Oc90 (otoconin 90) - Rat Genome Database

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Gene: Oc90 (otoconin 90) Rattus norvegicus
Analyze
Symbol: Oc90
Name: otoconin 90
RGD ID: 1593441
Description: Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in otolith mineralization; phosphatidylcholine metabolic process; and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human OC90 (otoconin 90); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690625; otoconin-90; otoconin-90-like; similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,524,975 - 99,558,386 (-)NCBIGRCr8
mRatBN7.2797,635,890 - 97,669,303 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx799,389,432 - 99,422,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,591,090 - 101,624,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,510,430 - 101,543,933 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,615,859 - 106,697,089 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07106,389,398 - 106,417,375 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,230,625 - 103,264,151 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera794,190,792 - 94,224,290 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9892667   PMID:12651873   PMID:15632090   PMID:21655225   PMID:24748133   PMID:34403090  


Genomics

Comparative Map Data
Oc90
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,524,975 - 99,558,386 (-)NCBIGRCr8
mRatBN7.2797,635,890 - 97,669,303 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx799,389,432 - 99,422,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,591,090 - 101,624,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,510,430 - 101,543,933 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,615,859 - 106,697,089 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07106,389,398 - 106,417,375 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,230,625 - 103,264,151 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera794,190,792 - 94,224,290 (-)NCBICelera
Cytogenetic Map7q33NCBI
OC90
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388132,024,216 - 132,059,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8132,024,216 - 132,059,382 (-)EnsemblGRCh38hg38GRCh38
GRCh378133,036,463 - 133,071,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,105,910 - 133,131,298 (-)NCBINCBI36Build 36hg18NCBI36
Celera8129,212,212 - 129,247,331 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8128,354,049 - 128,389,180 (-)NCBIHuRef
CHM1_18133,076,804 - 133,112,437 (-)NCBICHM1_1
T2T-CHM13v2.08133,147,149 - 133,182,286 (-)NCBIT2T-CHM13v2.0
Oc90
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391565,747,899 - 65,784,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1565,747,902 - 65,784,246 (-)EnsemblGRCm39 Ensembl
GRCm381565,876,050 - 65,912,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1565,876,053 - 65,912,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv371565,707,619 - 65,740,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361565,705,730 - 65,738,726 (-)NCBIMGSCv36mm8
Celera1567,383,723 - 67,416,687 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.16NCBI
Oc90
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554616,697,936 - 6,723,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554616,697,930 - 6,729,764 (-)NCBIChiLan1.0ChiLan1.0
OC90
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27149,406,762 - 149,442,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18124,921,364 - 124,957,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08128,672,427 - 128,708,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18131,650,395 - 131,685,172 (-)NCBIpanpan1.1PanPan1.1panPan2
OC90
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11328,680,910 - 28,700,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1328,653,732 - 28,681,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01329,035,487 - 29,060,155 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11328,762,634 - 28,790,706 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01328,862,287 - 28,886,939 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01329,174,271 - 29,198,930 (-)NCBIUU_Cfam_GSD_1.0
Oc90
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053039,642,906 - 9,673,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647017,072,435 - 17,099,118 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647017,072,435 - 17,099,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OC90
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl49,018,994 - 9,053,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.149,028,483 - 9,054,503 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.249,060,872 - 9,089,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OC90
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18126,468,666 - 126,500,293 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8126,469,272 - 126,499,919 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603913,604,150 - 13,639,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oc90
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473523,825,939 - 23,855,799 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473523,829,050 - 23,856,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Oc90
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:131
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000042522
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 7 13 45 26 26 3 18 3 1 63 47 32 4 20 23

Sequence


Ensembl Acc Id: ENSRNOT00000042522   ⟹   ENSRNOP00000046821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)Ensembl
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)Ensembl
RefSeq Acc Id: NM_001134765   ⟹   NP_001128237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,524,975 - 99,558,386 (-)NCBI
mRatBN7.2797,635,890 - 97,669,303 (-)NCBI
Rnor_6.07106,619,326 - 106,653,567 (-)NCBI
Rnor_5.07106,389,398 - 106,417,375 (-)NCBI
RGSC_v3.47103,230,625 - 103,264,151 (-)RGD
Celera794,190,792 - 94,224,290 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128237 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16165 (Get FASTA)   NCBI Sequence Viewer  
  EDM16166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046821.3
RefSeq Acc Id: NP_001128237   ⟸   NM_001134765
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000046821   ⟸   ENSRNOT00000042522
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9Z1-F1-model_v2 AlphaFold D3Z9Z1 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593441 AgrOrtholog
BioCyc Gene G2FUF-33130 BioCyc
Ensembl Genes ENSRNOG00000025516 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042522.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro Otoconin-90 UniProtKB/TrEMBL
  PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
KEGG Report rno:690625 UniProtKB/TrEMBL
NCBI Gene 690625 ENTREZGENE
PANTHER OTOCONIN-90 UniProtKB/TrEMBL
  PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PhenoGen Oc90 PhenoGen
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/TrEMBL
  PA2_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025516 RatGTEx
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A6HRQ7_RAT UniProtKB/TrEMBL
  D3Z9Z1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-17 Oc90  otoconin 90  LOC684671  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)  Data merged from RGD:1587903 1643240 APPROVED
2008-03-06 Oc90  otoconin 90  LOC690625  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690625  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684671  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)      Symbol and Name status set to provisional 70820 PROVISIONAL