10q22.1		 likely benign
NC_000010.10:g.(?_72179670)_(72360658_?)dup duplication Familial hemophagocytic lymphohistiocytosis 2 [RCV001322541]|Heterotaxy, visceral, 5, autosomal [RCV000707791] Chr10:72179670..72360658 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q22.1(chr10:71754361-72399690)x3 copy number gain not provided [RCV001832950] Chr10:71754361..72399690 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q21.3-22.3(chr10:68735254-78885714) copy number loss not specified [RCV002052875] Chr10:68735254..78885714 [GRCh37]
Chr10:10q21.3-22.3		 pathogenic
NM_014431.3(PALD1):c.2443G>A (p.Glu815Lys) single nucleotide variant not specified [RCV004234784] Chr10:70566605 [GRCh38]
Chr10:72326361 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.331G>A (p.Val111Met) single nucleotide variant not specified [RCV004158307] Chr10:70529931 [GRCh38]
Chr10:72289687 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.1328C>T (p.Pro443Leu) single nucleotide variant not specified [RCV004090109] Chr10:70538284 [GRCh38]
Chr10:72298040 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.964G>A (p.Gly322Ser) single nucleotide variant not specified [RCV004170222] Chr10:70534015 [GRCh38]
Chr10:72293771 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1769C>T (p.Pro590Leu) single nucleotide variant not specified [RCV004233088] Chr10:70539623 [GRCh38]
Chr10:72299379 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2308C>T (p.Arg770Trp) single nucleotide variant not specified [RCV004084078] Chr10:70564409 [GRCh38]
Chr10:72324165 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1841G>A (p.Arg614His) single nucleotide variant not specified [RCV004237663] Chr10:70539695 [GRCh38]
Chr10:72299451 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.698G>C (p.Trp233Ser) single nucleotide variant not specified [RCV004141292] Chr10:70532685 [GRCh38]
Chr10:72292441 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.748A>T (p.Thr250Ser) single nucleotide variant not specified [RCV004190169] Chr10:70532735 [GRCh38]
Chr10:72292491 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2126T>C (p.Val709Ala) single nucleotide variant not specified [RCV004155810] Chr10:70547310 [GRCh38]
Chr10:72307066 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1211C>T (p.Pro404Leu) single nucleotide variant not specified [RCV004214506] Chr10:70534827 [GRCh38]
Chr10:72294583 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.2509C>T (p.Arg837Cys) single nucleotide variant not specified [RCV004205308] Chr10:70566671 [GRCh38]
Chr10:72326427 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1781G>A (p.Gly594Asp) single nucleotide variant not specified [RCV004100568] Chr10:70539635 [GRCh38]
Chr10:72299391 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.530T>G (p.Phe177Cys) single nucleotide variant not specified [RCV004097095] Chr10:70531351 [GRCh38]
Chr10:72291107 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1013C>T (p.Ser338Phe) single nucleotide variant not specified [RCV004134195] Chr10:70534064 [GRCh38]
Chr10:72293820 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.523G>A (p.Glu175Lys) single nucleotide variant not specified [RCV004166609] Chr10:70531344 [GRCh38]
Chr10:72291100 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.229A>G (p.Lys77Glu) single nucleotide variant not specified [RCV004241115] Chr10:70529272 [GRCh38]
Chr10:72289028 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.877C>T (p.Pro293Ser) single nucleotide variant not specified [RCV004192640] Chr10:70533928 [GRCh38]
Chr10:72293684 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1249G>A (p.Val417Ile) single nucleotide variant not specified [RCV004126928] Chr10:70537832 [GRCh38]
Chr10:72297588 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.1019C>T (p.Pro340Leu) single nucleotide variant not specified [RCV004176021] Chr10:70534070 [GRCh38]
Chr10:72293826 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1618C>T (p.Arg540Trp) single nucleotide variant not specified [RCV004214461] Chr10:70539140 [GRCh38]
Chr10:72298896 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.997C>T (p.Arg333Cys) single nucleotide variant not specified [RCV004190219] Chr10:70534048 [GRCh38]
Chr10:72293804 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1420G>A (p.Ala474Thr) single nucleotide variant not specified [RCV004137790] Chr10:70538376 [GRCh38]
Chr10:72298132 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.718G>T (p.Ala240Ser) single nucleotide variant not specified [RCV004180754] Chr10:70532705 [GRCh38]
Chr10:72292461 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1355G>A (p.Arg452His) single nucleotide variant not specified [RCV004196484] Chr10:70538311 [GRCh38]
Chr10:72298067 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2293C>T (p.Arg765Trp) single nucleotide variant not specified [RCV004078238] Chr10:70564394 [GRCh38]
Chr10:72324150 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2461G>A (p.Gly821Ser) single nucleotide variant not specified [RCV004273731] Chr10:70566623 [GRCh38]
Chr10:72326379 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1217G>A (p.Ser406Asn) single nucleotide variant not specified [RCV004276559] Chr10:70534833 [GRCh38]
Chr10:72294589 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.308G>A (p.Arg103Gln) single nucleotide variant not specified [RCV004258918] Chr10:70529908 [GRCh38]
Chr10:72289664 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.657C>G (p.Ser219Arg) single nucleotide variant not specified [RCV004250319] Chr10:70532644 [GRCh38]
Chr10:72292400 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
NM_014431.3(PALD1):c.1354C>T (p.Arg452Cys) single nucleotide variant not specified [RCV004305265] Chr10:70538310 [GRCh38]
Chr10:72298066 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.727G>A (p.Gly243Ser) single nucleotide variant not specified [RCV004346368] Chr10:70532714 [GRCh38]
Chr10:72292470 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.242C>T (p.Thr81Met) single nucleotide variant not specified [RCV004342052] Chr10:70529285 [GRCh38]
Chr10:72289041 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1642C>T (p.Arg548Trp) single nucleotide variant not specified [RCV004347767] Chr10:70539164 [GRCh38]
Chr10:72298920 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1414C>T (p.Pro472Ser) single nucleotide variant not specified [RCV004347956] Chr10:70538370 [GRCh38]
Chr10:72298126 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
NM_014431.3(PALD1):c.186-5C>G single nucleotide variant not provided [RCV003417466] Chr10:70529224 [GRCh38]
Chr10:72288980 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.1025C>T (p.Ala342Val) single nucleotide variant not provided [RCV003417467] Chr10:70534427 [GRCh38]
Chr10:72294183 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.1937G>A (p.Arg646Gln) single nucleotide variant not provided [RCV003417468] Chr10:70541130 [GRCh38]
Chr10:72300886 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.2028C>T (p.Val676=) single nucleotide variant not provided [RCV003417469] Chr10:70541221 [GRCh38]
Chr10:72300977 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.2328G>C (p.Glu776Asp) single nucleotide variant not specified [RCV004500017] Chr10:70564429 [GRCh38]
Chr10:72324185 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2426C>T (p.Ser809Leu) single nucleotide variant not specified [RCV004500020] Chr10:70566588 [GRCh38]
Chr10:72326344 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.251G>A (p.Arg84Gln) single nucleotide variant not specified [RCV004500022] Chr10:70529294 [GRCh38]
Chr10:72289050 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.896G>A (p.Arg299His) single nucleotide variant not specified [RCV004500027] Chr10:70533947 [GRCh38]
Chr10:72293703 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1250T>G (p.Val417Gly) single nucleotide variant not specified [RCV004500009] Chr10:70537833 [GRCh38]
Chr10:72297589 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1699C>T (p.Pro567Ser) single nucleotide variant not specified [RCV004500013] Chr10:70539221 [GRCh38]
Chr10:72298977 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2353A>G (p.Asn785Asp) single nucleotide variant not specified [RCV004500018] Chr10:70564454 [GRCh38]
Chr10:72324210 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.257C>T (p.Ser86Leu) single nucleotide variant not specified [RCV004500023] Chr10:70529300 [GRCh38]
Chr10:72289056 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1034C>A (p.Thr345Lys) single nucleotide variant not specified [RCV004500005] Chr10:70534436 [GRCh38]
Chr10:72294192 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1088G>T (p.Arg363Leu) single nucleotide variant not specified [RCV004500007] Chr10:70534490 [GRCh38]
Chr10:72294246 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2356G>A (p.Ala786Thr) single nucleotide variant not specified [RCV004500019] Chr10:70564457 [GRCh38]
Chr10:72324213 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.436G>A (p.Val146Ile) single nucleotide variant not specified [RCV004500024] Chr10:70530036 [GRCh38]
Chr10:72289792 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.706C>A (p.Pro236Thr) single nucleotide variant not specified [RCV004500025] Chr10:70532693 [GRCh38]
Chr10:72292449 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1427G>C (p.Arg476Thr) single nucleotide variant not specified [RCV004500011] Chr10:70538383 [GRCh38]
Chr10:72298139 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1504G>A (p.Asp502Asn) single nucleotide variant not specified [RCV004500012] Chr10:70538943 [GRCh38]
