Ptx3 (pentraxin 3) - Rat Genome Database

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Gene: Ptx3 (pentraxin 3) Rattus norvegicus
Analyze
Symbol: Ptx3
Name: pentraxin 3
RGD ID: 1593476
Description: Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; complement component C1q complex binding activity; and virion binding activity. Predicted to be involved in host-mediated suppression of symbiont invasion; host-mediated suppression of viral proces; and negative regulation of glycoprotein metabolic process. Predicted to act upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC689388; pentraxin 3, long; pentraxin related; pentraxin related gene; pentraxin-related protein PTX3; similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,797,563 - 152,803,372 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2152,781,955 - 152,803,372 (+)EnsemblGRCr8
mRatBN7.22150,487,513 - 150,493,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2157,593,206 - 157,599,014 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,643,731 - 155,649,539 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02150,276,449 - 150,282,257 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02158,097,843 - 158,103,653 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)Ensemblrn6Rnor6.0
Rnor_5.02177,457,263 - 177,463,073 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42156,089,917 - 156,095,726 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2144,894,946 - 144,900,755 (+)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
(S)-nicotine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-naphthylamine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenamidone  (ISO)
fentanyl  (EXP)
fluoranthene  (ISO)
fonofos  (ISO)
furan  (EXP)
gardiquimod  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrates  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
terbufos  (ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
tricetin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Source of Circulating Pentraxin 3 in Septic Shock Patients. Albert Vega C, etal., Front Immunol. 2019 Jan 4;9:3048. doi: 10.3389/fimmu.2018.03048. eCollection 2018.
2. Genetic variation in PTX3 and plasma levels associated with hepatocellular carcinoma in patients with HCV. Carmo RF, etal., J Viral Hepat. 2016 Feb;23(2):116-22. doi: 10.1111/jvh.12472. Epub 2015 Sep 24.
3. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
4. PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients. Chiarini M, etal., Genes Immun. 2010 Dec;11(8):665-70. doi: 10.1038/gene.2010.41. Epub 2010 Oct 7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study. Hansen MB, etal., Crit Care. 2016 Feb 15;20:40. doi: 10.1186/s13054-016-1210-z.
7. Pentraxin 3 Gene Polymorphisms and Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Patients. He Q, etal., Clin Infect Dis. 2018 Jan 6;66(2):261-267. doi: 10.1093/cid/cix749.
8. Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients. Herrero-Sánchez MC, etal., Infect Immun. 2018 Nov 20;86(12). pii: IAI.00709-18. doi: 10.1128/IAI.00709-18. Print 2018 Dec.
9. Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis. Kabbani D, etal., J Heart Lung Transplant. 2017 Sep;36(9):973-979. doi: 10.1016/j.healun.2017.04.007. Epub 2017 Apr 19.
10. Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis. Li H, etal., Clin Microbiol Infect. 2019 Apr;25(4):504-510. doi: 10.1016/j.cmi.2018.06.015. Epub 2018 Jun 28.
11. Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection? Ozer Balin S, etal., Int Wound J. 2019 Jun;16(3):659-664. doi: 10.1111/iwj.13075. Epub 2019 Feb 15.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11483299   PMID:14726497   PMID:15060019   PMID:16020751   PMID:16936248   PMID:17675295   PMID:20363749   PMID:22966213   PMID:23544079   PMID:24006456   PMID:25510691   PMID:25786110  
PMID:26806786   PMID:26965847   PMID:29725602   PMID:38724075   PMID:39414396  


Genomics

Comparative Map Data
Ptx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,797,563 - 152,803,372 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2152,781,955 - 152,803,372 (+)EnsemblGRCr8
mRatBN7.22150,487,513 - 150,493,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2157,593,206 - 157,599,014 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,643,731 - 155,649,539 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02150,276,449 - 150,282,257 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02158,097,843 - 158,103,653 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)Ensemblrn6Rnor6.0
Rnor_5.02177,457,263 - 177,463,073 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42156,089,917 - 156,095,726 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2144,894,946 - 144,900,755 (+)NCBICelera
Cytogenetic Map2q31NCBI
PTX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383157,436,850 - 157,443,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3157,436,850 - 157,443,633 (+)Ensemblhg38GRCh38
GRCh373157,154,639 - 157,161,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363158,637,301 - 158,644,071 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343158,637,308 - 158,644,078NCBI
Celera3155,578,255 - 155,585,092 (+)NCBICelera
Cytogenetic Map3q25.32NCBI
HuRef3154,550,694 - 154,557,531 (+)NCBIHuRef
CHM1_13157,117,566 - 157,124,403 (+)NCBICHM1_1
T2T-CHM13v2.03160,211,418 - 160,218,201 (+)NCBIT2T-CHM13v2.0
Ptx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39366,127,308 - 66,133,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl366,127,331 - 66,133,226 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38366,219,887 - 66,225,806 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl366,219,910 - 66,225,805 (+)Ensemblmm10GRCm38
MGSCv37366,023,809 - 66,029,728 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36366,307,812 - 66,313,734 (+)NCBIMGSCv36mm8
Celera366,363,920 - 66,369,839 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.25NCBI
Ptx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554488,366,925 - 8,372,411 (+)Ensembl
ChiLan1.0NW_0049554488,366,795 - 8,373,010 (+)NCBIChiLan1.0ChiLan1.0
PTX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,347,564 - 155,354,440 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13155,347,508 - 155,359,171 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03154,485,470 - 154,492,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13162,537,440 - 162,544,263 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3162,537,577 - 162,543,652 (+)EnsemblpanPan2panpan1.1
PTX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12350,952,835 - 50,958,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2350,952,885 - 50,958,167 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2350,825,322 - 50,831,079 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02351,586,874 - 51,592,673 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2351,586,147 - 51,592,233 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12351,169,291 - 51,175,068 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02351,222,224 - 51,228,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02351,507,584 - 51,513,394 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560285,424,779 - 85,430,719 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365194,303,464 - 4,309,173 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365194,303,549 - 4,309,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1397,273,594 - 97,279,569 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11397,273,594 - 97,279,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213105,440,917 - 105,446,892 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11533,320,592 - 33,327,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1533,321,208 - 33,327,268 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660415,897,822 - 5,904,486 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473035,125,605 - 35,131,367 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473035,125,536 - 35,131,645 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptx3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1388,939,157 - 88,944,961 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptx3
46 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:64
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000016541
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
WI-7070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,492,709 - 150,493,058 (+)MAPPERmRatBN7.2
Rnor_6.02158,103,040 - 158,103,388NCBIRnor6.0
Rnor_5.02177,462,460 - 177,462,808UniSTSRnor5.0
RGSC_v3.42156,095,114 - 156,095,461UniSTSRGSC3.4
Celera2144,900,143 - 144,900,490UniSTS
Cytogenetic Map2q31UniSTS
BF387681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,487,923 - 150,488,105 (+)MAPPERmRatBN7.2
Rnor_6.02158,098,254 - 158,098,435NCBIRnor6.0
Rnor_5.02177,457,674 - 177,457,855UniSTSRnor5.0
RGSC_v3.42156,090,328 - 156,090,509UniSTSRGSC3.4
Celera2144,895,357 - 144,895,538UniSTS
RH 3.4 Map2981.0UniSTS
Cytogenetic Map2q31UniSTS
Ptx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82152,802,757 - 152,803,300 (+)Marker Load Pipeline
mRatBN7.22150,492,708 - 150,493,251 (+)MAPPERmRatBN7.2
Rnor_6.02158,103,039 - 158,103,581NCBIRnor6.0
Rnor_5.02177,462,459 - 177,463,001UniSTSRnor5.0
RGSC_v3.42156,095,113 - 156,095,654UniSTSRGSC3.4
Celera2144,900,142 - 144,900,683UniSTS
Cytogenetic Map2q31UniSTS
PMC304098P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,492,367 - 150,492,475 (+)MAPPERmRatBN7.2
Rnor_6.02158,102,698 - 158,102,805NCBIRnor6.0
Rnor_5.02177,462,118 - 177,462,225UniSTSRnor5.0
RGSC_v3.42156,094,772 - 156,094,879UniSTSRGSC3.4
Celera2144,899,801 - 144,899,908UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 64 133 76 75 48 20 48 6 260 117 11 111 72 92 27 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000016541   ⟹   ENSRNOP00000016541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2152,797,563 - 152,803,372 (+)Ensembl
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)Ensembl
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131571   ⟹   ENSRNOP00000108592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2152,782,064 - 152,803,372 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165877   ⟹   ENSRNOP00000109094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2152,781,955 - 152,803,372 (+)Ensembl
RefSeq Acc Id: NM_001109536   ⟹   NP_001103006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,797,563 - 152,803,372 (+)NCBI
mRatBN7.22150,487,513 - 150,493,323 (+)NCBI
Rnor_6.02158,097,843 - 158,103,653 (+)NCBI
Rnor_5.02177,457,263 - 177,463,073 (+)NCBI
RGSC_v3.42156,089,917 - 156,095,726 (+)RGD
Celera2144,894,946 - 144,900,755 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103006 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016541
  ENSRNOP00000016541.3
  ENSRNOP00000108592.1
  ENSRNOP00000109094.1
RefSeq Acc Id: NP_001103006   ⟸   NM_001109536
- Peptide Label: precursor
- UniProtKB: D3ZT94 (UniProtKB/TrEMBL),   A6J5K6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016541   ⟸   ENSRNOT00000016541
Ensembl Acc Id: ENSRNOP00000109094   ⟸   ENSRNOT00000165877
Ensembl Acc Id: ENSRNOP00000108592   ⟸   ENSRNOT00000131571
Protein Domains
LamG-like jellyroll fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT94-F1-model_v2 AlphaFold D3ZT94 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691362
Promoter ID:EPDNEW_R1887
Type:multiple initiation site
Name:Ptx3_1
Description:pentraxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02158,097,922 - 158,097,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593476 AgrOrtholog
BioCyc Gene G2FUF-52877 BioCyc
Ensembl Genes ENSRNOG00000012280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016541 ENTREZGENE
  ENSRNOT00000016541.6 UniProtKB/TrEMBL
  ENSRNOT00000131571.1 UniProtKB/TrEMBL
  ENSRNOT00000165877.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  Pentaxin UniProtKB/TrEMBL
  Pentaxin_CS UniProtKB/TrEMBL
  PTX3 UniProtKB/TrEMBL
KEGG Report rno:689388 UniProtKB/TrEMBL
NCBI Gene 689388 ENTREZGENE
PANTHER PENTRAXIN-RELATED PROTEIN PTX3 UniProtKB/TrEMBL
  PTHR46943 UniProtKB/TrEMBL
Pfam Pentaxin UniProtKB/TrEMBL
PhenoGen Ptx3 PhenoGen
PRINTS PENTAXIN UniProtKB/TrEMBL
PROSITE PENTAXIN UniProtKB/TrEMBL
  PTX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012280 RatGTEx
SMART LamGL UniProtKB/TrEMBL
  PTX UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
UniProt A0ABK0LXB5_RAT UniProtKB/TrEMBL
  A6J5K6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT94 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Ptx3  pentraxin 3  Ptx3  pentraxin 3, long  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-13 Ptx3  pentraxin 3, long  Ptx3  pentraxin related gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Ptx3  pentraxin related gene  Ptx3_mapped  pentraxin related gene (mapped)  Data merged from RGD:3456 1643240 APPROVED
2008-03-06 Ptx3  pentraxin related gene  LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  LOC682447  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  Data merged from RGD:1583445 1643240 APPROVED
2006-11-20 LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682447  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ptx3_mapped  pentraxin related gene (mapped)  Ptx3  pentraxin related gene  Symbol and Name updated 1556543 APPROVED
2002-06-10 Ptx3  pentaxin related gene      Symbol and Name status set to approved 70586 APPROVED