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Gene: Oc90 (otoconin 90) Rattus norvegicus

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Symbol:

Oc90

Name:

otoconin 90

RGD ID:

1593441

Description:

Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in otolith mineralization; phosphatidylcholine metabolic process; and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular matrix. Orthologous to human OC90 (otoconin 90); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC690625; otoconin-90; otoconin-90-like; similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OC90 (otoconin 90)	RGD	RGD
Mus musculus (house mouse):	Oc90 (otoconin 90)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Oc90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OC90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OC90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Oc90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OC90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OC90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Oc90 (otoconin 90)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	OC90 (otoconin 90)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Oc90 (otoconin 90)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	oc90 (otoconin 90)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	oc90	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	99,524,975 - 99,558,386 (-)	NCBI		GRCr8
mRatBN7.2	7	97,635,890 - 97,669,303 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	97,635,890 - 97,669,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	99,389,432 - 99,422,935 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	101,591,090 - 101,624,593 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	101,510,430 - 101,543,933 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	106,615,859 - 106,697,089 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	106,619,326 - 106,653,567 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	106,389,398 - 106,417,375 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	103,230,625 - 103,264,151 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	94,190,792 - 94,224,290 (-)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Oc90	Rat	vestibular disease		ISO	OC90 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21269433

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Oc90	Rat	1,2-dichloroethane	increases expression	ISO	Oc90 (Mus musculus)	6480464	ethylene dichloride results in increased expression of OC90 mRNA	CTD	PMID:28960355
Oc90	Rat	2,2',5,5'-tetrachlorobiphenyl	increases expression	EXP		6480464	2 more ...	CTD	PMID:23829299
Oc90	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of OC90 mRNA	CTD	PMID:24780913
Oc90	Rat	acrylamide	increases expression	ISO	Oc90 (Mus musculus)	6480464	Acrylamide results in increased expression of OC90 mRNA	CTD	PMID:30807115
Oc90	Rat	aflatoxin B1	increases methylation	ISO	OC90 (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of OC90 gene	CTD	PMID:27153756
Oc90	Rat	aflatoxin B1	decreases methylation	ISO	OC90 (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of OC90 exon	CTD	PMID:30157460
Oc90	Rat	Aflatoxin B2 alpha	increases methylation	ISO	OC90 (Homo sapiens)	6480464	aflatoxin B2 results in increased methylation of OC90 intron	CTD	PMID:30157460
Oc90	Rat	benzo[a]pyrene	affects methylation	ISO	OC90 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of OC90 exon	CTD	PMID:27901495
Oc90	Rat	benzo[a]pyrene	decreases methylation	ISO	OC90 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of OC90 5' UTR and Benzo(a)pyrene results in decreased methylation of OC90 promoter	CTD	PMID:27901495
Oc90	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of OC90 mRNA	CTD	PMID:25181051
Oc90	Rat	cadmium atom	multiple interactions	ISO	OC90 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OC90 mRNA	CTD	PMID:35301059
Oc90	Rat	cadmium dichloride	multiple interactions	ISO	OC90 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OC90 mRNA	CTD	PMID:35301059
Oc90	Rat	chlorpyrifos	increases expression	ISO	Oc90 (Mus musculus)	6480464	Chlorpyrifos results in increased expression of OC90 mRNA	CTD	PMID:32715474
Oc90	Rat	paracetamol	affects expression	ISO	Oc90 (Mus musculus)	6480464	Acetaminophen affects the expression of OC90 mRNA	CTD	PMID:17562736