Chr10:72298699 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1776G>T (p.Lys592Asn) single nucleotide variant not specified [RCV004500016] Chr10:70539630 [GRCh38]
Chr10:72299386 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.2491C>G (p.Gln831Glu) single nucleotide variant not specified [RCV004500021] Chr10:70566653 [GRCh38]
Chr10:72326409 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1139C>A (p.Thr380Asn) single nucleotide variant not specified [RCV004500008] Chr10:70534755 [GRCh38]
Chr10:72294511 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1367C>T (p.Ala456Val) single nucleotide variant not specified [RCV004500010] Chr10:70538323 [GRCh38]
Chr10:72298079 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.1735G>A (p.Ala579Thr) single nucleotide variant not specified [RCV004500014] Chr10:70539589 [GRCh38]
Chr10:72299345 [GRCh37]
Chr10:10q22.1		 likely benign
NM_014431.3(PALD1):c.719C>T (p.Ala240Val) single nucleotide variant not specified [RCV004500026] Chr10:70532706 [GRCh38]
Chr10:72292462 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.946G>A (p.Val316Met) single nucleotide variant not specified [RCV004500028] Chr10:70533997 [GRCh38]
Chr10:72293753 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_014431.3(PALD1):c.860G>C (p.Ser287Thr) single nucleotide variant not specified [RCV004340062] Chr10:70533060 [GRCh38]
Chr10:72292816 [GRCh37]
Chr10:10q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:975
Count of miRNA genes:645
Interacting mature miRNAs:733
Transcripts:ENST00000263563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SGC30714  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,318,553 - 72,318,688UniSTSGRCh37
GRCh371161,718,367 - 161,718,502UniSTSGRCh37
Build 361159,984,991 - 159,985,126RGDNCBI36
Celera1065,600,314 - 65,600,449UniSTS
Celera1134,821,795 - 134,821,930RGD
Cytogenetic Map1q21-q22UniSTS
Cytogenetic Map10q22.1UniSTS
HuRef1066,312,079 - 66,312,214UniSTS
HuRef1132,962,922 - 132,963,057UniSTS
GeneMap99-GB4 RH Map1592.58UniSTS
Whitehead-RH Map1733.6UniSTS
D10S292  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,315,876 - 72,316,019UniSTSGRCh37
Build 361071,985,882 - 71,986,025RGDNCBI36
Celera1065,597,620 - 65,597,763RGD
Cytogenetic Map10q22.1UniSTS
HuRef1066,309,384 - 66,309,527UniSTS
SHGC-153524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,298,372 - 72,298,701UniSTSGRCh37
Build 361071,968,378 - 71,968,707RGDNCBI36
Celera1065,580,111 - 65,580,440RGD
Cytogenetic Map10q22.1UniSTS
HuRef1066,292,069 - 66,292,398UniSTS
TNG Radiation Hybrid Map1032907.0UniSTS
SHGC-154231  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,272,038 - 72,272,380UniSTSGRCh37
Build 361071,942,044 - 71,942,386RGDNCBI36
Celera1065,553,151 - 65,553,493RGD
Cytogenetic Map10q22.1UniSTS
HuRef1066,265,860 - 66,266,202UniSTS
TNG Radiation Hybrid Map1032897.0UniSTS
PALD__5817  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,327,522 - 72,328,205UniSTSGRCh37
Build 361071,997,528 - 71,998,211RGDNCBI36
Celera1065,609,285 - 65,609,971RGD
HuRef1066,321,050 - 66,321,732UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1679 959 780 19 868 15 1830 826 2051 135 736 1290 6 481 1210 1
Low 740 1378 897 561 330 404 2476 1357 1655 256 697 265 164 1 723 1577 3 1
Below cutoff 11 647 41 39 705 41 24 10 22 10 15 39 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_014431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_945675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN335744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263563   ⟹   ENSP00000263563
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,767 - 70,568,450 (+)Ensembl
RefSeq Acc Id: ENST00000697546
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,568,418 (+)Ensembl
RefSeq Acc Id: ENST00000697547   ⟹   ENSP00000513330
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,568,376 (+)Ensembl
RefSeq Acc Id: ENST00000697548   ⟹   ENSP00000513331
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,538,373 - 70,568,416 (+)Ensembl
RefSeq Acc Id: ENST00000697549
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,539,595 - 70,568,428 (+)Ensembl
RefSeq Acc Id: ENST00000697550
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,546,687 - 70,568,374 (+)Ensembl
RefSeq Acc Id: ENST00000697570   ⟹   ENSP00000513341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,568,376 (+)Ensembl
RefSeq Acc Id: ENST00000697571   ⟹   ENSP00000513342
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,668,710 (+)Ensembl
RefSeq Acc Id: ENST00000697572   ⟹   ENSP00000513343
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,668,740 (+)Ensembl
RefSeq Acc Id: ENST00000697573   ⟹   ENSP00000513344
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,668,740 (+)Ensembl
RefSeq Acc Id: ENST00000697574
