Wars2 (tryptophanyl tRNA synthetase 2 (mitochondrial)) - Rat Genome Database

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Gene: Wars2 (tryptophanyl tRNA synthetase 2 (mitochondrial)) Rattus norvegicus
Analyze
Symbol: Wars2
Name: tryptophanyl tRNA synthetase 2 (mitochondrial)
RGD ID: 1593417
Description: Predicted to enable tryptophan-tRNA ligase activity. Involved in positive regulation of angiogenesis. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial); PARTICIPATES IN tryptophan metabolic pathway; aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690654; similar to mitochondrial tryptophanyl tRNA synthetase 2; tryptophan--tRNA ligase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR-Tg(EEF1A1-Wars2)Ipcv  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82189,150,322 - 189,233,606 (+)NCBIGRCr8
mRatBN7.22186,459,744 - 186,543,581 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,459,444 - 186,543,571 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2194,125,237 - 194,209,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,938,946 - 192,023,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,757,892 - 186,841,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02201,170,363 - 201,256,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2201,172,312 - 201,255,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02220,638,872 - 220,721,873 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,819,862 - 193,902,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,941,140 - 179,020,771 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Ratgenetic disease  ISOWARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
Wars2RatHajdu-Cheney syndrome  ISOWARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hajdu-Cheney syndromeClinVarPMID:28492532
Wars2RatMitochondrial Neurodevelopmental Disorder, with Abnormal Movements and Lactic Acidosis, with or without Seizures  ISOWARS2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Wars2RatNeurodevelopmental Disorders  ISOWARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 more ...
Wars2RatParkinsonism-Dystonia, Childhood-Onset, 3  ISOWARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinsonism-dystonia 3 and childhood-onsetClinVarPMID:25741868 more ...
Wars2RatPHGDH deficiency  ISOWARS2 (Homo sapiens)8554872ClinVar Annotator: match by term: PHGDH deficiencyClinVarPMID:14645240 more ...

1 to 20 of 54 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOWARS2 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WARS2 mRNACTDPMID:22079256
Wars2Rat(2,4,5-trichlorophenoxy)acetic acid increases expressionISOWars2 (Mus musculus)64804642 more ...CTDPMID:18579281
Wars2Rat1,2-dichloroethane decreases expressionISOWars2 (Mus musculus)6480464ethylene dichloride results in decreased expression of WARS2 mRNACTDPMID:28960355
Wars2Rat1,2-dimethylhydrazine decreases expressionISOWars2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of WARS2 mRNACTDPMID:22206623
Wars2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOWars2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of WARS2 mRNACTDPMID:21570461
Wars2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of WARS2 mRNACTDPMID:33387578
Wars2Rat3,4-methylenedioxymethamphetamine decreases expressionISOWars2 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of WARS2 mRNACTDPMID:26251327
Wars2Rat4,4'-sulfonyldiphenol decreases expressionISOWars2 (Mus musculus)6480464bisphenol S results in decreased expression of WARS2 mRNACTDPMID:39298647
Wars2Rat4,4'-sulfonyldiphenol affects expressionISOWARS2 (Homo sapiens)6480464bisphenol S affects the expression of WARS2 proteinCTDPMID:31945527
Wars2Rataflatoxin B1 decreases expressionISOWARS2 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of WARS2 mRNACTDPMID:22100608
Wars2Rataflatoxin B1 increases methylationISOWARS2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of WARS2 intronCTDPMID:30157460
Wars2RatAflatoxin B2 alpha increases methylationISOWARS2 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of WARS2 intronCTDPMID:30157460
Wars2Ratall-trans-retinoic acid decreases expressionISOWARS2 (Homo sapiens)6480464Tretinoin results in decreased expression of WARS2 mRNACTDPMID:33167477
Wars2Ratantirheumatic drug increases expressionISOWARS2 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of WARS2 mRNACTDPMID:24449571
Wars2Rataristolochic acid A decreases expressionISOWARS2 (Homo sapiens)6480464aristolochic acid I results in decreased expression of WARS2 mRNACTDPMID:33212167
Wars2Ratarsane increases methylationISOWARS2 (Homo sapiens)6480464Arsenic results in increased methylation of WARS2 promoterCTDPMID:21291286
Wars2Ratarsane affects methylationISOWARS2 (Homo sapiens)6480464Arsenic affects the methylation of WARS2 geneCTDPMID:25304211
Wars2Ratarsenic atom increases methylationISOWARS2 (Homo sapiens)6480464Arsenic results in increased methylation of WARS2 promoterCTDPMID:21291286
Wars2Ratarsenic atom affects methylationISOWARS2 (Homo sapiens)6480464Arsenic affects the methylation of WARS2 geneCTDPMID:25304211
Wars2Ratarsenite(3-) increases methylationISOWARS2 (Homo sapiens)6480464arsenite results in increased methylation of WARS2 promoterCTDPMID:23974009