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Oc90	Rat	arachidonate secretion	involved_in	IEA	InterPro:IPR016090 and InterPro:IPR036444	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Oc90	Rat	lipid catabolic process	involved_in	IEA	InterPro:IPR001211	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Oc90	Rat	otolith mineralization	involved_in	ISO	Oc90 (Mus musculus)	1624291	PMID:21655225 and PMID:24748133	RGD	PMID:21655225 and PMID:24748133
Oc90	Rat	otolith mineralization	involved_in	IEA	UniProtKB:Q9Z0L3 and ensembl:ENSMUSP00000062865	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Oc90	Rat	phosphatidylcholine metabolic process	involved_in	IBA	MGI:1341796 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	phosphatidylglycerol metabolic process	involved_in	IBA	MGI:1341796 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	phospholipid metabolic process	involved_in	IEA	InterPro:IPR016090 and InterPro:IPR036444	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Oc90	Rat	extracellular matrix	is_active_in	IBA	MGI:1313269 and PANTHER:PTN000919207	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	extracellular matrix	located_in	IEA	UniProtKB:Q9Z0L3 and ensembl:ENSMUSP00000062865	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Oc90	Rat	extracellular matrix	located_in	ISO	Oc90 (Mus musculus)	1624291	PMID:9892667	RGD	PMID:9892667
Oc90	Rat	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Oc90	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Oc90	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Oc90	Rat	calcium ion binding	enables	ISO	Oc90 (Mus musculus)	1624291	PMID:21655225	RGD	PMID:21655225
Oc90	Rat	calcium ion binding	enables	IBA	MGI:1313269 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	calcium ion binding	enables	IEA	UniProtKB:Q9Z0L3 and ensembl:ENSMUSP00000062865	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Oc90	Rat	calcium ion binding	enables	IEA	InterPro:IPR001211	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Oc90	Rat	calcium-dependent phospholipase A2 activity	enables	IBA	MGI:1341796 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Oc90	Rat	phospholipase A2 activity	enables	IEA	InterPro:IPR001211 more ...	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Oc90	Rat	phospholipase A2 activity	enables	IEA	ARBA:ARBA00028544	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Oc90	Rat	phospholipid binding	enables	IBA	PANTHER:PTN000919171 and UniProtKB:P14555	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Oc90	Rat	protein binding	enables	ISO	Oc90 (Mus musculus)	1624291	UniProtKB:Q4ZJM7 more ...	RGD	PMID:20856818 and PMID:21655225
Oc90	Rat	structural molecule activity	enables	IEA	UniProtKB:Q9Z0L3 and ensembl:ENSMUSP00000062865	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Oc90	Rat	structural molecule activity	enables	ISO	Oc90 (Mus musculus)	1624291	PMID:12651873	RGD	PMID:12651873

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:9892667	PMID:12651873	PMID:15632090	PMID:21655225	PMID:24748133	PMID:34403090

Oc90
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	99,524,975 - 99,558,386 (-)	NCBI		GRCr8
mRatBN7.2	7	97,635,890 - 97,669,303 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	97,635,890 - 97,669,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	99,389,432 - 99,422,935 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	101,591,090 - 101,624,593 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	101,510,430 - 101,543,933 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	106,615,859 - 106,697,089 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	106,619,326 - 106,653,567 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	106,389,398 - 106,417,375 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	103,230,625 - 103,264,151 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	94,190,792 - 94,224,290 (-)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

OC90
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	132,024,216 - 132,059,382 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	132,024,216 - 132,059,382 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	133,036,463 - 133,071,629 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	133,105,910 - 133,131,298 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	129,212,212 - 129,247,331 (-)	NCBI		Celera
Cytogenetic Map	8	q24.22	NCBI
HuRef	8	128,354,049 - 128,389,180 (-)	NCBI		HuRef
CHM1_1	8	133,076,804 - 133,112,437 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	133,147,149 - 133,182,286 (-)	NCBI		T2T-CHM13v2.0

Oc90
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	65,747,899 - 65,784,260 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	65,747,902 - 65,784,246 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	65,876,050 - 65,912,411 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	65,876,053 - 65,912,397 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	65,707,619 - 65,740,615 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	65,705,730 - 65,738,726 (-)	NCBI		MGSCv36	mm8
Celera	15	67,383,723 - 67,416,687 (-)	NCBI		Celera
Cytogenetic Map	15	D1	NCBI
cM Map	15	29.16	NCBI

Oc90
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955461	6,697,936 - 6,723,172 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955461	6,697,930 - 6,729,764 (-)	NCBI	ChiLan1.0	ChiLan1.0

OC90
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	149,406,762 - 149,442,651 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	124,921,364 - 124,957,250 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	128,672,427 - 128,708,307 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	131,650,395 - 131,685,172 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

OC90
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	28,680,910 - 28,700,816 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	28,653,732 - 28,681,822 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	29,035,487 - 29,060,155 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	13	28,762,634 - 28,790,706 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	28,862,287 - 28,886,939 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	29,174,271 - 29,198,930 (-)	NCBI		UU_Cfam_GSD_1.0

Oc90
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	9,642,906 - 9,673,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	17,072,435 - 17,099,118 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	17,072,435 - 17,099,520 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OC90
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	9,018,994 - 9,053,372 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	9,028,483 - 9,054,503 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	9,060,872 - 9,089,157 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OC90
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	126,468,666 - 126,500,293 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	126,469,272 - 126,499,919 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	13,604,150 - 13,639,411 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oc90
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	23,825,939 - 23,855,799 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	23,829,050 - 23,856,026 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Oc90
154 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	174
Count of miRNA genes:	131
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000042522
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
10450828	Scl79	Serum cholesterol level QTL 79	3.5	0.001	blood HDL cholesterol amount (VT:0000184)	blood low density lipoprotein cholesterol level (CMO:0000053)	7	89867376	101773158	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	93595647	106839474	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	80221299	109401111	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	7	13	45	26	26	3	18	3	1	63	47	32	4	20	23


RefSeq Transcripts	NM_001134765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042522 ⟹ ENSRNOP00000046821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	97,635,890 - 97,669,416 (-)	Ensembl
Rnor_6.0 Ensembl	7	106,619,326 - 106,653,567 (-)	Ensembl

RefSeq Acc Id:

NM_001134765 ⟹ NP_001128237

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	99,524,975 - 99,558,386 (-)	NCBI
mRatBN7.2	7	97,635,890 - 97,669,303 (-)	NCBI
Rnor_6.0	7	106,619,326 - 106,653,567 (-)	NCBI
Rnor_5.0	7	106,389,398 - 106,417,375 (-)	NCBI
RGSC_v3.4	7	103,230,625 - 103,264,151 (-)	RGD
Celera	7	94,190,792 - 94,224,290 (-)	RGD

Sequence:

show sequence

CACCTGCCAGAGTGCATGAAAAGCTCTGGATGTGAGTCAGGGAAGGTGCTCACATGACCAAGGGTCTTTGCCTGAGATATAAAAGAAGACCCTGTCCCCATTTACTCAAAGCCAAGCAACACTGGATC
ATCCAACAGCCTTTGAGTGGAGCTTCACTTCACAGAAGCTGCTCTAGCCTACGCCTACACCTTGTCCTCTGCATGGCAACAATGATTGTGCTGCTCATGGTCAGTATGCTGACGATCCCCTGTGTTGG
GGGCCATGCTCTGGACACACCAAATCCCCAGGAACTGCCTCCAGGATTGTCAAAAAATATCAATATCACTTTCTTCAACGGAGTGTTTAAAAACGTGGAAAGTGTGACCGAAATTTTTGACTGTCTAG
GCTCTCACTTCACCTGGCTGCAGGCTGTCTTCACCAACTTCCCTCTGCTGCTCCAGTTTGTAAACAGTATGAGGTGTGTGGCTGGCCTCTGTCCCCGGGACTTTGAAGACTATGGTTGTGCCTGCAGG
TTTGAGATGGAAGGGCTGCCTCTGGATGAGTCTGATAGCTGCTGCTTCCAGCATCGCAGGTGCTATGAGGAAGCTGTTGAGATGGACTGTCTCCAGGACCCTGCCAAGCTCAGTGCAGATGTGGATTG
CATCAGCAAACAGATCACATGTGAGTCCGAGGATCCCTGTGAGCGCCTTCTGTGTACCTGTGACAAGGCTGCCGTGGAATGCCTGGCTCAGTCTGGCATCAACTCTTCCCTGAATTTCCTGGATGCTT
CCTTCTGCCTGGTTCAGACTCCAGAGACAACTAGTGGGAAGGCTGTGACACCGCCGCCTAGAGGGGTTCCTGAAAAGCCCACAGACACCAGTCAGATAGCCCAGTCAGGAGAAGTGGCGGGTGAGAGA
AGAGCAGACACACTAACAACACTCTCCAGGACAAAATCTGTCCAAGATCTTCAAGATATACAAGCTTCTAGGACCACATCAAGTCCCGGATCTGCAGAGATTATTGCCATAGCTAAAGGTACAACCCA
TGGTTCTGCTGGCATTAAGTCAGTGAGGTTGGAAGTATCGTCTGTTGACAATAGTTCTCGGGAAACAACTGGAAAAGCCTGTGGCAGATTGGCCTTCCTGCATCTGGGTGATGGGGGCAGCATGAAGG
CCATGCTGCACCTTGGAGAGATGCTCTTCTGTCTAACATCCCACTGCCCAGAGGAATTTGAATCTTATGGCTGCTACTGTGGAAGAGAAGGAAGAGGAGTGCCAAGGGACACCCTTGATAGGTGCTGT
TTGTCCCATCACTGCTGTTTGGAGCAGATGAGACAGCTGGGCTGTCTCCATGGAAGGCATTCTCGGTCATCTGTGGTATGTGAACACCACACACCCAAATGTGTGGGGCAGAGCCTGTGTGAGAAGCT
ACTATGCGCCTGTGACCAGATGGCGGCTGAGTGCATGGCCTCTGCCTTCTTTAATCAAAGCCTCAAGTCACCTGACCAACCTGAGTGCCAAGGCGAGCCTGTGTCCTGTGAGGATGGCATGCTCGGGG
GAACCTTGGCCTCTTCTGTGGATTCCAGTTCTGAGGAGAATAGTGAGGAAGCTGCACCTCAGATGGAACCCCTAAGAAGCAGATTGCAGGAGAAGCCTTCTGGTCCCTTGGGGATCAGGACCCTTGGT
GGAAGATAAGATGCTACATGCTGTGCCAGTAGTTCTGAGCTGCCTGAGCTTTTTGGCCCTCAGTCCTCTGTCCATAAGAGCCTTAGCAGGATATCCAAGGGAGCAGGGACAGCCACCTCTTTACCCAT
AAGCCTCCTGAAACTTGTCAGCCTACAGACACGTGTGTCTGGAGACTGAATGCAGATGACAGCACTTCCCTTTTTCCTGTAGTTCGTTATGGAAGCTCAATAAATTCTCCATGCCATATG

hide sequence


Protein RefSeqs	NP_001128237	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16165	(Get FASTA)	NCBI Sequence Viewer
	EDM16166	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046821
	ENSRNOP00000046821.3

RefSeq Acc Id:	NP_001128237 ⟸ NM_001134765
- Peptide Label:	precursor
- UniProtKB:	A6HRQ7 (UniProtKB/TrEMBL), D3Z9Z1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTKGLCLRYKRRPCPHLLKAKQHWIIQQPLSGASLHRSCSSLRLHLVLCMATMIVLLMVSMLTIPCVGGHALDTPNPQELPPGLSKNINITFFNGVFKNVESVTEIFDCLGSHFTWLQAVFTNFPLLL QFVNSMRCVAGLCPRDFEDYGCACRFEMEGLPLDESDSCCFQHRRCYEEAVEMDCLQDPAKLSADVDCISKQITCESEDPCERLLCTCDKAAVECLAQSGINSSLNFLDASFCLVQTPETTSGKAVTP PPRGVPEKPTDTSQIAQSGEVAGERRADTLTTLSRTKSVQDLQDIQASRTTSSPGSAEIIAIAKGTTHGSAGIKSVRLEVSSVDNSSRETTGKACGRLAFLHLGDGGSMKAMLHLGEMLFCLTSHCPE EFESYGCYCGREGRGVPRDTLDRCCLSHHCCLEQMRQLGCLHGRHSRSSVVCEHHTPKCVGQSLCEKLLCACDQMAAECMASAFFNQSLKSPDQPECQGEPVSCEDGMLGGTLASSVDSSSEENSEEA APQMEPLRSRLQEKPSGPLGIRTLGGR hide sequence

Ensembl Acc Id:

ENSRNOP00000046821 ⟸ ENSRNOT00000042522

Protein Domains

Phospholipase A2

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z9Z1-F1-model_v2	AlphaFold	D3Z9Z1	1-539	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-33130	BioCyc
Ensembl Genes	ENSRNOG00000025516	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000042522	ENTREZGENE
	ENSRNOT00000042522.4	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/TrEMBL
InterPro	Otoconin-90	UniProtKB/TrEMBL
	PLipase_A2	UniProtKB/TrEMBL
	PLipase_A2_Asp_AS	UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/TrEMBL
KEGG Report	rno:690625	UniProtKB/TrEMBL
NCBI Gene	690625	ENTREZGENE
PANTHER	OTOCONIN-90	UniProtKB/TrEMBL
	PTHR11716	UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/TrEMBL
PhenoGen	Oc90	PhenoGen
PRINTS	PHPHLIPASEA2	UniProtKB/TrEMBL
PROSITE	PA2_ASP	UniProtKB/TrEMBL
	PA2_HIS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025516	RatGTEx
SMART	PA2c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/TrEMBL
UniProt	A6HRQ7	ENTREZGENE, UniProtKB/TrEMBL
	D3Z9Z1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-17	Oc90	otoconin 90	LOC684671	similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)	Data merged from RGD:1587903	1643240	APPROVED
2008-03-06	Oc90	otoconin 90	LOC690625	similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC690625	similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC684671	similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - CTD