Pebp4 (phosphatidylethanolamine binding protein 4) - Rat Genome Database

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Pathways
Gene: Pebp4 (phosphatidylethanolamine binding protein 4) Rattus norvegicus
Analyze
Symbol: Pebp4
Name: phosphatidylethanolamine binding protein 4
RGD ID: 1593295
Description: Orthologous to human PEBP4 (phosphatidylethanolamine binding protein 4); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07018326.1; LOC691997; phosphatidylethanolamine-binding protein 4; similar to PEBP family protein precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pebp4Tn(sb-T2/Bart3)2.299Mcwi
Genetic Models: F344-Pebp4Tn(sb-T2/Bart3)2.299Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,328,127 - 51,543,920 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1551,331,690 - 51,543,899 (+)EnsemblGRCr8
mRatBN7.21544,920,946 - 45,134,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)EnsemblmRatBN7.2
Rnor_6.01551,644,948 - 51,740,626 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01551,528,587 - 51,615,204 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,528,514 - 51,740,281 (+)NCBIrn6Rnor6.0
Rnor_5.01555,252,902 - 55,466,149 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41550,225,405 - 50,460,627 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1544,602,584 - 44,814,601 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:21873635   PMID:23533145  


Genomics

Comparative Map Data
Pebp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,328,127 - 51,543,920 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1551,331,690 - 51,543,899 (+)EnsemblGRCr8
mRatBN7.21544,920,946 - 45,134,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)EnsemblmRatBN7.2
Rnor_6.01551,644,948 - 51,740,626 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01551,528,587 - 51,615,204 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,528,514 - 51,740,281 (+)NCBIrn6Rnor6.0
Rnor_5.01555,252,902 - 55,466,149 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41550,225,405 - 50,460,627 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1544,602,584 - 44,814,601 (+)NCBICelera
Cytogenetic Map15p11NCBI
PEBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,713,251 - 22,941,077 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,713,237 - 23,000,000 (-)Ensemblhg38GRCh38
GRCh37822,570,764 - 22,798,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,626,710 - 22,841,366 (-)NCBIBuild 36Build 36hg18NCBI36
Celera821,533,122 - 21,747,804 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,113,907 - 21,329,903 (-)NCBIHuRef
CHM1_1822,773,101 - 22,987,671 (-)NCBICHM1_1
T2T-CHM13v2.0822,987,819 - 23,216,048 (-)NCBIT2T-CHM13v2.0
Pebp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,077,856 - 70,297,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,077,869 - 70,297,367 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381469,840,407 - 70,059,918 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,840,420 - 70,059,918 (+)Ensemblmm10GRCm38
MGSCv371470,240,227 - 70,459,693 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361468,575,487 - 68,794,959 (+)NCBIMGSCv36mm8
Celera1467,378,541 - 67,600,399 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
Pebp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,125,150 - 46,333,200 (-)Ensembl
ChiLan1.0NW_00495540346,126,263 - 46,317,830 (-)NCBIChiLan1.0ChiLan1.0
PEBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,218,356 - 41,505,203 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,945,744 - 17,232,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,963,297 - 22,250,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,902,616 - 19,117,229 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,902,734 - 19,117,025 (-)EnsemblpanPan2panpan1.1
PEBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,329,160 - 34,574,086 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,317,421 - 34,574,066 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2534,917,144 - 35,164,286 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02534,536,708 - 34,784,007 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,535,120 - 34,784,085 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12534,483,438 - 34,730,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,337,758 - 34,584,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02534,492,754 - 34,740,068 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pebp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494311,922,656 - 12,137,275 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365556,433,237 - 6,620,072 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365556,433,243 - 6,648,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,966,862 - 7,173,347 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1146,966,861 - 7,173,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,446,928 - 7,543,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2147,691,260 - 7,698,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PEBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,792,718 - 21,066,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,792,707 - 21,004,134 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605221,223,048 - 21,434,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pebp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475818,203,239 - 18,394,891 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pebp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11254,287,483 - 54,492,144 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pebp4
1831 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:131
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000039454
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
28.MMHAP16FRB10.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,054,716 - 45,054,885 (+)MAPPERmRatBN7.2
Rnor_6.01551,660,824 - 51,660,992NCBIRnor6.0
Rnor_5.01555,386,302 - 55,386,470UniSTSRnor5.0
RGSC_v3.41550,381,198 - 50,381,366UniSTSRGSC3.4
Celera1544,734,796 - 44,734,964UniSTS
Cytogenetic Map15p11UniSTS
D17S1860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,133,859 - 45,134,514 (+)MAPPERmRatBN7.2
Rnor_6.01551,739,958 - 51,740,612NCBIRnor6.0
Rnor_5.01555,465,805 - 55,466,459UniSTSRnor5.0
RGSC_v3.41550,460,302 - 50,460,956UniSTSRGSC3.4
Celera1544,813,933 - 44,814,587UniSTS
Cytogenetic Map15p11UniSTS