1 to 20 of 54 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Ratmitochondrial tryptophanyl-tRNA aminoacylation involved_inIBAPANTHER:PTN000006470 and SGD:S0000026761600115GO_REF:0000033GO_CentralGO_REF:0000033
Wars2Ratpositive regulation of angiogenesis  IMP 127338472 RGD 
Wars2Rattranslation involved_inIEAUniProtKB-KW:KW-06481600115GO_REF:0000043UniProtGO_REF:0000043
Wars2RattRNA aminoacylation for protein translation involved_inIEAInterPro:IPR001412 and InterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2RattRNA aminoacylation for protein translation involved_inIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2Rattryptophanyl-tRNA aminoacylation involved_inIEAInterPro:IPR0023061600115GO_REF:0000002InterProGO_REF:0000002
Wars2Ratvasculogenesis acts_upstream_of_or_withinISOWars2 (Mus musculus)1624291 PMID:16639024RGDPMID:16639024
Wars2Ratvasculogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9CYK1 and ensembl:ENSMUSP000000043431600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Ratmitochondrial matrix located_inISOWARS2 (Homo sapiens)1624291 PMID:28236339RGDPMID:28236339
Wars2Ratmitochondrial matrix located_inIEAUniProtKB:Q9UGM6 and ensembl:ENSP000002355211600115GO_REF:0000107EnsemblGO_REF:0000107
Wars2Ratmitochondrial matrix is_active_inIBAPANTHER:PTN000006470 and UniProtKB:Q9UGM61600115GO_REF:0000033GO_CentralGO_REF:0000033
Wars2Ratmitochondrion located_inISOWARS2 (Homo sapiens)1624291 PMID:10828066RGDPMID:10828066
Wars2Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Wars2Ratmitochondrion is_active_inIBAPANTHER:PTN000006468 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wars2Ratmitochondrion located_inIEAUniProtKB:Q9UGM6 and ensembl:ENSP000002355211600115GO_REF:0000107EnsemblGO_REF:0000107
Wars2Ratmitochondrion located_inISOWARS2 (Homo sapiens) and UniProtKB:Q9UGM6-11624291 RGDGO_REF:0000052
Wars2Ratnucleoplasm located_inIEAUniProtKB:Q9UGM6 and ensembl:ENSP000002355211600115GO_REF:0000107EnsemblGO_REF:0000107
Wars2Ratnucleoplasm located_inISOWARS2 (Homo sapiens) and UniProtKB:Q9UGM6-11624291 RGDGO_REF:0000052
Wars2Ratplasma membrane located_inISOWARS2 (Homo sapiens) and UniProtKB:Q9UGM6-11624291 RGDGO_REF:0000052
Wars2Ratplasma membrane located_inIEAUniProtKB:Q9UGM6 and ensembl:ENSP000002355211600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 12 of 12 rows

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Rataminoacyl-tRNA ligase activity enablesIEAUniProtKB-KW:KW-00301600115GO_REF:0000043UniProtGO_REF:0000043
Wars2Rataminoacyl-tRNA ligase activity enablesIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2Rataminoacyl-tRNA ligase activity enablesIEAInterPro:IPR001412 and InterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Wars2RatATP binding enablesIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2RatATP binding enablesIEAInterPro:IPR001412 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Wars2Ratligase activity enablesIEAUniProtKB-KW:KW-04361600115GO_REF:0000043UniProtGO_REF:0000043
Wars2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Wars2Ratnucleotide binding enablesIEAInterPro:IPR0023051600115GO_REF:0000002InterProGO_REF:0000002
Wars2Ratnucleotide binding enablesIEAInterPro:IPR001412 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Wars2Rattryptophan-tRNA ligase activity enablesISOWARS2 (Homo sapiens)1624291 PMID:10828066RGDPMID:10828066
Wars2Rattryptophan-tRNA ligase activity enablesIEAInterPro:IPR002306 and InterPro:IPR0241091600115GO_REF:0000002InterProGO_REF:0000002
Wars2Rattryptophan-tRNA ligase activity enablesIEAEC:6.1.1.21600115GO_REF:0000003UniProtGO_REF:0000003
Wars2Rattryptophan-tRNA ligase activity enablesIEAUniProtKB:Q9UGM6 and ensembl:ENSP000002355211600115GO_REF:0000107EnsemblGO_REF:0000107
Wars2Rattryptophan-tRNA ligase activity enablesIBAPANTHER:PTN001600076 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wars2Rattryptophan-tRNA ligase activity enablesIEAInterPro:IPR0023061600115GO_REF:0000002InterProGO_REF:0000002
1 to 16 of 16 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Rattryptophan metabolic pathway  ISOWARS2 (Homo sapiens)10402751 SMPDBSMP:00063

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Rataminoacyl-tRNA biosynthetic pathway  IEA 6907045 KEGGrno:00970
Wars2Rattryptophan metabolic pathway  IEA 6907045 KEGGrno:00380

External Pathway Database Links

KEGG Pathway Tryptophan metabolism

BioCyc Pathways

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wars2Ratdecreased angiogenesis  IMP 127338472 RGD 
Wars2Ratdecreased coronary flow rate  IMP 127338472 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Wars2 is a determinant of angiogenesis. Wang M, etal., Nat Commun. 2016 Jul 8;7:12061. doi: 10.1038/ncomms12061.
PMID:14651853   PMID:16639024   PMID:18614015   PMID:28236339   PMID:29261326  



Wars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82189,150,322 - 189,233,606 (+)NCBIGRCr8
mRatBN7.22186,459,744 - 186,543,581 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,459,444 - 186,543,571 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2194,125,237 - 194,209,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,938,946 - 192,023,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,757,892 - 186,841,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02201,170,363 - 201,256,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2201,172,312 - 201,255,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02220,638,872 - 220,721,873 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,819,862 - 193,902,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,941,140 - 179,020,771 (+)NCBICelera
Cytogenetic Map2q34NCBI
WARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,031,216 - 119,140,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,031,216 - 119,140,654 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,573,839 - 119,683,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,375,362 - 119,484,818 (-)NCBINCBI36Build 36hg18NCBI36
Build 341119,285,882 - 119,395,329NCBI
Celera1117,804,670 - 117,914,139 (-)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,432,899 - 117,542,355 (-)NCBIHuRef
CHM1_11119,689,114 - 119,798,567 (-)NCBICHM1_1
T2T-CHM13v2.01119,044,400 - 119,154,015 (-)NCBIT2T-CHM13v2.0
Wars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39399,047,423 - 99,128,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl399,048,384 - 99,146,502 (+)EnsemblGRCm39 Ensembl
GRCm38399,140,107 - 99,221,230 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl399,141,068 - 99,239,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv37398,945,013 - 99,024,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36399,270,151 - 99,349,264 (+)NCBIMGSCv36mm8
MGSCv36399,350,466 - 99,429,579 (+)NCBIMGSCv36mm8
Cytogenetic Map3F2.2NCBI
cM Map343.03NCBI
Wars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543522,032,230 - 22,115,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543522,032,230 - 22,115,138 (-)NCBIChiLan1.0ChiLan1.0
WARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,654,951 - 111,765,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,257,544 - 111,369,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,405,595 - 83,515,718 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,402,385 - 118,511,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,402,385 - 118,516,099 (+)Ensemblpanpan1.1panPan2
WARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,229,175 - 56,322,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,229,769 - 56,322,638 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1755,877,127 - 55,971,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01757,100,900 - 57,195,725 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,100,941 - 57,195,693 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,136,854 - 56,231,602 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,169,008 - 56,263,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01756,758,810 - 56,853,584 (-)NCBIUU_Cfam_GSD_1.0
Wars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505810,526,304 - 10,598,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366273,890,629 - 3,962,899 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366273,890,629 - 3,963,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,787,583 - 101,883,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14101,787,585 - 101,881,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,920,791 - 111,924,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,614,902 - 14,726,630 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,615,349 - 14,726,780 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603817,270,507 - 17,393,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477214,654,403 - 14,735,315 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477214,652,874 - 14,735,732 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Wars2
367 total Variants

