Mansc1 (MANSC domain containing 1) - Rat Genome Database

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Gene: Mansc1 (MANSC domain containing 1) Rattus norvegicus
Analyze
Symbol: Mansc1
Name: MANSC domain containing 1
RGD ID: 1593458
Description: Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human MANSC1 (MANSC domain containing 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cobalt dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690615; LOC690606; LOC690615; MANSC domain-containing protein 1; similar to MANSC domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,170,164 - 169,190,379 (-)NCBIGRCr8
mRatBN7.24167,438,817 - 167,459,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,439,071 - 167,479,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4173,733,052 - 173,745,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,516,132 - 169,528,330 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,141,773 - 168,154,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,363,192 - 168,382,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,363,190 - 168,382,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,645,332 - 232,664,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,511,259 - 171,531,129 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4156,039,204 - 156,051,395 (-)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mansc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,170,164 - 169,190,379 (-)NCBIGRCr8
mRatBN7.24167,438,817 - 167,459,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,439,071 - 167,479,606 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4173,733,052 - 173,745,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,516,132 - 169,528,330 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,141,773 - 168,154,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,363,192 - 168,382,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,363,190 - 168,382,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,645,332 - 232,664,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,511,259 - 171,531,129 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4156,039,204 - 156,051,395 (-)NCBICelera
Cytogenetic Map4q43NCBI
MANSC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,326,056 - 12,350,242 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,326,056 - 12,350,242 (-)EnsemblGRCh38hg38GRCh38
GRCh371212,478,990 - 12,503,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,373,485 - 12,394,436 (-)NCBINCBI36Build 36hg18NCBI36
Build 341212,373,484 - 12,394,436NCBI
Celera1217,625,840 - 17,646,790 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1212,247,559 - 12,268,271 (-)NCBIHuRef
CHM1_11212,447,239 - 12,468,154 (-)NCBICHM1_1
T2T-CHM13v2.01212,195,172 - 12,219,375 (-)NCBIT2T-CHM13v2.0
Mansc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,586,170 - 134,609,451 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,586,170 - 134,609,451 (-)EnsemblGRCm39 Ensembl
GRCm386134,609,207 - 134,632,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,609,207 - 134,632,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv376134,559,225 - 134,582,506 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366134,574,903 - 134,598,181 (-)NCBIMGSCv36mm8
Celera6137,556,137 - 137,580,838 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.75NCBI
Mansc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,286,500 - 9,309,549 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,288,565 - 9,309,762 (-)NCBIChiLan1.0ChiLan1.0
MANSC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21017,796,149 - 17,823,085 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,792,908 - 17,819,844 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,349,595 - 12,380,014 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11212,721,729 - 12,742,354 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,717,556 - 12,742,488 (-)Ensemblpanpan1.1panPan2
MANSC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12733,943,529 - 33,961,779 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,944,078 - 33,961,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,484,062 - 12,501,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02734,250,910 - 34,269,149 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2734,250,973 - 34,269,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12734,143,220 - 34,161,470 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02734,093,307 - 34,111,603 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02712,215,720 - 12,233,954 (-)NCBIUU_Cfam_GSD_1.0
Mansc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494595,184,010 - 95,205,639 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365874,917,865 - 4,933,284 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365874,911,517 - 4,933,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MANSC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1560,082,414 - 60,098,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MANSC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,232,129 - 12,246,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,228,890 - 12,253,050 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606923,063,183 - 23,090,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mansc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475225,513,781 - 25,532,017 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475225,513,972 - 25,531,198 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mansc1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000029510
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 10 5 3
Low 3 39 42 32 13 32 2 5 73 25 33 8 2
Below cutoff 4 15 9 6 9 6 6 3 6

Sequence


RefSeq Acc Id: ENSRNOT00000029510   ⟹   ENSRNOP00000029997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4167,439,071 - 167,479,606 (-)Ensembl
Rnor_6.0 Ensembl4168,363,190 - 168,382,837 (-)Ensembl
RefSeq Acc Id: NM_001109603   ⟹   NP_001103073
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84169,170,164 - 169,189,864 (-)NCBI
mRatBN7.24167,438,817 - 167,458,519 (-)NCBI
Rnor_6.04168,363,335 - 168,375,316 (-)NCBI
Rnor_5.04232,645,332 - 232,664,663 (-)NCBI
RGSC_v3.44171,511,259 - 171,531,129 (-)RGD
Celera4156,039,204 - 156,051,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237538   ⟹   XP_006237600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84169,170,164 - 169,190,379 (-)NCBI
mRatBN7.24167,438,817 - 167,459,047 (-)NCBI
Rnor_6.04168,363,192 - 168,382,605 (-)NCBI
Rnor_5.04232,645,332 - 232,664,663 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001103073 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237600 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM01656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029997
  ENSRNOP00000029997.2
RefSeq Acc Id: NP_001103073   ⟸   NM_001109603
- Peptide Label: precursor
- UniProtKB: D4AE21 (UniProtKB/TrEMBL),   A6IMD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237600   ⟸   XM_006237538
- Peptide Label: isoform X1
- UniProtKB: D4AE21 (UniProtKB/TrEMBL),   A6IMD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029997   ⟸   ENSRNOT00000029510
Protein Domains
MANSC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE21-F1-model_v2 AlphaFold D4AE21 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693450
Promoter ID:EPDNEW_R3975
Type:multiple initiation site
Name:Mansc1_1
Description:MANSC domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04168,382,270 - 168,382,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593458 AgrOrtholog
BioCyc Gene G2FUF-42652 BioCyc
Ensembl Genes ENSRNOG00000028526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029510 ENTREZGENE
  ENSRNOT00000029510.5 UniProtKB/TrEMBL
InterPro MANSC UniProtKB/TrEMBL
  MANSC_N UniProtKB/TrEMBL
KEGG Report rno:690606 UniProtKB/TrEMBL
NCBI Gene 690606 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 UniProtKB/TrEMBL
  MANSC DOMAIN CONTAINING 1 UniProtKB/TrEMBL
Pfam MANEC UniProtKB/TrEMBL
PhenoGen Mansc1 PhenoGen
PROSITE MANSC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028526 RatGTEx
SMART MANEC UniProtKB/TrEMBL
UniProt A6IMD3 ENTREZGENE, UniProtKB/TrEMBL
  D4AE21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Mansc1  MANSC domain containing 1  LOC690615  hypothetical protein LOC690615  Data merged from RGD:1593451 737654 PROVISIONAL
2008-03-06 Mansc1  MANSC domain containing 1  LOC690606  similar to MANSC domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690615  hypothetical protein LOC690615  LOC684649  hypothetical protein LOC684649  Data merged from RGD:1587925 1643240 APPROVED
2008-01-09 LOC690606  similar to MANSC domain containing 1  LOC684645  similar to MANSC domain containing 1  Data merged from RGD:1587928 1643240 APPROVED
2006-11-20 LOC690606  similar to MANSC domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC690615  hypothetical protein LOC690615      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684645  similar to MANSC domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684649  hypothetical protein LOC684649      Symbol and Name status set to provisional 70820 PROVISIONAL