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,538,172 - 70,568,378 (+)Ensembl
RefSeq Acc Id: ENST00000697575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,610,317 - 70,668,754 (+)Ensembl
RefSeq Acc Id: ENST00000697577
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,623,243 (+)Ensembl
RefSeq Acc Id: ENST00000697578
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1070,478,785 - 70,623,419 (+)Ensembl
RefSeq Acc Id: NM_014431   ⟹   NP_055246
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,767 - 70,568,450 (+)NCBI
GRCh371072,238,564 - 72,328,206 (+)RGD
Build 361071,908,570 - 71,998,211 (+)NCBI Archive
Celera1065,519,663 - 65,609,972 (+)RGD
HuRef1066,232,415 - 66,321,733 (+)RGD
CHM1_11072,520,781 - 72,610,384 (+)NCBI
T2T-CHM13v2.01071,348,188 - 71,438,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539637   ⟹   XP_011537939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,493,629 - 70,568,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539638   ⟹   XP_011537940
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,458,485 - 70,568,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017016072   ⟹   XP_016871561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,523,134 - 70,568,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047425055   ⟹   XP_047281011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,767 - 70,568,450 (+)NCBI
RefSeq Acc Id: XM_047425056   ⟹   XP_047281012
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,767 - 70,568,450 (+)NCBI
RefSeq Acc Id: XM_047425057   ⟹   XP_047281013
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,469,391 - 70,568,450 (+)NCBI
RefSeq Acc Id: XM_047425058   ⟹   XP_047281014
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,479,198 - 70,568,450 (+)NCBI
RefSeq Acc Id: XM_047425059   ⟹   XP_047281015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,767 - 70,551,762 (+)NCBI
RefSeq Acc Id: XM_047425060   ⟹   XP_047281016
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,493,629 - 70,551,762 (+)NCBI
RefSeq Acc Id: XM_054365545   ⟹   XP_054221520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,348,188 - 71,438,184 (+)NCBI
RefSeq Acc Id: XM_054365546   ⟹   XP_054221521
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,392,518 - 71,438,184 (+)NCBI
RefSeq Acc Id: XM_054365547   ⟹   XP_054221522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,361,155 - 71,438,184 (+)NCBI
RefSeq Acc Id: XM_054365548   ⟹   XP_054221523
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,348,188 - 71,438,184 (+)NCBI
RefSeq Acc Id: XM_054365549   ⟹   XP_054221524
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,327,903 - 71,438,184 (+)NCBI
RefSeq Acc Id: XM_054365550   ⟹   XP_054221525
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,338,815 - 71,438,184 (+)NCBI
RefSeq Acc Id: XR_008488196
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,348,188 - 71,434,183 (+)NCBI
RefSeq Acc Id: XR_008488197
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,361,154 - 71,434,183 (+)NCBI
RefSeq Acc Id: XR_008488198
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01071,348,188 - 71,408,359 (+)NCBI
RefSeq Acc Id: XR_945675
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,767 - 70,538,981 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_055246 (Get FASTA)   NCBI Sequence Viewer  
  XP_011537939 (Get FASTA)   NCBI Sequence Viewer  
  XP_011537940 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871561 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281011 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281012 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281013 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281014 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281015 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281016 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221520 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221521 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221522 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221523 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221524 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221525 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI36376 (Get FASTA)   NCBI Sequence Viewer  
  AAI36377 (Get FASTA)   NCBI Sequence Viewer  
  BAA86588 (Get FASTA)   NCBI Sequence Viewer  
  EAW54404 (Get FASTA)   NCBI Sequence Viewer  
  EAW54405 (Get FASTA)   NCBI Sequence Viewer  
  EAW54406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000263563
  ENSP00000263563.5
  ENSP00000513330
  ENSP00000513330.1
  ENSP00000513331.1
  ENSP00000513341.1
  ENSP00000513342.1
  ENSP00000513343.1
  ENSP00000513344.1
GenBank Protein Q9ULE6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_055246   ⟸   NM_014431
- UniProtKB: Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot),   Q9ULE6 (UniProtKB/Swiss-Prot),   A0A8V8TLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011537940   ⟸   XM_011539638
- Peptide Label: isoform X1
- UniProtKB: Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot),   Q9ULE6 (UniProtKB/Swiss-Prot),   A0A8V8TLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011537939   ⟸   XM_011539637
- Peptide Label: isoform X1
- UniProtKB: Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot),   Q9ULE6 (UniProtKB/Swiss-Prot),   A0A8V8TLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016871561   ⟸   XM_017016072
- Peptide Label: isoform X1
- UniProtKB: Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot),   Q9ULE6 (UniProtKB/Swiss-Prot),   A0A8V8TLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000263563   ⟸   ENST00000263563
RefSeq Acc Id: XP_047281013   ⟸   XM_047425057
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047281011   ⟸   XM_047425055
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047281012   ⟸   XM_047425056
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047281015   ⟸   XM_047425059
- Peptide Label: isoform X2
- UniProtKB: A0A8V8TL18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281014   ⟸   XM_047425058
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047281016   ⟸   XM_047425060
- Peptide Label: isoform X2
- UniProtKB: A0A8V8TL18 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000513341   ⟸   ENST00000697570
RefSeq Acc Id: ENSP00000513331   ⟸   ENST00000697548
RefSeq Acc Id: ENSP00000513343   ⟸   ENST00000697572
RefSeq Acc Id: ENSP00000513344   ⟸   ENST00000697573
RefSeq Acc Id: ENSP00000513330   ⟸   ENST00000697547
RefSeq Acc Id: ENSP00000513342   ⟸   ENST00000697571
RefSeq Acc Id: XP_054221524   ⟸   XM_054365549
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054221525   ⟸   XM_054365550
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054221520   ⟸   XM_054365545
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054221523   ⟸   XM_054365548
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054221522   ⟸   XM_054365547
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054221521   ⟸   XM_054365546
- Peptide Label: isoform X1
- UniProtKB: Q9ULE6 (UniProtKB/Swiss-Prot),   Q5JTK7 (UniProtKB/Swiss-Prot),   B9EGC6 (UniProtKB/Swiss-Prot),   B2RMS1 (UniProtKB/Swiss-Prot),   Q5JTK8 (UniProtKB/Swiss-Prot)
Protein Domains
Protein-tyrosine phosphatase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ULE6-F1-model_v2 AlphaFold Q9ULE6 1-856 view protein structure

Promoters
RGD ID:7217767
Promoter ID:EPDNEW_H14629
Type:initiation region
Name:PALD1_1
Description:phosphatase domain containing, paladin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381070,478,803 - 70,478,863EPDNEW
RGD ID:6787828
Promoter ID:HG_KWN:9923
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014431,   OTTHUMT00000048515
Position:
Human AssemblyChrPosition (strand)Source
Build 361071,907,611 - 71,908,777 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23530 AgrOrtholog
COSMIC PALD1 COSMIC
Ensembl Genes ENSG00000107719 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000263563 ENTREZGENE
  ENST00000263563.7 UniProtKB/Swiss-Prot
  ENST00000697547 ENTREZGENE
  ENST00000697547.1 UniProtKB/TrEMBL
  ENST00000697548.1 UniProtKB/TrEMBL
  ENST00000697570.1 UniProtKB/TrEMBL
  ENST00000697571.1 UniProtKB/TrEMBL
  ENST00000697572.1 UniProtKB/TrEMBL
  ENST00000697573.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000107719 GTEx
HGNC ID HGNC:23530 ENTREZGENE
Human Proteome Map PALD1 Human Proteome Map
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27143 UniProtKB/Swiss-Prot
NCBI Gene 27143 ENTREZGENE
OMIM 614656 OMIM
PANTHER PALADIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTPlike_phytase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134986569 PharmGKB
SMART PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPlike_phytase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8V8TL18 ENTREZGENE, UniProtKB/TrEMBL
  A0A8V8TL27_HUMAN UniProtKB/TrEMBL
  A0A8V8TL39_HUMAN UniProtKB/TrEMBL
  A0A8V8TL47_HUMAN UniProtKB/TrEMBL
  A0A8V8TLG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8V8TMP9_HUMAN UniProtKB/TrEMBL
  B2RMS1 ENTREZGENE
  B9EGC6 ENTREZGENE
  PALD_HUMAN UniProtKB/Swiss-Prot
  Q5JTK7 ENTREZGENE
  Q5JTK8 ENTREZGENE
  Q9ULE6 ENTREZGENE
UniProt Secondary B2RMS1 UniProtKB/Swiss-Prot
  B9EGC6 UniProtKB/Swiss-Prot
  Q5JTK7 UniProtKB/Swiss-Prot
  Q5JTK8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-02 PALD1  phosphatase domain containing paladin 1    phosphatase domain containing, paladin 1  Symbol and/or name change 5135510 APPROVED
2012-07-24 PALD1  phosphatase domain containing, paladin 1  KIAA1274  KIAA1274  Symbol and/or name change 5135510 APPROVED