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:99
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000026458
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 64 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

1 to 10 of 64 rows
D2Got121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,483,461 - 186,483,643 (+)MAPPERmRatBN7.2
Rnor_6.02201,193,606 - 201,193,787NCBIRnor6.0
Rnor_5.02220,662,101 - 220,662,282UniSTSRnor5.0
RGSC_v3.42193,841,658 - 193,841,840RGDRGSC3.4
RGSC_v3.42193,841,659 - 193,841,840UniSTSRGSC3.4
RGSC_v3.12193,804,413 - 193,804,594RGD
Celera2178,962,824 - 178,963,005UniSTS
RH 3.4 Map21262.7UniSTS
RH 3.4 Map21262.7RGD
RH 2.0 Map2955.2RGD
Cytogenetic Map2q34UniSTS
RH132180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,459,945 - 186,460,125 (+)MAPPERmRatBN7.2
Rnor_6.02201,170,596 - 201,170,775NCBIRnor6.0
Rnor_5.02220,639,091 - 220,639,270UniSTSRnor5.0
RGSC_v3.42193,818,146 - 193,818,325UniSTSRGSC3.4
Celera2178,939,424 - 178,939,603UniSTS
RH 3.4 Map21261.8UniSTS
Cytogenetic Map2q34UniSTS
RH142606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,492,919 - 186,493,123 (+)MAPPERmRatBN7.2
Rnor_6.02201,203,064 - 201,203,267NCBIRnor6.0
Rnor_5.02220,671,559 - 220,671,762UniSTSRnor5.0
RGSC_v3.42193,851,117 - 193,851,320UniSTSRGSC3.4
Celera2178,972,282 - 178,972,485UniSTS
RH 3.4 Map21257.6UniSTS
Cytogenetic Map2q34UniSTS
AU048494  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22186,543,013 - 186,543,294 (+)MAPPERmRatBN7.2
Rnor_6.02201,255,555 - 201,255,835NCBIRnor6.0
Rnor_5.02220,721,313 - 220,721,593UniSTSRnor5.0
RGSC_v3.42193,902,273 - 193,902,553UniSTSRGSC3.4
Celera2179,020,623 - 179,020,903UniSTS
Cytogenetic Map2q34UniSTS


The following Strains have been annotated to Wars2




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000026458   ⟹   ENSRNOP00000026458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,461,663 - 186,543,571 (+)Ensembl
Rnor_6.0 Ensembl2201,172,312 - 201,255,703 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104876   ⟹   ENSRNOP00000097628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,461,663 - 186,543,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106687   ⟹   ENSRNOP00000085515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,459,444 - 186,541,892 (+)Ensembl
RefSeq Acc Id: NM_001168641   ⟹   NP_001162112
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82189,150,361 - 189,231,857 (+)NCBI
mRatBN7.22186,461,662 - 186,543,162 (+)NCBI
Rnor_6.02201,172,312 - 201,255,703 (+)NCBI
Rnor_5.02220,638,872 - 220,721,873 (+)NCBI
RGSC_v3.42193,819,862 - 193,902,421 (+)RGD
Celera2178,941,140 - 179,020,771 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233028   ⟹   XP_006233090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82189,150,322 - 189,233,606 (+)NCBI
mRatBN7.22186,459,744 - 186,543,581 (+)NCBI
Rnor_6.02201,170,363 - 201,256,115 (+)NCBI
Rnor_5.02220,638,872 - 220,721,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103162   ⟹   XP_038959090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82189,150,358 - 189,233,606 (+)NCBI
mRatBN7.22186,459,744 - 186,543,581 (+)NCBI
RefSeq Acc Id: XM_039103163   ⟹   XP_038959091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82189,150,322 - 189,224,216 (+)NCBI
mRatBN7.22186,459,744 - 186,535,509 (+)NCBI
RefSeq Acc Id: XM_063282590   ⟹   XP_063138660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82189,150,322 - 189,230,554 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001162112 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233090 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959090 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959091 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138660 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026458.5
  ENSRNOP00000085515.1
  ENSRNOP00000097628
  ENSRNOP00000097628.1
  ENSRNOP00000111540
1 to 10 of 10 rows
RefSeq Acc Id: NP_001162112   ⟸   NM_001168641
- UniProtKB: F1M8H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233090   ⟸   XM_006233028
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026458   ⟸   ENSRNOT00000026458
RefSeq Acc Id: XP_038959090   ⟸   XM_039103162
- Peptide Label: isoform X2
- UniProtKB: A6K3E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959091   ⟸   XM_039103163
- Peptide Label: isoform X3

Name Modeler Protein Id AA Range Protein Structure
AF-F1M8H2-F1-model_v2 AlphaFold F1M8H2 1-360 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691604
Promoter ID:EPDNEW_R2129
Type:multiple initiation site
Name:Wars2_1
Description:tryptophanyl tRNA synthetase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02201,172,313 - 201,172,373EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51894 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000019508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026458.7 UniProtKB/TrEMBL
  ENSRNOT00000104876 ENTREZGENE
  ENSRNOT00000104876.1 UniProtKB/TrEMBL
  ENSRNOT00000106687.1 UniProtKB/TrEMBL
  ENSRNOT00000126675 ENTREZGENE
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  Tyrosyl-Transfer RNA Synthetase UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ic UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  Trp-tRNA-synth UniProtKB/TrEMBL
  Trp-tRNA-synth_bac-type UniProtKB/TrEMBL
  Trp-tRNA_synthetase UniProtKB/TrEMBL
KEGG Report rno:690654 UniProtKB/TrEMBL
NCBI Gene 690654 ENTREZGENE
PANTHER TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
  TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam tRNA-synt_1b UniProtKB/TrEMBL
PhenoGen Wars2 PhenoGen
PRINTS TRNASYNTHTRP UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019508 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
UniProt A0A8I6A3I6_RAT UniProtKB/TrEMBL
  A0A8I6ANK9 ENTREZGENE, UniProtKB/TrEMBL
  A6K3E6 ENTREZGENE, UniProtKB/TrEMBL
  F1M8H2 ENTREZGENE, UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Wars2  tryptophanyl tRNA synthetase 2 (mitochondrial)  LOC690654  similar to mitochondrial tryptophanyl tRNA synthetase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690654  similar to mitochondrial tryptophanyl tRNA synthetase 2  LOC683246  similar to mitochondrial tryptophanyl tRNA synthetase 2  Data merged from RGD:1589237 1643240 APPROVED
2006-11-20 LOC690654  similar to mitochondrial tryptophanyl tRNA synthetase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683246  similar to mitochondrial tryptophanyl tRNA synthetase 2      Symbol and Name status set to provisional 70820 PROVISIONAL