Genetic Models
This gene Pebp4 is modified in the following models/strains:


Expression

RNA-SEQ Expression

circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
sensory system
visual system
11 41 13 45 25 1 49 20 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000093193   ⟹   ENSRNOP00000095653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1551,331,690 - 51,543,899 (+)Ensembl
mRatBN7.2 Ensembl1544,921,886 - 45,134,191 (+)Ensembl
RefSeq Acc Id: XM_008770836   ⟹   XP_008769058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,920 (+)NCBI
mRatBN7.21544,920,954 - 45,134,188 (+)NCBI
Rnor_6.01551,644,948 - 51,740,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093942   ⟹   XP_038949870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,818 (+)NCBI
mRatBN7.21544,920,946 - 45,134,044 (+)NCBI
RefSeq Acc Id: XM_063274888   ⟹   XP_063130958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,328,127 - 51,543,920 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008769058 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949870 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130958 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02197 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095653
  ENSRNOP00000095653.1
RefSeq Acc Id: XP_008769058   ⟸   XM_008770836
- Peptide Label: isoform X1
- UniProtKB: A6HTI3 (UniProtKB/TrEMBL),   A0A8I6GL87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038949870   ⟸   XM_039093942
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GL87 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095653   ⟸   ENSRNOT00000093193
RefSeq Acc Id: XP_063130958   ⟸   XM_063274888
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593295 AgrOrtholog
BioCyc Gene G2FUF-13246 BioCyc
Ensembl Genes ENSRNOG00000026247 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093193 ENTREZGENE
  ENSRNOT00000093193.3 UniProtKB/TrEMBL
Gene3D-CATH 3.90.280.10 UniProtKB/TrEMBL
InterPro PEBP UniProtKB/TrEMBL
  PEBP-like_sf UniProtKB/TrEMBL
  PEBP_euk UniProtKB/TrEMBL
  Phosphatidylethanolamine-bd_CS UniProtKB/TrEMBL
NCBI Gene 691997 ENTREZGENE
PANTHER PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 UniProtKB/TrEMBL
  PTHR11362 UniProtKB/TrEMBL
Pfam PBP UniProtKB/TrEMBL
PhenoGen Pebp4 PhenoGen
PROSITE PBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026247 RatGTEx
Superfamily-SCOP SSF49777 UniProtKB/TrEMBL
UniProt A0A8I6GL87 ENTREZGENE, UniProtKB/TrEMBL
  A6HTI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Pebp4  phosphatidylethanolamine binding protein 4  AABR07018326.1    Data merged from RGD:15003630 737654 PROVISIONAL
2019-11-08 AABR07018326.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-12-02 Pebp4  phosphatidylethanolamine binding protein 4  Pebp4  phosphatidylethanolamine-binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Pebp4  phosphatidylethanolamine-binding protein 4  LOC691997  similar to PEBP family protein precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691997  similar to PEBP family protein precursor  LOC684210  similar to PEBP family protein precursor  Data merged from RGD:1592735 1643240 APPROVED
2006-11-20 LOC691997  similar to PEBP family protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684210  similar to PEBP family protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL