Thap2 (THAP domain containing 2) - Rat Genome Database

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Gene: Thap2 (THAP domain containing 2) Rattus norvegicus
Analyze
Symbol: Thap2
Name: THAP domain containing 2
RGD ID: 1593643
Description: Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be active in nucleus. Orthologous to human THAP2 (THAP domain containing 2); INTERACTS WITH amphetamine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC688019; similar to THAP domain containing, apoptosis associated protein 2; THAP domain containing, apoptosis associated protein 2; THAP domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,879,011 - 52,893,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,879,011 - 52,891,932 (-)EnsemblGRCr8
mRatBN7.2750,992,912 - 51,007,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,995,793 - 51,008,061 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,899,683 - 52,914,352 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,102,766 - 55,117,437 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,880,756 - 54,895,421 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,350,744 - 58,365,812 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,359,646 - 58,374,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,644,248 - 54,655,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,784,948 - 47,800,212 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Thap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,879,011 - 52,893,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,879,011 - 52,891,932 (-)EnsemblGRCr8
mRatBN7.2750,992,912 - 51,007,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl750,995,793 - 51,008,061 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,899,683 - 52,914,352 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,102,766 - 55,117,437 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,880,756 - 54,895,421 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,350,744 - 58,365,812 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,359,646 - 58,374,231 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,644,248 - 54,655,301 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,784,948 - 47,800,212 (-)NCBICelera
Cytogenetic Map7q22NCBI
THAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,664,301 - 71,680,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,664,301 - 71,680,644 (+)Ensemblhg38GRCh38
GRCh371272,058,081 - 72,074,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,344,051 - 70,360,686 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1271,720,131 - 71,736,767 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1269,106,790 - 69,123,547 (+)NCBIHuRef
CHM1_11272,024,918 - 72,041,669 (+)NCBICHM1_1
T2T-CHM13v2.01271,641,810 - 71,658,153 (+)NCBIT2T-CHM13v2.0
Thap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,204,303 - 115,220,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,204,309 - 115,220,348 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810115,368,398 - 115,384,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,368,404 - 115,384,443 (-)Ensemblmm10GRCm38
MGSCv3710114,807,022 - 114,821,491 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610114,774,076 - 114,788,545 (-)NCBIMGSCv36mm8
Celera10117,299,363 - 117,313,938 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Thap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,647,989 - 11,665,110 (+)Ensembl
ChiLan1.0NW_00495540511,647,989 - 11,665,110 (+)NCBIChiLan1.0ChiLan1.0
THAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,692,855 - 79,709,563 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,689,334 - 79,707,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01269,187,221 - 69,204,095 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11272,046,980 - 72,063,734 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1272,046,980 - 72,063,734 (+)EnsemblpanPan2panpan1.1
THAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,216,886 - 13,231,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1013,155,478 - 13,170,350 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01013,351,032 - 13,365,909 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,351,264 - 13,363,007 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,214,624 - 13,229,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,462,189 - 13,477,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,585,921 - 13,600,811 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
THAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,671,280 - 35,687,288 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1535,671,280 - 35,687,298 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,373,033 - 38,388,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,279,973 - 67,296,919 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,280,586 - 67,296,919 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037178,357,736 - 178,374,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,085,638 - 26,097,815 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475026,086,472 - 26,098,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Thap2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11193,537,660 - 193,548,931 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thap2
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:74
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000005443
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH143299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,007,257 - 51,007,472 (+)MAPPERmRatBN7.2
Rnor_6.0758,365,131 - 58,365,345NCBIRnor6.0
Rnor_5.0758,374,033 - 58,374,247UniSTSRnor5.0
RGSC_v3.4754,655,119 - 54,655,333UniSTSRGSC3.4
Celera747,799,528 - 47,799,742UniSTS
RH 3.4 Map7477.51UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005443   ⟹   ENSRNOP00000005443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl758,354,582 - 58,365,313 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145657   ⟹   ENSRNOP00000099892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,879,011 - 52,891,932 (-)Ensembl
RefSeq Acc Id: NM_001394993   ⟹   NP_001381922
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8752,879,011 - 52,893,680 (-)NCBI
mRatBN7.2750,992,912 - 51,007,582 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001381922 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000099892.1
Ensembl Acc Id: ENSRNOP00000005443   ⟸   ENSRNOT00000005443
RefSeq Acc Id: NP_001381922   ⟸   NM_001394993
- UniProtKB: A0A8I6B4Y1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099892   ⟸   ENSRNOT00000145657

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAX9-F1-model_v2 AlphaFold D3ZAX9 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695202
Promoter ID:EPDNEW_R5724
Type:single initiation site
Name:Thap2_1
Description:THAP domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0758,365,377 - 58,365,437EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593643 AgrOrtholog
Ensembl Genes ENSRNOG00000003993 Ensembl
  ENSRNOG00000066749 Ensembl
  ENSRNOG00000080951 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000145657.1 UniProtKB/TrEMBL
NCBI Gene 688019 ENTREZGENE
PhenoGen Thap2 PhenoGen
RatGTEx ENSRNOG00000003993 RatGTEx
  ENSRNOG00000066749 RatGTEx
  ENSRNOG00000080951 RatGTEx
UniProt A0A8I6B4Y1 ENTREZGENE
  A0ABK0KY80_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Thap2  THAP domain containing 2  Thap2  THAP domain containing, apoptosis associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-02 Thap2  THAP domain containing, apoptosis associated protein 2  LOC688019  similar to THAP domain containing, apoptosis associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688019  similar to THAP domain containing, apoptosis associated protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL